Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disorder first described among French Canadians in Quebec. To date, 24 mutations have been reported in the ...SACS gene of ARSACS patients. The authors report a clinical and genetic analysis of a Japanese family with ARSACS with novel compound heterozygous mutations in the SACS gene (N161fsX175, L802P). The phenotype is similar to that of previously reported ARSACS patients.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The neutron capture cross section of ^(88)Sr at incident neutron energies E_n = 10 - 89 keV and 510 keV has been measured by the time-of-flight method. Capture γ-rays were detected with an ...anti-Compton NaI(Tl) spectrometer and the pulse height weighting technique was applied to derive the neutron cross section as a function of incident neutron energy. Capture γ-ray spectra were also measured. The obtained capture cross section was compared with previous experimental data and evaluated data from ENDF/B-VII.0. KCI Citation Count: 0
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
► A prototype single phase liquid xenon detector was developed and operated. ► We have tested performance of this prototype detector. ► We have measured the physical properties of liquid xenon. ► We ...have established vertex and energy reconstruction methods. ► We have demonstrated liquid xenon’s self-shielding power against γ-rays.
Liquid xenon is a suitable material for a dark matter search. For future large scale experiments, single phase detectors are attractive due to their simple configuration and scalability. However, in order to reduce backgrounds, they need to fully rely on liquid xenon’s self-shielding property. A prototype detector was developed at Kamioka Observatory to establish vertex and energy reconstruction methods and to demonstrate the self-shielding power against γ-rays from outside of the detector. 662keV γ-rays from 137Cs are attenuated by a factor of about 50 over a distance of 20cm.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The use of the parallel-plate avalanche counter for slow-neutron counting is described. The choice of a suitable neutron converter is discussed on the basis of Monte Carlo simulation, and some ...experimental results are shown. Excellent γ-insensitivity, high rate capability, possibility of construction in large sensitive area and low production cost are among the promising features of this neutron detector.
Caspase-3 is thought to play an important role(s) in the nuclear morphological changes that occur in apoptotic cells and many nuclear substrates for caspase-3 have been identified despite the ...cytoplasmic localization of procaspase-3. Therefore, whether activated caspase-3 is localized in the nuclei and how active caspase-3 has access to its nuclear targets are important and unresolved questions. Here we confirmed nuclear localizations for both caspase-3-p17 and caspase-3-p12 subunits of active caspase in apoptotic cells using subcellular fractionation analysis. We also prepared polyclonal and monoclonal antibodies specific for active caspase-3 to define the subcellular localization of active caspase-3. Immunocytochemical observations using anti-active caspase-3 antibodies showed nuclear accumulation of active caspase-3 during apoptosis. In addition, caspase-3, but not caspase-7, translocated from the cytoplasm into the nucleus after induction of apoptosis. Mutations at the cleavage site between the p17 and p12 subunits and the substrate recognition site for the P3 amino acid of the DXXD substrate cleavage motif inhibited nuclear translocation of caspase-3, indicating that nuclear transport of active caspase-3 required proteolytic activation and substrate recognition. These results suggest that active caspase-3 is translocated in association with a substrate-like protein(s) from the cytoplasm into the nucleus during progression through apoptosis.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Commissioning of KEKB Akai, K.; Akasaka, N.; Enomoto, A. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
02/2003, Volume:
499, Issue:
1
Journal Article
Peer reviewed
KEKB has been operated since December, 1998, to deliver
B
B
̄
pairs for a physics detector. In this paper,we describe the commissioning procedure of KEKB.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Beam-beam effects limit the luminosity of circular colliders. Once the bunch population exceeds a threshold, the luminosity increases at a slower rate. This phenomenon is called the beam-beam limit. ...Onset of the beam-beam limit has been analyzed with various simulation methods based on the weak-strong and strong-strong models. We have observed that an incoherent phenomenon is mainly concerned in the beam-beam limit. The simulation have shown that equilibrium distributions of the two colliding beams are distorted from Gaussians when the luminosity is limited. The beam-beam limit is estimated to be xi approximately 0.1 for a B factory with damping time of several thousand turns.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
Systematic measurements and calculations of neutron capture cross sections and capture gamma-ray spectra of all stable Se isotopes ^(74, 76, 77, 78, 80, 82)Se were performed in a neutron energy ...region from 10 to 600 keV, using a pulsed neutron source by the ^7Li(p,n)^7Be reaction. Highly isotopically enriched Se samples and standard Au samples were used. The capture gamma rays from each sample were detected with an anti-Compton NaI(Tl) spectrometer by means of a time-of-flight method. The capture cross sections were derived by using a pulse-height weighting technique and the standard capture cross sections of ^(197)Au. The capture gamma-ray spectra were obtained by unfolding the observed capture gamma-ray pulse-height spectra. In the calculations, a computer code, POD, was utilized. The calculated results were compared with the experimental results. The present experimental and calculated results were compared with previous measurements and evaluated values. KCI Citation Count: 3
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