This study aimed to investigate the inhibitory effects of Colocasia antiquorum var. esculenta (CA) on Porphyromonas gingivalis (P. gingivalis) growth, inflammation, and osteoclastogenesis. CA was ...effective in inhibiting the growth of P. gingivalis when applied together with an experimental fluoride varnish. CA also significantly decreased the release of interleukin-6, tumor necrosis factor-α, and nitric oxide from lipopolysaccharide-induced RAW 264.7 cells. No significant differences in viability were noted between the cells treated with CA and the controls. In addition, CA significantly attenuated osteoclast differentiation on bone marrow macrophages. In conclusion, CA inhibited the growth of P. gingivalis and showed anti-inflammatory and anti-osteoclastogenic effects. Therefore, CA may have the potential to act as a novel natural agent for preventing periodontitis.
A cold roll-bonding (CRB) process is applied to study the effects of stacking number on the microstructure and mechanical properties of roll-bonded and age-treated Al sheets. Commercial AA1050 and ...AA6061 sheets with a thickness of 2 mm were stacked alternately on each other to two and four layers, and roll-bonded by multi-pass cold rolling. The roll-bonded Al sheets were then subjected to natural aging (T4) and artificial aging (T6) treatments. The as roll-bonded Al sheets showed a typical deformation structure, where the grains are elongated in the rolling direction regardless of the stacking number. However, after the T4 and T6 aging treatments, the Al sheets had a recrystallization structure consisting of coarse grains in both the AA5052 and AA6061 regions with different grain sizes in each. In addition, the sheets showed an inhomogeneous hardness distribution in the thickness direction, with higher hardness in AA6061 than in AA1050 after the T4 and T6 age treatments. The tensile strength of the T6-treated specimen was higher than that of the T4-treated one for both the 2 and 4-layer CRBs. In addition, both the tensile strength and elongation of the specimens processed by the 4-layer stack CRB were higher than those of the 2-layer stack CRB for all experimental conditions.
We consider the problem of detecting a shift in the mean of a multivariate time-series process with general marginal distributions and general cross- and auto-correlation structures. We propose a ...distribution-free monitoring procedure that does not need model fitting or trial-and-error calibration for control limits, which makes the procedure convenient to be implemented when a facility consists of many processes to be monitored. The main idea is to convert each observation vector into a one-dimensional T
2
quantity that captures cross-correlation. The T
2
quantities form a univariate auto-correlated process, and CUSUM statistics are constructed on the T
2
quantities. Then using the fact that the CUSUM statistics on the auto-correlated process behave as a reflected Brownian motion asymptotically under some conditions, the control limits of the CUSUM procedure are analytically determined by setting the first-passage time of the Brownian motion equal to a target in-control average run length. We compare the performance of our procedure with three competing procedures on simulated data with various cross- and auto-correlation and real data from a wafer etching process. The proposed procedure delivers actual in-control average run lengths close to the target and shows comparable or better performance in detecting a shift in mean than the competitors.
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Camphor tree (
) is an ornamental plant that has been cultivated for a long time to obtain wood or camphor. Furthermore, its essential oil can be used as an alternative medicine and is an important ...source of perfume. Camphor obtained from camphor trees has long been used as a treatment for various symptoms such as inflammation, infection, congestion, muscle pain, and irritation in various regions. The purpose of this literature review is to provide knowledge of the well-established, wide, and extensive applications of camphor both in traditional and modern applications. Despite many studies focused on the essential oil of the camphor tree, there is a lack of systematic studies of its extraction or separation. Besides, various components of camphor are not fully understood, and further research is needed on the medicinal effects of individual components of
. The genus
has crucial economic value and theoretical significance. However, further systematic reviews and investigative studies based on existing research are needed to promote the modernization process of traditional applications of camphor. For proper use of the essential oil of
, it is imperative to consider its possible effects on humans and the environment.
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Diversification of polymer structures is important for imparting various properties and functions to polymers, so as to realize novel applications of these polymers. In this regard, ...diversity‐oriented polymerization (DOP) is a powerful synthetic strategy for producing diverse and complex polymer structures. Multicomponent polymerization (MCP) is a key method for realizing DOP owing to its combinatorial features and high efficiency. Among the MCP methods, Cu‐catalyzed MCP (Cu‐MCP) has recently paved the way for DOP by overcoming the synthetic challenges of the previous MCP methods. Here the emergence and progress of Cu‐MCP, its current challenges, and future perspectives are discussed.
Diversity‐oriented polymerization (DOP) is a powerful synthetic strategy for producing diverse and complex polymer structures from common building blocks. Multicomponent polymerization (MCP) is a key method for realizing DOP owing to its combinatorial features and high efficiency. Here, the emergence and progress of Cu‐catalyzed MCP, its current challenges, and future perspectives are discussed.
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Previous research has shown that both heat-treated green tea extract (HTGT) and enzymatically modified isoquercitrin (EMIQ) have anti-obesity effects. Given the absence of in vivo evidence ...demonstrating their synergistic effects, our study aimed to elucidate the combined obesity prevention potential of HTGT and EMIQ in mice. Mice were treated with these compounds for 8 weeks, while being fed a high-fat diet, to investigate their preventive anti-obesity effects. We demonstrated that the co-treatment of HTGT and EMIQ results in a synergistic anti-obesity effect, as determined by a Kruskal-Wallis test. Furthermore, the combined treatment of HTGT and EMIQ was more effective than orlistat in reducing body weight gain and adipocyte hypertrophy induced by high-fat diet. The co-treatment also significantly reduced total body fat mass and abdominal fat volume. Additionally, the group receiving the co-treatment exhibited increased energy expenditure and higher glucose intolerance. We observed a dose-dependent upregulation of genes associated with mitochondrial oxidative metabolism and PKA signaling, which is linked to lipolysis, in response to the co-treatment. The co-treatment group displayed elevated cAMP levels and AMPK activation in adipose tissue and increased excretion of fecal lipids. The results indicate that the co-treatment of HTGT and EMIQ holds the potential to be a promising combination therapy for combating obesity. To further validate the anti-obesity effect of the combined treatment of HTGT and EMIQ in human subjects, additional clinical studies are warranted.
Canine parvovirus type 2 (CPV‐2) is an aetiological agent that causes acute haemorrhagic enteritis and fatal myocarditis in dogs. Since CPV‐2 first emerged in the late 1970s, its rapid evolution has ...resulted in three antigenic variants: CPV‐2a, CPV‐2b and CPV‐2c. Here, we report, for the first time in Korea, two cases of CPV‐2c infection in two dogs with severe diarrhoea. The complete open reading frame (4,269nt) of CPV‐2, encoding both non‐structural (NS) and structural (VP) proteins, was sequenced. Based on the amino acid Gln present at residue 426 of the VP2 gene, these strains were typed as CPV‐2c, and were named Korea CPV‐2c_1 and Korea CPV‐2c_2. These strains shared 99.48% reciprocal nucleotide sequence identity and had the highest nucleotide identity (99.77%–99.34%) with Asian CPV strains isolated in China, Italy (found in a dog imported from Thailand), and Vietnam from 2013 to 2017. Phylogenetic analysis based on the non‐structural (NS1) and capsid (VP2) genes revealed that Korean CPV‐2c strains clustered closely to Asian CPV strains, and separately from strains isolated in Europe, South America and North America. Amino acid changes never reported before were observed in NS1 (Thr70Pro, Cys287Tyr), VP1 (Lys17Arg, Phe33Leu) and VP2 (Gln365His, Ala516Val). Additional observed mutations, including Phe267Tyr, Tyr324Ile and Gln370Arg, have been previously reported in the recent CPV‐2c strains with Asian origins. These results suggest that the Korean CPV‐2c strains were potentially introduced via neighbouring Asian countries.
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Tomato yellow leaf curl virus (TYLCV) is one of the most well-known tomato-infecting begomoviruses and transmitted by Bemisia tabaci. Seed transmission has previously been reported for some RNA ...viruses, but TYLCV has not previously been described as a seed-borne virus. In 2013 and 2014, without whitefly-mediated transmission, TYLCV was detected in young tomato plants germinated from fallen fruits produced from TYLCV-infected tomato plants in the previous cultivation season. In addition, TYLCV-Israel (TYLCV-IL) was also detected in seeds and their seedlings of TYLCV-infected tomato plants that were infected by both viruliferous whitefly-mediated transmission and agro-inoculation. The seed infectivity was 20-100%, respectively, and the average transmission rate to seedlings was also 84.62% and 80.77%, respectively. TYLCV-tolerant tomatoes also produced TYLCV-infected seeds, but the amount of viral genome was less than seen in TYLCV-susceptible tomato plants. When tomato plants germinated from TYLCV-infected seeds, non-viruliferous whiteflies and healthy tomato plants were placed in an insect cage together, TYLCV was detected from whiteflies as well as receiver tomato plants six weeks later. Taken together, TYLCV-IL can be transmitted via seeds, and tomato plants germinated from TYLCV-infected seeds can be an inoculum source of TYLCV. This is the first report about TYLCV seed transmission in tomato.
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Redox‐inactive metal ions are one of the most important co‐factors involved in dioxygen activation and formation reactions by metalloenzymes. In this study, we have shown that the logarithm of the ...rate constants of electron‐transfer and C−H bond activation reactions by nonheme iron(III)–peroxo complexes binding redox‐inactive metal ions, (TMC)FeIII(O2)+‐Mn+ (Mn+=Sc3+, Y3+, Lu3+, and La3+), increases linearly with the increase of the Lewis acidity of the redox‐inactive metal ions (ΔE), which is determined from the gzz values of EPR spectra of O2.−‐Mn+ complexes. In contrast, the logarithm of the rate constants of the (TMC)FeIII(O2)+‐Mn+ complexes in nucleophilic reactions with aldehydes decreases linearly as the ΔE value increases. Thus, the Lewis acidity of the redox‐inactive metal ions bound to the mononuclear nonheme iron(III)–peroxo complex modulates the reactivity of the (TMC)FeIII(O2)+‐Mn+ complexes in electron‐transfer, electrophilic, and nucleophilic reactions.
Inactive but influential: The Lewis acidity of the redox‐inactive metal ions bound to a mononuclear nonheme iron(III)–peroxo complex, (TMC)FeIII(O2)+‐Mn+ (1‐Mn+; Mn+=Sc3+, Y3+, Lu3+, and La3+), determines the reactivities of 1‐Mn+ in electron‐transfer, electrophilic, and nucleophilic reactions.
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