Abstract
We introduce a new method for detecting ultra-diffuse galaxies by searching for over-densities in intergalactic globular cluster populations. Our approach is based on an application of the ...log-Gaussian Cox process, which is a commonly used model in the spatial statistics literature but rarely used in astronomy. This method is applied to the globular cluster data obtained from the PIPER survey, a Hubble Space Telescope imaging program targeting the Perseus cluster. We successfully detect all confirmed ultra-diffuse galaxies with known globular cluster populations in the survey. We also identify a potential galaxy that has no detected diffuse stellar content. Preliminary analysis shows that it is unlikely to be merely an accidental clump of globular clusters or other objects. If confirmed, this system would be the first of its kind. Simulations are used to assess how the physical parameters of the globular cluster systems within ultra-diffuse galaxies affect their detectability using our method. We quantify the correlation of the detection probability with the total number of globular clusters in the galaxy and the anticorrelation with increasing half-number radius of the globular cluster system. The Sérsic index of the globular cluster distribution has little impact on detectability.
CDG-1 is a tight grouping of four likely globular clusters in the Perseus cluster, and a candidate dark galaxy with little or no diffuse light. Here we provide new constraints on the luminosity of ...any underlying stellar emission, using HST/UVIS F200LP imaging. No diffuse emission is detected, with a 2\(\sigma\) upper limit of F200LP>28.1 mag/arcsec\(^2\) on the 5'' scale of CDG-1. This surface brightness limit corresponds to a 2\(\sigma\) lower limit of >0.5 for the fraction of the total luminosity that is in the form of globular clusters. The most likely alternative, although improbable, is that CDG-1 is a chance grouping of four globular clusters in the halo of the Perseus galaxy IC312.
Abstract CDG-1 is a tight grouping of four likely globular clusters in the Perseus cluster, and a candidate dark galaxy with little or no diffuse light. Here we provide new constraints on the ...luminosity of any underlying stellar emission, using Hubble Space Telescope/UVIS F200LP imaging. No diffuse emission is detected, with a 2 σ upper limit of F200LP > 28.1 mag arcsec −2 on the 5″ scale of CDG-1. This surface brightness limit corresponds to a 2 σ lower limit of >0.5 for the fraction of the total luminosity that is in the form of globular clusters. The most likely alternative, although improbable, is that CDG-1 is a chance grouping of four globular clusters in the halo of the Perseus galaxy IC 312.
Lymphoid cells that produce interleukin (IL)-17 cytokines protect barrier tissues from pathogenic microbes but are also prominent effectors of inflammation and autoimmune disease. T helper 17 (Th17) ...cells, defined by RORγt-dependent production of IL-17A and IL-17F, exert homeostatic functions in the gut upon microbiota-directed differentiation from naive CD4+ T cells. In the non-pathogenic setting, their cytokine production is regulated by serum amyloid A proteins (SAA1 and SAA2) secreted by adjacent intestinal epithelial cells. However, Th17 cell behaviors vary markedly according to their environment. Here, we show that SAAs additionally direct a pathogenic pro-inflammatory Th17 cell differentiation program, acting directly on T cells in collaboration with STAT3-activating cytokines. Using loss- and gain-of-function mouse models, we show that SAA1, SAA2, and SAA3 have distinct systemic and local functions in promoting Th17-mediated inflammatory diseases. These studies suggest that T cell signaling pathways modulated by the SAAs may be attractive targets for anti-inflammatory therapies.
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•SAAs direct a distinct Th17 cell differentiation program independently of TGF-β•Expression of SAAs is associated with inflamed colon of IBD patients•Systemic SAAs in serum promote differentiation of pathogenic Th17 cells•Local SAA expression fuels pathogenicity of activated Th17 cells
Serum amyloid A proteins dictate the balance between homeostatic and inflammatory Th17 cells.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Left ventricular (LV) twist is manifested in oppositely directed apical and basal rotation. We studied a new 3-dimensional (3D) echocardiography program (wall motion tracking; Toshiba America Medical ...Systems, Inc, Tustin, CA) for left ventricular rotation.
We used a rotation model with a variable-speed motor to rotate hearts in a water bath. We studied 10 freshly harvested pig hearts, which were mounted on the rotary actuator of our twist phantom with the heart base rotating and the apex held fixed to avoid translational motion, at rotations of 0 degrees , 15 degrees , 20 degrees , and 25 degrees . Full-volume 3D image loops were acquired on a Toshiba Aplio Artida ultrasound system at a maximized frame rate.
As the actual heart rotation increased, computed segmental and global rotation also increased accordingly, with the measured rotations of the basal and middle segments greater than that of the apex (both P < .001). Segmental and global rotation at all 3 levels correlated well with the actual rotation (base: r = 0.93; middle: r = 0.92; apex: r = 0.82; global: r = 0.95; all P < .001).
The new 3D program tracked LV rotation accurately.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Objective. Left ventricular (LV) twist is manifested in oppositely directed apical and basal rotation. We studied a new 3‐dimensional (3D) echocardiography program (wall motion tracking; Toshiba ...America Medical Systems, Inc, Tustin, CA) for left ventricular rotation. Methods. We used a rotation model with a variable‐speed motor to rotate hearts in a water bath. We studied 10 freshly harvested pig hearts, which were mounted on the rotary actuator of our twist phantom with the heart base rotating and the apex held fixed to avoid translational motion, at rotations of 0°, 15°, 20°, and 25°. Full‐volume 3D image loops were acquired on a Toshiba Aplio Artida ultrasound system at a maximized frame rate. Results. As the actual heart rotation increased, computed segmental and global rotation also increased accordingly, with the measured rotations of the basal and middle segments greater than that of the apex (both P < .001). Segmental and global rotation at all 3 levels correlated well with the actual rotation (base: r = 0.93; middle: r = 0.92; apex: r = 0.82; global: r = 0.95; all P < .001). Conclusions. The new 3D program tracked LV rotation accurately.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
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