The paper presents the results of diagnosis and treatment of patients with liver abscesses. In the surgery of Dnipropetrovsk Regional Hospital named after І.І. Mechnikov 183 patients diagnosed with ...liver abscess aged 18 to 81 years were treated. In 118 (64.5%) patients the period from the first complaints to the diagnosis was up to 1 month, in 48 (26,2%)from 1 to 3 months,in 15 (8,2%)from 3 to 6 months, in 2 (1.1%) from 6 to 12.To diagnose abscesses of the liver ultrasound of abdominal cavity, computer tomography, laparoscopy were used. Treatment of liver abscesses included both conservative therapy and surgical intervention. Only 14 (7.6%) patients received conservative treatment. Surgical treatment included minimally invasive interventions under U.S. control, laparoscopic, open drainage and resection techniques. The method of choice of surgical treatment for patients with uncomplicated liver abscesses with a diameter of 3 cm or more was echocontrolled peritoneal pelvic drainage, performed in 146 (79.8%) patients. Complications of surgical treatment were found in 15 (8.2%) cases: drainage dislocation –in 12 (6.6%) patients, purulent fistula – in 1 (0.5%), intestinal obstruction – in 1 (0.5%), peritonitis –in 1 (0.5%).
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Tomography of the red supergiant star μ Cep Kravchenko, K.; Chiavassa, A.; Van Eck, S. ...
Proceedings of the International Astronomical Union,
08/2018, Volume:
14, Issue:
S343
Journal Article
Peer reviewed
Abstract
A tomographic method, aiming at probing velocity fields at depth in stellar atmospheres, is applied to the red supergiant star
μ
Cep and to snapshots of 3D radiative-hydrodynamics simulation ...in order to constrain atmospheric motions and relate them to photometric variability.
In 2006, a pandemic of previously unknown fungal disease suddenly broke out in caves of North America, affecting bats during winter hibernation. Between 2006 and 2012, six million bats of ten species ...died, and the infection was spreading from the east coast of the United States into the continent for several hundred kilometers per year. The mass mortality of bats from this disease and the high rate of its spread attracted close attention from researchers. In 2009, the causative agent of this disease, named White Nose Syndrome (WNS), was identified as Geomyces destructans Blehert et Gargas, a fungal species previously unknown to science whose mycelium grows into the surface body tissues of hibernating bats.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Follicular lymphoma (FL) is a tumor that develops from the B cells of the germinal center; characterized by recurrent and remitting course of the disease, the transformation of a tumor into diffuse ...large B-cell lymphoma (DLBCL) is possible. In generalized lesions and progression of FL, the most commonly used courses are R-CHOP and R-B. The choice of therapy for different cytological types, clinical and laboratory parameters remains disputable. Aim. To analyze the clinical, laboratory, morphological parameters of patients with FL, who got R-B and R-CHOP therapy; determine the criteria for selecting induction therapy. Materials and methods. The study included 203 patients with FL from 2000 to 2018. R-CHOP treatment was initiated in 126 patients, 14 of whom later received high - dose therapy (HDT) (R-DHAP: rituximab, dexamethasone, cisplatin, cytarabine) without autologous stem cell transplantation (autoSCT), 21 - HDT with autoSCT; treatment of 89 patients was limited to courses of R-CHOP and maintenance therapy with rituximab, two patients (in whom the disease progressed, despite R-CHOP therapy) were assigned the mNHL-BFM-90 program. The efficacy of treatment on various treatment regimens was evaluated primarily by overall survival. Results and discussion. R-B. 77 patients received R-B therapy. Complete remission of the disease was achieved in 47/77 (61%) patients (3 of them later developed a relapse of the disease), partial remission was achieved in 15/77 (19%) patients, in 13/77 (17%) cases progression was recorded tumors. 70 patients had 1-2 cytological type of tumor, 6 patients - 3A cytological type. In cases of progression, 3 of 13 patients (46%) were diagnosed with 3A cytological type FL. Median observation (at the time of analysis) - 34 months. R-CHOP. 89 patients with FL received high - dose therapy with R-CHOP (6-8 courses) and maintenance therapy with rituximab. In 39 (44%) patients, the disease remained in remission, and in 50 (56%), a relapse of the disease developed. 50 patients had 1-2 cytological types, 39 - 3 cytological types. In cases of recurrence of FL, a 3A cytologic type (36%) was diagnosed in 18/50 patients. Median observation - 93 months. R-CHOP + HDT and autoSCT. 21 patients after the R-CHOP courses continued (due to insufficient antitumor response) high - dose chemotherapy (HDT) and auto-SCT were performed. In 18/21 (86%) cases, complete remission of the disease was achieved and maintained, in 3 (14%) cases relapse developed. 16 patients had 1-2 cytological types, 5 - 3 cytological types. Median observation - 81 months. R-CHOP + HDT without autoSCT. 14 patients started therapy under the R-CHOP program as induction therapy, but then (due to insufficient antitumor response), the treatment was continued according to the HDT without autoSCT. 11 (79%) patients are currently in remission of the disease, in 3 (21%) - there was a relapse. 10 patients had 2 cytological types of PL, 4 - 3 cytological types. 11 (79%) patients are currently in remission of the disease, in 3 (21%) - there was a relapse. Median observation - 80 months. 7-year OS of patients with FL on RB therapy was 89% (95% CI 75-99), on R-CHOP therapy - 85% (95% CI 73-90), on R-CHOP + HDT and autoSCT - 87% (95% CI 57-100), on R-CHOP + HDT without autoSCT - 82%. 7-year PFS of FL patients on RB therapy was 70% (95% CI 75-99), on R-CHOP therapy - 44% (95% CI 73-90), on R-CHOP + HDT and autoSCT - 74% (95% CI 57-100), on R-CHOP + HDT without autoSCT - 80%. Conclusion. The R-B is most effective in FL 1 and 2 cytological types. The cytological type does not correspond to the type of tumor growth: at 3A and 3A + 3B cytological types, nodular / nodular - diffuse and diffuse types of growth are found. When choosing an induction course, one should look at the cytological type of FL. A high proliferative activity index (according to Ki67) is a predictor of resistance to R-B therapy. The absence of an interfollicular T-cell reaction in tumor tissue FL is associated with tumor chemoresistance. The presence of the bulky factor is associated (in most patients) with the FLIPI index with values from 3 to 5, and is a predictor of a poor response to therapy. Patients with bulky, high (more than 35%) Ki67 index and FLIPI from 3 to 5 in the debut of the disease as the first line therapy, it is preferable to choose the R-CHOP mode, and in the absence of (after 4-6 courses) to complete or partial remission to continue conducting the HDT.
Mediastinal gray-zone lymphoma (MGZL, lymphoma with features intermediate between classical Hodgkin lymphoma and diffuse large B-cell lymphoma) was declared as a separate entity in WHO classification ...of Tumors of Haematopoetic and Lymphoid Tissues in 2008 and 2017 years. Despite of similar pathomorphological characteristics between primary mediastinal B-cell lymphoma and Hodgkin lymphoma, clinical features and optimal therapeutic approach to MGZL are not clearly defined. Usually MGZL manifests with mediastinal lymphadenopathy, although extranodal lesions often occur (grey-zone lymphoma, GZL). Patients with MGZL have unfavorable prognosis, taking into account high rate of relapse. This article describes two cases of MGZL. First case manifested by arrhythmias due to primary heart involvement. In spite of cardiac failure antracycline-containing chemotherapy (6 courses of R-DA-EPOCH) it allowed to achieve a complete remission and resolving of arrhythmias. Second case was represented by metachronous tumors: primary mediastinal B-cell lymphoma at the time of disease onset and classical Hodgkin lymphoma, NS II, diagnosed after disease progression. Thus, we demonstrated two examples of MGZL that differ by clinical manifestation, response to chemotherapy, which emphasizes an importance of pathogenesis studying, and using of new therapeutic approaches.
The existing methods of regeneration of sulfo-acidic solutions, which contain iron sulfate, formed after technological operations for the preparation and etching of metal parts at metalworking ...enterprises are not effective and therefore are not used at Ukrainian enterprises. They are either aimed at sedimentation of the sludge of sparingly soluble iron compounds after neutralization of unreacted sulfuric acid or at dilution of the formed spent sulfo-acid solutions. The electrochemical method of regeneration of such spent sulfo-acid solutions is not properly researched. A feature of the development of technology and equipment for regeneration is a decrease in the content of iron ions and an increase in the concentration of sulfuric acid during the regeneration process. The process of electrochemical regeneration of spent steel etching solutions is characterized by a significant change in the composition of the etching solution and the temperature of the etching process. At the beginning of work, the initial solution of sulfuric acid reaches a concentration of 2.0 mol·dm-3 and does not contain iron (II) sulfate. In the process of digestion, the concentration of sulfuric acid decreases to 0.5 mol·dm-3, and the concentration of iron (II) sulfate increases accordingly. Therefore, the course of the anodic process was studied for the following solution compositions: 0.5 mol·dm-3; 1.0 mol·dm-3 and 1.5 mol·dm-3 H2SO4. Under the conditions of a decrease in the concentration of sulfuric acid, its chemical activity also decreases when interacting with iron oxides and hydroxides. An increase in the temperature of the entire process is used to increase the reactivity of the pickling solutions. The main process at the platinum anode is the release of oxygen in a wide range of current densities and a significant overvoltage of the entire process. Taking into account the obtained voltage-voltage dependences, it can be seen that the current rises when reaching potentials that significantly exceed the standard potential for obtaining oxygen from water. The advantage of the platinum anode is the slight influence of the concentration of sulfuric acid on the kinetics of the anode process. The obtained results were used for comparison with other alternative anode materials. Manganese dioxide was obtained by the method of pyrolysis of a coating solution of manganese monoacid applied to a titanium current lead, which can be represented by reaction (5) of the decomposition of manganese nitrate on a titanium plate. Due to the developed surface, the real current density was more than an order of magnitude lower on the TDMA than on the platinum anode with the same geometric dimensions. A lower current density contributed to a decrease in the steady-state potentials of oxygen release. The current density can be increased by an order of magnitude if surfactants are added to the working solution. A comparison of voltage-voltage dependences on platinum and TDMA indicates that the use of TDMA gives a more significant gain in energy consumption during the regeneration process. Taking into account that the range of current densities of 4-5 A/dm2 was determined for the cathode process according to the research results, the difference in the reduced polarization of the anode on TDMA, compared to platinum, is more than 400 mV, which will significantly reduce costs during unit operation. The use of TDMA is expedient in the galvanostatic mode of operation of the electrode unit for the process of electrochemical regeneration of spent sulfo-acid solutions of steel pickling.
The green blowfly, Lucilia sericata (Meigen) (Diptera: Calliphoridae), is a cosmopolitan species of great medical, veterinary, and forensic importance. In addition, their larvae are among the most ...promising agents for the bioconversion of low‐quality biomass, such as organic waste, into sustainable and nutritionally valuable proteins for farmed fish and poultry. Despite the considerable medical and economic importance, the current literature provides limited information about microbiota associated with larvae. The present study aims to fill this knowledge gap. Freshly harvested L. sericata larvae (maggots) grown on fish wastes were investigated by conventional and molecular approaches to evaluate culturable microbial numbers and unculturable microbial diversity associated with the larval cuticle (external samples) and the internal body. In total 200 bacterial isolates were obtained; 46% of the strains originated from external samples and 58% originated from internal body samples produced extracellular protease enzymes, which may be involved in the digestion of proteins during larval feeding. In total 12 predominant bacteria with high proteolytic activity were further identified by morphological, physiological, biochemical, and molecular tools. Proteolytic bacteria in internal samples included Proteus, Providencia, Micrococcus, Deinococcus, whereas in external samples Providencia, Pseudomonas, and Acinetobacter were found. 16S rRNA clone library analysis revealed that the majority of internal bacteria (35%) were taxonomically assigned as Xanthomonadaceae (Schineria, Xylella, Ignnatzchineria), 28% Morganellaceae (Proteus, Providencia, Serratia), and 14% Enterobacteriaceae (Vagococcus, Serratia). Less abundant were bacteria of the genera Clostridium (3%), Erypelothrix (3%), and Oceanispherum (2%). This knowledge will be useful for biotechnological application of L. sericata.
The green blowfly, Lucilia sericata (Diptera: Calliphoridae), is a cosmopolitan species of great medical, veterinary, and forensic importance. In addition, their larvae are among the most promising agents for the bioconversion of wastes into nutritionally valuable proteins for farmed fish and poultry. Information about the safety of the edible insects as far as the diversity and activity of microorganisms providing them with the essential nutrients is scarce. Our study provides knowledge about the microbial communities associated with green blowflies.
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Assessment of the response of soil microbial communities, performing important ecological and biospheric functions, to natural or anthropogenic impacts is one of the promising approaches to solve the ...problems of stress resilience of ecosystems. A model experiment with soddy-podzolic soil (Eutric Albic Retisol (Abruptic, Loamic)) has shown the inhibitory effect of ammonium and the stimulating effect of lanthanum on methane oxidation by soil microorganisms. The application of ammonium and lanthanum reduced the taxonomic diversity of the soil bacterial community and changed its structure: the relative content of gram-positive bacteria of Actinobacteriota and Bacillota phyla decreased, while the portion of gram-negative bacteria of the phylum Pseudomonadota increased. Applied lanthanum causes a significant (by several orders of magnitude) rise in the relative content of methanotrophs of
Methylobacter
genus and of obligate methylotrophs of
Methylotenera
genus in the community. The results of this work may be used to develop approaches for the control of the activity of the soil methane filter and of the accompanying microbiota.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
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