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•Successful valorisation of cellulose fabric via facile radiation grafting approach.•PVBSA-g-cellulose adsorbent successfully regenerated and reused in multiple cycles.•High uptake ...capacity of ∼320 mg.g-1demonstrated by anionic adsorbent for BR-29dye.•Successful semi pilot scale demonstration of process for dye wastewater treatment.•Proposed proof of concept for low cost, large scale wastewater treatment solution.
A low cost, cellulose based anionic adsorbent has been synthesized at room temperature by single step gamma radiation induced grafting of 4-vinylbenzenesulfonic acid sodium salt (VBSA) onto cellulose using water as solvent. Grafting parameters, namely, radiation dose, monomer concentration, volume/weight ratio, were studied to optimize the radiation grafting process. Poly(VBSA) grafted cellulose (PVBSA-g-cellulose) samples were characterized by grafting yield estimation, Elemental analysis, FTIR, TGA and SEM. The radiation grafted adsorbent was tested for textile dyes removal from aqueous solutions, in batch and continuous flow column operation mode, using Basic Red-29 (BR-29) dye as a model textile dye. Adsorbent with 25% grafting yield exhibited an adsorption capacity of 320 mg.g-1, which was corroborated by the equilibrium adsorption and kinetic studies. The adsorbent was regenerated and demonstrated to be reusable for multiple cycles with minimal attrition losses. The process was successfully upscaled and demonstrated at a semi pilot scale treatment.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Chronic wounds impose a significant financial burden for the healthcare system. Currently, assessment and monitoring of hard-to-heal wounds are often based on visual means and measuring the size of ...the wound. The primary wound dressings must be removed before assessment can be done. We have developed a quasi-monopolar bioimpedance-measurement-based method and a measurement system to determine the status of wound healing. The objective of this study was to demonstrate that with an appropriate setup, long-term monitoring of wound healing from beneath the primary dressings is feasible. The developed multielectrode sensor array was applied on the wound area and left under the primary dressings for 142 h. The impedance of the wounds and the surrounding intact skin area was measured regularly during the study at 150 Hz, 300 Hz, 1 kHz, and 5 kHz frequencies. At the end of the follow-up period, the wound impedance had reached the impedance of the intact skin at the higher frequencies and increased significantly at the lowest frequencies. The measurement frequency affected the measurement sensitivity in wound monitoring. The skin impedance remained stable over the measurement period. The sensor array also enabled the administration of periodical low-intensity direct current (LIDC) stimulation in order to create an antimicrobial environment across the wound area via the controlled formation of hydrogen peroxide (H2O2).
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
•The textile cotton cellulose waste was transformed in to a functional adsorbent for treatment of textile dye wastewater.•A green synthesis route, viz. one step-aqueous based radiation grafting ...process was employed.•Critical scientific analysis of equilibrium and kinetic dye adsorption experimental data presented.•Recyclable radiation grafted adsorbent offers a promising method for treatment of textiles dye effluents.
A cationized adsorbent was prepared from cellulosic cotton fabric waste via a single step-green-radiation grafting process using gamma radiation source, wherein poly2-(methacryloyloxy) ethyltrimethylammonium chloride (PMAETC) was covalently attached to cotton cellulose substrate. Radiation grafted (PMAETC-g-cellulose) adsorbent was investigated for removal of acid dyes from aqueous solutions using two model dyes: Acid Blue 25 (AB25) and Acid Blue 74 (AB74). The equilibrium adsorption data was analyzed by Langmuir and Freundlich isotherms, whereas kinetic data was analyzed by pseudo first order, pseudo second order, intra particle diffusion and Boyd's models. The PMAETC-g-cellulose adsorbent with 25% grafting yield exhibited equilibrium adsorption capacities of ∼540.0mg/g and ∼340.0mg/g for AB25 and AB74, respectively. Linear and nonlinear fitting of adsorption data suggested that the equilibrium adsorption process followed Langmuir adsorption isotherm model, whereas, the kinetic adsorption process followed pseudo-second order model. The multi-linearities observed in the intra-particle kinetic plots suggested that the intraparticle diffusion was not the only rate-controlling process in the adsorption of acid dyes on the adsorbent, which was further supported by Boyd's model. The adsorbent could be regenerated by eluting the adsorbed dye from the adsorbent and could be repeatedly used.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The enzymatic degradation of textile dyes offers an alternative approach over the conventional waste water treatment processes. Covalent immobilization of the enzymes onto insoluble supports not only ...permits their reusability and easy separation of enzymes from the product but also, if properly performed, may improve their activities, stability and hence reduces the cost of process. In the present work, epoxy functionalized polyethersulfone (PES) was synthesized via radiation induced polymerization of poly(2,3-epoxypropyl methacrylate) poly(EPMA) in PES-NMP (N-methyl-2-pyrrolidone) solution using 60Co-gamma radiation source. Poly(EPMA)-functionalized-PES poly(EPMA)-f-PES beads were fabricated via phase inversion route using water as the anti solvent. Laccase was covalently immobilized on to the beads via one step-room temperature coupling reaction of amine group of enzyme with the epoxy group of poly(EPMA). Enzyme activity was assayed using 2,2′-azino-bis(3-ethylthiazoline-6-sulfonate) (ABTS) as the substrate. Effect of temperature and pH on the free and immobilized enzyme activity was studied. The immobilized laccase was successfully employed to degrade Acid Red 1 (AR1) dye in aqueous solution. Room temperature incubation of the laccase immobilized poly(EPMA)-f-PES beads with AR1 dye (∼10 ppm) resulted in ∼88% degradation of the dye over a period of 15 days.
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•Single step-radiation induced polymerization process for epoxy functionalization of PES.•Phase inversion process was used for fabrication of poly(EPMA)-f-PES beads.•Single step-covalent immobilization of laccase onto poly(EPMA)-f-PES beads.•Immobilized laccase shows good storage stability and reusability.•Immobilized laccase was employed for dye waste water treatment.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Low immunization coverage in India attributes to many factors including sociodemographic factors and people's behavior. COVID-19 pandemic resulted in disruptions in achieving optimum availability and ...utilization of immunization services. This study was carried out to find out the immunization status of children in the post COVID era and various factors responsible for non-immunization during the pandemic.
This cross-sectional study included parents of 225 admitted children aged 1-6 years were interviewed using a semi-structured open-ended questionnaire. Children were classified as completely immunized, partially immunized and unimmunized on the basis of vaccines missed given under first year of life. Reasons for non-immunization and delay/missed vaccination during COVID-19 pandemic were recorded.
Of the 225 children, 162 (72%; 95% CI 66-78%) were completely immunized, 55 (24.4%; 95% CI 19-30%) were partially immunized and 8 (3.6%; 95% CI 1-6%) were unimmunized. Parents with hospital deliveries, higher education level and lesser birth order were more likely to have children with better immunization status (p < 0.05). First dose of measles scheduled at 9 months and 3rd dose of pentavalent vaccine/OPV/Rotavirus vaccine scheduled at 14 weeks were most commonly missed vaccines among partially immunized. Lack of awareness (n = 36, 57.1%; 95% CI 45-70%) was the common reason for partial and non-immunization followed by illness of child (n = 21, 33.3%; 95% CI 21-45%) and COVID-19 pandemic (n = 11, 17.4%; 95% CI 8-27%). Pandemic was reason for delay in 50 (22.2%; 95% CI 17-28%) children. Restrictions of movement (64%; 95% CI 50-78%), fear of being exposed to COVID-19 (52%; 95% CI 38-66%) were the most common reasons for delay during the pandemic. Of the 50 children who had delay due to pandemic, 39 children (17.3%; 95% CI 12-22%) received their catch-up immunization after the pandemic. No child remained completely unimmunized due to COVID-19 pandemic.
Although COVID-19 pandemic resulted in disruptions in routine immunization services, sociodemographic factors such as awareness for immunization, parental education and various beliefs for immunization were responsible for the children remaining unimmunized or partially immunized after the pandemic.
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DOBA, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
Grey wolf optimization (GWO) is a recent and popular swarm-based metaheuristic approach. It has been used in numerous fields such as numerical optimization, engineering problems, and machine ...learning. The different variants of GWO have been developed in the last 5 years for solving optimization problems in diverse fields. Like other metaheuristic algorithms, GWO also suffers from local optima and slow convergence problems, resulted in degraded performance. An adequate equilibrium among exploration and exploitation is a key factor to the success of meta-heuristic algorithms especially for optimization task. In this paper, a new variant of GWO, called inertia motivated GWO (IMGWO) is proposed. The aim of IMGWO is to establish better balance between exploration and exploitation. Traditionally, artificial neural network (ANN) with backpropagation (BP) depends on initial values and in turn, attains poor convergence. The metaheuristic approaches are better alternative instead of BP. The proposed IMGWO is used to train the ANN to prove its competency in terms of prediction. The proposed IMGWO-ANN is used for medical diagnosis task. Some benchmark medical datasets including heart disease, breast cancer, hepatitis, and parkinson's diseases are used for assessing the performance of IMGWO-ANN. The performance measures are described in terms of mean squared errors (MSEs), classification accuracies, sensitivities, specificities, the area under the curve (AUC), and receiver operating characteristic (ROC) curve. It is found that IMGWO outperforms than three popular metaheuristic approaches including GWO, genetic algorithm (GA), and particle swarm optimization (PSO). Results confirmed the potency of IMGWO as a viable learning technique for an ANN.
Egg quality parameters are very crucial for the egg industry as egg configuration affects grading, price, hatchability, chick weight, and consumer preference. Current study was undertaken to assess ...and compare the egg quality parameters in 2 important Indian breeds Aseel and Kadaknath reared under backyard system. Different parameters of external and internal egg quality were measured. Biochemical parameters of egg yolk estimated were egg yolk cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and triacylglycerol. Means for external characters of Aseel eggs viz., egg weight, egg length, egg width, shape index, shell weight, shell thickness, and shell ratio were 41.7 g, 5.16 cm, 3.85 cm, 74.75%, 4.65 g, 0.35 mm, and 11.23%, and corresponding values for Kadaknath eggs were 40.59 g, 5.13 cm, 3.79 cm, 74.02%, 4.28 g, 0.34 mm, and 10.61%, respectively. Average albumin length, width, height, and albumin index were 83.73 mm, 65.4 mm, 6.02 mm, and 9.26% for Aseel eggs and 82.27 mm, 64.80 mm, 5.52 mm and 8.52% for Kadaknath eggs, respectively. Mean values for yolk length, width, height and yolk index were 43.32 mm, 40.10 mm, 15.30 mm, and 38.30% in Aseel and 42.15 mm, 38.97 mm, 14.26 mm and 36.66% in Kadaknath breed, respectively. Mean values for egg yolk cholesterol, HDL, LDL, and triacylglycerol were estimated as 9.38, 1.74, 0.17, and 1.94 mg/g in Aseel eggs and 8.38, 1.84, 0.11, and 1.76 mg/g in Kadaknath eggs, respectively. Biochemical analysis revealed that egg yolk quality of Kadaknath eggs was comparatively better than Aseel eggs.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The cyclin-dependent kinase inhibitor SIAMESE (SIM) targets both CDKA;1 and CDKB1 complexes, leading to establishment of endoreplication, and SIM interacts with the cyclin CYCA2;3 via SIM motif A.
...Abstract
Endoreplication, also known as endoreduplication, is a modified cell cycle in which DNA is replicated without subsequent cell division. Endoreplication plays important roles in both normal plant development and in stress responses. The SIAMESE (SIM) gene of Arabidopsis (Arabidopsis thaliana) encodes a cyclin-dependent kinase (CDK) inhibitor that plays a central role in establishing endoreplication, and is the founding member of the SIAMESE-RELATED (SMR) family of plant-specific CDK inhibitor genes. However, there has been conflicting evidence regarding which specific cyclin/CDK complexes are inhibited by SIM in vivo. In this work, we use genetic evidence to show that SIM likely inhibits both CDKA;1- and CDKB1-containing CDK complexes in vivo, thus promoting endoreplication in developing Arabidopsis trichomes. We also show that SIM interacts with CYCA2;3, a binding partner of CDKB1;1, via SIM motif A, which we previously identified as a CDK-binding motif. By contrast, SIM motif C, which has been indicated as a cyclin binding motif in other contexts, appears to be relatively unimportant for interaction between SIM and CYCA2;3. Together with earlier results, our work suggests that SIM and other SMRs likely have a multivalent interaction with CYC/CDK complexes.
Pancreatic Cancer and Venous Thromboembolism Prouse, Teagan; Mohammad, Mohammad A; Ghosh, Sonali ...
International journal of molecular sciences,
06/2024, Volume:
25, Issue:
11
Journal Article
Peer reviewed
Open access
Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic cancers and is the most fatal of all cancers. The treatment response from combination chemotherapies is far from ...satisfactory and surgery remains the mainstay of curative strategies. These challenges warrant identifying effective treatments for combating this deadly cancer. PDAC tumor progression is associated with the robust activation of the coagulation system. Notably, cancer-associated thrombosis (CAT) is a significant risk factor in PDAC. CAT is a concept whereby cancer cells promote thromboembolism, primarily venous thromboembolism (VTE). Of all cancer types, PDAC is associated with the highest risk of developing VTE. Hypoxia in a PDAC tumor microenvironment also elevates thrombotic risk. Direct oral anticoagulants (DOACs) or low-molecular-weight heparin (LMWH) are used only as thromboprophylaxis in PDAC. However, a precision medicine approach is recommended to determine the precise dose and duration of thromboprophylaxis in clinical setting.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The present study was performed to utilize the shrimp shell waste for chitin and chitosan production, characterization by Fourier transform infrared (FT-IR) technique and to evaluate the ...antimicrobial effects of chitosan oligomers produced by depolymerization of chitosan by nitrous acid.
Chitosan was extracted from the shrimp shell waste by the chemical method and characterized by FT-IR. Chitooligomers were produced by depolymerising chitosan using nitrous acid, and the chitooligomers were tested for antimicrobial effect against four gut pathogenic organisms, i.e.,
(National Collection of Dairy Culture NCDC 106),
(NCDC 119),
(NCDC 134), and
(NCDC 109) by well diffusion method using Muller-Hinton agar. A pure culture of pathogenic organisms was collected from NCDC, ICAR-National Dairy Research Institute, Karnal.
Extracted chitosan characterized by FT-IR and chitooligomers demonstrated antimicrobial effect against four gut pathogenic organisms used in this study. Zone of inhibitions (mm) were observed in
(13±0.20),
(11.5±0.4),
(10.7±0.2), and
(10.7±0.3).
showed larger inhibition zone as compared to all other organisms and inhibitions zones of
and
were comparable to each other.
Shrimp waste can be utilized for chitosan production, and the chitooligomers can be used as feed additive for gut health enhancement and have potential to replace antibiotics from the feed. Along with value addition pollutant load could be reduced by waste utilization.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
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