Objective: To determine whether rapid correction of anemia improves the functional and cognitive performance of postoperative orthopedic patients.
Design: A randomized, double-blind, ...placebo-controlled clinical trial.
Setting: A rehabilitation institute.
Patients: Persons having orthopedic surgery at least 2 weeks previously, and a hemoglobin concentration < 10g/dL.
Interventions: Recombinant human erythropoietin (rH-EPO) or the EPO vehicle for up to 8 weeks. All patients received ferrous sulfate.
Measurements: Blood counts were performed at weekly intervals, and functional and cognitive tests at baseline and weeks 4 and 8.
Results: In patients receiving vehicle only, hemoglobin levels increased from a mean of 9.0 at baseline to 11.0 at 4 weeks and 11.7 at 8 weeks; corresponding values for rH-EPO were 8.8 (
p =
NS), 12.6 (
p = .02), and 13.5 (
p = .01). However, functional improvement in dressing, toileting, and mobility was similar between groups, and the results of neuropsychological tests showed no trends favoring rH-EPO.
Conclusions:) Although hemoglobin increases more rapidly in anemic orthopedic patients treated with rH-EPO, equally rapid functional improvement occurs in those who receive only iron therapy.
Recent experimental discoveries have brought a diverse set of broken symmetry states to the center stage of research on cuprate superconductors. Here, we focus on a thematic understanding of the ...diverse phenomenology by exploring a strong-coupling mechanism of symmetry breaking driven by frustration of antiferromagnetic order. We achieve this through a variational study of a three-band model of the CuO\(_2\) plane with Kondo-type exchange couplings between doped oxygen holes and classical copper spins. Two main findings from this strong-coupling multi-band perspective are 1) that the symmetry hierarchy of spin stripe, charge stripe, intra-unit-cell nematic order and isotropic phases are all accessible microscopically within the model, 2) many symmetry-breaking patterns compete with energy differences within a few meV per Cu atom to produce a rich phase diagram. These results indicate that the diverse phenomenology of broken-symmetry states in hole-doped antiferromagnetic charge-transfer insulators may indeed arise from hole-doped frustration of antiferromagnetism.
Thromboapondin 1 (TSP-1) is a trimeric matricellular protein that is expressed by many cells. It contains several different domains that allow it to participate in cell adhesion, cell migration, and ...cell signaling. Recently TSP-1 has been shown to activate transforming growth factor beta (TGF-beta) and to inhibit both angiogenesis and tumor growth. This unit contains protocols for the purification of TSP-1 from platelet-rich plasma and the purification of TSP-1 proteolytic fragments.
We present 1.3 mm observations of the Sun-like star \(\tau\) Ceti with the Atacama Large Millimeter/submillimeter Array (ALMA) that probe angular scales of \(\sim1\)'' (4 AU). This first ...interferometric image of the \(\tau\) Ceti system, which hosts both a debris disk and possible multiplanet system, shows emission from a nearly face-on belt of cold dust with a position angle of \(90^\circ\) surrounding an unresolved central source at the stellar position. To characterize this emission structure, we fit parametric models to the millimeter visibilities. The resulting best-fit model yields an inner belt edge of \(6.2^{+9.8}_{-4.6}\) AU, consistent with inferences from lower resolution, far-infrared Herschel observations. While the limited data at sufficiently short baselines preclude us from placing stronger constraints on the belt properties and its relation to the proposed five planet system, the observations do provide a strong lower limit on the fractional width of the belt, \(\Delta R/R > 0.75\) with \(99\%\) confidence. This fractional width is more similar to broad disks such as HD 107146 than narrow belts such as the Kuiper Belt and Fomalhaut. The unresolved central source has a higher flux density than the predicted flux of the stellar photosphere at 1.3 mm. Given previous measurements of an excess by a factor of \(\sim2\) at 8.7 mm, this emission is likely due to a hot stellar chromosphere.
Astrophysics advances, in part, through laboratory astrophysics studies of the underlying processes controlling the observed properties of the Cosmos. These studies encompass both theoretical and ...experimental research. Robust support for laboratory astrophysics is critically needed to maximize the scientific return of astronomical observations.
Molecular orbital calculations of the extended Hückel type on the polyamidoimidonitride clusters of zirconium indicate that there is little metal‐metal bonding in the clusters; instead the clusters ...are held together by strong interactions with an interstitial nitride, and bridging and capping ligands. The centering nitride is shown to be important in stabilizing the cluster. The reactivity of these clusters is also examined, in particular, the possible activity of a lone pair on the interstitial nitride and the ability of the clusters to undergo reduction.
Polyamidoimidonitrid‐Cluster des Zirconiums – eine Molekularorbital‐Untersuchung
Extended‐Hückel‐MO‐Rechnungen an Polyamidoimidonitrid‐Clustern von Zirconium zeigen, daß nur schwache Metall–Metall‐Bindung in den Clustern vorliegt, die durch starke Wechselwirkungen mit dem interstitiellen Stickstoff und durch überbrückende und bekappende Liganden zusammengehalten werden. Es wird gezeigt, daß das zentrierende Stickstoff‐Atom für die Stabilität des Clusters wesentlich ist. Die Reaktivität dieser Cluster wird untersucht, insbesondere die Aktivität eines einsamen Elektronenpaars des interstitiellen Stickstoff‐Atoms sowie die Möglichkeit zur Reduktion des Clusters.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Chemical substitution plays a key role in controlling the electronic and magnetic properties of complex materials. For instance, in EuO, carrier doping can induce a spin-polarized metallic state, ...colossal magnetoresistance, and significantly enhance the Curie temperature. Here, we employ a combination of molecular-beam epitaxy, angle-resolved photoemission spectroscopy, and an effective model calculation to investigate and understand how semi-localized states evolve in lightly electron doped Eu\(_{1-x}\)Gd\(_{x}\)O above the ferromagnetic Curie temperature. Our studies reveal a characteristic length scale for the spatial extent of the donor wavefunctions which remains constant as a function of doping, consistent with recent tunneling studies of doped EuO. Our work sheds light on the nature of the semiconductor-to-metal transition in Eu\(_{1-x}\)Gd\(_{x}\)O and should be generally applicable for doped complex oxides.
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