A previously healthy 40-year-old man developed febrile episodes of unknown origin, articular symptoms, venous occlusion of the lower limb and transient elevation of hepatic enzymes, and cutaneous ...symptoms. Computed tomography scanning revealed enlarged lymph nodes, but no sample was collected. In addition to microcytic anemia, a high serum ferritin level and an increased IL-2 receptor value in serum were found. Drug therapy against tuberculosis and borreliosis was started, but febrile episodes continued and in a few days the patient developed multiorgan dysfunction. Hemophagocytic lymphohistiocytosis associated with T-cell lymphoma was revealed as the underlying condition.
Is lymphoma curable with antibody therapy? Leppä, Sirpa; Nyman, Heidi; Karjalainen-Lindsberg, Marja-Liisa
Duodecim (Helsinki, Finland : 1961),
2009, Volume:
125, Issue:
3
Magazine Article
Diagnostics of non-Hodgkin's lymphomas has improved significantly over the last decades. Predictors have been found and new biological therapies developed. Rituximab, an antibody recognizing the CD20 ...B cell antigen, has proven to be of especially high clinical importance. In a proportion of follicular lymphomas, long responses are achieved with rituximab alone, without the adverse effects of cytotoxic agents. On the other hand, combining rituximab with cytotoxic agents extends the non-diseased period and total survival period both in follicular and diffuse large B cell lymphoma.
A previously quite healthy 65-year-old woman sought emergency hospital care due to fatigue, weight loss and sensation of thirst appearing over a couple of months. Further analysis revealed a process ...affecting the neurohypophysis and extensive lytic sclerotic bone lesions. Eventually a rare generalized underlying disease was unraveled: the diagnosis included both Langerhans cell histiocytosis and Erdheim-Chester disease.
