A 58-year-old female was admitted diagnosed with gastric adenoma. Endoscopic findings revealed an adenoma with protruding lesion, approximately 15mm in length on the posterior wall of the gastric ...antrum. A EMR performed without abdominal pain or evidence of bleeding. A resected specimen was revealed Group III. Liquid antacid, thrombin, and ranitidine were prescribed with the patient initially responding well. However, five days after the EMR the patient experienced epigastric discomfort followed by massive tarry stool. Blood pressure indicated pronounced hemorrhagic shock with systoric pressure measuring 70mmHg. Emergency endoscopic hemostasis was performed using hemoclipping technique, however, aggrevated hemorrhaging resulted from the procedure. A partial gastrectomy was performed with subsequent histological findings revealing a bleeding ulcer (Ul II) .
In order to evaluate the clinical usefulness of carbocisteine (S-CMC) in the treatment of chronic paranasal sinusitis, a double blind trial was carried out by comparing S-CMC with L-cysteine ...ethylester hydrochloride (L-cysteine) as a control drug. S-CMC group (S-Group) was administered orally two tablets of S-CMC and one placebo tablet in place of active L-cysteine (1,500mg of S-CMC/day), and L-cysteine group (L-Group) one tablet of L-cysteine and two placebo tablets in place of active S-CMC (300mg of L-cysteine/day) t, i, d, after meal for four weeks. Following results were obtained: 1) The ratio of excellent or good utility of S-Group was significantly higher than that of L-Group. 2) The ratio of marked or moderate improvement of S-Group was significantly higher than that of L-Group. 3) The improvement ratio for subjective and objective symptoms of S-Group was significantly higher than that in L-Group. 4) No significant difference was found in the judgement of X-ray findings between the two groups. 5) In the respective evaluation items classified as subjective symptoms (rhinorrhea, postnasal drip, nasal obstruction) and as objective symptoms (volume of rhinorrhea, mucus rhinorrhea, postnasal drip), S-Group showed significantly superior improvement ratio in those items to L-Group. 6) Side effects were observed in two cases (1.5%) in S-Group and one case (0.8%) in L-Group. The side effects were not serious and disappeared soon after the administration was discontinued. From the above results, it is concluded that S-CMC is highly effective in the treatment of chronic paranasal sinusitis.
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