Aesthetic processing has profound implications for everyday life. Although liking and beauty judgements are outcomes of aesthetic processing and derive from a common hedonic value, there may be some ...differences in how they engage working memory. This study used maintenance and aesthetic judgement tasks to examine whether liking and beauty judgements make different demands on domain-specific working memory resources. Sixty participants (30 males) were instructed to rate picture for liking or beauty while maintaining the subjective affect or brightness of the presented pictures. Results indicated that liking judgements selectively impaired participants’ performance in the affect maintenance task, and beauty judgements selectively impaired their performance in the brightness maintenance task. In addition, maintaining affect and brightness feelings in the mind increased image ratings on beauty but not on liking. Our findings provide evidence that liking judgements draw more on affective working memory resources than beauty judgements, and beauty judgements draw more on visual working memory resources than liking judgements.
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NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
Mechanical resonators are important components of devices that range from gravitational wave detectors to cellular telephones. They serve as high-performance transducers, sensors and filters by ...offering low dissipation, tunable coupling to diverse physical systems, and compatibility with a wide range of frequencies, materials and fabrication processes. Systems of mechanical resonators typically obey reciprocity, which ensures that the phonon transmission coefficient between any two resonators is independent of the direction of transmission
. Reciprocity must be broken to realize devices (such as isolators and circulators) that provide one-way propagation of acoustic energy between resonators. Such devices are crucial for protecting active elements, mitigating noise and operating full-duplex transceivers. Until now, nonreciprocal phononic devices
have not simultaneously combined the features necessary for robust operation: strong nonreciprocity, in situ tunability, compact integration and continuous operation. Furthermore, they have been applied only to coherent signals (rather than fluctuations or noise), and have been realized exclusively in travelling-wave systems (rather than resonators). Here we describe a scheme that uses the standard cavity-optomechanical interaction to produce robust nonreciprocal coupling between phononic resonators. This scheme provides about 30 decibels of isolation in continuous operation and can be tuned in situ simply via the phases of the drive tones applied to the cavity. In addition, by directly monitoring the dynamics of the resonators we show that this nonreciprocity can control thermal fluctuations, and that this control represents a way to cool phononic resonators.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Effect of Al addition on microstructure and texture evolution during hot rolling of Mg alloys was investigated using Mg-(3, 6 and 9 wt%)Al-Zn series alloys. The results showed deformation behaviors, ...including twinning, dynamic recrystallization and activation of slip system, were affected by the increase of Al content. Compared with AZ31 Mg alloys, the rolled AZ91 sample exhibited strong basal texture and intensity of basal texture decreased by increasing rolling strain. Unlike double twins and contraction twins which were commonly observed in the hot rolling of AZ31 Mg alloys, twinning behavior was strongly suppressed by the addition of Al content. It was observed some grain-like extension twins nucleated inside unrecrystallized grains with ultrafine size in AZ91. The size of dynamic recrystallized grains in AZ91 was ultrafine compared to that of AZ31 due to pinning effect produced by small Mg17Al12 particles. These recrystallized grains were distributed along grain boundaries and would continuously coordinate further deformation strain after their nucleation. The increase of the area fraction of recrystallized grains resulted in a texture weakness during large strain rolling in AZ91. Geometrically necessary dislocation information was analyzed for the rolled samples. It showed prismatic slip took an advantage in AZ31 rather than AZ91 during hot rolling, which may be a reason for the weaker basal texture of unrecrystallized grains in AZ31.
•Content of Al remarkably affects rolling deformation behavior in Mg alloys.•Texture is sensitive to Al content due to its impact on deformation behavior.•Twinning is suppressed by increasing Al content during hot rolling.•Non-basal slip systems show high activities in low Al content sample.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Our previous study showed that glycyrrhizin (GLY) inhibited porcine epidemic diarrhea virus (PEDV) infection, but the mechanisms of GLY anti-PEDV action remain unclear. In this study, we focused on ...the anti-PEDV and anti-proinflammatory cytokine secretion mechanisms of GLY. We found that PEDV infection had no effect on toll-like receptor 4 (TLR4) protein and mRNA levels, but that TLR4 regulated PEDV infection and the mRNA levels of proinflammatory cytokines. In addition, we demonstrated that TLR4 regulated p38 phosphorylation but not extracellular regulated protein kinases1/2 (Erk1/2) and c-Jun N-terminal kinases (JNK) phosphorylation, and that GLY inhibited p38 phosphorylation but not Erk1/2 and JNK phosphorylation. Therefore, we further explored the relationship between high mobility group box-1 (HMGB1) and p38. We demonstrated that inhibition of HMGB1 using an antibody, mutation, or knockdown decreased p38 phosphorylation. Thus, HMGB1 participated in activation of p38 through TLR4. Collectively, our data indicated that GLY inhibited PEDV infection and decreased proinflammatory cytokine secretion via the HMGB1/TLR4-mitogen-activated protein kinase (MAPK) p38 pathway.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The influence of the rolling speed on microstructure and mechanical properties of as-rolled AZ31 Mg alloys sheet was critically examined. Samples were hot rolled by nearly 55% thickness reduction in ...a single rolling pass at rolling speeds varying between 3.5 and 12.1m/min. The results showed that twinning dominated the deformation at lower rolling speed and dynamic recrystallization was constricted in shear bands. While, at high rolling speed, dynamic recrystallization behavior was largely extended and microstructure became homogeneous. The yield behavior of as-rolled sheets was affected by the recrystallized grains formed during rolling. The tensile ductility was gradually improved as rolling speed increased, due to the enhancement of dynamic recrystallization. The dynamic recrystallization is an effective way to consume the deformation energy, which may suppress edge crack initiation.
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GEOZS, IMTLJ, KISLJ, NUK, OILJ, PNG, SAZU, SBJE, UL, UM, UPCLJ, UPUK
Pathogenic missense mutation of the FGF12 gene is responsible for a variable disease phenotypic spectrum. Disease-specific therapies require precise dissection of the relationship between different ...mutations and phenotypes. The lack of a proper animal model hinders the investigation of related diseases, such as early-onset epileptic encephalopathy. Here, an FGF12AV52H mouse model was generated using CRISPR/Cas9 technology, which altered the A isoform without affecting the B isoform. The FGF12AV52H mice exhibited seizure susceptibility, while no spontaneous seizures were observed. The increased excitability in dorsal hippocampal CA3 neurons was confirmed by patch-clamp recordings. Furthermore, immunostaining showed that the balance of excitatory/inhibitory neurons in the hippocampus of the FGF12AV52H mice was perturbed. The increases in inhibitory SOM+ neurons and excitatory CaMKII+ neurons were heterogeneous. Moreover, the locomotion, anxiety levels, risk assessment behavior, social behavior, and cognition of the FGF12AV52H mice were investigated by elevated plus maze, open field, three-chamber sociability, and novel object tests, respectively. Cognition deficit, impaired risk assessment, and social behavior with normal social indexes were observed, implying complex consequences of V52H FGF12A in mice. Together, these data suggest that the function of FGF12A in neurons can be immediate or long-term and involves modulation of ion channels and the differentiation and maturation of neurons. The FGF12AV52H mouse model increases the understanding of the function of FGF12A, and it is of great importance for revealing the complex network of the FGF12 gene in physiological and pathological processes.
•FGF12AV52H mice exhibit susceptibility to seizures.•FGF12AV52H mutation alters the excitability of neurons in hippocampus.•Behavioral phenotyping shows cognitive deficit and impaired risk assessment in FGF12AV52H mice.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The contribution of recrystallization and grain growth to the texture evolution in AZ31 alloy and a modified version AZ31+0.5 wt.% Ca was investigated utilizing a multi-step annealing process. The ...results showed that the addition of Ca triggered a considerable texture modification by increasing the texture spread and decreasing the overall texture intensity. This effect was found to be temperature dependent. When the annealing temperature remained lower than 450 °C, a weak double peak texture with large basal pole tilt towards the RD was formed. This is correlated to microstructure observations of a large number of Ca-containing nano-sized particles that seemed to suppress grain growth below 450 °C, which stabilized the weak recrystallization texture. This favorable texture was lost upon annealing at higher temperatures. In AZ31, recrystallization nuclei were found to preserve the orientation of their deformed parents, which offered limited potential to optimize the texture via annealing treatments. Grain growth of recrystallized grains resulted in a distinct sheet texture transition from a double-peak to a single-peak basal texture. Aspects of grain boundary energy and grain topology are discussed to explain the growth advantage of the sharp basal component over other orientations.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Pseudorabies have caused enormous economic losses in China's pig industry and have recurred on many large pig farms since late 2011. The disease is caused by highly pathogenic, antigenic variant ...pseudorabies virus (vPRV) strains. Our laboratory isolated a pseudorabies virus in 2015 and named it XJ5. The pathogenic ability of this mutant strain was much stronger than that of the original isolate. After we sequenced its whole genome (GenBank accession number: OP512542), we found that its overall structure was not greatly changed compared with that of the previous strain Ea (KX423960.1). The whole genome alignment showed that XJ5 had a strong genetic relationship with the strains isolated in China after 2012 reported in GenBank. Based on the isolation time of XJ5 and the mutation and recombination analysis of programs, we found that the whole genome homology of XJ5 and other strains with Chinese isolates was greater than 95%, while the homology with strains outside Asia was less than 94%, which indicated that there may be some recombination and mutation patterns. We found that virulent PRV isolates emerged successively in China in 2011 and formed two different evolutionary clades from foreign isolates. At the same time, this may be due to improper immunization and the presence of wild strains in the field, and recent reports have confirmed that Bartha vaccine strains recombine with wild strains to obtain new pathogenic strains. We performed genetic evolution analysis of XJ5 isolated and sequenced in our laboratory to trace its possible mutations and recombination. We found that XJ5 may be the result of natural mutation of a virus in a branch of mutant strains widely existing in China.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
•Thermodynamic and precipitation kinetics calculation was used to analyze aging hardening after addition of Sn.•Precipitation sequences were determined by the content of Sn element.•The ...microstructure of Mg17Al12 discontinuous precipitates were influenced by Mg2Sn precipitates.
The microstructure and mechanical properties of AZ80 wrought magnesium alloys with varying Sn contents (0, 1, 2 and 4wt.%) have been studied by thermodynamic and precipitation kinetics calculation and examined using scanning electron microscopy (SEM), transmission electron microscopy (TEM), hardness test and uniaxial tensile test at room temperature in this paper. The results of thermodynamic and precipitation kinetics calculation showed that the precipitation sequences were determined by the content of Sn element. It was found that in the aging treatment of this work, Mg17Al12 phase precipitated sooner than Mg2Sn phase in the alloys with less than 1.72wt.% Sn and there was a contrary precipitation sequence of these two phases in the alloys with more than 1.72wt.% Sn. Experimental results were in agreement with those of calculation. According to SEM and TEM observation, Sn promoted precipitation of Mg17Al12 on aging temperature, however the preferential Mg2Sn phase suppressed discontinuous Mg17Al12 precipitates by hindering the growth of these in their growth direction. AZ80 with 1–2wt.% Sn as-aged alloys exhibited outstanding mechanical property that UTS, YS and EL were ∼420MPa, ∼290MPa and ∼5%, respectively.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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