In the minutes to days after myocardial infarction, endogenous lysis of an occlusive coronary arterial thrombus occurs in most subjects. Compared with those in whom thrombolysis does not occur, those ...with antegrade flow in the infarct artery have improved left ventricular performance, less left ventricular dilatation, and improved survival. This study was performed to assess intrinsic hemostasis and fibrinolysis in survivors of myocardial infarction with or without antegrade perfusion of the infarct artery.
In 105 survivors of infarction (75 men, 30 women; age, 30 to 80 years) not given thrombolytic therapy, coronary angiography revealed a patent (group 1, n = 52) or occluded (group 2, n = 53) infarct artery. Plasma concentrations of plasminogen, fibrinogen, tissue plasminogen activator activity, infarct artery. Plasma concentrations of plasminogen, fibrinogen, tissue plasminogen activator activity, plasminogen activator inhibitor activity, cholesterol, triglycerides, and lipoproteins, including lipoprotein(a) (Lpa), were measured in blood procured 23 +/- 13 (mean +/- SD) months after infarction. Groups 1 and 2 were similar in age, sex, race, cardioactive medications, infarct artery, extent of coronary artery disease, and left ventricular performance. Of the plasma constituents assayed, the groups were similar except that Lp(a) averaged 18.5 +/- 21.7 mg/dL in group 1 and 49.1 +/- 44.8 mg/dL in group 2 (P < .001). This difference was evident in both Caucasian (n = 65) (P = .009) and African American (n = 40) (P = .01) subjects.
Survivors of myocardial infarction who failed to recanalize the infarct artery have higher plasma Lp(a) concentrations than those with a patent infarct artery. Lp(a) may inhibit intrinsic fibrinolysis.
The purpose of this study is to examine the WAIS-III General Ability Index (GAI) in a sample of 33 neuropsychiatry inpatients and 47 forensic psychiatry inpatients. The GAI is comprised of the six ...subtests that form the Verbal Comprehension and the Perceptual Organization Indexes. The GAI, although highly correlated with the FSIQ, was on average 5.3 points higher in the neuropsychiatry sample and 4.2 points higher in the forensic psychiatry sample. The GAI was significantly higher than the Working Memory and the Processing Speed Indexes in both groups. The GAI, a composite measure of verbal and nonverbal intellect, appears to be an appropriate measure for use in day-to-day clinical practice in neuropsychology. To facilitate clinical use, statistically reliable difference scores between the GAI and the WMI and PSI, for the 95% confidence interval, are presented.
To evaluate the chest radiographic filling pattern associated with partial liquid ventilation (PLV) with the perfluorochemical perflubron (LiquiVent; Alliance Pharmaceutical Corp; San Diego CA) as a ...function of dose and timing.
Post hoc review of chest radiographs by three independent observers with correlation to clinical variables.
Phase II randomized, uncontrolled, prospective, multicenter clinical trial.
Sixteen adult patients with diffuse bilateral infiltrates consistent with acute lung injury and a Pao2/fraction of inspired oxygen (Fio2) ratio < 300 with positive end-expiratory pressure of 13 cm H2O and Fio2 ≥ 0.5.
All patients were treated with either a 10-mL/kg or 20-mL/kg loading dose of perflubron followed by maintenance dosing at 3-h intervals to protocol-determined levels.
There was a significant relationship between inhomogeneous radiographic filling during the first 48 h of treatment and the use of the lower loading dose of perflubron. Inhomogeneous radiographic filling (in 5 patients) was associated with a lower high-dose/Fio2 ratio at 24 h compared with the remaining patients. These differences resolved by 48 h. There were no other statistically significant correlations identified.
The radiographic appearance of PLV with perflubron appears to depend on the dose administered. Lower doses can be associated with both inhomogeneous radiographic filling and a transient deterioration in oxygenation during the first 24 to 48 h of treatment.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Objective: To examine the association between performance validity, ICD-10 diagnostic criteria for postconcussional syndrome, and DSM-IV criteria for major and mild neurocognitive disorder in ...military service members. Method: Service members n = 254; 94.1% men; Age: M = 27.7 (SD = 7.1) with MTBIs assessed on average 3.9 months (SD = 4.4) post-injury at Walter Reed Army Medical Center were divided ...
Objective: Sleep is known to be critical to a wide range of restorative and recuperative functions. When sleep is significantly disrupted, it may interfere with recovery from Mild Traumatic Brain ...Injury (MTBI). The purpose of this study is to examine the relation between sleep disruption and health-related quality of life following MTBI. Method: Participants were '...
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