Background
There are limited data on surgical complications for patients that have delayed surgery after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. We aimed to analyze ...the surgical outcomes of patients submitted to surgery after recovery from SARS‐CoV‐2 infection.
Methods
Asymptomatic patients that had surgery delayed after preoperative reverse‐transcription polymerase chain reaction (RT‐PCR) for SARS‐CoV‐2 were matched in a 1:2 ratio for age, type of surgery and American Society of Anesthesiologists to patients with negative RT‐PCR for SARS‐CoV‐2.
Results
About 1253 patients underwent surgical procedures and were subjected to screening for SARS‐CoV‐2. Forty‐nine cases with a delayed surgery were included in the coronavirus disease (COVID) recovery (COVID‐rec) group and were matched to 98 patients included in the COVID negative (COVID‐neg) group. Overall, 22 (15%) patients had 30‐days postoperative complications, but there was no statistically difference between groups –16.3% for COVID‐rec and 14.3% for COVID‐neg, respectively (odds ratio OR 1.17:95% confidence interval CI 0.45–3.0; p = .74). Moreover, we did not find difference regarding grades more than or equal to 3 complication rates – 8.2% for COVID‐rec and 6.1% for COVID‐neg (OR 1.36:95%CI 0.36‐5.0; p = .64). There were no pulmonary complications or SARS‐CoV‐2 related infection and no deaths within the 30‐days after surgery.
Conclusions
Our study suggests that patients with delayed elective surgeries due to asymptomatic preoperative positive SARS‐CoV‐2 test are not at higher risk of postoperative complications.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
This work presents a new methodology for fabrication of membrane-assisted elongated YIG nanostructures through the sol-gel method using low-cost materials, and the estimation of the average size of ...the geometries formed within the pores through ferromagnetic resonance measurements. A precursor solution was deposited on the internal surface of porous aluminum oxide membrane, using an assembly consisting of a vacuum system coupled to an apparatus, which assists in the entry of the used precursor solution, breaking the barriers related to the existing surface tension, with subsequent heat treatment to form the single phase of yttrium iron garnet (YIG). The data collected by X-ray diffraction and Raman spectroscopy indicated this result. The study of the contact angle of the precursor solution and the alumina template indicated great compatibility, an angle of 35.4°. SEM analysis showed that elongated structures were deposited inside the pore’s walls, with different lengths up to 3 micrometers and the EDS analysis showed the presence of the main elements of the YIG phase. The Kittel’s equation and FMR spectral data were used to estimate the mean size of the elongated nanostructures. We found six different size categories with 1856, 1768, 1661, 1588, 1570, 1498 nm . The methodology proved to be efficient for the characterization of elongated YIG nanostructures, becoming a perspective of future applications.
Graphical Abstract
Highlights
Setup for the infiltration of the alumina membrane with the YIG precursor was proposed.
Elongated YIG structures were obtained with diverse potential applications.
The FMR was used to estimate the mean size of elongated YIG structures.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Aim: This article describes the changes and relationships between biochemical and immunological parameters in the colostrum and serum of diabetic women.
Methods: Colostrum and blood samples were ...collected from 30 diabetic and 15 normoglycaemic women. Glucose, total protein, antibody, complement proteins (C3 and C4), fat and calorie content, amylase, lipase and superoxide dismutase (SOD) were determined.
Results: Glucose was higher in both the colostrum and serum of diabetic mothers compared to that of their normoglycaemic counterparts. In both groups, total protein was higher in colostrum than in serum. IgA and IgG were lower in the colostrum of hyperglycaemic mothers, whereas IgM did not vary between the groups. Colostral C3 protein was significantly lower in diabetic mothers, but colostral C4 protein was similar between normoglycaemic and hyperglycaemic mothers. Fat content was lower in the colostrum of the diabetic mothers, although calorie content did not vary between the groups. Amylase was lower in colostrum than in serum in both groups. Lipase was higher in the colostrum and serum of diabetic mothers. Colostral SOD was similar between the groups.
Conclusions: Our results support the hypothesis that the colostrum of diabetic mothers suffers biochemical and immunological alterations that affect the levels of its components.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
This study investigated the expression of the neonatal Fc receptor (FcRn) in maternal blood, cord blood and placental cells and determined IgG levels in maternal blood and cord blood from diabetic ...mothers. Peripheral blood, cord blood and placenta samples were collected from 26 mothers with normoglycaemia (non‐diabetic, ND group) and 52 with hyperglycaemia (26 with mild gestational hyperglycaemia, MGH group, and 26 with type 2 diabetes mellitus, DM‐2 group). Cells expressing CD19+ and FcRn were identified by flow cytometry. Total IgG and its subclasses were quantified by ELISA. Maternal blood from DM‐2 and cord blood from MGH exhibited a higher proportion of CD19+ expression by B cells. DM‐2 showed a lower proportion of CD19+ cells in placenta. FcRn expression increased in cells from cord blood and placenta from MGH. Maternal blood, cord blood and placenta cells from DM‐2 showed lower FcRn expression. Blood IgG levels were lower in DM‐2, and cord blood IgG levels were higher in MGH. The highest levels of IgG4 were detected in the blood of hyperglycaemic mothers. The highest IgG3 and IgG4 levels in cord blood were detected in MGH, and the lowest IgG2 and IgG3 levels in DM‐2. Maternal hyperglycaemia compromised placental transfer of IgG1, IgG3 and IgG4. The results suggest that regardless of hyperglycaemia degree, it decreases FcRn expression in placenta and blood cells and compromises the production and transfer of antibodies from maternal blood to newborns.
Full text
Available for:
DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
•Ceramic samples of Na0.5Bi0.5−xYbxTiO3 (x = 0.005, 0.010, 0.015 and 0.020) were prepared.•The addition of Yb distorted the structure, increased the crystalline density and the porosity.•The magnetic ...moment associated to the ions of Y3+ introduced paramagnetism.•The addition of Yb enhanced the permittivity and reduced the dielectric losses.•For x = 0.020 the permittivity is higher than 103 for a broad range of frequencies.
In the present work, the magnetic and electrical properties of ceramic samples of Na0.5Bi0.5−xYbxTiO3 with x = 0.005, 0.010, 0.015 and 0.020 prepared by a solid-state reaction were investigated. X-ray diffraction (XRD) patterns revealed that the addition of Yb3+ ions led to distortions in the rhombohedral perovskite structure. The microstructure morphology investigated by scanning electron microscopy revealed the presence of micro-pores, diminishing the overall mass density of the ceramics for increasing values of x. This behaviour is opposite to the one observed for the mass density determined by using the XRD data. Despite of the contraction in the lattice parameter, the<Ti–O>bond length was found to increase for increasing values of x, shifting the corresponding Raman modes towards lower values of energy. The magnetization and the ac and dc magnetic susceptibilities were measured from 300 K down to 5 K. The magnetic moment associated to the Yb3+ ions added a paramagnetic behavior to the NBT samples that increases for increasing values of x. The electrical permittivity was measured at room temperature by impedance spectroscopy for frequencies (f) in the range 20 Hz–2.0 GHz. The f-dependence for the permittivity was accounted for by using the Cole-Davidson model. It was observed that the addition of the Yb3+ ions enhances the values of the dielectric constants, yielding an increase of about 70% for x = 0.020, while the overall dielectric losses are significantly reduced.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The objective of this study was to identify Brazil's most critical garbage codes (GCs) reclassified to Chagas disease (ChD) in mortality data and their proportions. We also estimated the potential ...impact of misclassification on the number of deaths attributed to ChD.
Population-based descriptive study.
We used the Mortality Information System (SIM; in Portuguese) data before and after routine GC investigation in 2015–2019 to evaluate ChD deaths detected among them. We identified priority GCs, which contributed more than 0.1 % to the percentage of total ChD deaths registered. Spearman's correlation was used to evaluate the association between the reclassification of priority GCs and ChD prevalence. Then, we applied the GC correction factors to estimate the number of deaths attributed to ChD.
22,154 deaths were reported as ChD in the study period. Among them, 1004 deaths originally listed as priority GCs were deaths reclassified to ChD after an investigation in the SIM final database. Unspecific cardiomyopathy (10.2 %), unspecific heart diseases (4.7 %), and heart failure (2.8 %) were GCs with the highest proportions of reclassification to ChD in Brazil. Higher ChD prevalence at the state level was associated with a higher proportion of GC deaths reclassified as ChD. When applying correction factors identified after investigation, we estimated an increase of 26.4 % in registered ChD deaths, mostly in states with higher endemicity.
GCs might conceal deaths due to ChD, particularly in Brazil's states with higher endemicity. The approach suggested in this study may offer an alternative method for estimating ChD-related deaths in endemic countries.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has impacted health across all sectors of society. A cytokine-release syndrome, combined with an inefficient response of innate immune ...cells to directly combat the virus, characterizes the severe form of COVID-19. While immune factors involved in the development of severe COVID-19 in the general population are becoming clearer, identification of the immune mechanisms behind severe disease in oncologic patients remains uncertain.
Here we evaluated the systemic immune response through the analysis of soluble blood immune factors and anti-SARS-CoV-2 antibodies within the early days of a positive SARS-CoV-2 diagnostic in oncologic patients.
Individuals with hematologic malignancies that went on to die from COVID-19 displayed at diagnosis severe leukopenia, low antibody production against SARS-CoV-2 proteins, and elevated production of innate immune cell recruitment and activation factors. These patients also displayed correlation networks in which IL-2, IL-13, TNF-alpha, IFN-gamma, and FGF2 were the focal points. Hematologic cancer patients that showed highly networked and coordinated anti-SARS-CoV-2 antibody production, with central importance of IL-4, IL-5, IL-12A, IL-15, and IL-17A, presented only mild COVID-19. Conversely, solid tumor patients that had elevated levels of inflammatory cytokines IL-6, CXCL8, and lost the coordinate production of anti-virus antibodies developed severe COVID-19 and died. Patients that displayed positive correlation networks between anti-virus antibodies, and a regulatory axis involving IL-10 and inflammatory cytokines recovered from the disease. We also provided evidence that CXCL8 is a strong predictor of death for oncologic patients and could be an indicator of poor prognosis within days of the positive diagnostic of SARS-CoV-2 infection.
Our findings defined distinct systemic immune profiles associated with COVID-19 clinical outcome of patients with cancer and COVID-19. These systemic immune networks shed light on potential immune mechanisms involved in disease outcome, as well as identify potential clinically useful biomarkers.
We present a background model for dark matter searches using an array of NaI(Tl) crystals in the COSINE-100 experiment that is located in the Yangyang underground laboratory. The model includes ...background contributions from both internal and external sources, including cosmogenic radionuclides and surface
210
Pb contamination. To build the model in the low energy region, with a threshold of 1 keV, we used a depth profile of
210
Pb contamination in the surface of the NaI(Tl) crystals determined in a comparison between measured and simulated spectra. We also considered the effect of the energy scale errors propagated from the statistical uncertainties and the nonlinear detector response at low energies. The 1.7 years COSINE-100 data taken between October 21, 2016 and July 18, 2018 were used for this analysis. Our Monte Carlo simulation provides a non-Gaussian peak around 50 keV originating from beta decays of bulk
210
Pb in a good agreement with the measured background. This model estimates that the activities of bulk
210
Pb and
3
H are dominating the background rate that amounts to an average level of
2.85
±
0.15
counts/day/keV/kg in the energy region of (1–6) keV, using COSINE-100 data with a total exposure of 97.7 kg
·
years.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
PDF
