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  • Single-molecule visualizati... Single-molecule visualization of DNA G-quadruplex formation in live cells
    Di Antonio, Marco; Ponjavic, Aleks; Radzevičius, Antanas ... Nature chemistry, 09/2020, Volume: 12, Issue: 9
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    Substantial evidence now exists to support that formation of DNA G-quadruplexes (G4s) is coupled to altered gene expression. However, approaches that allow us to probe G4s in living cells without ...
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  • Insoluble tau aggregates in... Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase
    Esteras, Noemi; Kundel, Franziska; Amodeo, Giuseppe F. ... The FEBS journal, January 2021, Volume: 288, Issue: 1
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    Most neurodegenerative disorders are associated with aggregation and accumulation of misfolded proteins. One of these proteins, tau, is involved in a number of pathologies including Alzheimer's ...
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  • Kinetic diversity of amyloi... Kinetic diversity of amyloid oligomers
    Dear, Alexander J.; Michaels, Thomas C. T.; Meisl, Georg ... Proceedings of the National Academy of Sciences - PNAS, 06/2020, Volume: 117, Issue: 22
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    The spontaneous assembly of proteins into amyloid fibrils is a phenomenon central to many increasingly common and currently incurable human disorders, including Alzheimer’s and Parkinson’s diseases. ...
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  • α-synuclein oligomers inter... α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease
    Ludtmann, Marthe H R; Angelova, Plamena R; Horrocks, Mathew H ... Nature communications, 06/2018, Volume: 9, Issue: 1
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    Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase ...
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  • Alpha synuclein aggregation... Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
    Angelova, Plamena R; Choi, Minee L; Berezhnov, Alexey V ... Cell death and differentiation, 10/2020, Volume: 27, Issue: 10
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    Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a ...
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  • Different soluble aggregate... Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
    De, Suman; Wirthensohn, David C; Flagmeier, Patrick ... Nature communications, 04/2019, Volume: 10, Issue: 1
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    Protein aggregation is a complex process resulting in the formation of heterogeneous mixtures of aggregate populations that are closely linked to neurodegenerative conditions, such as Alzheimer's ...
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  • Nanopore extended field-eff... Nanopore extended field-effect transistor for selective single-molecule biosensing
    Ren, Ren; Zhang, Yanjun; Nadappuram, Binoy Paulose ... Nature communications, 09/2017, Volume: 8, Issue: 1
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    There has been a significant drive to deliver nanotechnological solutions to biosensing, yet there remains an unmet need in the development of biosensors that are affordable, integrated, fast, ...
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  • Structural characterization... Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
    Chen, Serene W.; Drakulic, Srdja; Deas, Emma ... Proceedings of the National Academy of Sciences - PNAS, 04/2015, Volume: 112, Issue: 16
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    Significance Certain oligomeric species generated during the self-assembly of specific proteins into ordered fibrillar aggregates are likely to be key players in the initiation and spreading of ...
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  • Picomolar concentrations of... Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
    Hughes, Craig D.; Choi, Minee L.; Ryten, Mina ... Acta neuropathologica, 01/2019, Volume: 137, Issue: 1
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    Despite the wealth of genomic and transcriptomic data in Parkinson’s disease (PD), the initial molecular events are unknown. Using LD score regression analysis, we show significant enrichment in PD ...
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  • Multi-dimensional super-res... Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping
    Bongiovanni, Marie N; Godet, Julien; Horrocks, Mathew H ... Nature communications, 12/2016, Volume: 7, Issue: 1
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    Super-resolution microscopy allows biological systems to be studied at the nanoscale, but has been restricted to providing only positional information. Here, we show that it is possible to perform ...
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