The Internet has become an essential part of our daily life, but excessive Internet use may lead to a number of risks such as Internet addiction. In order to protect teenagers from the risks, it is ...important to guide them to use the Internet in a safe, responsible, and ethical way. Cyber wellness literacy, as the core issue of digital citizenship, plays a vital role in the physical and mental well-being of individuals and should be given high priority. While some studies have explored the integration of digital citizenship into school education through digital game-based learning (DGBL), the influence of digital games on teenagers’ learning outcomes, learning motivation, and engagement in the field of cyber wellness remains unclear. It is, therefore, a challenge to provide cyber wellness literacy learning activities that empower students to keep away from Internet addiction and maintain a happy, healthy, and safe digital life. This study addressed the issue of Internet addiction from the perspective of digital citizenship, and designed and implemented a digital game-based course in a middle school. The study then explored the potential impact of DGBL on improving students’ cyber wellness literacy, motivation, and engagement. The statistical results show that DGBL not only promoted the students’ cyber wellness literacy in preventing Internet addiction, but also enhanced their motivations and emotional engagement.
Minimal residual disease (MRD) is considered an essential factor leading to relapse within 2 years (early relapse) after radical surgery, which is challenging to be detected by conventional imaging. ...Circulating tumor DNA (ctDNA) provides a novel approach for detecting MRD and predicting clinical outcomes. Here, we tried to construct a fixed panel for plasma-only ctDNA NGS to enable tumor-uninformed MRD detection in hepatocellular carcinoma (HCC).
Here, we performed the followings: (i) profiling genomic alteration spectrum of ctDNA from the Chinese HCC cohort consisting of 493 individuals by NGS; (ii) screening of MRD monitoring genes; and (iii) performance evaluation of MRD monitoring genes in predicting early relapse in the ZJZS2020 cohort comprising 20 HCC patients who underwent curative resection.
A total of 493 plasma samples from the Chinese HCC cohort were detected using a 381/733-gene NGS panel to characterize the mutational spectrum of ctDNA. Most patients (94.1%, 464/493) had at least one mutation in ctDNA. The variants fell most frequently in
(45.1%),
(20.2%),
(20.2%),
(16.2%), and
(13.4%). By customized filtering strategy, 13 MRD monitoring genes were identified, and any plasma sample with one or more MRD monitoring gene mutations was considered MRD-positive. In the ZJZS2020 cohort, MRD positivity presented a sensitivity of 75% (6/8) and a specificity of 100% (6/6) in identifying early postoperative relapse. The Kaplan-Meier analysis revealed a significantly short relapse-free survival (RFS; median RFS, 4.2 months
. NR, P=0.002) in the MRD-positive patients versus those with MRD negativity. Cox regression analyses revealed MRD positivity as an independent predictor of poor RFS (HR 13.00, 95% CI 2.60-69.00, P=0.002).
We successfully developed a 13-gene panel for plasma-only MRD detection, which was effective and convenient for predicting the risk of early postoperative relapse in HCC.
Monoclinic phase LiFeSO4F has a triplite like structure in which Li+/Fe2+ is fully mixing. Not 100% Li can be extracted from the lattice easily even at a rate of C/20, and the valence of Fe changes ...between ca +2 and +2.5 observed by XANES for a Li/LiFeSO4F cell cycled between 2.2 and 4.6 V. Two-phase reaction mechanism is verified by GITT due to the appearance of a flat plateau, and large polarization appears after more than 50% Li extracted from triplite-LiFeSO4F. A core–shell model has been mentioned to explain its extreme polarization. In the fully mixing structure, there is no intact long-range pathway for Li+, so leading to sluggish kinetics effect and “inert” Li+ in the lattice.
► The triplite-phase LiFeSO4F was obtained by solid state reactions. ► Not 100% Li can be extracted from the lattice by XANES. ► A core–shell model was mentioned to explain the polarization phenomenon.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
A large eddy simulation is used in this study to explore wake control for a square cylinder based on vertical axis wind turbines. These vertical axis wind turbines are installed around a chamfered ...square cylinder, and the effects of the wind turbine diameter and the spacing between the wind turbine and the chamfered square cylinder on the aerodynamic forces and wake characteristics of the chamfered square cylinder are investigated. The analysis results indicate that wind turbines continuously transport high-speed fluid to the wake and the negative pressure value in the square cylinder wake decreases, which leads to a reduction in the downwind drag. Further, the time-averaged main vortex in the chamfered square cylinder wake is elongated and the center of the main vortex is farther away from the square cylinder; this considerably reduces the surface pressure and lift coefficient fluctuation. The optimal control effect for the square cylinder wake is obtained when h is 1/8d and the ratio of d to D (the side length of square cylinder) is 0.25. Compared with the results of flow around an uncontrolled chamfered square cylinder, the root mean square value of the lift coefficient and the mean value of the drag coefficient are reduced by 80.5% and 19.8%, respectively. Thus, the aerodynamic control method based on the vertical axis wind turbines can effectively suppress the vortex shedding mode of a square-cylinder wake, so as to reduce the aerodynamic forces and vortex-induced vibration.
•Explored wake control for square cylinder based on vertical axis wind turbines.•Analyzed effects of wind turbine diameter and distance between turbine and cylinder.•h = 1/8d and d/D = 0.25 achieve optimal control effect for square cylinder wake.•Lift coefficient fluctuation and mean drag coefficient reduced by 80.5% and 19.8%, respectively.•Aerodynamic control method effectively suppresses vortex shedding mode.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Ti-based implant materials still face implant-related infections and poor osseointegration as two major clinical challenges; thus, high-quality implantation demands a strategy that can provide ...Ti-based implants with long-term antibacterial ability and high osteogenic activity. In this study, gallium was successfully loaded into polydopamine-functionalised SrTiO3 nanotubes (PDA-SrTiO3 NTs) on a titanium substrate through a facile immersion method. The release of strontium and gallium from gallium-doped SrTiO3 NTs was controllably constant and had negligible cytotoxicity. The antibacterial efficacy of the NT coating was demonstrated by the inhibition zones of Escherichia coli and Staphylococcus aureus. The optimum contents of gallium and strontium in the coating led to enhanced cytocompatibility, osteoblast spreading and osseointegration because of the synergistic effects of strontium as a bioactive element and the porous topography of the coating surface. As observed in vivo, bone formation in rabbit-bone-defect models was improved by the proposed coating four weeks after it was implanted. According to literature, the present results show for the first time that the gallium doping of PDA-SrTiO3 NTs can effectively stimulate osteointegration—thanks to its efficacy in enhancing implant osteoinductivity—and can prevent infections. Therefore, gallium-doped PDA-SrTiO3 NT coatings can potentially function as promising bone implants for clinical applications.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
We present a valid and reproducible nomogram that combined the TNM stage as well as the Ki-67 index and carcinoembryonic antigen levels; the nomogram may be an indispensable tool to help predict ...individualized risks of death and help clinicians manage patients with gastric neuroendocrine carcinoma.
To analyze the long-term outcomes of patients with grade 3 GNEC who underwent curative surgery and investigated whether the combination of carcinoembryonic antigen (CEA) levels and Ki-67 index can predict the prognosis of patients with gastric neuroendocrine carcinoma (GNEC) and constructed a nomogram to predict patient survival.
In the training cohort, data were collected from 405 patients with GNEC after radical surgery at seven Chinese centers. A nomogram was constructed to predict long-term prognosis. Data for the validation cohort were collected from 305 patients.
The 5-year overall survival (OS) was worse in the high CEA group than in the normal CEA group (40.5% vs. 55.2%, p = 0.013). The 5-year OS was significantly worse in the high Ki-67 index group than in the low Ki-67 index group (47.9% vs. 57.2%, p = 0.012). Accordingly, we divided the whole cohort into a KC(-) group (low Ki-67 index and normal CEA) and KC(+) group (high Ki-67 index and/or high CEA). The KC(+) group had a worse prognosis than the KC(-) group (64.6% vs. 46.8%, p < 0.001). KC(+) and the AJCC 8
stage were independent factors for OS. Then, we combined KC status and the AJCC 8
stage to establish a nomogram; the C-index and area under the curve (AUC) were higher for the nomogram than for the AJCC 8
stage (C-index: 0.660 vs. 0.635, p = 0.005; AUC: 0.700 vs. 0.675, p = 0.020). The calibration curve verified that the nomogram had a good predictive value, with similar findings in the validation groups.
The nomogram based on KC status and the AJCC 8
stage predicted the prognosis of patients with GNEC well.
Postpartum depression (PPD) is a common public health concern. A wide range of functional abnormalities in various brain regions have been reported in fMRI studies on PPD, however, a consistent ...functional changing pattern is still lacking. Herein, we obtained functional Magnetic Resonance Imaging (fMRI) data from 52 patients with PPD and 24 healthy postpartum women (HPW). Functional indexes (low-frequency fluctuation, degree centrality, and regional homogeneity) were calculated and compared among these groups to explore the functional changing patterns of PPD. Then, correlation analyses were performed to investigate the relationship between changed functional indexes and clinical measurements in the PPD. Finally, support vector machine (SVM) was performed to test whether these abnormal features can be used to distinguish PPD from HPW. As a result, we identified significantly and consistently functional changing pattern characterizing by increased functional activity in the left inferior occipital gyrus and decreased functional activity right anterior cingulate cortex in the PPD as compared to HPW. These functional values in the right anterior cingulate cortex were significantly correlated with depression symptoms in the PPD, and can be used as features to distinguish PPD from HPW. In conclusion, our results suggested that the right anterior cingulate cortex could be served as a functional neuro-imaging biomarker for PPD, which might be used as a potential target for neuro-modulation.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
By utilizing the convenient physical vapor deposition procedure, a simple and low-cost synthesis route is developed to fabricate high-quality orthorhombic MoO3 crystals with single crystallinity and ...significant size (bigger than 10 mm × 10 mm2). A combined characterization techniques of atomic force microscopy, X-ray photoelectron spectroscopy, synchrotron-based X-ray diffraction and Raman spectroscopy confirm the high quality of α-MoO3 crystal from the point view of both electronic and physical structures. Compared to previous reports in literature, we demonstrate herein a rather simplified one-step approach with only the MoO3 powder needed. In the end, corresponding electrochromic performance has also been tested which reveals high transmittance and remarkable optical properties which may broadens the potential applications of MoO3 single crystal in nanosensors, nanoelectronics and so on.
PVD growth of centimeter-size MoO3 single crystal with appealing properties. Display omitted
•A low-cost simplified approach is demonstrated to fabricate high-quality orthorhombic MoO3 single crystal with significant size (10×10 mm2).•Layers with a least thickness of 0.7nm and micrometers width have been demonstrated, which is promising to facilitate veritable 2D MoO3 sheet.•With the potential appealing application, the high performance of synthesized crystals on optical modulation and conductivity has been claimed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
As global warming exacerbates and urbanization accelerates, extreme climatic events occur frequently. Urban waterlogging is seriously spreading in China, resulting in a high level of vulnerability in ...urban societies and economies. It has been urgent for regional sustainable development to effectively identify and analyze the risk factors behind urban waterlogging. A novel model incorporating satellite image semantic segmentation into extreme gradient boosting (XGBoost) is employed for identifying and forecasting the urban waterlogging risk factors. Ground object features of waterlogging points are extracted by the satellite image semantic segmentation, and XGBoost is employed to predict waterlogging points and identify the primary factors affecting urban waterlogging. This paper selects the coastal cities of Haikou, Xiamen, Shanghai, and Qingdao as research areas, and obtains data from social media. According to the comprehensive performance evaluation of the semantic segmentation and XGBoost models, the semantic segmentation model could effectively identify and extract water bodies, roads, and green spaces in satellite images, and the XGBoost model is more accurate and reliable than other common machine learning methods in prediction performance and precision. Among all waterlogging risk factors, elevation is the main factor affecting waterlogging in the research areas. For Shanghai and Qingdao, the secondary factor affecting waterlogging is roads. Water bodies are the secondary factor affecting urban waterlogging in Haikou. For Xiamen, the four indicators other than the elevation are equally significant, which could all be regarded as secondary factors affecting urban waterlogging.
Previous researches have highlighted that low-expressing deoxyribonuclease1-like 3 (DNASE1L3) may play a role as a potential prognostic biomarker in several cancers. However, the diagnosis and ...prognosis roles of DNASE1L3 gene in lung adenocarcinoma (LUAD) remain largely unknown. This research aimed to explore the diagnosis value, prognostic value, and potential oncogenic roles of DNASE1L3 in LUAD. We performed bioinformatics analysis on LUAD datasets downloaded from TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus), and jointly analyzed with various online databases. We found that both the mRNA and protein levels of DNASE1L3 in patients with LUAD were noticeably lower than that in normal tissues. Low DNASE1L3 expression was significantly associated with higher pathological stages, T stages, and poor prognosis in LUAD cohorts. Multivariate analysis revealed that DNASE1L3 was an independent factor affecting overall survival (HR = 0.680,
p
= 0.027). Moreover, decreased DNASE1L3 showed strong diagnostic efficiency for LUAD. Results indicated that the mRNA level of DNASE1L3 was positively correlated with the infiltration of various immune cells, immune checkpoints in LUAD, especially with some m6A methylation regulators. In addition, enrichment function analysis revealed that the co-expressed genes may participate in the process of intercellular signal transduction and transmission. GSEA indicated that DNASE1L3 was positively related to G protein-coupled receptor ligand biding (NES = 1.738; P adjust = 0.044; FDR = 0.033) and G alpha (i) signaling events (NES = 1.635; P adjust = 0.044; FDR = 0.033). Our results demonstrated that decreased DNASE1L3 may serve as a novel diagnostic and prognostic biomarker associating with immune infiltrates in lung adenocarcinoma.
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