This study investigates modulation of El Niño–Southern Oscillation (ENSO) on the Madden–Julian oscillation (MJO) propagation during boreal winter. Results show that the spatiotemporal evolution of ...MJO manifests as a fast equatorially symmetric propagation from the Indian Ocean to the equatorial western Pacific (EWP) during El Niño, whereas the MJO during La Niña is very slow and tends to frequently “detour” via the southern Maritime Continent (MC). The westward group velocity of the MJO is also more significant during El Niño. Based on the dynamics-oriented diagnostics, it is found that, during El Niño, the much stronger leading suppressed convection over the EWP excites a significant front Walker cell, which further triggers a larger Kelvin wave easterly wind anomaly and premoistening and heating effects to the east. However, the equatorial Rossby wave to the west tends to decouple with the MJO convection. Both effects can result in fast MJO propagation. The opposite holds during La Niña. A column-integrated moisture budget analysis reveals that the sea surface temperature anomaly driving both the eastward and equatorward gradients of the low-frequency moisture anomaly during El Niño, as opposed to the westward and poleward gradients during La Niña, induces moist advection over the equatorial eastern MC–EWP region due to the intraseasonal wind anomaly and therefore enhances the zonal asymmetry of the moisture tendency, supporting fast propagation. The role of nonlinear advection by synoptic-scale Kelvin waves is also nonnegligible in distinguishing fast and slow MJO modes. This study emphasizes the crucial roles of dynamical wave feedback and moisture–convection feedback in modulating the MJO propagation by ENSO.
Full text
Available for:
BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
•The resistive ignition experiments of ADN based liquid propellant were conducted.•Comparison investigation was done in inert gas and oxidizing gas atmospheres.•Ignition delay time and burning ...duration of ADN based liquid propellant were studied.•The variation of droplet equivalent diameter of ADN based liquid propellant was analyzed.
An experimental investigation was performed to study combustion characteristics of ADN based liquid propellant droplet with resistive ignition method. The experiment was conducted in Ar atmosphere and different oxidizing gas atmospheres under an on-load voltage range of 190–230 V; the oxidizing gases included N2O, NO and O2. The influence of the atmosphere, on-load voltage, droplet volume on the ignition energy, ignition delay time, burning duration, and droplet equivalent diameter development during ignition and combustion was studied. ADN based liquid propellant showed feasibility to combustion by the resistive ignition method in the inert gas atmosphere. The ignition energy accounted for more than 80 % of the total energy during the ignition and combustion process. With the increase of the droplet volume, the value of the ignition delay time and burning duration increased. The atmosphere had a significant influence on the burning duration and droplet diameter, but had little influence on the ignition delay time. Under our experiment conditions, the N2O and O2 atmospheres improved the combustion process, while, the NO atmosphere inhibited the oxidation of methanol.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
SUMMARY
Chloroplasts play a crucial role in plant growth and fruit quality. However, the molecular mechanisms of chloroplast development are still poorly understood in fruits. In this study, we ...investigated the role of the transcription factor SlBEL2 (BEL1‐LIKE HOMEODOMAIN 2) in fruit of Solanum lycopersicum (tomato). Phenotypic analysis of SlBEL2 overexpression (OE‐SlBEL2) and SlBEL2 knockout (KO‐SlBEL2) plants revealed that SlBEL2 has the function of inhibiting green shoulder formation in tomato fruits by affecting the development of fruit chloroplasts. Transcriptome profiling revealed that the expression of chloroplast‐related genes such as SlGLK2 and SlLHCB1 changed significantly in the fruit of OE‐SlBEL2 and KO‐SlBEL2 plants. Further analysis showed that SlBEL2 could not only bind to the promoter of SlGLK2 to inhibit its transcription, but also interacted with the SlGLK2 protein to inhibit the transcriptional activity of SlGLK2 and its downstream target genes. SlGLK2 knockout (KO‐SlGLK2) plants exhibited a complete absence of the green shoulder, which was consistent with the fruit phenotype of OE‐SlBEL2 plants. SlBEL2 showed an expression gradient in fruits, in contrast with that reported for SlGLK2. In conclusion, our study reveals that SlBEL2 affects the formation of green shoulder in tomato fruits by negatively regulating the gradient expression of SlGLK2, thus providing new insights into the molecular mechanism of fruit green shoulder formation.
Significance Statement
Chloroplasts play a crucial role in plant growth and fruit quality, but the molecular mechanisms underlying chloroplast development in fruits remain poorly understood. Here, our study reveals that SlBEL2 is expressed in a gradient in tomato fruits and affects the formation of the green shoulder in fruits by regulating chloroplast development, which provides new insights into the molecular mechanism of green shoulder formation in fruits.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is ...expected to solve major medical problems. Currently, most studies focus on tissue repair and regeneration, and mesenchymal stem cells (MSCs) are among the most common research topics. MSCs are applicable as seed cells, and they represent one of the current hot topics in regenerative medicine research. However, due to storage limitations and because cell senescence occurs during in vitro expansion, their clinical application is challenging. Exosomes, which are secreted by MSCs through paracrine signalling, not only have the same effects as MSCs, but they also have the advantages of targeted delivery, low immunogenicity, and high repairability. This article reviews the acquisition methods, characteristics, biological functions, and clinical applications of exosomes.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Preclinical and clinical studies have suggested a neuroprotective effect of remote ischemic conditioning (RIC), which involves repeated occlusion/release cycles on bilateral upper limb arteries; ...however, robust evidence in patients with ischemic stroke is lacking.
To assess the efficacy of RIC for acute moderate ischemic stroke.
This multicenter, open-label, blinded-end point, randomized clinical trial including 1893 patients with acute moderate ischemic stroke was conducted at 55 hospitals in China from December 26, 2018, through January 19, 2021, and the date of final follow-up was April 19, 2021.
Eligible patients were randomly assigned within 48 hours after symptom onset to receive treatment with RIC (using a pneumatic electronic device and consisting of 5 cycles of cuff inflation for 5 minutes and deflation for 5 minutes to the bilateral upper limbs to 200 mm Hg) for 10 to 14 days as an adjunct to guideline-based treatment (n = 922) or guideline-based treatment alone (n = 971).
The primary end point was excellent functional outcome at 90 days, defined as a modified Rankin Scale score of 0 to 1. All end points had blinded assessment and were analyzed on a full analysis set.
Among 1893 eligible patients with acute moderate ischemic stroke who were randomized (mean SD age, 65 10.3 years; 606 women 34.1%), 1776 (93.8%) completed the trial. The number with excellent functional outcome at 90 days was 582 (67.4%) in the RIC group and 566 (62.0%) in the control group (risk difference, 5.4% 95% CI, 1.0%-9.9%; odds ratio, 1.27 95% CI, 1.05-1.54; P = .02). The proportion of patients with any adverse events was 6.8% (59/863) in the RIC group and 5.6% (51/913) in the control group.
Among adults with acute moderate ischemic stroke, treatment with remote ischemic conditioning compared with usual care significantly increased the likelihood of excellent neurologic function at 90 days. However, these findings require replication in another trial before concluding efficacy for this intervention.
ClinicalTrials.gov Identifier: NCT03740971.
Decline in the ovarian hormones with menopause may influence somatosensory, cognitive, and affective processing. The present study investigated whether hormonal depletion alters the nociceptive, ...depressive-like and learning behaviors in experimental rats after ovariectomy (OVX), a common method to deplete animals of their gonadal hormones. OVX rats developed thermal hyperalgesia in proximal and distal tail that was established 2 weeks after OVX and lasted the 7 weeks of the experiment. A robust mechanical allodynia was also occurred at 5 weeks after OVX. In the 5th week after OVX, dilute formalin (5%)-induced nociceptive responses (such as elevating and licking or biting) during the second phase were significantly increased as compared to intact and sham-OVX females. However, chronic constriction injury (CCI) of the sciatic nerve-induced mechanical allodynia did not differ as hormonal status (e.g. OVX and ovarian intact). Using formalin-induced conditioned place avoidance (F-CPA), which is believed to reflect the pain-related negative emotion, we further found that OVX significantly attenuated F-CPA scores but did not alter electric foot-shock-induced CPA (S-CPA). In the open field and forced swimming test, there was an increase in depressive-like behaviors in OVX rats. There was no detectable impairment of spatial performance by Morris water maze task in OVX rats up to 5 weeks after surgery. Estrogen replacement retrieved OVX-induced nociceptive hypersensitivity and depressive-like behaviors. This is the first study to investigate the impacts of ovarian removal on nociceptive perception, negative emotion, depressive-like behaviors and spatial learning in adult female rats in a uniform and standard way.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Solid-state batteries have been attracting wide attention for next generation energy storage devices due to the probability to realize higher energy density and superior safety performance compared ...with the state-of-the-art lithium ion batteries. However, there are still intimidating challenges for developing low cost and industrially scalable solid-state batteries with high energy density and stable cycling life for large-scale energy storage and electric vehicle applications. This review presents an overview on the scientific challenges, fundamental mechanisms, and design strategies for solid-state batteries, specifically focusing on the stability issues of solid-state electrolytes and the associated interfaces with both cathode and anode electrodes. First, we give a brief overview on the history of solid-state battery technologies, followed by introduction and discussion on different types of solid-state electrolytes. Then, the associated stability issues, from phenomena to fundamental understandings, are intensively discussed, including chemical, electrochemical, mechanical, and thermal stability issues; effective optimization strategies are also summarized. State-of-the-art characterization techniques and in situ and operando measurement methods deployed and developed to study the aforementioned issues are summarized as well. Following the obtained insights, perspectives are given in the end on how to design practically accessible solid-state batteries in the future.
Full text
Available for:
IJS, KILJ, NUK, PNG, UL, UM
The long-term pulmonary function and related physiological characteristics of COVID-19 survivors have not been studied in depth, thus many aspects are not understood.
COVID-19 survivors were ...recruited for high resolution computed tomography (HRCT) of the thorax, lung function and serum levels of SARS-CoV-2 IgG antibody tests 3 months after discharge. The relationship between the clinical characteristics and the pulmonary function or CT scores were investigated.
Fifty-five recovered patients participated in this study. SARS-CoV-2 infection related symptoms were detected in 35 of them and different degrees of radiological abnormalities were detected in 39 patients. Urea nitrogen concentration at admission was associated with the presence of CT abnormalities (P = 0.046, OR 7.149, 95% CI 1.038 to 49.216). Lung function abnormalities were detected in 14 patients and the measurement of D-dimer levels at admission may be useful for prediction of impaired diffusion defect (P = 0.031, OR 1.066, 95% CI 1.006 to 1.129). Of all the subjects, 47 of 55 patients tested positive for SARS-CoV-2 IgG in serum, among which the generation of Immunoglobulin G (IgG) antibody in female patients was stronger than male patients in infection rehabilitation phase.
Radiological and physiological abnormalities were still found in a considerable proportion of COVID-19 survivors without critical cases 3 months after discharge. Higher level of D-dimer on admission could effectively predict impaired DLCO after 3 months discharge. It is necessary to follow up the COVID-19 patients to appropriately manage any persistent or emerging long-term sequelae.
Key Scientific Research Projects of Henan Higher Education Institutions
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Inspired by Lemma 1 in 36, a new fractional differential inequality is derived by means of inequality techniques and reduction to absurdity.•Without the participation of sign function, two kinds of ...finite-time control strategies are designed.•Non-separation method is first employed to explore the robust F-TS for the uncertain F-OQ-VNNs.•Easily-verified robust F-TS criteria are derived, and settling time is explicitly reckoned.
In this paper, robust finite-time synchronization (F-TS) issue is addressed for a class of uncertain fractional-order quaternion-valued neural networks by employing non-separation method instead of separation method. First, a general fractional differential inequality is developed to provide new insight into the research about finite-time stability and synchronization of fractional-order systems. Next, quaternion-valued feedback controller and quaternion-valued adaptive controller are designed. On the basis of the newly developed inequality, quaternion inequality techniques, together with the properties of fractional calculus and reduction to absurdity, some easily-verified algebraic criteria for robust F-TS are established, and the settling time for robust F-TS is explicitly reckoned, which depends on not only the controller parameters but also the initial values and order of the considered systems. Eventually, numerical results are provided to substantiate our robust F-TS criteria.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
PDF
