Positive cognitions contribute directly to psychological well-being, whilst negative cognitions are associated with many mental disorders including depression and anxiety. Psychometric properties of ...the Oxford Positive Self-Scale were analyzed in a Turkish sample group to assess positive beliefs about the self. In this context, two studies were conducted with two different sample groups. Study I included 403 participants (57 % female, mean age: 25.66) and Study II included 375 participants (56 % female, mean age: 26). Confirmatory factor analyses conducted within the scope of Study I confirmed the 8-item short form of the scale with a 4-factor structure. Configural, metric and scalar analyses also confirmed the measurement invariance. Reliability analyses showed that the scale was in the acceptable reliability range. Item Response Theory analysis provided discrimination. Furthermore, positive self was positively correlated with openness, conscientiousness, extraversion, agreeableness, subjective happiness, self-esteem and negatively correlated with neuroticism. Structural equation modeling in Study II revealed that psychological distress and subjective wellbeing mediate the relationship between positive self-regard and psychological well-being, highlighting their roles in predictive validity analysis. The results suggest that the Oxford Positive Self-Scale short form is valid and reliable for assessing individuals' positive self-cognitions.
•The Oxford Positive Self Scale (OxPos) measures people's cognitions of happiness.•OxPos-short form is in the acceptable validity and reliability range in Turkish.•The present study was carried out with two separate sample groups.•Positive self is negatively associated to anxiety, stress, and depression.•Positive self and psychological well-being are mediated by distress and vitality.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
This study aimed to synthesize and characterize juglone-entrapped poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles and compare the antifungal properties of free juglone with its PLGA ...nanoparticle formulation for the first time. The juglone-loaded nanoparticles prepared using the oil-in-water (o/w) single-emulsion solvent evaporation method were characterized by the reaction yield (RY), encapsulation efficiency (EE), polydispersity index (PDI), particle size, zeta potential (ZP), FT-IR, and in vitro release properties and evaluated for their morphological features using SEM. The nanoparticle formulation had size, RY, ZP, EE, and PDI values of 212 nm, 66.91 ± 2.4%, −16.3 ± 0.7 mV, 70.66 ± 3.1%, and 0.083 ± 0.024, respectively. In vitro release showed a triphasic pattern with initial burst followed by sustained release and dormant phase over the study period, releasing about 72.8% in total after 42 days. The antifungal studies against Aspergillus flavus, Candida albicans, and Fusarium spp. using agar dilution and top agar dilution methods indicated that the juglone-encapsulated nanoparticle was more effective than free juglone. This study showed that the top agar method, which was applied for the first time on antifungal activity, is more suitable for the nanoparticular system based on sustained release. Therefore, PLGA nanoparticle formulations may be an important tool for application in many areas for the effective and beneficial use of hydrophobic compounds such as juglone.
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IJS, KILJ, NUK, PNG, UL, UM, UPUK
Günümüz pazarlama konseptleri arasında önemli bir yere sahip olan Lovemark kavramı; gizem, duyusallık ve samimiyeti harekete geçirebilme olarak ifade edilmektedir. Tüketicinin markaya yönelik ...dikkatini, ilgisini, arzusunu ve isteğini satın alma davranışına dönüştürmesi Lovemark olarak tanımlanmaktadır. Markaların, Lovemark oluşum sürecinde tüketicilerin sevgisini, saygısını, ilgisini ve güvenini kazanarak marka imajını ve markaya olan tüketici bağlılığını artırmaları önem arz etmektedir. Bu doğrultuda çalışmanın amacı; Lovemark oluşum sürecinde marka imajı ve marka bağlılığı arasındaki ilişkiyi Z nesli özelinde incelemektir. Araştırma kapsamında Z neslinin tamamına ulaşmak zaman kısıtı ve örnekleme ulaşım zorluğu nedeniyle mümkün olmadığı için araştırma olasılığa dayalı olmayan örnekleme türlerinden amaçlı örnekleme yöntemi kullanılarak gerçekleştirilmiştir. Araştırmada, Lovemark oluşum sürecinde marka imajı ve marka bağlılığı ölçekleri Starbucks markası üzerinden kurgulanmıştır. Araştırma, online olarak gerçekleştirilmiş olup araştırmaya katılan n=310 katılımcıya ait veriler üzerinden değişkenler arasındaki ilişkiler test edilmiş ve belirlenen araştırma sorularına cevap aranmıştır. Verilerin analizinde istatistiksel paket programı kullanılarak, betimleyici istatistikler, t-testi ve korelasyon analizi gerçekleştirilmiştir. Araştırmanın sonuçlarına göre Lovemark oluşum sürecinde marka imajı ve marka bağlılığı gözlenen değişkenlerinin tanımlayıcı istatistikleri incelendiğinde, katılımcıların ilgili markayı başarılı, güçlü, canlı vb. bulurken, marka bağlılığı gözlenen değişkenlerinin ortalamalarının düşük olduğu tespit edilmiştir. Öte yandan marka imajı alt boyutlarından samimiyet (r=689; p=,000) ve yeterlilik/coşku (r=,355; p=,000) değişkenleri ile marka bağlılığı arasında anlamlı bir ilişki olduğu belirlenmiştir. T-testi sonuçları incelendiğinde ise cinsiyet değişkenine göre marka imajı ve marka bağlılığı gözlenen değişkenlerine yönelik grup ortalamalarının kadınların lehine olduğu tespit edilmiştir.
The concept of Lovemark, which has an important place among nowadays marketing concepts, is expressed as the ability to activate mystery, sensuality and sincerity. It is defined as Lovemark when the consumer turns the attention, interest, desire and desire towards the brand into a buying behavior. It is important for brands to increase their brand image and consumer loyalty to the brand by gaining the love, respect, interest and trust of consumers during the Lovemark formation process. In this direction, the aim of the study is to examine the relationship between brand image and brand loyalty in the generation Z sample during the Lovemark formation process. Within the scope of the research, it was not possible to reach the entire generation Z due to time constraints and difficulty of sampling, so the research was carried out using purposeful sampling method from sampling types that are not based on probability. In the research, the brand image and brand loyalty scales were built over the Starbucks brand in the process of lovemark formation. The research was conducted online, and the relationships between variables were tested over the data of n=310 participants participating in the study, and answers were sought for the determined research questions. Descriptive statistics, t-test and correlation analysis were performed using the statistical package program in the analysis of the data. According to the results of the research, when the descriptive statistics of the variables of brand image and brand loyalty observed in the Lovemark formation process were examined, it was found that the participants found the relevant brand successful, strong and lively, while the averages of the variables observed brand loyalty were low. On the other hand, it was determined that there is a significant relationship between brand image sub-dimensions of sincerity (r=689; p=,000) and competence-enthusiasm (r=,355; p=,000) and brand loyalty. When the t-test results were examined, it was determined that the group averages for the variables of brand image and brand loyalty by gender variable were in favor of women.
Üniversitelerde eğitim-öğretim faaliyetlerinin dijitalleşmesi durumunu, teknostres kavramı ve iletişim akademisyenleri üzerinden incelemeyi amaçlayan bu çalışmada, nitel araştırma türlerinden biri ...olan görüşme tekniği kullanılmıştır. Bu araştırmanın desenini ise nitel araştırma deseni olan fenomenolojik yaklaşım oluşturmaktadır. İlgili teknik ve desen ile katılımcıların teknostrese ilişkin deneyimlerini yansıtmak, bu araştırmanın öncelikli amacıdır. Araştırmanın bulguları değerlendirildiğinde katılımcıların eğitim-öğretim faaliyetlerini gerçekleştirirken farklı dijital araç ve platformlar ile birlikte çeşitli dijital eğitim-öğretim modellerini kullandıkları görülmektedir. İletişim akademisyenlerinin teknostrese ilişkin sorulara verdikleri yanıtlar incelendiğinde, katılımcıların ifadelerinde genel anlamda tekno aşırı yüke maruz kaldıklarını dile getirdikleri görülmektedir. Katılımcı deneyimlerinin ifadelerine yansımasından hareketle, iletişim akademisyenlerinin tekno istilaya maruz kalıp kalmamalarına ilişkin eşit oranda görüş bildirdikleri anlaşılmaktadır. Bununla birlikte, katılımcıların yanıtları incelendiğinde tam tersi cevaplara nazaran, tekno karmaşıklık ve tekno belirsizlik yaşadıkları görülmektedir. Son olarak ise tekno güvensizliğe yönelik katılımcı ifadeleri incelendiğinde, iletişim akademisyenlerinin eğitim-öğretim faaliyetlerindeki dijitalleşme sürecini güvensiz bulmadıkları anlaşılmaktadır. Bu doğrultuda, iletişim akademisyenlerinin eğitim-öğretim faaliyetlerindeki dijitalleşme sürecinde teknostres kavramı ile yüzleştikleri ve bu bağlamda konuya ilişkin olumlu ya da olumsuz yönde bir görüş bildirecek tecrübeye eriştikleri yine bu araştırmanın sonuçları arasındadır.
The interview technique, which is one of the qualitative research types, was used in this study which aims to examine the digitalization of education activities in universities through the concept of technostress and communication academics. The pattern of this research is the phenomenological approach which is a qualitative research design. The purpose of this research is to reflect the participants' technostress experiences with the relevant technique and design. Coming up to the results of the research, it is realized that the participants use different types of digital education models, digital tools, and platforms while performing their educational activities. When the responses of the communication academics to the questions about technostress are examined, it is seen that the participants stated that they were generally exposed to techno overload. Based on the reflection of the participant’s experiences in their statements, it is understood that communication academics equally expressed opinions on whether they are exposed to techno invasion. Additionally, when the responses of the participants are analyzed, it is seen that they experience techno complexity and techno uncertainty with a slight difference compared to the opposite responses. Finally, when the participant expressions regarding techno insecurity are examined, it is understood that communication academics do not find the digitalization process in education activities insecure, with a slight lead. Regarding all these, it is also among the results of this research that communication academics face the concept of technostress in the digitalization process of education activities and that, in this context, they have the experience to express a positive or negative opinion on this subject.
In this study, our goal was to synthesize novel aryl tacrine derivatives and assess their potential as anticancer, antibacterial agents, and enzyme inhibitors. We adopted a two‐step approach, ...initiating with the synthesis of dibromotacrine derivatives 3 and 4 through the Friedlander reaction. These intermediates underwent further transformation into diarylated tacrine derivatives 3a–e and 4a–e using a Suzuki–Miyaura cross‐coupling reaction. Thorough characterization of these novel diarylated tacrines was achieved using various spectroscopic techniques. Our findings highlighted the potent anticancer effects of these innovative compounds across a range of cancer cell lines, including lung, gynecologic, bone, colon, and breast cancers, while demonstrating low cytotoxicity against normal cells. Notably, these compounds surpassed the control drug, 5‐Fluorouracil, in terms of antiproliferative activity in numerous cancer cell lines. Moreover, our investigation included an analysis of the inhibitory properties of these novel compounds against various microorganisms and cytosolic carbonic anhydrase enzymes. The results suggest their potential for further exploration as cancer‐specific, enzyme inhibitory, and antibacterial therapeutic agents. Notably, four compounds, namely, 5,7‐bis(4‐(methylthio)phenyl)tacrine (3d), 5,7‐bis(4‐(trifluoromethoxy)phenyl)tacrine (3e), 2,4‐bis(4‐(trifluoromethoxy)phenyl)‐7,8,9,10‐tetrahydro‐6H‐cycloheptabquinolin‐11‐amine (4e), and 6,8‐dibromotacrine (3), emerged as the most promising candidates for preclinical studies.
The novel aryl substituted tacrine were efficiently synthesized and their anticancer potentials were highlighted in this study. Their inducing apoptosis, cell migration, and mitochondrial membrane potentials were screened.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
The education process, which has undergone digital transformation due to factors such as the transition
to information society, change in technology, social dynamics, and globalization, has also ...affected the
discipline of public relations. In this direction, the study aims to systematically obtain expert opinions
on the digitalization process in public relations education. In addition, this study further aims to make
predictions of public relations education, reveal expert opinions, and reach consensus with the panel
members consisting of 15 academicians/experts in the field of public relations. The results of the
research, which applied Delphi technique as a method, pointed out that the panel members reached
a consensus on 50 variables in 3 rounds in total. In this regard, there was one particular opinion that
was emphasized in the field work: flipped and blended education models were considered as the most
successful and efficient digital education models during public relations education’s digitalization
process. According to another finding of the study, flexibility and adaptability, social and cross-cultural
skills, communication and collaboration, information literacy, ICT literacy, and global awareness are
among the most important skills and themes that both academics and students should have in public
relations education’s digitalization process. Finally, the research findings show that in competencies
(proficiency-qualification), learner competence for academicians and creative communicator
competence for students came to the fore.
Bilgi toplumuna geçiş, teknolojideki değişim, toplumsal dinamikler ve küreselleşme gibi faktörlerin
etkisiyle dijital dönüşüme uğrayan eğitim süreci halkla ilişkiler disiplinini de etkilemiştir. Bu doğrultuda
araştırmada, halkla ilişkiler eğitiminde dijitalleşme sürecine ilişkin uzman görüşlerinin sistematik bir
şekilde elde edilmesi amaçlanmıştır. Ayrıca, halkla ilişkiler alanında 15 akademisyenden/uzmandan
oluşan panel üyeleri ile halkla ilişkiler eğitiminin geleceğine ilişkin tahminlerde bulunmak, uzman
görüşlerini ortaya çıkarmak ve uzlaşma sağlamak çalışmanın bir diğer amacıdır. Araştırmada yöntem
olarak Delphi tekniği kullanılmıştır. Araştırma sonucunda, panel üyelerinin 50 değişken üzerinde
toplamda 3 turda tamamen fikir birliğine ulaştıkları görülmüştür. Araştırma bulgularına göre halkla
ilişkiler eğitiminde dijitalleşme sürecinde en başarılı ve verimli dijital eğitim modellerinin ters-yüz
edilmiş ve harmanlanmış eğitim modelleri olduğu görüşü ön plana çıkmıştır. Araştırmanın diğer
bir bulgusuna göre, halkla ilişkiler eğitiminde dijitalleşme sürecinde hem akademisyenlerin hem de
öğrencilerin sahip olması gereken en önemli beceriler ve temalar arasında, esneklik ve uyum, sosyal
ve kültürlerarası beceriler, iletişim ve iş birliği, bilgi okuryazarlığı, bilişim teknolojileri okuryazarlığı
ve küresel farkındalık unsurları yer almaktadır. Sonuç olarak, yeterliliklerde (yetkinlik-nitelik) ise
akademisyenler için öğrenen yeterliliği, öğrenciler için yaratıcı iletişimci yeterliliği ön plana çıkmıştır.
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