Previous studies have noted consequences of ultra-distance trail running on health, but few studies are available regarding the temporal variations of renal biomarker injury during the running. The ...aim of this study was to assess the of kidney function parameters temporal variation during and on short-term after an ultra-distance race.
We performed an observational study with 47 subjects participating in an ultra-distance race (80 km). Urine (47 subjects) and blood (21 subjects) samples were serially collected before (baseline-km 0), during (21 and 53 km), on arrival (80 km), and 9 days after the race (d9).
Mean serum creatinine increased during the race from 90±14 μmol/L (km0) to 136±32 μmol/L (km 80-p<0.0001) corresponding to a 52% increase. Mean creatininuria progressively increased from 4.7±4.5 mmol/L (km 0) to 22.8±12.0 mmol/L (km 80) (p<0.0001). Both urinary biomarkers (Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1) of acute kidney injury (AKI) progressively increased during the race (p<0.05 vs baseline). However, after adjustment to urine dilution by urine creatinine, no significant changes remained (p>0.05). On day 9, no significant difference remains in blood and urine biomarkers compared to their respective baseline levels.
During an ultra-distance race, despite an acute and transient increase in the serum creatinine levels, urinary biomarkers of AKI displayed only limited changes with a complete regression on day 9. These results suggest the absence of the short-term impact of an ultra-distance race kidney function.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
...since it was a pragmatic study, the physician decisions were based on our service’s procedures, which are public 7. ...trying to obtain cut-off points with a predictive value for decision-making, ...if it can be achieved, it would be a later study. ...we really intended to find a different decision-making tool that helps the physician on scene, some kind of metabolic watch.
...the animal model used, i.e., a swine model of asphyxia associated cardiac arrest, resulting in acidosis and hypoxemia, may partly explain the lack of epinephrine efficacy on CBF and cerebral ...tissue oxygenation observed after the third dose (see additional File 2) because of the negative effects of hypoxemia and acidosis to the response to sympathomimetic agents 4. 1, that, despite the exact mechanisms of epinephrine’s effects on CBF and cerebral oxygenation, CPR methods, including epinephrine administration, aim to maintain CBF in order to limit cerebral hypoperfusion and neurologic injury. ...even if CPR methods allow to maintain CBF, pending cardiac arrest etiological treatment, short and long-term survival increase requires a true bundle of care, including, CPR methods and cerebral protection, implemented complementarily to the chain of survival 5. ...we are not convinced that epinephrine’s ineffectiveness later in CPR was a function of our asphyxial model, but rather that it may be indicative of metabolic and physiologic changes that occur with prolonged CPR in general. Panchal AR, Berg KM, Hirsch KG, Kudenchuk PJ, Del Rios M, Cabanas JG, et al. 2019 American heart association focused update on advanced cardiovascular life support: use of advanced airways, vasopressors, and extracorporeal cardiopulmonary resuscitation during cardiac arrest: an update to the American heart association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care.
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