•Guaiacyl phenylacetate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, ...read-across, and/or TTC.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•2-Octenoic acid, 4-ethyl-, (2E)-; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target ...data, read-across, and/or TTC.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•2,11-Dodecadienal, (E)- (9CI); a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, ...read-across, and/or TTC.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Hale crater, a 125
×
150
km impact crater located near the intersection of Uzboi Vallis and the northern rim of Argyre basin at 35.7°S, 323.6°E, is surrounded by channels that radiate from, incise, ...and transport material within Hale’s ejecta. The spatial and temporal relationship between the channels and Hale’s ejecta strongly suggests the impact event created or modified the channels and emplaced fluidized debris flow lobes over an extensive area (>200,000
km
2). We estimate ∼10
10
m
3 of liquid water was required to form some of Hale’s smaller channels, a volume we propose was supplied by subsurface ice melted and mobilized by the Hale-forming impact. If 10% of the subsurface volume was ice, based on a conservative porosity estimate for the upper martian crust, 10
12
m
3 of liquid water could have been present in the ejecta. We determine a crater-retention age of 1
Ga inside the primary cavity, providing a minimum age for Hale and a time at which we propose the subsurface was volatile-rich. Hale crater demonstrates the important role impacts may play in supplying liquid water to the martian surface: they are capable of producing fluvially-modified terrains that may be analogous to some landforms of Noachian Mars.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
IntroductionSupporting people subjected to sexual violence includes provision of sexual and reproductive healthcare. There is a need to ensure an environment for safe and supported disclosure of ...sexual violence in these clinical settings. The purpose of this research is to gain a deeper understanding of how, why, for whom and in what circumstances safe and supported disclosure occurs in sexual health services.Methods and analysisTo understand how safe and supported disclosure of sexual violence works within sexual health services a realist review will be undertaken with the following steps: (1) Focussing of the review including a scoping literature search and guidance from an advisory group. (2) Developing the initial programme theories and a search strategy using context-mechanism-outcome (CMO) configurations. (3) Selection, data extraction and appraisal based on relevance and rigour. (4) Data analysis and synthesis to further develop and refine programme theory, CMO configurations with consideration of middle-range and substantive theories.Data analysisA realist logic of analysis will be used to align data from each phase of the review, with CMO configurations being developed. Programme theories will be sought from the review that can be further tested in the field.Ethics and disseminationThis study has been approved by the ethics committee at University of Birmingham, and has Health Research Authority approval. Findings will be disseminated through knowledge exchange with stakeholders, publications in peer-reviewed journals, conference presentations and formal and informal reports. In addition, as part of a doctoral study, the findings will be tested in multisite case studies.PROSPERO registration detailsCRD4201912998. Dates of the planned realist review, from protocol design to completion, January 2019 to July 2020.
We present new molecular modeling for 14NO and 15NO and a deep, blind molecular line survey at low radio frequencies (99-129 MHz). This survey is the third in a series completed with the Murchison ...Widefield Array (MWA), but in comparison with the previous surveys, uses 4 times more data (17 hr versus 4 hr) and is 3 times better in angular resolution (1′ versus 3′). The new molecular modeling for nitric oxide and its main isotopologue has seven transitions within the MWA frequency band (although we also present the higher-frequency transitions). Although we did not detect any new molecular lines at a limit of 0.21 Jy beam−1, this work is an important step in understanding the data processing challenges for the future Square Kilometre Array and places solid limits on what is expected in the future of low-frequency surveys. The modeling can be utilized for future searches of nitric oxide.
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