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  • Management of Hereditary Br... Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline
    Tung, Nadine M; Boughey, Judy C; Pierce, Lori J ... Journal of clinical oncology, 06/2020, Volume: 38, Issue: 18
    Journal Article
    Peer reviewed
    Open access

    To develop recommendations for management of patients with breast cancer (BC) with germline mutations in BC susceptibility genes. The American Society of Clinical Oncology, American Society for ...
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  • Molecular Alterations and E... Molecular Alterations and Everolimus Efficacy in Human Epidermal Growth Factor Receptor 2-Overexpressing Metastatic Breast Cancers: Combined Exploratory Biomarker Analysis From BOLERO-1 and BOLERO-3
    André, Fabrice; Hurvitz, Sara; Fasolo, Angelica ... Journal of clinical oncology, 06/2016, Volume: 34, Issue: 18
    Journal Article, Web Resource
    Peer reviewed

    Two recent phase III trials, BOLERO-1 and BOLERO-3 (Breast Cancer Trials of Oral Everolimus), evaluated the addition of everolimus to trastuzumab and chemotherapy in human epidermal growth factor ...
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  • Everolimus for women with t... Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial
    André, Fabrice, Prof; O'Regan, Ruth, Prof; Ozguroglu, Mustafa, Prof ... The lancet oncology, 05/2014, Volume: 15, Issue: 6
    Journal Article, Web Resource
    Peer reviewed

    Summary Background Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We ...
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Available for: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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  • Colorectal-Cancer Incidence... Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy
    Schoen, Robert E; Pinsky, Paul F; Weissfeld, Joel L ... The New England journal of medicine, 06/2012, Volume: 366, Issue: 25
    Journal Article
    Peer reviewed
    Open access

    After nearly 12 years of follow-up, the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial has shown that screening with flexible sigmoidoscopy reduces colorectal-cancer incidence by 21% ...
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  • Randomized Noninferiority T... Randomized Noninferiority Trial of Telephone Versus In-Person Genetic Counseling for Hereditary Breast and Ovarian Cancer
    SCHWARTZ, Marc D; VALDIMARSDOTTIR, Heiddis B; MCKINNON, Wendy ... Journal of clinical oncology, 03/2014, Volume: 32, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Although guidelines recommend in-person counseling before BRCA1/BRCA2 gene testing, genetic counseling is increasingly offered by telephone. As genomic testing becomes more common, evaluating ...
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  • Attenuation of RNA polymera... Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
    Zhang, Xiaowen; Chiang, Huai-Chin; Wang, Yao ... Nature communications, 06/2017, Volume: 8, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication ...
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  • Frailty and long-term morta... Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance)
    Mandelblatt, Jeanne S.; Cai, Ling; Luta, George ... Breast cancer research and treatment, 07/2017, Volume: 164, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Purpose Breast cancer patients aged 65+ (“older”) vary in frailty status. We tested whether a deficits accumulation frailty index predicted long-term mortality. Methods Older patients ( n  = 1280) ...
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  • Early Detection of Ovarian ... Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials
    Skates, Steven J; Greene, Mark H; Buys, Saundra S ... Clinical cancer research, 07/2017, Volume: 23, Issue: 14
    Journal Article
    Peer reviewed
    Open access

    Women at familial/genetic ovarian cancer risk often undergo screening despite unproven efficacy. Research suggests each woman has her own CA125 baseline; significant increases above this level may ...
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  • PLAC1 as a serum biomarker ... PLAC1 as a serum biomarker for breast cancer
    Yuan, Hongyan; Chen, Vincent; Boisvert, Marc ... PloS one, 02/2018, Volume: 13, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Placental-specific protein 1 (PLAC1) is an X-linked trophoblast gene that is re-expressed in several malignancies, including breast cancer, and is therefore a potential biomarker to follow disease ...
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