The development of luminescent metal-organic frameworks (MOFs) has attracted extensive attention due to their applications in photoelectric devices, organic light-emitting diodes (OLEDs), ...anti-counterfeiting, biological imaging and so on. In this work, a novel anthracene based metal-organic framework, Cd(DCPA)(DMF)·(H
2
O) (
1
) (H
2
DCPA = 9,10-di(
p
-carboxyphenyl)anthracene), has been successfully synthesized under solvothermal conditions. The highly ordered arrangement and special spatial conformation of the anthracene chromophore play a significant role in the photophysical properties of
1
. The combination of theoretical calculations and experiments shows that the molecular orbitals have good separation for inhibiting the recombination of electrons and holes. Furthermore, the fluorescence emission of
1
can be instantaneously and reversibly tuned between blue and green at different polarizing angles. Temperature-dependent fluorescence measurements indicate a good linear relationship between the maximum emission intensity/wavelength and the temperature for efficient thermochromism and luminescence thermometry. Photoelectric measurements reveal that
1
shows high performance of photocurrent generation under light illumination. Therefore, our research affords a new perspective to extend the application of luminescent MOFs in the fields of polarized emission, thermometry and photoelectronic response.
The packing mode/configuration and photophysical performance relationship of an anthracene based MOF was studied by theoretical calculations and experiments. The MOF shows efficient luminescent polarized emission, luminescence thermometry, and photoelectronic response.
The spikelet number per spike (SNS) contributes greatly to grain yield in wheat. Identifying various genes that control wheat SNS is vital for yield improvement. This study used a recombinant inbred ...line population genotyped by the Wheat55K single-nucleotide polymorphism array to identify two major and stably expressed quantitative trait loci (QTLs) for SNS. One of them (QSns.sau-2SY-2D.1) was reported previously, while the other (QSns.sau-2SY-7A) was newly detected and further analyzed in this study. QSns.sau-2SY-7A had a high LOD value ranging from 4.46 to 16.00 and explained 10.21–40.78％ of the phenotypic variances. QSns.sau-2SY-7A was flanked by the markers AX-110518554 and AX-110094527 in a 4.75-cM interval on chromosome arm 7AL. The contributions and interactions of both major QTLs were further analyzed and discussed. The effect of QSns.sau-2SY-7A was successfully validated by developing a tightly linked kompetitive allele specific PCR marker in an F2:3 population and a panel of 101 high-generation breeding wheat lines. Furthermore, several genes including the previously reported WHEAT ORTHOLOG OF APO1 (WAPO1), an ortholog of the rice gene ABERRANT PANICLE ORGANIZATION 1 (APO1) related to SNS, were predicted in the interval of QSns.sau-2SY-7A. In summary, these results revealed the genetic basis of the multi-spikelet genotype of wheat line 20828 and will facilitate subsequent fine mapping and breeding utilization of the major QTLs.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Advanced metastatic melanoma is a malignant tumor for which there is currently no effective treatment due to resistance development. Ginsenoside Rg3, a saponin component extracted from ginseng roots, ...has been shown to reduce melanoma cell proliferation by decreasing histone deacetylase 3 and increasing p53 acetylation. The availability of data on the role of Rg3 in melanoma is currently extremely limited. The aim of the present study was to further investigate the effects of Rg3 on B16 melanoma cells and the underlying molecular events. The findings demonst rated t hat Rg3 suppresse d t he proliferation and DNA synthesis of B16 cells. Rg3 exposure induced tumor cell cycle arrest at the S phase and reduced the expression of proliferating cell nuclear antigen (PCNA). Rg3 treatment also decreased metastasis of B16 cells in vitro and in vivo. The results indicated that this reduction was due to downregulation of matrix metalloproteinase (MMP)-2 and MMP-9. Moreover, Rg3 inhibited melanoma-induced angiogenesis, most likely by downregulating vascular endothelial growth factor (VEGF) in B16 cells. Rg3 exposure decreased the expression of VEGF in B16 cells and the VEGF downregulation further suppressed angiogenesis by attenuating the proliferation and migration of vascular endothelial cells. Finally, the western blotting data demonstrated that Rg3 reduced the expression of extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) in vitro and in vivo. This result indicated that the antimelanoma effects of Rg3 may be mediated through suppression of ERK and Akt signaling. Further research is required to assess the value of Rg3 as a novel therapeutic strategy for melanoma in the clinical setting.
A novel metal-organic framework (MOF) host-guest material Cd
3
(EtOIPA)
4
(HAD)
2
·H
2
O has been successfully synthesized by the reaction of 5-ethoxyisophthalic acid (EtOIPA), acridine (AD) and Cd(
...ii
) salts under hydrothermal conditions. Structurally, the title MOF possesses a trinucleate Cd(
ii
) based 2D double-layer with the protonated AD cations as the template encapsulated into the grids. The combination of experiments and theoretical calculations reveals that the orderly arrangement of EtOIPA dimers, protonated AD cations and trinucleate Cd(
ii
) clusters generates highly delocalized π-electron channels with a prolonged exciton lifetime. The MOF powders show bright yellow emission with a long lifetime of 50.63 ns. Photoelectrochemical measurements reveal a high photocurrent density ratio of 290 between light and dark conditions at 0 V bias potential, making it a perfect self-driven photodetector. By coating the yellow phosphor on a commercially available blue LED, a high performance white LED with CIE, CCT and CRI values of (0.325, 0.336), 88.2 and 5844 K, respectively can be obtained.
The host-guest interactions, charge transfer and photophysical performance of acridine based MOF were well studied, which can be applied as efficient photodetector and white LED.
Purpose
This study aimed to investigate the gut microbiome composition in pregnant women with digestive diseases to analyze the relationships between the microflora changes and digestive diseases ...during pregnancy.
Methods
Fecal samples obtained from 71 pregnant women six acute fatty liver (AF group), 21 constipation (C group), 24 excessive vomiting (V group) and 20 normal pregnancy (CP group) and 26 non-pregnant (NP group) women were subjected to 16 s rRNA sequencing. Differential analysis of intestinal flora at the genera level was performed.
Results
The relative abundance of
Coprobacillus
,
Acinetobacter
,
Enterococcus
,
Weissella
and
Lysinibacillus
was increased in the digestive diseases (AF, C and V) groups compared with CP group, whereas that of five common genera, including
Terrisporobacter
,
Dysgonomonas
,
Adlercreutzia
,
Fusicatenibacter
and
Blautia
, was decreased in digestive diseases groups. Additionally, in digestive diseases (AF, C and V) groups, the abundance of 13 common genera, such as
Carnobacterium
,
Coprobacillus
and
Psychrobacter
, was higher than NP group, whereas that of 27 common genera, such as
Blautia
and
Terrisporobacter
, was lower than NP group. About 69 genera were differentially abundant between AF and C groups; two genera (
Aerococcus
and
Senegalimassilia
) were identified between AF and V groups; moreover, total 63 genera were obtained between C and V groups.
Conclusion
Our data revealed that the abundance of
Acinetobacter
,
Enterococci
,
Paenibacillus
,
Blautia
and
Collinsella
might be associated with the digestive diseases during pregnancy. These findings further supported the idea that targeting the gut microbiota could be a new prevention or therapeutic approach for improving digestive diseases during pregnancy.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Nanofluid offers more opportunities and challenges over the traditional surfactant and polymer solutions during enhanced oil recovery (commonly referred to as tertiary oil recovery) due to its ...remarkable properties. This review mainly discusses the preparation methods of amphiphilic nanoparticles due to their higher interface activity than sole hydrophilic or hydrophobic nanoparticles (SHNPs). The nanofluids' stability is reviewed in this work. Moreover, the mechanisms of nanofluids in enhancing oil recovery (N-EOR) in terms of interfacial tension reduction, wettability alteration, foam stabilization, emulsion stabilization, structural disjoining pressure, and depressurization-increasing injection are mainly summarized and reviewed. Also, the synergistic effects of nanofluids and traditional surfactants and polymers are discussed. Finally, nanofluids’ challenges and prospects are also outlined. The nanofluids can still be regarded as an outstanding candidate for enhancing oil recovery significantly in the future although there are limitations on their applications from laboratory scale to field scale.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
A novel high conversion ratio bidirectional C-dual transformers-LC (CDT-LC) resonant dc-dc converter is proposed in this paper. Based on the traditional LLC, an auxiliary transformer and an extra ...resonant capacitance are employed in the CDT-LC structure. It not only harvests high efficiency, but exhibits a good voltage gain feature. Especially for the case of light load, CDT-LC still harvests a high efficiency, compared with traditional converters. Also, it can achieve a fast gain reduction when the switching frequency is higher than resonant frequency. In this paper, the operating principles of the converter are analyzed in both bidirectional operation modes. In addition, its dual-transformers structure feature and voltage gain characteristics are discussed in details. Furthermore, the parameter design method is provided. Moreover, the loss breakdown for the converter is given in details. Finally, a 2.5-kW prototype is established to verify the performance of the CDT-LC converter, and its maximum efficiency reaches 97%.
The brown planthopper (BPH), Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), a major pest of rice in Asia, is able to successfully puncture sieve tubes in rice with its piercing stylet and then ...to ingest phloem sap. How BPH manages to continuously feed on rice remains unclear. Here, we cloned the gene NlSEF1, which is highly expressed in the salivary glands of BPH. The NlSEF1 protein has EF-hand Ca
-binding activity and can be secreted into rice plants when BPH feed. Infestation of rice by BPH nymphs whose NlSEF1 was knocked down elicited higher levels of Ca
and H
O
but not jasmonic acid, jasmonoyl-isoleucine (JA-Ile) and SA in rice than did infestation by control nymphs; Consistently, wounding plus the recombination protein NlSEF1 suppressed the production of H
O
in rice. Bioassays revealed that NlSEF1-knockdown BPH nymphs had a higher mortality rate and lower feeding capacity on rice than control nymphs. These results indicate that the salivary protein in BPH, NlSEF1, functions as an effector and plays important roles in interactions between BPH and rice by mediating the plant's defense responses.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Phytohormones are key regulators of plant growth, development, and signalling networks involved in responses to diverse biotic and abiotic stresses. Transcriptional reference maps of hormone ...responses have been reported for several model plant species such as Arabidopsis thaliana, Oryza sativa, and Brachypodium distachyon. However, because of species differences and the complexity of the wheat genome, these transcriptome data are not appropriate reference material for wheat studies.
We comprehensively analysed the transcriptomic responses in wheat spikes to seven phytohormones, including indole acetic acid (IAA), gibberellic acid (GA), abscisic acid (ABA), ethylene (ET), cytokinin (CK), salicylic acid (SA), and methyl jasmonic acid (MeJA). A total of 3386 genes were differentially expressed at 24 h after the hormone treatments. Furthermore, 22.7% of these genes exhibited overlapping transcriptional responses for at least two hormones, implying there is crosstalk among phytohormones. We subsequently identified genes with expression levels that were significantly and differentially induced by a specific phytohormone (i.e., hormone-specific responses). The data for these hormone-responsive genes were then compared with the transcriptome data for wheat spikes exposed to biotic (Fusarium head blight) and abiotic (water deficit) stresses.
Our data were used to develop a transcriptional reference map of hormone responses in wheat spikes.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
To investigate the diagnostic efficacy of mDIXON-Quant technique for prediction of bone loss in male adults.
One hundred thirty-eight male adults were divided into normal, osteopenia, and ...osteoporosis groups based on DXA and QCT for the lumbar spine. Differences in mDIXON-Quant parameters fat fraction (FF) and T2
value among three groups, as well as the correlation of mDIXON-Quant parameters and bone mineral density (BMD) were analyzed. The areas under the curves (AUCs) for mDIXON-Quant parameters for prediction of low bone mass were calculated.
According to DXA standard, FF and T2
value were significantly increased in osteoporosis group compared with normal group (P = 0.012 and P < 0.001). According to QCT standard, FF was significantly increased in osteopenia and osteoporosis groups compared with normal group (both P < 0.001). T2
values were significantly different among three groups (all P < 0.05). After correction for age and body mass index, FF was negatively correlated with areal BMD and volumetric BMD (r = -0.205 and -0.604, respectively; both P < 0.05), and so was T2
value (r = -0.324 and -0.444, respectively; both P < 0.05). The AUCs for predicting low bone mass according to DXA and QCT standards were 0.642 and 0.898 for FF, 0.648 and 0.740 for T2
value, and 0.677 and 0.920 for both combined, respectively.
FF combined with T2
value has a better diagnostic efficacy than FF or T2
value alone in prediction of low bone mass in male adults, which is expected to be a promising MRI method for the screening of bone quality.
ChiCTR1900024511 (Registered 13-07-2019).
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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