The Northern Hemisphere hydrological cycle is a key factor coupling ice sheets, ocean circulation, and polar amplification of climate change. Here we present a Northern Hemisphere deuterium excess ...profile covering one climatic cycle, constructed with the use of δ18O and 5D Greenland Ice Core Project (GRIP) records. Past changes in Greenland source and site temperatures are quantified with precipitation seasonality taken into account. The imprint of obliquity is evidenced in the site-to-source temperature gradient at orbital scale. At the millennial time scale, GRIP source temperature changes reflect southward shifts of the geographical locations of moisture sources during cold events, and these rapid shifts are associated with large-scale changes in atmospheric circulation.
Full text
Available for:
BFBNIB, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK
The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high ...level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of relapsed MM thus represents a vital aspect of the overall care for patients with MM and a critical area of ongoing scientific and clinical research. This comprehensive manuscript from the International Myeloma Working Group provides detailed recommendations on management of relapsed disease, with sections dedicated to diagnostic evaluation, determinants of therapy, and general approach to patients with specific disease characteristics. In addition, the manuscript provides a summary of evidence from clinical trials that have significantly impacted the field, including those evaluating conventional dose therapies, as well as both autologous and allogeneic stem cell transplantation. Specific recommendations are offered for management of first and second relapse, relapsed and refractory disease, and both autologous and allogeneic transplant. Finally, perspective is provided regarding new agents and promising directions in management of relapsed MM.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
On entering an era of global warming, the stability of the Greenland ice sheet (GIS) is an important concern, especially in the light of new evidence of rapidly changing flow and melt conditions at ...the GIS margins. Studying the response of the GIS to past climatic change may help to advance our understanding of GIS dynamics. The previous interpretation of evidence from stable isotopes ( 18O) in water from GIS ice cores was that Holocene climate variability on the GIS differed spatially and that a consistent Holocene climate optimum-the unusually warm period from about 9,000 to 6,000 years ago found in many northern-latitude palaeoclimate records-did not exist. Here we extract both the Greenland Holocene temperature history and the evolution of GIS surface elevation at four GIS locations. We achieve this by comparing 18O from GIS ice cores with 18O from ice cores from small marginal icecaps. Contrary to the earlier interpretation of 18O evidence from ice cores, our new temperature history reveals a pronounced Holocene climatic optimum in Greenland coinciding with maximum thinning near the GIS margins. Our 18O-based results are corroborated by the air content of ice cores, a proxy for surface elevation. State-of-the-art ice sheet models are generally found to be underestimating the extent and changes in GIS elevation and area; our findings may help to improve the ability of models to reproduce the GIS response to Holocene climate.
Full text
Available for:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
As part of the effort to create the new Greenland Ice Core Chronology 2005 (GICC05) a synchronized stratigraphical timescale for the Holocene parts of the DYE‐3, Greenland Ice Core Project (GRIP), ...and North Greenland Ice Core Project (NGRIP) ice cores is made by using volcanic reference horizons in electrical conductivity measurements to match the cores. The main annual layer counting is carried out on the most suited records only, exploiting that the three ice cores have been drilled at locations with different climatic conditions and differences in ice flow. However, supplemental counting on data from all cores has been performed between each set of reference horizons in order to verify the validity of the match. After the verification, the main dating is transferred to all records using the volcanic reference horizons as tie points. An assessment of the mean annual layer thickness in each core section confirms that the new synchronized dating is consistent for all three cores. The data used for the main annual layer counting of the past 7900 years are the DYE‐3, GRIP, and NGRIP stable isotope records. As the high accumulation rate at the DYE‐3 drill site makes the seasonal cycle in the DYE‐3 stable isotopes very resistant to firn diffusion, an effort has been made to extend the DYE‐3 Holocene record. The new synchronized dating relies heavily on this record of ∼75,000 stable isotope samples. The dating of the early Holocene consists of an already established part of GICC05 for GRIP and NGRIP which has now been transferred to the DYE‐3 core. GICC05 dates the Younger Dryas termination, as defined from deuterium excess, to 11,703 years before A. D. 2000 (b2k), 130 years earlier than the previous GRIP dating.
Despite the extensive use of 10Be as the most significant information source on past solar activity, there has been only one record (Dye‐3, Greenland) providing annual resolution over several ...centuries. Here we report a new annual resolution 10Be record spanning the period 1389–1994 AD, measured in an ice core from the NGRIP site in Greenland. NGRIP and Dye‐3 10Be exhibits similar long‐term variability, although occasional short term differences between the two sites indicate that at least two high resolution 10Be records are needed to assess local variations and to confidently reconstruct past solar activity. A comparison with sunspot and neutron records confirms that ice core 10Be reflects solar Schwabe cycle variations, and continued 10Be variability suggests cyclic solar activity throughout the Maunder and Spörer grand solar activity minima. Recent 10Be values are low; however, they do not indicate unusually high recent solar activity compared to the last 600 years.
Full text
Available for:
FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Oxygen-isotope ratios of precipitation ($\delta^{18}$O$_p$) inferred from deep-lake ostracods from the Ammersee (southern Germany) provide a climate record with decadal resolution. The record in ...detail shows many of the rapid climate shifts seen in central Greenland ice cores between 15,000 and 5000 years before the present (B.P.). Negative excursions in the estimated $\delta^{18}$O$_p$ from both of these records likely reflect short weakenings of the thermohaline circulation caused by episodic discharges of continental freshwater into the North Atlantic. Deviating millennial-scale trends, however, indicate that climate gradients between Europe and Greenland changed systematically, reflecting a gradual rearrangement of North Atlantic circulation during deglaciation.
Full text
Available for:
BFBNIB, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK
A central issue in climate dynamics is to understand how the Northern and Southern hemispheres are coupled during climate events. The strongest of the fast temperature changes observed in Greenland ...(so-called Dansgaard-Oeschger events) during the last glaciation have an analogue in the temperature record from Antarctica.
Full text
Available for:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We present a new common stratigraphic timescale for the North Greenland Ice Core Project (NGRIP) and GRIP ice cores. The timescale covers the period 7.9–14.8 kyr before present and includes the ...Bølling, Allerød, Younger Dryas, and early Holocene periods. We use a combination of new and previously published data, the most prominent being new high‐resolution Continuous Flow Analysis (CFA) impurity records from the NGRIP ice core. Several investigators have identified and counted annual layers using a multiparameter approach, and the maximum counting error is estimated to be up to 2% in the Holocene part and about 3% for the older parts. These counting error estimates reflect the number of annual layers that were hard to interpret, but not a possible bias in the set of rules used for annual layer identification. As the GRIP and NGRIP ice cores are not optimal for annual layer counting in the middle and late Holocene, the timescale is tied to a prominent volcanic event inside the 8.2 kyr cold event, recently dated in the DYE‐3 ice core to 8236 years before A. D. 2000 (b2k) with a maximum counting error of 47 years. The new timescale dates the Younger Dryas‐Preboreal transition to 11,703 b2k, which is 100–150 years older than according to the present GRIP and NGRIP timescales. The age of the transition matches the GISP2 timescale within a few years, but viewed over the entire 7.9–14.8 kyr section, there are significant differences between the new timescale and the GISP2 timescale. The transition from the glacial into the Bølling interstadial is dated to 14,692 b2k. The presented timescale is a part of a new Greenland ice core chronology common to the DYE‐3, GRIP, and NGRIP ice cores, named the Greenland Ice Core Chronology 2005 (GICC05). The annual layer thicknesses are observed to be log‐normally distributed with good approximation, and compared to the early Holocene, the mean accumulation rates in the Younger Dryas and Bølling periods are found to be 47 ± 2% and 88 ± 2%, respectively.
Characteristic patterns of gene expression measured by DNA microarrays have been used to classify tumors into clinically relevant sub-groups. In this study, we have refined the previously defined ...sub-types of breast tumors that could be distinguished by their distinct patterns of gene expression. A total of 115 malignant breast tumors were analyzed by hierarchical clustering based on patterns of expression of 534 "intrinsic" genes and shown to subdivide into one basal-like, one ERBB2-overexpressing, two luminal-like, and one normal breast tissue-like subgroup. The genes used for classification were selected based on their similar expression levels between pairs of consecutive samples taken from the same tumor separated by 15 weeks of neoadjuvant treatment. Similar cluster analyses of two published, independent data sets representing different patient cohorts from different laboratories, uncovered some of the same breast cancer subtypes. In the one data set that included information on time to development of distant metastasis, subtypes were associated with significant differences in this clinical feature. By including a group of tumors from BRCA1 carriers in the analysis, we found that this genotype predisposes to the basal tumor subtype. Our results strongly support the idea that many of these breast tumor subtypes represent biologically distinct disease entities.
Full text
Available for:
BFBNIB, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK
PDF
