The Canadian Centre for Climate Modelling and Analysis third generation atmospheric general circulation model (AGCM3) is described. The discussion summarizes the details of the complete physics ...package emphasizing the changes made relative to the second generation version of the model. AGCM3 is the underlying model for applications which include the IPCC fourth assessment, coupled atmosphere-ocean seasonal forecasting, the first generation of the CCCma earth system model (CanESM1), and middle-atmosphere chemistry-climate modelling (CCM). Here we shall focus on issues related to an upwardly extended version of AGCM3, the Canadian Middle-Atmosphere Model (CMAM). The CCM version of CMAM participated in the 2006 WMO/UNEP Scientific Assessment of Ozone Depletion and issues concerning its climate such as the impact of gravity-wave drag, the modelling of a spontaneous QBO, and the seasonality of the breakdown of the Southern Hemisphere polar vortex are discussed here.
Polymyxins have re-emerged in clinical practice owing to the dry antibiotic development pipeline and worldwide increasing prevalence of nosocomial infections caused by multidrug-resistant (MDR) ...Gram-negative bacteria. Polymyxin B and colistin (polymyxin E) have been ultimately considered as the last-resort treatment of such infections. Microbiological, pharmacokinetic, pharmacodynamic and clinical data available for polymyxin B are reviewed in this paper. Polymyxin B has rapid in vitro bactericidal activity against major MDR Gram-negative bacteria, such as Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Acquired resistance to this agent is still rare among these pathogens. However, optimized dosage regimens are not known yet. Good clinical outcomes have been observed in the majority of the patients treated with intravenous polymyxin B in recent studies. However, these studies failed to provide definitive conclusions due to limitations of study design and additional clinical trials are required. Although combination therapy may be an attractive option based on some currently available in vitro data, clinical data supporting such recommendations are lacking. Since polymyxins will be increasingly used for the treatment of infections caused by MDR bacteria, clinical pharmacokinetic, pharmacodynamic and toxicodynamic studies underpinning the optimal use of these drugs are urgently required.
Aims
To evaluate the effects of various epiphytic microbiota from Italian ryegrass (IR), maize (MZ) and sorghum (SG) on fermentative profile and microbial community dynamics in sterile IR.
Methods ...and Results
Using microbiota transplantation, the irradiated IR was treated with the following: (i) sterile water; (ii) epiphytic microbiota on IR (IRIR); (iii) epiphytic microbiota on MZ (IRMZ); (iv) epiphytic microbiota on SG (IRSG). After 60 days of ensiling, MZ and SG microbiota significantly (P < 0·05) decreased lactic acid (LA) and acetic acid (AA) concentrations compared to IR microbiota, while SG microbiota notably (P < 0·05) reduced the ratio of LA to AA than MZ and IR microbiota. Apparently (P < 0·01) higher amounts of Lactobacillus genus were observed in IRIR and IRMZ groups on 60 day compared to IRSG group, and the dominant Lactococcus genus on 3 day was eventually replaced by Enterobacteriaceae and Lactobacillus in IRSG group.
Conclusions
Exogenous microbiota could evidently affect the fermentative profile and microbial community dynamics of IR silage. The numbers of Enterobacteriaceae and Lactobacillus were mainly responsible for this.
Significance and Impact of the Study
Identifying the role of microbe during ensiling is of great significance to manipulate the fermentation products and improve the preservation of silage.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
In this paper, the modular consequent-pole (MCP) rotor is adopted in the fractional-slot interior permanent magnet (IPM) machine to utilize the strong flux-focusing effect and reduce the leakage ...flux. Hence, the torque density and utilization ratio of permanent magnet (PM) material can be improved. However, the unacceptable unbalanced magnetic force (UMF) may arise due to asymmetric airgap flux density produced by consequent-pole topology. Thus, a pole-shaping method based on three-sectional arcs is proposed to suppress it. Due to the relatively complex rotor structure, the multiobjective optimization combined finite-element method with genetic algorithm is performed in this paper. Furthermore, the electromagnetic performance of the IPM machine with MCP rotor (namely IPM-MCP machine), including the open-circuit airgap flux density, phase back EMF, torque, PM utilization ratio, efficiency, flux-weakening capability and UMF, are compared with the conventional surface-mounted PM (SPM), IPM, and consequent-pole IPM (IPM-CP) machines. It is demonstrated that the IPM-MCP machine obtains the largest output torque in these machines. Meanwhile, the IPM-MCP and IPM-CP machines respectively have >30% and >20% higher PM utilization ratio than the conventional SPM and IPM machines while they obtain similar torque ripple and efficiency. Moreover, the IPM-MCP machine can obtain much lower UMF than the IPM-CP machine due to the effective suppression of asymmetric airgap flux density. Finally, a 12-slot/10-pole IPM-MCP machine is fabricated to verify the analyses.
High-performance and long-pulse operation is a crucial goal of current magnetic fusion research. Here, we demonstrate a high-connement plasma regime known as an H-mode with a record pulse length of ...over 30 s in the Experimental Advanced Superconducting Tokamak sustained by lower hybrid wave current drive (LHCD) with advanced lithium wall conditioning. We nd that LHCD provides a exible boundary control for a ubiquitous edge instability in H-mode plasmas known as an edge-localized mode, which leads to a marked reduction in the heat load on the vessel wall compared with standard edge-localized modes. LHCD also induces edge plasma ergodization that broadens the heat deposition footprint. The heat transport caused by this ergodization can be actively controlled by regulating the edge plasma conditions. This potentially offers a new means for heat-ux control, which is a key issue for next-step fusion development. PUBLICATION ABSTRACT
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IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
High-β_{θe} (a ratio of the electron thermal pressure to the poloidal magnetic pressure) steady-state long-pulse plasmas with steep central electron temperature gradient are achieved in the ...Experimental Advanced Superconducting Tokamak. An intrinsic current is observed to be modulated by turbulence driven by the electron temperature gradient. This turbulent current is generated in the countercurrent direction and can reach a maximum ratio of 25% of the bootstrap current. Gyrokinetic simulations and experimental observations indicate that the turbulence is the electron temperature gradient mode (ETG). The dominant mechanism for the turbulent current generation is due to the divergence of ETG-driven residual flux of current. Good agreement has been found between experiments and theory for the critical value of the electron temperature gradient triggering ETG and for the level of the turbulent current. The maximum values of turbulent current and electron temperature gradient lead to the destabilization of an m/n=1/1 kink mode, which by counteraction reduces the turbulence level (m and n are the poloidal and toroidal mode number, respectively). These observations suggest that the self-regulation system including turbulence, turbulent current, and kink mode is a contributing mechanism for sustaining the steady-state long-pulse high-β_{θe} regime.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM
Aims
Cellulase‐producing Enterococcus species isolated from the rumen of Tibetan yak (Bos grunniens) were characterized, and their combined effects on the silage quality of various forages were ...studied.
Methods and Results
The two isolated strains with high cellulolytic potential were identified as Enterococcus faecalis (EF85) and E. faecium (EF83) by 16S rRNA sequencing. Both EF85 and EF83 could grow well at 15–55°C, pH 3·0–6·0 and in 3·0–6·5% NaCl. The cellulase secreted by EF85 and EF83 showed good stability at temperatures from 20 to 45°C and pH from 4·5 to 7·0. A commercial inoculant (CLP), a commercial cellulase (CE) and the two cellulolytic strains (EF85 + EF83) were added to whole‐crop corn, sweet sorghum and Napier grass ensiling for 120 days respectively. In Napier grass silage, all inoculants significantly increased lactic acid content and ratio of lactic to acetic acid and decreased pH, butyric acid and ammonia nitrogen contents. The acid detergent fibre and cellulose contents in EF85 + EF83 treatment were significantly lower than those in the other treatments. In whole‐crop corn and sweet sorghum silages, all additives had no significant effect on the fermentation quality, while CE and EF85 + EF83 markedly enhanced cellulose degradation and increased free sugar content.
Conclusion
The combined inoculation of the cellulolytic strain EF85 and EF83 to various forages reduced the fibre content of the resulting silages.
Significance and Impact of the Study
Few studies involved inoculation of silage with Enterococcus species in different forage types. The isolated cellulolytic strains of E. faecalis EF85 and E. faecium EF83 could be a great alternative for commercial inoculants and enzymes in silage production.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
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