In most areas of the world, thyroid cancer incidence has been appreciably increasing over the last few decades, whereas mortality has steadily declined. We updated global trends in thyroid cancer ...mortality and incidence using official mortality data from the World Health Organization (1970–2012) and incidence data from the Cancer Incidence in Five Continents (1960–2007). Male mortality declined in all the major countries considered, with annual percent changes around −2/−3% over the last decades. Only in the United States mortality declined up to the mid 1980s and increased thereafter. Similarly, in women mortality declined in most countries considered, with APCs around −2/−5% over the last decades, with the exception of the UK, the United States and Australia, where mortality has been declining up to the late 1980s/late 1990s to level off (or increase) thereafter. In 2008–2012, most countries had mortality rates (age‐standardized, world population) between 0.20 and 0.40/100,000 men and 0.20 and 0.60/100,000 women, the highest rates being in Latvia, Hungary, the Republic of Moldova and Israel (over 0.40/100,000) for men and in Ecuador, Colombia and Israel (over 0.60/100,000) for women. In most countries, a steady increase in the incidence of thyroid cancer (mainly papillary carcinomas) was observed in both sexes. The declines in thyroid cancer mortality reflect both variations in risk factor exposure and changes in the diagnosis and treatment of the disease, while the increases in the incidence are likely due to the increase in the detection of this neoplasm over the last few decades.
What's New?
Trends in thyroid cancer incidence and mortality vary widely by country, but for most areas of the world, the data indicate an upward trend in incidence and a downward trend in mortality. Those trends are supported by the present analysis of thyroid cancer mortality and incidence globally. The analyses are based on data maintained by the World Health Organization (1970–2012) and Cancer Incidence in Five Continents (1960–2007). The authors attribute the rise in thyroid cancer incidence to increased detection of the disease and the decline in mortality to changes in diagnosis, treatment, and risk factor exposure.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
A primary challenge in single-cell RNA sequencing (scRNA-seq) studies comes from the massive amount of data and the excess noise level. To address this challenge, we introduce an analysis framework, ...named single-cell Decomposition using Hierarchical Autoencoder (scDHA), that reliably extracts representative information of each cell. The scDHA pipeline consists of two core modules. The first module is a non-negative kernel autoencoder able to remove genes or components that have insignificant contributions to the part-based representation of the data. The second module is a stacked Bayesian autoencoder that projects the data onto a low-dimensional space (compressed). To diminish the tendency to overfit of neural networks, we repeatedly perturb the compressed space to learn a more generalized representation of the data. In an extensive analysis, we demonstrate that scDHA outperforms state-of-the-art techniques in many research sub-fields of scRNA-seq analysis, including cell segregation through unsupervised learning, visualization of transcriptome landscape, cell classification, and pseudo-time inference.
...the median age at death of patients who died and tested positive for SARS-CoV-2 infection was 82 years; 95% of them had at least one comorbidity, and 60% had at least three comorbidities before ...being infected. ...total mortality in Italy showed that the COVID-19 pandemic had severely hit the country in the month of March, 2020, but there was a remarkable attenuation of the excess mortality in April and a lack of excess deaths in May. ...total mortality is a key indicator of the COVID-19 effect; the excess total mortality in March and April, 2020, in Italy was substantial (ie, a total of over 45 000 deaths), corresponding to an overall excess about 60% greater than the number of officially registered COVID-19 deaths; there was a substantial under-registration of COVID-19 deaths in March, 2020, and a smaller under-registration in April, 2020; there was no residual excess total mortality in May, 2020, when COVID-19 deaths were probably over-registered.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Hepatocellular carcinoma epidemiology Bosetti, Cristina, ScD; Turati, Federica, ScD; La Vecchia, Carlo, MD
Baillière's best practice & research. Clinical gastroenterology,
10/2014, Volume:
28, Issue:
5
Journal Article
Peer reviewed
Abstract Primary liver cancer (namely hepatocellular carcinoma, HCC) is worldwide the fifth most common cancer in men and the seventh one in women, and it represents the third most frequent cause of ...cancer death. HCC rates are particularly high in eastern/south-eastern Asia and in Africa, intermediate in Southern Europe, and low in most high-income countries. Persistent infections by HBV or HCV are the main recognized risk factors for HCC. Aflatoxin exposure is also an important risk factor for HCC development in Africa and eastern Asia. In high-income countries heavy alcohol drinking, tobacco smoking, overweight, diabetes, familial/genetic factors, and selected dietary aspects, have a relevant role. Updated geographic patterns and time trends in mortality from HCC in Europe, USA, Japan, and Australia are provided in the present review, together with an overview of relevant etiologic factors for HCC and main measures for the prevention of this neoplasm.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Abstract This is a systematic review and meta-analysis aimed at providing a comprehensive and quantitative review of risk factors for falls in older people in nursing homes and hospitals. Using ...MEDLINE, we searched for prospective studies investigating risk factors for falls in nursing home residents (NHR) and older hospital inpatients (HI). When there were at least 3 studies investigating a factor in a comparable way in a specific setting, we computed the pooled odds ratio (OR) using random effect models. Twenty-four studies met the inclusion criteria. Eighteen risk factors for NHR and six for HI were considered, including socio-demographic, mobility, sensory, medical factors, and medication use. For NHR, the strongest associations were with history of falls (OR = 3.06), walking aid use (OR = 2.08) and moderate disability (OR = 2.08). For HI, the strongest association was found for history of falls (OR = 2.85). No association emerged with age in NHR (OR = 1.00), while the OR for a 5 years increase in age of HI was 1.04. Female sex was, if anything, associated with a decreased risk. A few other medical conditions and medications were also associated with a moderately increased risk. For some important factors (e.g. balance and muscle weakness), a summary estimate was not computed because the measures used in various studies were not comparable. Falls in older people in nursing homes and hospitals have multifactorial etiology. History of falls, use of walking aids and disability are strong predictors of future falls.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Nowadays the food production, supply and consumption chain represent a major cause of ecological pressure on the natural environment, and diet links worldwide human health with environmental ...sustainability. Food policy, dietary guidelines and food security strategies need to evolve from the limited historical approach, mainly focused on nutrients and health, to a new one considering the environmental, socio-economic and cultural impact-and thus the sustainability-of diets.
To present an updated version of the Mediterranean Diet Pyramid (MDP) to reflect multiple environmental concerns.
We performed a revision and restructuring of the MDP to incorporate more recent findings on the sustainability and environmental impact of the Mediterranean Diet pattern, as well as its associations with nutrition and health. For each level of the MDP we provided a third dimension featuring the corresponding environmental aspects related to it.
The new environmental dimension of the MDP enhances food intake recommendations addressing both health and environmental issues. Compared to the previous 2011 version, it emphasizes more strongly a lower consumption of red meat and bovine dairy products, and a higher consumption of legumes and locally grown eco-friendly plant foods as much as possible.
We analysed data on 2842 subjects aged ≥40 years enrolled in the National Diet and Nutrition Survey (NDNS 2008–2019). Based on serum 25(OH)D concentrations, study subjects were grouped in three ...categories: vitamin D deficiency (<25 nmol/L), vitamin D insufficiency (25–49 nmol/L) and vitamin D sufficiency status (≥50 nmol/L). Differences in CVD risk factors between vitamin D deficiency or insufficiency and vitamin D sufficiency status were expressed in standard deviation scores (SDS) and estimated through weighted multiple linear regression models.
Nationally representative data source UK National Diet and Nutrition Survey (2008–2019) is analysed. Vitamin D status is determined according to serum concentration of 25(OH)D – deficiency: <25 nmol/L; insufficiency: 25–49 nmol/L; sufficiency: ≥50 nmol/L. Cardiovascular risk factors are compared between individuals with vitamin D deficiency and those with vitamin D sufficiency. Differences are expressed in standard deviation scores. Vitamin D deficiency is associated with high cardiovascular risk profile.
Key points
Nationally representative data source UK National Diet and Nutrition Survey (2008–2019) is analysed.
Vitamin D status is determined according to serum concentration of 25(OH)D deficiency: <25 nmol/L; insufficiency: 25–49 nmol/L; sufficiency: ≥50 nmol/L.
Cardiovascular risk factors are compared between individuals with vitamin D deficiency and those with vitamin D sufficiency.
Differences are expressed in standard deviation scores.
Vitamin D deficiency is associated with a higher cardiovascular risk profile.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Objectives
To report worldwide trends in suicide mortality during a period that covers 7 years after the 2008 global crisis.
Methods
We performed a time trend analysis with joinpoint regression.
...Results
Over the 2000s, suicide mortality decreased with the largest declines observed in some Eastern European countries. The downward trends were followed by an increase in concomitance with the 2008 global crisis in some countries, including Greece (annual percentage change = + 6 in men and + 11.8 in women), the Netherlands (+ 4.2 in men and + 4.0 in women), and the UK (+ 1.6 in men), while the pre-crisis downward trends stopped in Germany, Italy, and Spain. The joinpoint analysis also revealed long-term rises in Brazil (+ 0.8 since 1990 in men and + 1.8 since 1999 in women), Mexico (+ 1.3 since 1995 in men and + 3.6 since 1990 in women), the USA (+ 1.7 since 2005 in men and + 4.2 since 2010 in women), and Australia (+ 1.8 in men and + 3.7 in women, since 2006 in both sexes).
Conclusions
Despite downward trends in several areas of the world, in some countries suicide rates increased since the 2008 global crisis.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Abstract The incidence of liver cancer is high in all low-resource regions of the world, with the exception of Northern Africa and Western Asia. The estimated worldwide number of new cases of liver ...cancer in 2002 is 600,000, of which 82% are from developing countries. Given the poor survival from this disease, the estimated number of deaths is similar to that of new cases. Hepatocellular carcinoma (HCC) is the main form of liver cancer. A part from chronic infections with Hepatitis B and Hepatitis C viruses, which are the main causes of HCC, contamination of foodstuff with aflatoxins, a group of mycotoxins produced by the fungi Aspergillus flavus and Aspergillus parasiticus , is an important contributor to HCC burden in many low-income country. Alcoholic cirrhosis is an important risk factor for HCC in populations with low prevalence of HBV and HCV infection, and the association between tobacco smoking and HCC is now established. Diabetes is also related to an excess risk of HCC and the increased prevalence of overweight and obesity likely contributes to it. The second most important type of liver cancer is cholangiocarcinoma, whose main known cause is infestation with the liver flukes, Opistorchis viverrini and Clonorchis sinensis , which is frequent in some areas in South-East Asia. Angiosarcoma is a rare form of liver cancer whose occurence is linked to occupational exposure to vinyl chloride.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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