A kind of compact all-fiber-optic vector magnetic sensor is proposed and demonstrated. The sensor consists of a side-polished-fiber (SPF)-integrated with singlemode-no core-singlemode (SNS) fiber ...structure. A section of side-polished fiber breaks the axially symmetry of the composite structure. The as-fabricated sensor supports vector sensing and has a magnetic field strength sensitivity of up to -2370 pm/mT over 2-6 mT range. The physical mechanism is that the modal interference is strongly influenced by the refractive index (RI) near the side-polished surface. The advantages of the proposed sensor lie in low cost, simple structure and easy manufacture, which make it attractive in the field of magnetic field vector sensing.
•This study focused on the molecular regulatory mechanisms of spores under non-thermal processing.•Data-independent-acquisition method was used to quantify the protein responses to stress.•Spores ...down-regulated key proteins in energy metabolic and transportation pathways under stress.•Spores obtained stress resistance under the external stress.
Ultrasound is a green nonthermal technology with promising applications in microbial inactivation. Electrolyzed water has been investigated and found to have a synergistic inactivation effect of ultrasound on spores. This study used a data-independent-acquisition method to analyze the stress response of Bacillus cereus spores following ultrasound combined with electrolyzed water treatment. We identified 197 differentially expressed proteins under ultrasound combined with an electrolyzed water treatment for which the ratio in the metabolic pathway was the highest. Spores downregulated key proteins in energy metabolic and transportation pathways, in particular in phosphotransferase systems and ATP synthase under ultrasound, electrolyzed water, and combined stress. The results of this study revealed that the key proteins in intracellular metabolism decreased after ultrasound treatment, and the expression of small acid-soluble spore protein and cell wall biosynthesis protein increased. Meanwhile, DNA integration, recombination, and inversion protein and small acid-soluble spore protein were upregulated after electrolyzed water treatment. In general, the spores exhibited stress resistance under external stress. The inactivation of spores by further stress was reduced, which we called “cross-protection.”
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Background
Many studies have shown an association between COVID-19 and autoimmune diseases (ADs). Studies on COVID-19 and ADs have also increased significantly, but there is no bibliometric analysis ...to summarize the association between COVID-19 and ADs. The purpose of this study was to perform a bibliometric and visual analysis of published studies related to COVID-19 and ADs.
Methods
Based on the Web of Science Core Collection SCI-Expanded database, we utilize Excel 2019 and visualization analysis tools Co-Occurrence13.2 (COOC13.2), VOSviewer, CiteSpace, and HistCite for analysis.
Results
A total of 1736 related kinds of papers were included, and the number of papers presented an overall increasing trend. The country/region with the most publications is the USA, the institution is the Harvard Medical School, the author is Yehuda Shoenfeld from Israel, and the journal is
Frontiers in Immunology
. Research hotspots include immune responses (such as cytokines storm), multisystem ADs (such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis), treatment modalities (such as hydroxychloroquine, rituximab), vaccination and autoimmune mechanisms (such as autoantibodies, molecular mimicry). The future research direction may be the mechanisms and treatment ideas of the association between ADs and COVID-19 (such as NF-κB, hyperinflammation, antiphospholipid antibodies, neutrophil extracellular traps, granulocyte-macrophage colony-stimulating factor), other cross-diseases of COVID-19 and ADs (such as inflammatory bowel disease, chronic mucocutaneous candidiasis, acute respiratory distress syndrome).
Conclusion
The growth rate of publications regarding ADs and COVID-19 has risen sharply. Our research results can help researchers grasp the current status of ADs and COVID-19 research and find new research directions in the future.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
DNA damage shuts down genome-wide transcription to prevent transcriptional mutagenesis and to initiate repair signalling, but the mechanism to stall elongating RNA polymerase II (Pol II) is not fully ...understood. Central to the DNA damage response, poly(ADP-ribose) polymerase 1 (PARP1) initiates DNA repair by translocating to the lesions where it catalyses protein poly(ADP-ribosylation). Here we report that PARP1 inhibits Pol II elongation by inactivating the transcription elongation factor P-TEFb, a CDK9-cyclin T1 (CycT1) heterodimer. After sensing damage, the activated PARP1 binds to transcriptionally engaged P-TEFb and modifies CycT1 at multiple positions, including histidine residues that are rarely used as an acceptor site. This prevents CycT1 from undergoing liquid-liquid phase separation that is required for CDK9 to hyperphosphorylate Pol II and to stimulate elongation. Functionally, poly(ADP-ribosylation) of CycT1 promotes DNA repair and cell survival. Thus, the P-TEFb-PARP1 signalling plays a protective role in transcription quality control and genomic stability maintenance after DNA damage.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
As the blood pressure threshold for commencing antihypertensive treatment diminishes, the cohort suffering from resistant hypertension (RH) correspondingly expands. Notwithstanding the availability ...of known antihypertensive medications, there exists a conspicuous lacuna in therapeutic options specifically intended for the management of RH. Currently, aprocitentan is the sole endothelin receptor antagonist (ERA) under development for addressing this pressing clinical challenge. Aprocitentan (ACT‐132577), deriving its active form as a metabolite of macitentan, demonstrates oral potency as a dual endothelin (ET) receptor antagonist. This compound effectively obstructs the binding of endothelin‐1 (ET‐1) to both ETA and ETB receptors, exhibiting an inhibitory potency ratio of 1:16. Clinical investigation of aprocitentan has advanced to phase 3 trials, yielding promising preliminary outcomes.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the body's ability to counteract their harmful effects, playing a key role in the pathogenesis ...of brain and lung-related diseases. This review comprehensively examines the intricate mechanisms by which oxidative stress influences cellular and molecular pathways, contributing to neurodegenerative, cardiovascular, and respiratory disorders. Emphasizing the detrimental effects on both brain and lung health, we discuss innovative diagnostic biomarkers, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), and the potential of antioxidant therapies. For these topics, we provide insights into future research directions in the field of oxidative stress treatment, including the development of personalized treatment approaches, the discovery and validation of novel biomarkers, and the development of new drug delivery systems. This review not only provides a new perspective on understanding the role of oxidative stress in brain and lung-related diseases but also offers new insights for future clinical treatments.
This paper describes a method to fabricate the 3D microfluidic channel using the free-standing, phase-change gallium mold. Three approaches to prepare the free-standing gallium molds are described. ...The solid metal framework is strong enough to stand against the gravity. After casting, the embedded gallium molds are melted from solid to liquid and then extracted from the encasing elastomer to form the 3D microfluidic channel due to the phase change property. Since this method is compatible with many encasing materials (e.g., elastomers, gels, resins, ceramics), the encasing materials will bring novel functionalities to the microfluidic chip. Two proof-of-concept experiments have been demonstrated. Firstly, a soft, sticky, on-skin microfluidic cooler is developed based on this method to deliver the focused, minimal invasive cooling power at arbitrary skins of human body with temperature control. Secondly, an ultra-stretchable viscoelastic microchannel with the ultra-soft base is fabricated to continuously tune the viscoelastic particle focusing with a large dynamic range. This proposed technique suggests the new possibilities for the development of lab-on-a-chip applications.
With the global net-zero strategy implementation, decarbonisation of transport by massive deployment of electric vehicles (EVs) has been considered to be an essential solution. However, charging EVs ...and integration into electricity grids is going to be a fundamental challenge to future electricity systems. Hence, in this situation, how to effectively deploy massive numbers of EVs, and in the meantime what can be developed to deliver vehicle-to-grid (V2G) services, become a fundamental yet interesting tech-economical issues. Furthermore, uncertainty in lack of vehicle availability and EV battery degradation could lead to revenue loss when using EVs as ancillary services aggregators. With such considerations, this paper presents a new optimised V2G aggregator scheduling service that has taken into consideration of a number of risks, including EV availability and battery degradation through conditional value-at-risk. The proposed method for V2G scheduling service, as an independent aggregator, is formulated as a bi-level optimisation problem. The performance of the proposed method is to be evaluated through case studies on the Birmingham International Airport parking lot with onsite renewable generation. Uncertainties of EVs and the differences in weekdays and weekends are also compared.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Changes in the relationship between El Niño-Southern Oscillation (ENSO) and the East Asian winter monsoon (EAWM) at various global warming levels during the 21st century are examined using the Max ...Planck Institute Grand Ensemble Representative Concentration Pathway 8.5 experiments. The externally forced component of this relationship (i.e. forced by greenhouse gases and anthropogenic aerosols emissions) strengthens from present-day to +1.5 °C, and then weakens until +3 °C. These changes are characterized by variations in strength and location of the core of El Niño-related warming and associated deep convection anomalies over the equatorial Pacific leading to circulation anomalies across the Asian-Pacific region. Under global warming, the ENSO–EAWM relationship is strongly related to the background mean state of both the EAWM and ENSO, through changes in the EAWM strength and the shift of the ENSO pattern. Anthropogenic aerosols play a key role in influencing the ENSO–EAWM relationship under moderate warming (up to 1.5 °C).
The rapid development of electric vehicles (EVs) has benefited from the fact that more and more countries or regions have begun to attach importance to clean energy and environmental protection. This ...paper focuses on the optimization of EV charging, which cannot be ignored in the rapid development of EVs. The increase in the penetration of EVs will generate new electrical loads during the charging process, which will bring new challenges to local power systems. Moreover, the uncoordinated charging of EVs may increase the peak-to-valley difference in the load, aggravate harmonic distortions, and affect auxiliary services. To stabilize the operations of power grids, many studies have been carried out to optimize EV charging. This paper reviews these studies from two aspects: EV charging forecasting and coordinated EV charging strategies. Comparative analyses are carried out to identify the advantages and disadvantages of different methods or models. At the end of this paper, recommendations are given to address the challenges of EV charging and associated charging strategies.
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