Context. Gaia data and stellar surveys open the way to the construction of detailed 3D maps of the Galactic interstellar (IS) dust based on the synthesis of star distances and extinctions. Dust maps ...are tools of broad use, also for Gaia-related Milky Way studies. Aims. Reliable extinction measurements require very accurate photometric calibrations. We show the first step of an iterative process linking 3D dust maps and photometric calibrations, and improving them simultaneously. Methods. Our previous 3D map of nearby IS dust was used to select low-reddening SDSS/APOGEE-DR14 red giants, and this database served for an empirical effective temperature- and metallicity-dependent photometric calibration in the Gaia G and 2MASS Ks bands. This calibration has been combined with Gaia G-band empirical extinction coefficients recently published, G, J, and Ks photometry and APOGEE atmospheric parameters to derive the extinction of a large fraction of the survey targets. Distances were estimated independently using isochrones and the magnitude-independent extinction KJ−Ks. This new dataset has been merged with the one used for the earlier version of dust map. A new Bayesian inversion of distance-extinction pairs has been performed to produce an updated 3D map. Results. We present several properties of the new map. A comparison with 2D dust emission reveals that all large dust shells seen in emission at middle and high latitudes are closer than 300 pc. The updated distribution constrains the well-debated, X-ray bright North Polar Spur to originate beyond 800 pc. We use the Orion region to illustrate additional details and distant clouds. On the large scale the map reveals a complex structure of the Local Arm. Chains of clouds of 2–3 kpc in length appear in planes tilted by ≃15° with respect to the Galactic plane. A series of cavities oriented along a l ≃ 60–240° axis crosses the Arm. Conclusions. The results illustrate the ongoing synergy between 3D mapping of IS dust and stellar calibrations in the context of Gaia. Dust maps provide prior foregrounds for future calibrations appropriate to different target characteristics or ranges of extinction, allowing us in turn to increase extinction data and produce more detailed and extended maps.
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Given sea ice's importance in global climate regulation, fully understanding the role of natural temperature and atmospheric patterns like the Arctic Oscillation (AO), North Atlantic Oscillation ...(NAO) and Atlantic Multidecadal Oscillation (AMO) in its variability is critical. While instrumental AMO and reliable AO records are available since the mid‐1800s and 1958, respectively, satellite sea‐ice concentration data sets start only in 1979, limiting the shared timespan to study their interplay. Growth increments of the coralline algae, Clathromorphum compactum, can provide sea‐ice proxy information for years prior to 1979. We present a seasonal 210‐year algal record from Lancaster Sound in the Canadian Arctic Archipelago capturing low frequency AMO/NAO variability and high frequency interannual AO/NAO prior to 2000. We suggest that sea‐ice variability here is strongly coupled to these large‐scale climate processes, and that sea‐ice cover was greater and the AO more negative in the early and late 19th century compared to the 20th.
Plain Language Summary
Arctic sea‐ice variability is dually related to air/ocean temperatures and dynamic forces (wind patterns and ocean currents). While long‐term basin‐averaged temperature trends (i.e., Atlantic Multidecadal Oscillation) tend to influence variability over decades, cyclical wind patterns (e.g., Arctic Oscillation), may instead influence it seasonally and interannually. When the Atlantic Multidecadal and/or Arctic Oscillation (AMO/AO) are in a positive phase, warmer air and winds tend to export sea‐ice out of the Arctic, and vice‐versa during negative phases. Unfortunately, the span of the satellite sea‐ice cover record is too short to study long‐term sea‐ice variability driven by these patterns. Therefore, proxy records are required to fill this gap. The tree‐ring‐like growth bands of an Arctic coralline red algae have produced multi‐centennial proxy sea‐ice cover records. We present a 210‐year algal sea‐ice proxy record, showing a relationship with instrumental AMO (1861–present) and AO records (1958–2000). It also suggests that the AO was more negative and sea‐ice cover was greater during the 19th century in comparison to the 20th century. Due to sea‐ice's role in global climate at different timescales, this record can be utilized to tune climate models or constrain the relative influence of internal forcing on sea‐ice behavior.
Key Points
Annual algal growth increment widths (sea ice cover proxy) correlate most strongly with summer Arctic Oscillation (AO) trends
Abrupt width increases in the early 1800s and 1920s capture sea‐ice cover decreases in phase with or slightly lagging behind +AMO phases
The algal proxy record from Lancaster Sound captures +AO‐related sea‐ice export into the Canadian Arctic Archipelago
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
We have fabricated organic field‐effect transistors based on thin films of 2,7‐carbazole oligomeric semiconductors 1,4‐bis(vinylene‐(N‐hexyl‐2‐carbazole))phenylene (CPC), ...1,4‐bis(vinylene‐(N′‐methyl‐7′‐hexyl‐2′‐carbazole))benzene (RCPCR), N‐hexyl‐2,7‐bis(vinylene‐(N‐hexyl‐2‐carbazole))carbazole (CCC), and N‐methyl‐2,7‐bis(vinylene‐(7‐hexyl‐N‐methyl‐2‐carbazole))carbazole (RCCCR). The organic semiconductors are deposited by thermal evaporation on bare and chemically modified silicon dioxide surfaces (SiO2/Si) held at different temperatures varying from 25 to 200 °C during deposition. The resulting thin films have been characterized using UV‐vis and Fourier‐transform infrared spectroscopies, scanning electron microscopy, and X‐ray diffraction, and the observed top‐contact transistor performances have been correlated with thin‐film properties. We found that these new π‐conjugated oligomers can form highly ordered structures and reach high hole mobilities. Devices using CPC as the active semiconductor have exhibited mobilities as high as 0.3 cm2 V–1 s–1 with on/off current ratios of up to 107. These features make CPC and 2,7‐carbazolenevinylene‐based oligomers attractive candidates for device applications.
Top‐contact organic thin‐film transistors (see Figure, inset) using 2,7‐carbazolenevinylene‐based oligomers as active semiconductors show hole mobilities of up to 0.3 cm2 V–1 s–1 with an excellent current modulation (Ion/Ioff) of 107. The high hole field‐effect mobility in these materials is reached through molecular organization in the evaporated thin films (see Figure), making such oligomers attractive candidates for device applications.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Indoor air quality was characterized in 10 recently built energy‐efficient French schools during two periods of 4.5 days. Carbon dioxide time‐resolved measurements during occupancy clearly highlight ...the key role of the ventilation rate (scheduled or occupancy indexed), especially in this type of building, which was tightly sealed and equipped with a dual‐flow ventilation system to provide air refreshment. Volatile organic compounds (VOCs) and inorganic gases (ozone and NO2) were measured indoors and outdoors by passive techniques during the occupied and the unoccupied periods. Over 150 VOC species were identified. Among them, 27 species were selected for quantification, based on their occurrence. High concentrations were found for acetone, 2‐butanone, formaldehyde, toluene, and hexaldehyde. However, these concentrations are lower than those previously observed in conventional school buildings. The indoor/outdoor and unoccupied/occupied ratios are informative regarding emission sources. Except for benzene, ozone, and NO2, all the pollutants in these buildings have an indoor source. Occupancy is associated with increased levels of acetone, 2‐butanone, pentanal, butyl acetate, and alkanes.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Cultured pearls are unique gems produced by living organisms, mainly molluscs of the Pinctada genus, through the biomineralization properties of pearl sac tissue. Improvement of P. margaritifera ...pearl quality is one of the biggest challenges that Polynesian research has faced to date. To achieve this goal, a better understanding of the complex mechanisms related to nacre and pearl formation is essential and can now be approached through the use of massive parallel sequencing technologies. The aim of this study was to use RNA-seq to compare whole transcriptome expression of pearl sacs that had producing pearls with high and low quality. For this purpose, a comprehensive reference transcriptome of P. margaritifera was built based on multi-tissue sampling (mantle, gonad, whole animal), including different living stages (juvenile, adults) and phenotypes (colour morphotypes, sex).
Strikingly, few genes were found to be up-regulated for high quality pearls (n = 16) compared to the up-regulated genes in low quality pearls (n = 246). Biomineralization genes up-regulated in low quality pearls were specific to prismatic and prism-nacre layers. Alternative splicing was further identified in several key biomineralization genes based on a recent P. margaritifera draft genome.
This study lifts the veil on the multi-level regulation of biomineralization genes associated with pearl quality determination.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The synthesis and characterization of bis(difluoroboryl)-1,2-bis((1H-pyrrol-2-yl)methylene)hydrazone functionalized with two lateral vinyl-thienyl modules and exhibiting strong absorption in the ...400-800 nm window in thin films are reported. Bulk heterojunction solar cells assembled with these dyes and a fullerene derivative (PC71BM), using very small quantities of the additive diiodooctane, give a power conversion efficiency as high as 4.3% with short-circuit current values of 10.9 mA cm(-2), an open-circuit voltage of 0.7 V and external quantum efficiencies higher than 70% over a broad range of wavelengths (580 to 720 nm).
New electroactive and photoactive conjugated copolymers consisting of alternating 2,7‐carbazole and oligothiophene moieties linked by vinylene groups have been developed. Different oligothiophene ...units have been introduced to study the relationship between the polymer structure and the electronic properties. The resulting copolymers are characterized by UV‐vis spectroscopy, size‐exclusion chromatography, and thermal and electrochemical analyses. Bulk heterojunction photovoltaic cells from different copolymers and a soluble fullerene derivative, 6,6‐phenyl‐C61 butyric acid methyl ester, have been fabricated, and promising preliminary results are obtained. For instance, non‐optimized devices using poly(N‐(4‐octyloxyphenyl)‐2,7‐carbazolenevinylene‐alt‐3″,4″‐dihexyl‐2,2′;5′,2″;5″,2″′;5″′,2″″‐quinquethiophenevinylene 1″,1″‐dioxide) as an absorbing and hole‐carrier semiconductor exhibit power conversion efficiency up to 0.8 % under air mass (AM) 1.5 illumination. These features make 2,7‐carbazolenevinylene‐based and related polymers attractive candidates for solar‐cell applications.
Copolymers based on carbazolenevinylene units coupled with different oligothiophene units have been synthesized (see figure). The electrochemical and optical properties have been characterized, leading to a better understanding of the structure–property relationships in conjugated polymers. Bulk heterojunction photovoltaic devices have been made, and power‐conversion efficiencies up to 0.8% are obtained with standard (non‐optimized) configurations.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Context. The Gaia Collaboration has recently reported the detection of a 33 M ⊙ black hole in a wide binary system located in the solar neighbourhood. Aims. Here we explore the relationship between ...this black hole, known as Gaia BH3, and the nearby ED-2 halo stellar stream. Methods. We studied the orbital characteristics of the Gaia BH3 binary and present measurements of the chemical abundances of ED-2 member stars derived from high-resolution spectra obtained with the VLT. Results. We find that the Galactic orbit of the Gaia BH3 system and its metallicity are entirely consistent with being part of the ED-2 stream. The characteristics of the stream, particularly its negligible spread in metallicity and in other chemical elements, as well as its single stellar population, suggest that it originated from a disrupted star cluster of low mass. Its age is comparable to that of the globular cluster M92 that has been estimated to be as old as the Universe. Conclusions. This is the first black hole unambiguously associated with a disrupted star cluster. We infer the plausible mass range for the cluster to be relatively narrow, between 2 × 10 3 M ⊙ and 5.2 × 10 4 M ⊙ . This implies that the black hole could have formed directly from the collapse of a massive very metal-poor star, but that the alternative scenario of binary interactions inside the cluster environment also deserves to be explored.
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Abstract Tau, an axonal microtubule-associated protein, becomes hyperphosphorylated in several neurodegenerative diseases including Alzheimer disease (AD). In AD brain, tau is phosphorylated at ...pathological multiple-site epitopes recognized by the antibodies AT8 (S199/S202/T205), AT100 (T212/S214/T217), AT180 (T231/S235) and PHF-1 (S396/S404) and at individual sites such as S262 and S422. Although it is believed that the hyperphosphorylation of tau occurs in a precise cascade of phosphorylation events, this cascade remains to be demonstrated in mammalian neuronal cells. In the present study, human tau mutants in which disease-related sites associated with either an early (AT8, T231 and S262) or intermediate (T217) stage of tau pathology were mutated in alanine to inhibit their phosphorylation were overexpressed in primary hippocampal neurons to examine their impact on the phosphorylation of other disease-related sites. The mutation in alanine of S262 decreased the phosphorylation of the AT8 and PHF-1 epitopes and that of T217. When the sites included in the AT8 epitope were mutated in alanine, the phosphorylation of T217 and PHF-1 epitope was significantly reduced indicating that the decrease of AT8 phosphorylation was a key event in the impaired phosphorylation of T217 and PHF-1 by the S262 alanine mutant. Most interestingly, the mutation in alanine of T217 had a positive impact on the phosphorylation of the AT8 epitope, indicating the presence of a feedback loop between AT8 and T217 in rat hippocampal neurons. The phosphorylation of the AT180 epitope was increased when S262 and the sites forming the AT8 epitope were mutated in alanine. The mutation of the AT8 epitope also increased the phosphorylation of S422. All together, our data show that the sites forming the AT8 epitope could play a central role in regulating the phosphorylation of tau at disease-associated sites and that priming and feedback events take place to regulate the overall level of tau phosphorylation in rat hippocampal neurons.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPUK
Background
Mutations of BRAF, NRAS and c‐KIT oncogenes are preferentially described in certain histological subtypes of melanoma and linked to specific histopathological features. BRAF‐, MEK‐ and ...KIT‐inhibitors led to improvement in overall survival of patients harbouring mutated metastatic melanoma.
Objectives
To assess the prevalence and types of BRAF, NRAS, c‐KIT and MITF mutations in cutaneous and mucous melanoma and to correlate mutation status with clinicopathological features and outcome.
Methods
Clinicopathological features and mutation status of 108 samples and of 98 consecutive patients were, respectively, assessed in one retrospective and one prospective study. Clinicopathological features were correlated with mutation status and the predictive value of these mutations was studied.
Results
This work identified significant correlations between BRAF mutations and melanoma occurring on non‐chronic sun‐damaged skin and superficial spreading melanoma (P < 0.05) on one hand, and between NRAS mutations and nodular melanoma (P < 0.05) on the other hand. Younger age (P < 0.05), microscopic (P < 0.05) and macroscopic (P < 0.05) lymphatic involvement at diagnosis of primary melanoma were significantly linked to BRAF mutations. A mutated status was a positive predictive factor of a response to BRAF inhibitors (OR = 3.44). Mutated melanoma showed a significantly (P = 0.038) higher objective response rate to cytotoxic chemotherapy (26.3%) than wild‐type tumours (6.7%).
Conclusion
Clinical and pathological characteristics of the primary melanoma differed between wild‐type and BRAF‐ or NRAS‐mutated tumours. Patients with BRAF‐mutated tumours were younger at diagnosis of primary melanoma. Patients carrying mutations showed better responses better to specific kinase inhibitors and interestingly also to systemic cytotoxic chemotherapy.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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