The experience of the operation of rail transport shows that a significant part of emergency situations with significant negative environmental consequences are related to tank cars carrying liquid ...goods of a wide range, including liquefied gas, petroleum products, concentrated acids, toxic and explosive products of chemical origin. The article presents the peculiarities and result of carrying out of the corresponding tests. In order to address the question of the possibility of further safe operation of tank cars in the over-term period, their technical diagnostics and control tests are carried out. In this case, the control of the technical condition includes visual inspection of the tank wagon, measurements of the thickness of the metal at the control points of the boiler and the frame of the car, conducting of the magnetopowder, ultrasonic and acoustic emission control of the bearing metal constructions. Control tests include static vertical load tests, test for a low cyclic load by boiler pressure, typical, resource shock tests, and possible emergencies testing.
The article deals with the problem of correlation between the illocutionary force of indirect commissive acts and shields as deictic mitigating markers that reduce the level of promises by ...influencing their felicity conditions. The purpose of the article is to clarify the types of deictic shields and their function in weakening the illocutionary force of indirect promises in the European political discourse of assistance to Ukraine. The purpose is achieved by solving the following objectives that determine the research algorithm, including (a) felicity conditions revealing for commissives, weakened by shields that affect the illocutionary force of acts; (b) identifying those deictic coordinates of statements, the reference to which weakens the illocutionary force of commissives; (c) lexical-semantic and syntactic deictic mitigators complex determination. To achieve the purpose and objectives set in the article, the following research methods are used: the method of speech acts analysis and the method of inferencing the shields-based conventional implicatures, supplemented by elements of componential analysis. The article reached the following principal results. Firstly, among the felicity conditions for commissives weakened by shields, the article highlights the condition of speaker’s sincerity and the preparatory condition of his / her ability to perform a promissive act. Due to the shields, the promise is transferred from the scope of the action to the scope of the speaker’s possibilities. Secondly, based on the understanding of shields as the markers affecting either the speaker’s / addresser’s face-protecting attitude to the proposition or the deictic space-temporal-object coordinates of the utterance, the paper has identified that the illocutionary force of indirect commissives is mitigated by personal, temporal and object shields. Thirdly, we have singled out and specified a set of illocution-mitigating deictic devices, including means of role-playing deixis, epistemological modal verbs and their substitutes, which denote or connotate semes of “capabilities” and “possibilities”, means of negation, temporary deixis devices, i.e. the lexical and grammatical markers of future tense, resulting in the vagueness of promises / obligations; presuppositional adverbs with inference pattern of “impediment to a promised action”; passive structures that withdraw the speaker from the position of phrasal subject and an agent of the promising action; verbs and adverbs, which in their inference patterns contain the denotative or contextually connotated semes of a temporal reference to an indefinite future; metonymic generalization of the agent of action. The prospect for further research is the analysis of all types of mitigators, including bushes, hedges and shields, in their projection on rhetorical and manipulative methods of argumentation in political discourse as manifested by the discourse-forming concept “Caution”.
The sustainable development of the Russian economy is inextricably linked with the digital economy. The main objective of the “Program for the Development of the Digital Economy in the Russian ...Federation until 2035” is to form a system of support and incentive measures that provides motivation for financial and economic entities to digital innovations and research in the field of digital technologies. As practice shows, the need for the introduction and development of digital technologies in the forest industry remains very relevant. Since effective forestry is impossible without high-quality, accessible and complete information about forest resources.
The purpose of the work: to consider the features of the development of digitalization in the forest complex in the context of the impact on the economic security of Russia. Identify key digital trends that will contribute to the development of the timber industry.
Research methods: the methodological basis was made up of systematic, generalized, analytical and comparative approaches, as well as a set of methods of economic and statistical analysis.
Results: the development and widespread use of digital technologies in forest management will be able to increase the accuracy and completeness of information about forests, as well as make it more accessible. The introduction of digitalization in forestry will reduce the number of errors that lead to inefficiency in the use of forest resources.
Scope of application of the results: it is advisable to apply the results obtained in the development of national programs for the development of a new generation of economy, including the development and implementation of innovative technologies in the timber industry.
To understand the pathogenesis of dilated cardiomyopathy (DCMP), it is necessary to establish the molecular-cellular mechanisms of myocardial aging, including those associated with programmed cell ...death, the molecular mechanisms of which have not been practically studied. The aim of this work is to study markers of apoptosis in cardiomyocytes of patients with DCMP in vitro. We used the method of primary dissociated cell cultures and the method of immunofluorescence confocal laser microscopy. Cells of the 3rd and 14th passages, corresponding to «young» and «old» cultures, were used to simulate cellular senescence. Results. At the molecular level, aging of cardiomyocyte cells was accompanied by a twofold increase in the expression of p16INK4a compared to «young cultures» both in the control group and in the group with DCMP. It was also found that the expression of p16INK4a in cultures taken from patients with pathology was 2 times higher than in similar cultures from healthy patients. The expression of p21 was increased in the group with DCMP compared to the control; however, with aging of the culture, the expression of p21 did not change, remaining at a significant level. The most significant differences were obtained when comparing the expression of Bax in the cell culture of cardiomyocytes from the group with DCMP in a «young» culture compared with the norm, 3,2 times. Aging of myocardial cells at the molecular level was manifested in an increase in the expression of the Bax protein, which is the triggering mechanism of the mitochondrial apoptosis pathway. It is possible that this pathway of cell death is prevalent in DCMP.
Bats are volant and highly mobile mammals that could cover up to 2000 km seasonally (one-way migration). But the level of mobility among different roosts sites in a breeding season, and among ...breeding areas and hibernation sites is poorly studied. With this communication, we aimed to present results of recaptures (51 cases with a distance of 0.5 km and more) of bats ringed in Kharkiv Region, Ukraine, from 2006 to 2018. The recaptures were obtained of three main study areas (NNP “Homilsha Forests” — 17 cases, Izium District — 5, Kharkiv City and surroundings — 27) and at two other localities of the Kharkiv Region. One recapture was obtained in Lugansk Region. The recaptures were received for five bat species (Nyctalus noctula — 35, Myotis daubentonii — 11, Eptesicus serotinus — 1, Pipistrellus nathusii — 1 and Pipistrellus pygmaeus — 3). The maximum distances were obtained to different species as follow N. noctula — 209.7 km, M. daubentonii — 24.8, E. serotinus — 14.5 km, P. nathusii — 1.1 km and P. pygmaeus — 1.2 km. For the first time, we confirmed that N. noctula that were born in forested areas of Kharkiv City surroundings moved to the built-up area of the city for hibernation. It is the first direct evidence of the existence of the resident population of this species in Ukraine.
Convection plays a major part in many astrophysical processes, including energy transport, pulsation, dynamos and winds on evolved stars, in dust clouds and on brown dwarfs. Most of our knowledge ...about stellar convection has come from studying the Sun: about two million convective cells with typical sizes of around 2,000 kilometres across are present on the surface of the Sun-a phenomenon known as granulation. But on the surfaces of giant and supergiant stars there should be only a few large (several tens of thousands of times larger than those on the Sun) convective cells, owing to low surface gravity. Deriving the characteristic properties of convection (such as granule size and contrast) for the most evolved giant and supergiant stars is challenging because their photospheres are obscured by dust, which partially masks the convective patterns. These properties can be inferred from geometric model fitting, but this indirect method does not provide information about the physical origin of the convective cells. Here we report interferometric images of the surface of the evolved giant star π1 Gruis, of spectral type S5,7. Our images show a nearly circular, dust-free atmosphere, which is very compact and only weakly affected by molecular opacity. We find that the stellar surface has a complex convective pattern with an average intensity contrast of 12 per cent, which increases towards shorter wavelengths. We derive a characteristic horizontal granule size of about 1.2 × 10 metres, which corresponds to 27 per cent of the diameter of the star. Our measurements fall along the scaling relations between granule size, effective temperature and surface gravity that are predicted by simulations of stellar surface convection.
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IJS, KISLJ, NUK, SBMB, UL, UM, UPUK
The article provides a definition of a bilateral gunshot wound to the chest, the features of diagnosis and treatment according to the level of medical care. The isolation of this pathology into a ...separate nosological unit is justified due to the peculiarities of the lesions of the respiratory system and mediastinum, severe injury, high mortality, long duration of treatment and the existing complications of the same type.
This study conducted the possibilities of diffusion-weighted magnetic resonance imaging of the whole body diffusion WB-MRI (in comparison with positron emission tomography with computed tomography ...PET/CT) in assessing the volume and prevalence of the tumor, as well as determining bone marrow (BM) damage (for various cytological types) in the diagnosis and staging of the disease in patients with FL.
A prospective comparative search study included 15 patients (4 men and 11 women, with a median age of 53 years) with newly diagnosed FL. Patients have not received antitumor chemotherapy previously. After the diagnosis was established, all patients (with the blindness of both the cases themselves and some specialists regarding the results of other specialists) were examined by PET/CT and diffusion WB-MRI, after which a BM examination was performed (histological examination and determination of B-cell clonality in BM puncture by PCR). Using the diffusion WB-MRI method, the prevalence of tumor lesion (nodal and extranodal foci) in each patient was estimated, and the total tumor volume was calculated, BM lesion was detected, and BM lesion volume was calculated. For lesions of different localization, the measured diffusion coefficient (DC) of the diffusion WB-MRI and the standardized rate of accumulation of the radiopharmaceutical in tissues (SUV) of the PET/CT method were determined and compared with each other (for the same areas). Statistical analysis was performed using the estimate of agreement (by Cohens kappa coefficient and asymptotic test) of the results of the compared methods.
Estimates of the prevalence of tumor damage (lymph nodes and extranodal foci) using the diffusion WB-MRI and PET/CT methods were the same. High DC and SUV were observed in the peripheral lymph nodes, extranodal foci and bulky, low DC and SUV in the foci of BM. All 4 methods successfully determined BM damage, however, the diffusion WB-MRI had comparatively less negative results. The highest values of SUV and CD were noted in cases of the 3 grade of FL. Using the diffusion WB-MRI method, the prevalence of tumor lesion was assessed in each patient (nodal and extranodal foci were detected) and the total tumor volume was calculated, BM lesion detection was performed, and the volume of BM lesion was calculated. It is important to note that with the help of diffusion WB-MRI, it was possible to measure separately the total tumor volume (462025 cm3) and separately the volume of bulky (251358 cm3). The diffusion WB-MRI allowed us to differentiate the volume of tumor tissue (reduced as a result of treatment) and residual (fibrous-adipose) tissue in residual formations (which averaged 21% of the initial volume). The predictors of a poor antitumor response were the maximum SUV values (more than 14.0) and the minimum DC values (0.510-3mm2/s) in the BM foci.
The diffusion WB-MRI allows for detailed visualization of BM lesions and surrounding soft tissues both in the debut of the FL and in the process of tracking the effectiveness of chemotherapy, which makes it possible to use it along with PET/CT. Diffusion WB-MRI allows to separately evaluate the volume of true tumor tissue and residual tissue. Cases of the 3 grade of FL (including the transformation of FL into diffuse B-large cell lymphoma) are isolated due to low DC values (and high SUV values) in the tumor tissue. BM foci of FL lesion also have (in comparison with nodal and extranodal foci) lower DC values. The predictors of a poor antitumor response were high (from 14.0 or more) SUV valuesin the tumor (and especially in bulky), and low (about 0.5103mm2/s) DC values of BM foci. The PET/CT and diffusion WB-MRI have proven to be reliable diagnostic tools for establishing the stage of FL and detecting BM damage. Diffusion WB-MRI for FL is an informative first-line diagnostic method that allows regular monitoring of the disease and early detection of foci of relapse and disease progression.
Aim of the issue was to determine indications for intratecal chemotherapy drugs administration to prevent relapse of diffuse large B-cell lymphoma (DLBCL) with central nervous system (CNS) ...involvement. Materials and methods. Since January 2009 to December 2018 102 patients with primary nodal DLBCL over 18 years old were treated in the National Research Center for Hematology, Moscow, Russian Federation. Diagnosis were established in all cases according to histological and immunohistochemical studies which made it possible to exclude the transformation of mature B-cell lymphoma into DLBCL. Results. Isolated leptomeningeal involvement of CNS in the debut of the disease was detected in 1 (0.98%) out of 102 patients with DLBCL. Focal brain tissue involvement was not detected in any patient. More than half of the patients (54%) had a high risk of disease recurrence or progression with CNS involvement: in 8 (7.8%) patients had kidney/adrenal involvement, in the same proportion - bone marrow involvement, paranasal sinuses involvement - in 5 (4.9 %), epidural space - in 7 (6.9%) and breast - in 5 (4.9%) of patients. In 82 (80%) patients, a non-GCB (postgerminal differentiation of B-cell analog) molecular subtype of DLBCL was determined. Conclusion. The introduction of chemotherapy drugs into the spinal canal is recommended in isolated cases of leptomeningeal involvement of CNS at the time of DLBCL onset and is carried out according to standard recommendations. Prevention of relapse with involvement of central nervous system using intratecal chemotherapy in patients with nodal form of DLBCL is not indicated due to the absence of cases with disease progression or recurrence into CNS when patients were treated with R-m-NHL-BFM-90, R-DA-EPOCH and R-CHOP protocol.
Mantle cell lymphoma (MCL) is aggressive B-cell neoplasm diagnosed predominantly among older men. R-CHOP-like regimens allow to achieve high response rate, but the overall survival (OS) are ...disappointingly short - 3-4 years. An addition of high - dose cytarabine to the upfront therapy and autoSCT significantly improved outcomes but remain feasible largely for medically fit patients. Based on the activity and good tolerance of gemcitabine - oxaliplatin schemes in relapsed and refractory MCL patients, we developed an alternative first - line course for patients who are not eligible for R-HD-MTX-AraC. Aim. Assess toxicity and efficacy of R-DA-EPOCH/ R-HD-MTX-AraC and R-DA-EPOCH/R-GIDIOX schemes, autoSCT and R-maintenance in untreated MCL patients. Materials and methods. 47 untreated MCL patients from 6 centers were enrolled in prospective study between April 2008 and September 2013. All patients have stage II-V; ECOG 0-3; median age 55 years (29-64); Male/Female 76%/24%. MIPIb: 28% low, 33% intermediate and 39% high risk. Following 1st R-EPOCH patients were assigned to receive either R-DA-EPOCH/ R-HD-MTX-AraC or R-DA-EPOCH/ R-GIDIOX regimen. In the absence of renal failure, hematological toxicity grade 4 more than 3 days and severe infections patients received R-HD-MTX-AraC scheme (R 375 mg/m2 Day 0, Methotrexate 1000 mg/m2/24 hours Day 1, AraC 3000 mg/m2 q 12 hrs Days 2-3). Patients who had at least one of these complications received R-GIDIOX scheme (R 375 mg/m2 day 0, gemcitabine 800 mg/m2 days 1 and 4, ifosfamide 1000 mg/m2 days 1-5, dexamethasone 10 mg/m2 IV days 1-5, irinotecan 100 mg/m2 day 3, oxaliplatin 120 mg/m2 day 2). Subsequently these courses were alternating with R-DA-EPOCH in each arm of the protocol. Depending on the time of achieving CR patients received 6 or 8 courses, unless they progressed on therapy. Those patients who achieved PR/CR/CRu underwent autoSCT (BEAM-R). Post - transplant R-maintenance was administered for 3 years (R - 375 mg/m2 every 3 months). Results. 29/47 patients were treated on R-HD-MTX-AraC arm (median 50 years; MIPIb: 35.7% low, 28.6% intermediate, 35.7% high risk) and 18/47 patients were on R-GIDIOX arm (median 60 years; MIPIb: 16.7% low, 38.9% intermediate, 44.4% high risk). In R-HD-MTX-AraC arm CR rate was 96.5%. In R-GIDIOX arm OR and CR rates were 94.4% and 77.7% respectively. Main hematological toxicity of R-GIDIOX was leukopenia gr. 4 occurred in 74.1%. With median follow - up of 76 months, the estimated 7-years OS and EFS in R-HD-MTX-AraC arm are 76% and 57% respectively. In R-GIDIOX arm the estimated 7-years OS and EFS are 59% and 44%, respectively. There are no statistical differences in EFS (p=0.47) and OS (p=0.06) between two arms. Conclusions. The use of a risk - adapted strategy allowed 95.7% of patients achieve PR/CR/CRu, performed autoSCT and begun R-maintenance therapy with rituximab. None of the patients needed a premature discontinuation of therapy because of unacceptable toxicity. The performance of autoSCT and R-maintenance apparently allowed to partially offset differences in the intensity of induction therapy and to maintain comparable results of therapy in both induction arms.
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