Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H2O2 into the highly toxic hydroxyl radical (.OH). There is a paucity of ...Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with .OH scavenging ability greatly reduces CDT efficacy. A self‐reinforcing CDT nanoagent based on MnO2 is reported that has both Fenton‐like Mn2+ delivery and GSH depletion properties. In the presence of HCO3−, which is abundant in the physiological medium, Mn2+ exerts Fenton‐like activity to generate .OH from H2O2. Upon uptake of MnO2‐coated mesoporous silica nanoparticles (MS@MnO2 NPs) by cancer cells, the MnO2 shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn2+, resulting in GSH depletion‐enhanced CDT. This, together with the GSH‐activated MRI contrast effect and dissociation of MnO2, allows MS@MnO2 NPs to achieve MRI‐monitored chemo–chemodynamic combination therapy.
Self‐reinforcing weapon: The Fenton‐like Mn2+ delivery and glutathione (GSH) depletion abilities of MnO2 allow it to exert enhanced chemodynamic efficacy in cancer treatment. An activatable theranostic platform based on multifunctional MnO2‐coated mesoporous silica nanoparticles (MS@MnO2 NPs) has been developed for MRI‐monitored combination chemotherapy and chemodynamic therapy (CDT). ADS=antioxidant defense system.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
In this work, we discovered that polypyrrole nanoparticles (PPy NPs) displayed a low non-specific protein adsorption. We herein present the first PPy NP-based biosensing platform for intracellular ...mRNA detection in living cells. We also demonstrate that PPy NPs exhibit high NIR absorbance and can be utilized for cancer photothermal therapy.
Multifunctional nanoplatforms with integrated diagnostic and therapeutic functions have attracted tremendous attention. Especially, the second near-infrared (NIR-II) light response-based ...nanoplatforms hold great potential in cancer theranostic applications, which is because the NIR-II window provides larger tissue penetration depth and higher maximum permissible exposure (MPE) than that of the well-studied first near-infrared (NIR-I) window. Herein, we for the first time present a two-dimensional (2D)-nanoplatform based on Cu
MnS
nanoplates (NPs) for magnetic resonance imaging (MRI)/multispectral optoacoustic tomography (MSOT) dual-modal imaging-guided photothermal therapy (PTT) of cancer in the NIR-II window.
Cu
MnS
NPs were synthesized through a facile and environmentally friendly process. A series of experiments, including the characterization of Cu
MnS
NPs, the long-term toxicity of Cu
MnS
NPs in BALB/c nude mice, the applications of Cu
MnS
NPs for
and
MRI/MSOT dual-modal imaging and NIR-II PTT of cancer were carried out.
The as-synthesized Cu
MnS
NPs exhibit low cytotoxicity, excellent biocompatibility as well as high photothermal conversion efficiency (~49.38%) and outstanding photostability. Together with their good
-shortening effect and strong absorbance in the NIR-I and NIR-II region, the Cu
MnS
NPs display high-contrast imaging performance both in MRI and MSOT (900 nm laser source). Moreover, the subsequent
and
results demonstrate that the Cu
MnS
NPs possess excellent PTT efficacy under 1064 nm laser irradiation with a low power density (0.6 W cm
). In addition, the detailed long-term toxicity studies further confirming the safety of Cu
MnS
NPs
.
We have developed a new 2D Cu
MnS
NPs as multifunctional theranostic agents for MRI/MSOT dual-modal imaging-guided PTT of cancer in the NIR-II window. Such biocompatible Cu
MnS
NPs might provide a new perspective for exploring new 2D-based nanoplatforms with improved properties for clinical applications in the future.
In this work, we discovered that polypyrrole nanoparticles (PPy NPs) displayed a low non-specific protein adsorption. We herein present the first PPy NP-based biosensing platform for intracellular ...mRNA detection in living cells. We also demonstrate that PPy NPs exhibit high NIR absorbance and can be utilized for cancer photothermal therapy.
Polypyrrole-DNA nanoprobes for intracellular mRNA detection and photothermal therapy.
Chemodynamic therapy (CDT) utilizes iron-initiated Fenton chemistry to destroy tumor cells by converting endogenous H
O
into the highly toxic hydroxyl radical (
OH). There is a paucity of Fenton-like ...metal-based CDT agents. Intracellular glutathione (GSH) with
OH scavenging ability greatly reduces CDT efficacy. A self-reinforcing CDT nanoagent based on MnO
is reported that has both Fenton-like Mn
delivery and GSH depletion properties. In the presence of HCO
, which is abundant in the physiological medium, Mn
exerts Fenton-like activity to generate
OH from H
O
. Upon uptake of MnO
-coated mesoporous silica nanoparticles (MS@MnO
NPs) by cancer cells, the MnO
shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn
, resulting in GSH depletion-enhanced CDT. This, together with the GSH-activated MRI contrast effect and dissociation of MnO
, allows MS@MnO
NPs to achieve MRI-monitored chemo-chemodynamic combination therapy.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Abstract
Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H
2
O
2
into the highly toxic hydroxyl radical (
.
OH). There is a paucity ...of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with
.
OH scavenging ability greatly reduces CDT efficacy. A self‐reinforcing CDT nanoagent based on MnO
2
is reported that has both Fenton‐like Mn
2+
delivery and GSH depletion properties. In the presence of HCO
3
−
, which is abundant in the physiological medium, Mn
2+
exerts Fenton‐like activity to generate
.
OH from H
2
O
2
. Upon uptake of MnO
2
‐coated mesoporous silica nanoparticles (MS@MnO
2
NPs) by cancer cells, the MnO
2
shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn
2+
, resulting in GSH depletion‐enhanced CDT. This, together with the GSH‐activated MRI contrast effect and dissociation of MnO
2
, allows MS@MnO
2
NPs to achieve MRI‐monitored chemo–chemodynamic combination therapy.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H2O2 into the highly toxic hydroxyl radical (.OH). There is a paucity of ...Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with .OH scavenging ability greatly reduces CDT efficacy. A self‐reinforcing CDT nanoagent based on MnO2 is reported that has both Fenton‐like Mn2+ delivery and GSH depletion properties. In the presence of HCO3−, which is abundant in the physiological medium, Mn2+ exerts Fenton‐like activity to generate .OH from H2O2. Upon uptake of MnO2‐coated mesoporous silica nanoparticles (MS@MnO2 NPs) by cancer cells, the MnO2 shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn2+, resulting in GSH depletion‐enhanced CDT. This, together with the GSH‐activated MRI contrast effect and dissociation of MnO2, allows MS@MnO2 NPs to achieve MRI‐monitored chemo–chemodynamic combination therapy.
MnO2 zeigt Fenton‐ähnliche Eigenschaften in Bezug auf Mn2+‐Freisetzung und Glutathion(GSH)‐Abbau; hieraus resultiert eine verbesserte chemodynamische Wirksamkeit bei der Krebsbehandlung. Eine aktivierbare theranostische Plattform auf Basis multifunktionaler MnO2‐beschichteter mesoporöser Siliciumoxidnanopartikel (MS@MnO2‐NPs) wurde für die MRI‐überwachte kombinierte chemotherapeutische und ‐dynamische Therapie (CDT) entwickelt. ADS=antioxidatives Abwehrsystem.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Two series of novel steroidal17,16-
pyrimidines derived from natural epiandrosterone and androsterone were designed and synthesized, and these compounds were screened for their potential anticancer ...activities. The preliminary bioassay indicated that some of these prepared compounds exhibited significantly good cytotoxic activities against human gastric cancer (SGC-7901), lung cancer (A549), and hepatocellular liver carcinoma (HepG2) cell lines compared with 5-fluorouracil (5-FU), epiandrosterone, and androsterone. Especially the respective pairs from epiandrosterone and androsterone showed significantly different inhibitory activities, and the possible configuration-activity relationships have also been summarized and discussed based on kinase assay and molecular docking, which indicated that the inhibition activities of these steroidal17,16-
pyrimidines might obviously be affected by the configuration of the hydroxyl group in the part of the steroidal scaffold.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Weeds had caused significant loss for crop production in the process of agriculture. Herbicides have played an important role in securing crop production. However, the high reliance on herbicides has ...led to environmental issues as well as the evolution of herbicide resistance. Thus, there is an urgent need for new herbicides with safer toxicological profiles and novel modes of action. Actinomycetes produce very diverse bioactive compounds, of which some show potent biopesticidal activity. The herbicidal secondary metabolites from actinomycetes can be classified into several groups, such as amino acids, peptides, nucleosides, macrolides, lactones, amide, amines, etc., some of which have been successfully developed as commercial herbicides. The structure diversity and evolved biological activity of secondary metabolites from actinomycetes can offer opportunities for the development of both directly used bioherbicides and synthetic herbicides with new target sites, and thus, this review focuses on the structure, herbicidal activity, and modes of action of secondary metabolites from actinomycetes.
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IJS, KILJ, NUK, PNG, UL, UM, UPUK
Synthetic chemicals have been widely used in modern agriculture as fertilizer, plant growth regulators and pesticides. Although the chemical inputs improved the crop production, it is well known ...about their negative effects, such as environmental residues in water, soil and animals, pest resistance and resurgence and the residues in agricultural produces. The demands for safer food and more friendly environment are now more preferred by humankind in the world. Microbes have already become an alternate for chemical inputs in some aspects in agriculture. The microbes can produce very diverse volatile organic compounds (mVOCs) which play important roles in the interactions between plant and microbes, or among intraspecies or interspecies of microbes. Many mVOCs showed diverse agroactivities, such as insecticidal, bactericidal, fungicidal, herbicidal, plant growth promotion and abiotic stress-tolerance inducing activities. The agroactive mVOCs have diverse structure-types, such as alkane, alkenes, alcohols, aldehydes, ketones, carboxylic acid, esters and lactones, ethers, aromatic ring, terpenes, heterocycles, sulphur-containing VOCs. The promising agroactive properties make it possible to apply mVOCs and their producing microorganisms or synthetic mimics or agroactive mVOCs in crop protection, and so this review focuses on the chemical diversity, agroactivities, and potential application of mVOCs.
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•A systematic review on agroactive volatile organic compounds from microbes (mVOCs).•mVOCs indicated diverse agroactivities and chemical diversities.•mVOCs and their producing microorganisms can be applied in crop protection.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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