The efficiency of magnetic laser therapy was evaluated in patients with essential hypertension (stages I and II). The role of angiotensinogen, angiotensin-converting enzyme, type II bradykinin ...receptor, and endothelial nitrogen oxide synthetase gene polymorphism in the realization of hypotensive effect of magnetic laser therapy was evaluated. The hypotensive effect of magnetic laser therapy depends on the polymorphism of the studied genes and is maximum in patients with MM polymorphism of angiotensinogen gene and DD polymorphism of angiotensin-converting enzyme gene. Additive interaction between angiotensin-converting enzyme and angiotensinogen genes in the formation of hemodynamic effects of magnetic laser therapy was detected.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Conformational models of the active site of adenosine deaminase (ADA) and its complexes in the basic state with adenosine and 13-isosteric analogues of the aza, deaza, and azadeaza series were ...constructed. The optimization of the conformational energy of the active site and the nucleoside bound with it in the complex was achieved in the force field of the whole enzyme the structure of ADA complex with 1-deazaadenosine (1ADD) was used within the molecular mechanics model using the AMBER 99 potentials. The stable conformational states of each of the complexes, as well as the optimal conformation of ADA in the absence of ligand, were determined. It was proved that the conformational state that is close to the structure of the ADA complex with 1ADD known from X-ray study corresponds to one of the local minima of the potential surface. Another, a significantly deeper minimum was determined; it differs from the first minimum by the mutual orientation of side chains of amino acid residues. A similar conformational state is optimal for the ADA active site in the absence of bound ligand. A qualitative correlation exists between the values of potential energies of the complexes in this conformation and the enzymatic activity of ADA toward the corresponding nucleosides. The dynamics of conformational conversions of the active site after the binding of substrate or its analogues, as well as the possibility of the estimation of the inhibitory properties of nucleosides on the basis of calculations, are discussed.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Thermal conditions of the process of manufacturing large-block, optically pure products based on polystyrene and polymethyl methacrylate (scintillators, light concentrators, bulletproof glass, etc.) ...have been experimentally and theoretically studied. The flow sheet of the process includes two sequentially connected reaction apparatuses, i.e., a tubular reactor for frontal polymerization and a semi-continuous molding reactor. Prepolymer is formed in the tubular reactor and is fed to the molding reactor. As this reactor is being filled, polymerization continues under autothermal heating conditions. After filling, the molding reactor is replaced by a similar one, while the filled reactor is kept in a temperature-controlled oven for final polymerization followed by cooling and removal of the product.
Full text
Available for:
DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
A procedure of ANSYS software application for solving an inverse problem of composite elastic element strength of the helicopter main rotor is presented. The simplex method is used to select ...parameters in minimization of the objective residual functional. Both one-dimensional and three-dimensional variants of searching are considered. The elasticity characteristics of elastic hub materials as a function of temperature, obtained as a result of adjustment, are presented.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The spatiotemporal structures induced by a weak localized stimulus in excitable contractile fibers are studied by using a two-component reaction–diffusion model with global coupling. The character of ...the induced structures is analyzed, and the regimes of excitation spreading over the fiber are determined depending on the global coupling strength and the contraction type (associated with the mechanical fiber fixation conditions). It is shown that the global coupling can lead to long-lasting transient dynamics and new oscillatory attractor modes.
Quite often, it is necessary to quickly determine variation range of the function. If the function values are known at some points, then it is easy to construct the local spline approximation of this ...function and use the interval analysis rules. As a result, we get the area within which the approximation of this function changes. It is necessary to take into account the approximation error when studying the obtained area of change of function approximation. Thus, we get the range of changing the function with the approximation error. This paper discusses the features of using polynomial and trigonometrical splines of the third order approximation to determine the upper and lower boundaries of the area (domain) in which the values of the approximation are contained. Theorems of approximation by these local trigonometric and polynomial splines are formulated. The values of the constants in the estimates of the errors of approximation by the trigonometrical and polynomial splines are given. It is shown that these constants cannot be reduced. An algorithm for constructing the variation domain of the approximation of the function is described. The results of the numerical experiments are given.
Carboxypeptidase A3 (CPA3) is a specific protease of mast cells (MC) with variable expression and appears to be one of the preformed components of the secretome. CPA3 is involved in regulation of the ...state of a specifi tissue microenvironment and components of the integrative-buffer metabolic environment in adaptive and pathological processes; it affects implementation of the innate immunity, mechanisms of angiogenesis, processes of the extracellular matrix remodeling, etc. CPA3 identification using protocols of multiplex immunohistochemistry allows specifying details of the organ-specific mast cell population features, including the protease phenotype, mechanisms of biogenesis with cyto- and histotopographic criteria, and features of secretory pathways. Numerous biological effects of CPA3, including participation in the regulation of the pulmonary parenchyma and systemic blood flow, in biogenesis and remodeling of the fibrous component of the extracellular matrix, in epigenetic reprogramming, determine the importance of fundamental investigation of the biological activity and regulation of pathological processes of CPA3. Further studies will contribute to the detection of the true value of the mast cell CPA3 expression features as a prognostic factor and a promising molecular target for treatment of socially significant diseases.
PDF
