Each sleep phase is characterized by specific chemical, cellular and anatomic events
of vital importance for normal neural functioning. Different forms of sleep deprivation may lead to a
decline of ...cognitive functions in individuals. Studies in this field make a distinction between total sleep
deprivation, chronic sleep restriction, and the situation of sleep disruption. Investigations covering the
acute effects of sleep deprivation on the brain show that the discovered behavioral deficits in most cases
regenerate after two nights of complete sleep. However, some studies done on mice emphasize the
possible chronic effects of long-term sleep deprivation or chronic restriction on the occurrence of neurodegenerative
diseases such as Alzheimer’s disease and dementia. In order to better understand the acute
and chronic effects of sleep loss, the mechanisms of neural adaptation in the situations of insufficient
sleep need to be further investigated. Future integrative research on the impact of sleep deprivation on
neural functioning measured through the macro level of cognitive functions and the micro molecular and
cell level could contribute to more accurate conclusions about the basic cellular mechanisms responsible
for the detected behavioral deficits occurring due to sleep deprivation.
This paper describes virtual reality and some of its potential applications in rehabilitation and therapy. Some aspects of this technology are discussed with respect to different problem areas ...(sensorimotor impairments, autism, learning difficulties), as well as previous research which investigated changes within some motor and motivation parameters in relation to rehabilitation of children with motor impairments. Emphasis is on the positive effects of virtual reality as a method in which rehabilitation and therapy can be offered and evaluated within a functional, purposeful and motivating context.
Pacijenti s upalnim reumatskim bolestima, osobito s reumatoidnim artritisom (RA) imaju značajno povećani rizik za nastanak kardiovaskularnih (KV) bolesti u odnosu na opću populaciju. Ovo se osobito ...odnosi na povišeni rizik od infarkta miokarda i ishemijske bolesti srca. KV događaji i stope smrtnosti u RA veće su za 40-50 % u odnosu na opću populaciju, a rizik za ishemijsku bolest srca nešto je veći nego za moždani udar. Povećanje KV rizika u RA uzrokovano je kompleksnom sinergijom tradicionalnih i netradicionalnih faktora KV rizika, gdje upala izravnim ili neizravnim učincima na vaskularni sustav ima važnu ulogu i neovisni je čimbenik rizika. Pacijenti s jačom aktivnosti bolesti u RA imaju povećani rizik za razvoj srčanog zatajenja. Liječnici trebaju biti svjesni visokog KV rizika i osigurati dobar nadzor i liječenje KV bolesti u pacijenata s RA.
We reported a case of a 71-year-old woman with progressive low back pain and neurologic symptoms of lower extremities, who in the background had the coexistence of spondyloarthritis (SpA) and non ...Hodgkin's lymphoma of the paravertebral location. This example describes a situation where SpA with minimal sacroiliac joints affection has nevertheless led to the overt axial SpA. This situation included undifferentiated or reactive SpA, as well as unusual disease context, presented with late-life disease onset, older age, female gender and no obvious hereditary predisposition. This combination of comorbid factors could allow environmental and disease-specific factors to accumulate over time and to, by modifying the primary, low-penetrant genetic background, lead to the development of lymphoma. By achieving better understanding of disease pathophysiology dynamic, we will be able to improve our capabilities to navigate biologic therapy in the future, in order to prevent the development of both, overt SpA and lymphoproliferative disease.
The early child development, from birth until the age of one year is, amongst other changes, characterized by intense motor learning. During that period, the voluntary learning patterns evolve from ...reflexive patterns to coordinated voluntary patterns. All of the child's voluntary movements present active forms in which the child communicates with the environment. In this communication, the hand plays an important role. Its brain representation covers one-third of the entire motor region, situated in the close proximity to the speech region. For this reason, some authors refer to hand as a "speech organ". According to numerous studies, each separate finger also has a relatively large representation in the cerebral cortex, which points to the importance of the fine motor skills development, or precise, highly differentiated movements of hand muscles following the principles of differentiation and hierarchical integration. Development of the fine motor skills in the hand is important for the overall child development, and it also serves as a predictor pointing to immaturity of the central nervous system. The aim of this paper is to present the development of hand motoricity from birth until the age of one year, as well as the most frequent deviations observed in children hospitalized at Children's Department of Rehabilitation, Clinical Department of Rheumatology, Physical Medicine and Rehabilitation, Sestre milosrdnice University Hospital Center.
Utjecaj gubitka sna na mozak Trošt Bobić, Tatjana; Šečić, Ana; Zavoreo, Iris ...
Acta clinica Croatica (Tisak),
11/2016, Volume:
55., Issue:
3.
Journal Article
Peer reviewed
Open access
Svaku fazu sna opisuju određeni kemijski, stanični i anatomski procesi koji su iznimno važni za održavanje fiziološke neuralne funkcije. Različiti oblici gubitka sna mogu kod čovjeka uzrokovati pad ...kognitivnih funkcija. Istraživanja u ovom znanstvenom području razlikuju situaciju potpunog gubitka sna, kronične restrikcije (ograničavanja) sna te stanje isprekidanog sna. Proučavanje akutnih učinaka neispavanosti na moždanu funkciju ukazuje na činjenicu da se otkriveni deficiti kognitivnih funkcija u većini slučajeva regeneriraju nakon dvije noći potpunog sna. Ipak, studije na miševima naglašavaju mogućnost utjecaja dugotrajne neispavanosti na nastanak nekih neurodegenerativnih bolesti kao što su Alzheimerova bolest i demencija. Kako bismo bolje razumjeli akutne i kronične učinke gubitka sna potrebno je dodatno istražiti mehanizme
neurološke adaptacije na situacije neispavanosti. Buduća bi istraživanja o utjecaju gubitka sna na neurološke funkcije trebala
pratiti makro razinu fenomena mjerenjem kognitivnih funkcija, ali i mikro razinu kroz molekularne i stanične procese. Takav bi pristup mogao doprinijeti točnijim zaključcima o osnovnim staničnim mehanizmima odgovornima za otkriveni kognitivni
deficit uslijed nedostatka sna.
The PROMO (preference for once monthly bisphosphonate) Study, conducted in seven hospital centres in Croatia between June 2007 and June 2008, was designed to analyse patient preference for weekly and ...monthly bisphosphonates in everyday clinical practice where the significant proportion of patients are not completely satisfied with the current osteoporosis treatment. Eligible participants were women with postmenopausal osteoporosis taking weekly bisphosphonates for the last 6 months. Those who agreed to be enrolled were transferred from weekly to monthly ibandronate for the next 6 months. There was no washout period between the two treatment regimens. At the baseline, patients expressed their satisfaction with the weekly treatment. At the end of the study, all patients were asked to complete the five-question survey specially designed for this study. Study population comprised 258 participants. Among 248 patients who completed the study, 244 (98.4%) declared their preference for one of the regimens or they had no preference. Once-monthly regimen was preferred by 231 patients (94.7%), whereas once-weekly regimen was preferred by five patients (2.0%). Eight patients (3.3%) indicated no preference. Furthermore, 93.0% of patients thought that monthly dosing was more convenient. Compared to weekly regimen, monthly dosing was associated with significantly higher satisfaction with the treatment and with significantly less adverse events. In line with these data, 85.9% of patients stated improved quality of life with monthly ibandronate. In summary, the PROMO Study demonstrated strong patient preference for monthly over weekly dosing which is expected to improve suboptimal adherence to weekly bisphosphonates.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
U radu se prikazuje opis virtualne stvarnosti i neke mogućnosti njezine primjene u rehabilitaciji i terapiji. Navedeni su neki vidovi primjene ove tehnologije u različitim problemskim područjima ...(senzomotorički poremećaji, autizam, teškoće u učenju), kao i neka znanstvena istraživanja u kojima su se ispitivale promjene nekih parametara motorike i motivacije vezane uz rehabilitaciju djece s motoričkim poremećajima. Naglašeni su pozitivni učinci virtualne stvarnosti kao metode u kojoj se rehabilitacijski i terapijski postupci mogu provoditi i ocjenjivati unutar funkcionalnog, planiranog i motivirajućeg konteksta.
Cilj ovog istraživanja bio je utvrditi učinkovitost terapijskog ultrazvuka na vertebralnu cirkulaciju u bolesnika s vratoboljom. Terapijski ultrazvuk će u kliničkoj ocjeni dovesti do smanjenja bolova ...u vratu, a može promijeniti i ekstrakranijsku hemodinamiku u vertebralnim arterijama, što može biti jedan od mehanizama smanjenja bolova i mišićnog spazma.
Mehanizam smanjenja bolova poboljšanjem protoka temelji se na poznatoj činjenici da bolje otplavljivanje ostatnih produkata metabolizma dovodi do manjeg podražaja nociceptora.
Ispitivanje je provedeno na 100 bolesnika s vratoboljom (prosječna dob 55 godina), 69 žena i 31 muškarac. Ispitanici su bili podijeljeni u ispitivanu i kontrolnu skupinu. Ispitivana skupina dobivala je terapijski ultrazvuk mobilnom tehnikom paravertebralno cervikalno (1 MHz, 0,5 W/cm2, 5 min.). Kontrolna skupina tijekom primjene terapijskog ultrazvuka imala je aparat isključen. Trajanje intervencije
iznosilo je 15 tretmana (3 tjedna). Obje skupine ispitanika provodile su medicinsku gimnastiku i dobivale su transkutanu električnu nervnu stimulaciju paravertebralno
cervikalno.
Rezultati su pokazali da ne postoji statistički značajna razlika između ispitivane i kontrolne skupine u brzini protoka u vertebralnim arterijama kako nakon 15 tretmana tako i nakon mjesec dana od provedene fizikalne terapije. Brzina protoka u vertebralnim arterijama bila je najniža prije tretmana u obje skupine ispitanika.
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