Although the term transgender is increasingly used to refer to those whose gender identity or expression diverges from culturally defined categories of sex and gender, less is known about the ...self-identities of those who fall within this category. Historically, recruitment of transgender populations has also been limited to specialized clinics and support groups. This study was conducted online, with the aim of exploring the gender identities, sexual orientation identities, and surgery and hormonal statuses of those who identify with a gender identity other than, or in addition to, that associated with their birth sex (n = 292). Genderqueer was the most commonly endorsed gender identity, and pansexual and queer were the most commonly endorsed sexual orientation identities. Participants indentified with a mean of 2.5 current gender identities, 1.4 past gender identities, and 2 past sexual orientation identities. The majority of participants either did not desire or were unsure of their desire to take hormones or undergo sexual reassignment surgery. However, birth sex and age were significant predictors of "bottom" surgery and hormone status/desire, along with several identities and orientations. This study explores explanations and implications for these patterns of identification, along with the potential distinctiveness of this sample.
Full text
Available for:
BFBNIB, DOBA, IJS, INZLJ, IZUM, KILJ, NMLJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, ZRSKP
Abstract Using the 1.32 $$\hbox {pb}^{-1}$$ pb - 1 statistics collected at the $$J/\psi $$ J / ψ peak with the KEDR detector at the VEPP-4M $$e^{+}e^{-\, }$$ e + e - collider, we measured the ...branching fractions of $$J/\psi $$ J / ψ meson decays to the final states 2( $$\pi ^{+}\pi ^{-})\pi ^{0}$$ π + π - ) π 0 , $$K^{+}K^{-}\pi ^{+}\pi ^{-}\pi ^{0}$$ K + K - π + π - π 0 , 2( $$\pi ^{+}\pi ^{-})$$ π + π - ) and $$K^{+}K^{-}\pi ^{+}\pi ^{-}$$ K + K - π + π - . The results obtained for the decays $$J/\psi \rightarrow $$ J / ψ → 2( $$\pi ^{+}\pi ^{-})\pi ^{0}$$ π + π - ) π 0 , $$J/\psi \rightarrow K^{+}K^{-}\pi ^{+}\pi ^{-}\pi ^{0}$$ J / ψ → K + K - π + π - π 0 contradict the measurements performed by other groups in the last century, but agree well with recent results of BABAR and BESIII collaborations.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Cross-sectional studies have identified a strong link between interpersonal minority stress and mental health among transgender youth. However, very little is known about how experiences of minority ...stress change over time and how these changes relate to mental health. Further, few quantitative studies have examined the extent to which changes in gender dysphoria drive the improvements witnessed in mental health following gender-affirming medical treatment.
Transgender youth (N = 115; age 12–18) completed measures of interpersonal minority stress (e.g., family and peer support, parent support of gender, victimization), body dissatisfaction, and mental health (e.g., depression, anxiety, psychosocial functioning) at baseline and one year after initiating medical treatment with a multidisciplinary gender-affirming program.
Significant reductions in body dissatisfaction, victimization, depression, and anxiety were found along with improvements in parent gender-related nonaffirmation and psychosocial functioning. Higher levels of baseline family support, parent gender-related acceptance, and lower levels of baseline victimization were associated with better mental health at one-year follow-up. Reductions in body dissatisfaction were also associated with fewer symptoms of depression and better psychosocial functioning and follow-up.
Results provide further confirmation of the broad, short-term benefits of gender-affirming hormone therapy and highlight the importance of monitoring youth's experience of dysphoria while receiving treatment. Results also continue to highlight the importance of family support and suggest some forms of minority stress improve over time; however, the relationship between short-term changes in minority stress and mental health may be more complex.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Using the KEDR detector at the VEPP-4M e+e− collider, we have determined the values of R at thirteen points of the center-of-mass energy between 1.84 and 3.05 GeV. The achieved accuracy is about or ...better than 3.9% at most of the energy points with a systematic uncertainty less than 2.4%.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Using the KEDR detector at the VEPP-4M e+e− collider, we have measured the values of Ruds and R at seven points of the center-of-mass energy between 3.12 and 3.72 GeV. The total achieved accuracy is ...about or better than 3.3% at most of energy points with a systematic uncertainty of about 2.1%. At the moment it is the most accurate measurement of R(s) in this energy range.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The juvenile form of neuronal ceroid Lipofuscinosis (JNCL) is the most common form within this group of rare lysosomal storage disorders, causing pediatric neurodegeneration. The genetic disorder, ...which is caused by recessive mutations affecting the CLN3 gene, features progressive vision loss, cognitive and motor decline and other psychiatric conditions, seizure episodes, leading to premature death. Animal models have traditionally aid the understanding of the disease mechanisms and pathology and are very relevant for biomarker research and therapeutic testing. Nevertheless, there is a need for establishing reliable and predictive human cellular models to study the disease. Since patient material, particularly from children, is scarce and difficult to obtain, we generated an engineered a CLN3-mutant isogenic human induced pluripotent stem cell (hiPSC) line carrying the c.1054C → T pathologic variant, using state of the art CRISPR/Cas9 technology. To prove the suitability of the isogenic pair to model JNCL, we screened for disease-specific phenotypes in non-neuronal two-dimensional cell culture models as well as in cerebral brain organoids. Our data demonstrates that the sole introduction of the pathogenic variant gives rise to classical hallmarks of JNCL in vitro. Additionally, we discovered an alteration of the splicing caused by this particular mutation. Next, we derived cerebral organoids and used them as a neurodevelopmental model to study the particular effects of the CLN3
mutation during brain formation in the disease context. About half of the mutation -carrying cerebral organoids completely failed to develop normally. The other half, which escaped this severe defect were used for the analysis of more subtle alterations. In these escapers, whole-transcriptome analysis demonstrated early disease signatures, affecting pathways related to development, corticogenesis and synapses. Complementary metabolomics analysis confirmed decreased levels of cerebral tissue metabolites, some particularly relevant for synapse formation and neurotransmission, such as gamma-amino butyric acid (GABA). Our data suggests that a mutation in CLN3 severely affects brain development. Furthermore, before disease onset, disease -associated neurodevelopmental changes, particular concerning synapse formation and function, occur.
Free electron lasers (FELs) are unique sources of electromagnetic radiation with tunable wavelength. A high-power FEL has been created at the G. I.Budker Institute for Nuclear Physics. Its radiation ...frequency can be tuned over a wide range in the terahertz and infrared spectral ranges. As the source of electron bunches, this FEL uses a multi-turn energy-recovery linac, which has five straight sections. Three sections are used for three FELs which operate in different wavelength ranges (90–240 μm for the first, 37–80 μm for the second, and 5–20 μm for the third ones). The first and the second FELs were commissioned in 2003 and 2009, respectively. They are used for various applied and research problems now. The third FEL is installed on the last, forth accelerator loop, in which the electron energy is the maximum. It comprises three undulator sections and a 40 m optical cavity. The first lasing of this FEL was obtained in the summer of 2015. The radiation wavelength was 9 μm and the average power was about 100 W. The design power is 1 kW at a pulse repetition rate of 3.75 MHz. Radiation of the third FEL will be delivered to user stations from the protected hall in the near future. The third FEL commissioning results are presented and the current status of the first and second FELs as well as their future development prospects are described.
Full text
Available for:
DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We report the final results of a study of the ψ(3770) meson using a data sample collected with the KEDR detector at the VEPP-4M electron–positron collider. The data analysis takes into account ...interference between the resonant and nonresonant DD¯ production, where the latter is related to the nonresonant part of the energy-dependent form factor FD. The vector dominance approach and several empirical parameterizations have been tried for the nonresonant FDNR(s).
Our results for the mass and total width of ψ(3770) areM=3779.2−1.7+1.8−0.7+0.5−0.3+0.3 MeV,Γ=24.9−4.0+4.6−0.6+0.5−0.9+0.2 MeV, where the first, second and third uncertainties are statistical, systematic and model, respectively. For the electron partial width two possible solutions have been found:(1)Γee=154−58+79−9+17−25+13 eV,(2)Γee=414−80+72−26+24−10+90 eV. Our statistics are insufficient to prefer one solution to another. The Solution (2) mitigates the problem of non-DD¯ decays but is disfavored by potential models.
It is shown that taking into account the resonance–continuum interference in the near-threshold region affects resonance parameters, thus the results presented cannot be directly compared with the corresponding PDG values obtained ignoring this effect.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
To investigate whether the reason for discontinuation of the first tumor necrosis factor (TNF) blocking agent influences the effect of a second TNF blocking agent.
Data were used from 2 Dutch ...registries including patients with rheumatoid arthritis (RA) treated with TNF blocking agents. Patients were divided into 3 groups based on reason for discontinuation of the first: nonresponse, loss of response, or adverse events. The primary outcome was the change from baseline of the disease activity (by DAS28) at 6 months, corrected for the baseline DAS28 score. Secondary outcomes were the change from baseline at 3 months, EULAR response rates, and the percentages of patients who reached a DAS28 score < or = 3.2 at 3 and at 6 months.
In total, 49 patients who failed due to nonresponse, 75 due to loss of response, and 73 due to adverse events were included. At 6 months, the change of DAS28 score from baseline did not differ significantly between the groups (-0.6 to -1.3; p > or = 0.173) and similar good and moderate response rates were found (12% to 18%, p > or = 0.523, and 34% to 55%, p > or = 0.078, respectively). The secondary outcomes were also comparable between the 3 groups.
The results of our observational study suggest that a second TNF blocking agent may be effective after failure of the first, regardless of the reason for discontinuation of the first TNF blocking agent.
PDF
