Food preferences and dietary habits are heavily influenced by taste perception. There is growing interest in characterizing taste preferences based on genetic variation. Genetic differences in the ...ability to perceive key tastes may impact eating behavior and nutritional intake. Therefore, increased understanding of taste biology and genetics may lead to new personalized strategies, which may prevent or influence the trajectory of chronic disease risk. Recent advances show that single nucleotide polymorphisms (SNPs) in the CD36 fat taste receptor are linked to differences in fat perception, fat preference, and chronic-disease biomarkers. Genetic variation in the sweet taste receptor T1R2 has been shown to alter sweet taste preferences, eating behaviors, and risk of dental caries. Polymorphisms in the bitter taste receptor T2R38 have been shown to influence taste for brassica vegetables. Individuals that intensely taste the bitterness of brassica vegetables ("supertasters") may avoid vegetable consumption and compensate by increasing their consumption of sweet and fatty foods, which may increase risk for chronic disease. Emerging evidence also suggests that the role of genetics in taste perception may be more impactful in children due to the lack of cultural influence compared to adults. This review examines the current knowledge of SNPs in taste receptors associated with fat, sweet, bitter, umami, and salt taste modalities and their contributions to food preferences, and chronic disease. Overall, these SNPs demonstrate the potential to influence food preferences and consequently health.
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BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
Background No evaluation has been done on the relationship of the critical shoulder angle (CSA) with retear after rotator cuff repair. Our purpose was to evaluate whether a higher CSA is associated ...with retear after rotator cuff repair. Methods This was a retrospective review of 76 patients who had undergone rotator cuff repair with postoperative ultrasound examination. Ultrasound findings were graded no retear (NT), partial-thickness (PT) retear, or full-thickness (FT) retear. Preoperative radiographs were used to measure CSA, glenoid inclination, lateral acromion angle, and acromion index. Results Average age was 61.9 years (45.3-74.9 years). On ultrasound examination, 57 shoulders (74.0%) had NT, 11 (14.2%) had PT retears, and 8 (10.3%) had FT retears. There was no significant difference in retear rate by age, gender, or tension of repair. Average CSA was significantly lower for the NT group at 34.3° ± 2.9° than for the FT group at 38.6° ± 3.5° ( P < .01). If CSA was >38°, the odds ratio of having an FT retear was 14.8 ( P < .01). In addition, higher CSA inversely correlated with postoperative American Shoulder and Elbow Surgeons scores ( P < .03). Average glenoid inclination was significantly lower in the NT group at 12.3° ± 2.7° compared with 17.3° ± 2.6° in the FT group ( P < .01). If glenoid inclination was >14, the odds ratio of having a FT retear was 15.0 ( P < .01). Conclusion At short-term follow-up, higher CSA significantly increased the risk of an FT retear after rotator cuff repair. Also, increasing CSA correlated with worse postoperative American Shoulder and Elbow Surgeons scores. This radiographic marker may help manage expectations for rotator cuff tear patients.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
23.
The CCSM4 Land Simulation, 1850–2005 Lawrence, David M.; Oleson, Keith W.; Flanner, Mark G. ...
Journal of climate,
04/2012, Volume:
25, Issue:
7
Journal Article
Peer reviewed
Open access
This paper reviews developments for the Community Land Model, version 4 (CLM4), examines the land surface climate simulation of the Community Climate System Model, version 4 (CCSM4) compared to ...CCSM3, and assesses new earth system features of CLM4 within CCSM4. CLM4 incorporates a broad set of improvements including additions of a carbon–nitrogen (CN) biogeochemical model, an urban canyon model, and transient land cover and land use change, as well as revised soil and snow submodels.
Several aspects of the surface climate simulation are improved in CCSM4. Improvements in the simulation of soil water storage, evapotranspiration, surface albedo, and permafrost that are apparent in offline CLM4 simulations are generally retained in CCSM4. The global land air temperature bias is reduced and the annual cycle is improved in many locations, especially at high latitudes. The global land precipitation bias is larger in CCSM4 because of bigger wet biases in central and southern Africa and Australia.
New earth system capabilities are assessed. The present-day air temperature within urban areas is warmer than surrounding rural areas by 1°–2°C, which is comparable to or greater than the change in climate occurring over the last 130 years. The snow albedo feedback is more realistic and the radiative forcing of snow aerosol deposition is calculated as +0.083 W m−2for present day. The land carbon flux due to land use, wildfire, and net ecosystem production is a source of carbon to the atmosphere throughout most of the historical simulation. CCSM4 is increasingly suited for studies of the role of land processes in climate and climate change.
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BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
piRNAs are critical for transposable element (TE) repression and germ cell survival during the early phases of spermatogenesis, however, their role in adult germ cells and the relative importance of ...piRNA methylation is poorly defined in mammals. Using a mouse model of HEN methyltransferase 1 (HENMT1) loss-of-function, RNA-Seq and a range of RNA assays we show that HENMT1 is required for the 2' O-methylation of mammalian piRNAs. HENMT1 loss leads to piRNA instability, reduced piRNA bulk and length, and ultimately male sterility characterized by a germ cell arrest at the elongating germ cell phase of spermatogenesis. HENMT1 loss-of-function, and the concomitant loss of piRNAs, resulted in TE de-repression in adult meiotic and haploid germ cells, and the precocious, and selective, expression of many haploid-transcripts in meiotic cells. Precocious expression was associated with a more active chromatin state in meiotic cells, elevated levels of DNA damage and a catastrophic deregulation of the haploid germ cell gene expression. Collectively these results define a critical role for HENMT1 and piRNAs in the maintenance of TE repression in adult germ cells and setting the spermatogenic program.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Target Selection and Validation of DESI Quasars Chaussidon, Edmond; Yèche, Christophe; Palanque-Delabrouille, Nathalie ...
The Astrophysical journal,
02/2023, Volume:
944, Issue:
1
Journal Article
Peer reviewed
Open access
Abstract
The Dark Energy Spectroscopic Instrument (DESI) survey will measure large-scale structures using quasars as direct tracers of dark matter in the redshift range 0.9 <
z
< 2.1 and using Ly
α
...forests in quasar spectra at
z
> 2.1. We present several methods to select candidate quasars for DESI, using input photometric imaging in three optical bands (
g
,
r
,
z
) from the DESI Legacy Imaging Surveys and two infrared bands (W1, W2) from the Wide-field Infrared Survey Explorer. These methods were extensively tested during the Survey Validation of DESI. In this paper, we report on the results obtained with the different methods and present the selection we optimized for the DESI main survey. The final quasar target selection is based on a random forest algorithm and selects quasars in the magnitude range of 16.5 <
r
< 23. Visual selection of ultra-deep observations indicates that the main selection consists of 71% quasars, 16% galaxies, 6% stars, and 7% inconclusive spectra. Using the spectra based on this selection, we build an automated quasar catalog that achieves a fraction of true QSOs higher than 99% for a nominal effective exposure time of ∼1000 s. With a 310 deg
−2
target density, the main selection allows DESI to select more than 200 deg
−2
quasars (including 60 deg
−2
quasars with
z
> 2.1), exceeding the project requirements by 20%. The redshift distribution of the selected quasars is in excellent agreement with quasar luminosity function predictions.
Abstract
By deriving analytical solutions to radiative–convective equilibrium (RCE), it is shown mathematically that convective available potential energy (CAPE) exhibits Clausius–Clapeyron (CC) ...scaling over a wide range of surface temperatures up to 310 K. Above 310 K, CAPE deviates from CC scaling and even decreases with warming at very high surface temperatures. At the surface temperature of the current tropics, the analytical solutions predict that CAPE increases at a rate of about 6%–7% per kelvin of surface warming. The analytical solutions also provide insight on how the tropopause height and stratospheric humidity change with warming. Changes in the tropopause height exhibit CC scaling, with the tropopause rising by about 400 m per kelvin of surface warming at current tropical temperatures and by about 1–2 km K−1 at surface temperatures in the range of 320–340 K. The specific humidity of the stratosphere exhibits super-CC scaling at temperatures moderately warmer than the current tropics. With a surface temperature of the current tropics, the stratospheric specific humidity increases by about 6% per kelvin of surface warming, but the rate of increase is as high as 30% K−1 at warmer surface temperatures.
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Representation of subsurface hydrology in global land surface models has been advanced but outstanding challenges and opportunities remain, especially in better simulating lateral groundwater flow ...and aquifer pumping for irrigation. This study improves the representation of groundwater in the latest version of the Community Land Model (version 5) by implementing a prognostic groundwater module that accounts for lateral groundwater flow, aquifer pumping, and conjunctive use of groundwater and surface water for irrigation. In particular, we introduce—for the first time—explicit representation of steady‐state well equation in large‐scale hydrological modeling. Simulations are conducted at ∼5 km resolution over the conterminous US. Groundwater level, terrestrial water storage (TWS), and river discharge are evaluated over the major US aquifers and river basins using in situ observations of groundwater and river discharge and the TWS inferred from the Gravity Recovery and Climate Experiment (GRACE) satellites. The implementation of groundwater pumping results in significant improvements in simulation of spatiotemporal water‐level change over the US High Plains and Central Valley Aquifer (CVA) and that of TWS over the CVA. Improvements in river discharge over the major US river basins are also achieved but are not substantial. Furthermore, the representation of pumping leads to certain overestimation in TWS trend compared to GRACE data in regions with high groundwater withdrawals. The consideration of lateral groundwater flow provides improvements in the subsurface response to pumping and natural wet and dry cycles, particularly at the grid cell level. These results provide a basis for improved groundwater modeling over large scales.
Key Points
A new prognostic groundwater model is implemented into the latest version of the Community Land Model (CLM5)
The new model accounts for lateral groundwater flow and conjunctive use of groundwater and surface water for irrigation
Significant improvements are achieved in simulating the spatiotemporal dynamics of water level over the heavily exploited US aquifers
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Biophysical effects from deforestation have the potential to amplify carbon losses but are often neglected in carbon accounting systems. Here we use both Earth system model simulations and ...satellite-derived estimates of aboveground biomass to assess losses of vegetation carbon caused by the influence of tropical deforestation on regional climate across different continents. In the Amazon, warming and drying arising from deforestation result in an additional 5.1 ± 3.7% loss of aboveground biomass. Biophysical effects also amplify carbon losses in the Congo (3.8 ± 2.5%) but do not lead to significant additional carbon losses in tropical Asia due to its high levels of annual mean precipitation. These findings indicate that tropical forests may be undervalued in carbon accounting systems that neglect climate feedbacks from surface biophysical changes and that the positive carbon-climate feedback from deforestation-driven climate change is higher than the feedback originating from fossil fuel emissions.
Future climate change projections for phase 5 of the Coupled Model Intercomparison Project (CMIP5) are presented for the Community Earth System Model version 1 that includes the Community Atmospheric ...Model version 5 CESM1(CAM5). These results are compared to the Community Climate System Model, version 4 (CCSM4) and include simulations using the representative concentration pathway (RCP) mitigation scenarios, and extensions for those scenarios beyond 2100 to 2300. Equilibrium climate sensitivity of CESM1 (CAM5) is 4.10°C, which is higher than the CCSM4 value of 3.20°C. The transient climate response is 2.33°C, compared to the CCSM4 value of 1.73°C. Thus, even though CESM1(CAM5) includes both the direct and indirect effects of aerosols (CCSM4 had only the direct effect), the overall climate system response including forcing and feedbacks is greater in CESM1(CAM5) compared to CCSM4. The Atlantic Ocean meridional overturning circulation (AMOC) in CESM1(CAM5) weakens considerably in the twenty-first century in all the RCP scenarios, and recovers more slowly in the lower forcing scenarios. The total aerosol optical depth (AOD) changes from ∼0.12 in 2006 to ∼0.10 in 2100, compared to a preindustrial 1850 value of 0.08, so there is less negative forcing (a net positive forcing) from that source during the twenty-first century. Consequently, the change from 2006 to 2100 in aerosol direct forcing in CESM1(CAM5) contributes to greater twenty-first century warming relative to CCSM4. There is greater Arctic warming and sea ice loss in CESM1(CAM5), with an ice-free summer Arctic occurring by about 2060 in RCP8.5 (2040s in September) as opposed to about 2100 in CCSM4 (2060s in September).
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BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase
, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis
. Depletion of tetrahydrofolate ...causes cell death by suppressing DNA and RNA production
. Although methotrexate is widely used as an anticancer agent and is the subject of over a thousand ongoing clinical trials
, its high toxicity often leads to the premature termination of its use, which reduces its potential efficacy
. To identify genes that modulate the response of cancer cells to methotrexate, we performed a CRISPR-Cas9-based screen
. This screen yielded FTCD, which encodes an enzyme-formimidoyltransferase cyclodeaminase-that is required for the catabolism of the amino acid histidine
, a process that has not previously been linked to methotrexate sensitivity. In cultured cancer cells, depletion of several genes in the histidine degradation pathway markedly decreased sensitivity to methotrexate. Mechanistically, histidine catabolism drains the cellular pool of tetrahydrofolate, which is particularly detrimental to methotrexate-treated cells. Moreover, expression of the rate-limiting enzyme in histidine catabolism is associated with methotrexate sensitivity in cancer cell lines and with survival rate in patients. In vivo dietary supplementation of histidine increased flux through the histidine degradation pathway and enhanced the sensitivity of leukaemia xenografts to methotrexate. The histidine degradation pathway markedly influences the sensitivity of cancer cells to methotrexate and may be exploited to improve methotrexate efficacy through a simple dietary intervention.
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KISLJ, NUK, SBMB, UL, UM, UPUK
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