Lycopene (Lyc) as a natural antioxidant has attracted widespread attention. Di(2-ethylhexyl) phthalate (DEHP) can cause serious spleen injury in animals via the environment and food chain. For ...investigation of whether Lyc could alleviate DEHP-exerted pyroptosis in spleen through inhibiting the Caspase-1/NLRP3 pathway activation, 140 male mice were randomly divided into 7 groups: control group, vehicle control group, Lyc group (5 mg/kg BW/day), DEHP-exposed group (500 or 1000 mg/kg BW/day, respectively), and DEHP + Lyc groups by daily administration for 28 days. Pathological results showed that the supplementation of Lyc alleviated DEHP-induced inflammatory infiltration. Moreover, the addition of Lyc inhibited DEHP-induced Caspase-1, NLRP3, ASC, NF-κB, IL-1β, and IL-18 overexpression and GSDMD down-expression. These results indicate that Lyc could inhibit DEHP-induced Caspase-1-dependent pyroptosis and the inflammatory response. Taken together, the study provided new evidence that Lyc may be a strategy to mitigate spleen injury induced by DEHP.
Full text
Available for:
IJS, KILJ, NUK, PNG, UL, UM, UPUK
Non-Hermiticity from nonreciprocal hoppings has been shown recently to demonstrate the non-Hermitian skin effect (NHSE) under open boundary conditions (OBCs). Here we study the interplay of this ...effect and the Anderson localization (AL) in a nonreciprocal quasiperiodic lattice, dubbed nonreciprocal Aubry-André model, and a rescaled transition point is exactly proved. The nonreciprocity can induce not only NHSEs but also the asymmetry in localized states, characterized by two Lyapunov exponents. Meanwhile, this transition is also topological, in the sense of a winding number associated with complex eigenenergies under periodic boundary conditions (PBCs), establishing a bulk-bulk correspondence. This interplay can be realized straightforwardly by an electrical circuit with only linear passive RLC components instead of elusive nonreciprocal ones, showing the transport of a continuous wave undergoes a transition between insulating and amplifying. This paradigmatic scheme can be immediately accessed in experiments even for more nonreciprocal models and will definitely inspire the study of interplay of NHSEs and ALs as well as more other quantum/topological phenomena in various systems.
Full text
Available for:
CMK, CTK, FMFMET, IJS, NUK, PNG, UM
Non-Hermitian systems can exhibit exotic topological and localization properties. Here we elucidate the non-Hermitian effects on disordered topological systems using a nonreciprocal disordered ...Su-Schrieffer-Heeger model. We show that the non-Hermiticity can enhance the topological phase against disorders by increasing bulk gaps. Moreover, we uncover a topological phase which emerges under both moderate non-Hermiticity and disorders, and is characterized by localized insulating bulk states with a disorder-averaged winding number and zero-energy edge modes. Such topological phases induced by the combination of non-Hermiticity and disorders are dubbed
non-Hermitian topological Anderson insulators
. We reveal that the system has unique non-monotonous localization behavior and the topological transition is accompanied by an Anderson transition. These properties are general in other non-Hermitian models.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We present a systematic investigation of the possible molecular states composed of a pair of doubly charmed baryons (ΞccΞcc) or one doubly charmed baryon and one doubly charmed antibaryon (ΞccΞ¯cc) ...within the framework of the one-boson-exchange-potential model. For the spin-triplet systems, we take into account the mixing between the S31 and D31 channels. For the baryon-baryon system ΞccΞcc with (R,I)=(3¯,1/2) and (3¯,0), where R and I represent the group representation and the isospin of the system, respectively, there exist loosely bound molecular states. For the baryon-antibaryon system ΞccΞ¯cc with (R,I)=(8,1), (8,1/2) and (8,0), there also exist deuteron-like molecules. The BccB¯cc molecular states may be produced at LHC. The proximity of their masses to the threshold of two doubly charmed baryons provides a clean clue to identify them.
Full text
Available for:
CMK, CTK, FMFMET, IJS, NUK, PNG, UM
An increasing number of epidemiologic studies show that women have a special exposure profile to phthalates, and the exposures have attracted attention regarding their potential health hazards. Here, ...we developed a model for studying the ovarian action of di-(2-ethylhexyl) phthalate (DEHP) and its major metabolite monoethylhexyl phthalate (MEHP). In vivo, treatment with DEHP (250, 500, and 1000 mg kg^-1) induced decreased thickness of ovarian granulosa cell layer and mitochondrial damage in quail, caused oxidative stress, interfered with the transcription of hypothalamic-pituitary-ovarian axis (HPOA) steroid hormone-related factors (increased transcription of StAR, 3β-HSD, P450scc, and LH and decreased transcription of 17β-HSD, P450arom, FSH, and ERβ), and blocked the secretion of steroid hormones (decreased FSH, E2, and T levels and increased LH, P, and PRL levels). In vitro, granulosa cells were cultured with MEHP (50, 100, and 200 μM), activator of PPARγ (rosiglitazone, 50 μM), or antagonist of PPARγ (GW9662, 10 μM) for 24 h and gene and protein expression were analyzed by real time RT-PCR and western blot. Rosiglitazone, like MEHP, significantly decreased mRNA and protein levels of P450arom. Antagonist GW9662 partially blocked the suppression of P450arom by MEHP, suggesting that MEHP acts through PPARγ, but not exclusively. Our model shows that MEHP acts on granulosa cells in quail by stimulating PPARs, which leads to decreased gene and protein expression of P450arom. Therefore, the environmental endocrine disruptor DEHP and its major metabolite MEHP act through a receptor-mediated signaling pathway to inhibit the production of estradiol, interfere with the modulation of HPOA, suppress the synthesis of sex hormones, and cause sex hormone secretion disorders, resulting in severe toxicity in the female reproductive system. A framework for an adverse outcome pathway of DEHP/MEHP-induced ovarian toxicity was constructed, which can facilitate an improved understanding of the mechanism of female reproductive toxicity.
The environmental contaminant DEHP and its metabolite MEHP act through a receptor-mediated signaling pathway to suppress estradiol production in the ovary, interfere with the regulation of the hypothalamus-pituitary-ovarian gonadal axis, hinder the synthesis of sex hormones, and trigger sex hormone secretion disorders, leading to serious dose-dependent toxicity of the reproductive system. A framework for an adverse outcome pathway of DEHP/MEHP-induced ovarian toxicity was constructed, which can facilitate an improved understanding of the mechanism of female reproductive toxicity. Display omitted
•Exposure to DEHP induced ovarian developmental disorders in quail.•DEHP disrupted sex hormone levels by interfering with the regulation of HPOA.•MEHP decreased aromatase level in the granulosa cell by activating the PPARs.•DEHP and its metabolite MEHP lead to toxicity on the reproductive system.•A framework for an AOP of DEHP/MEHP-induced ovarian toxicity was constructed.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
We systematically study the mass spectrum and strong decays of the S-wave
c
¯
s
¯
q
q
states in the compact tetraquark scenario with the quark model. The key ingredients of the model are the Coulomb, ...the linear confinement, and the hyperfine interactions. The hyperfine potential leads to the mixing between different color configurations, and to the large mass splitting between the two ground states with
I
(
J
P
)
=
0
(
0
+
)
and
I
(
J
P
)
=
1
(
0
+
)
. We calculate their strong decay amplitudes into the
D
¯
(
∗
)
K
(
∗
)
channels with the wave functions from the mass spectrum calculation and the quark-interchange method. We examine the interpretation of the recently observed
X
0
(
2900
)
as a tetraquark state. The mass and decay width of the
I
(
J
P
)
=
1
(
0
+
)
state are
M
=
2941
MeV and
Γ
X
=
26.6
MeV, respectively, which indicates that it might be a good candidate for
X
0
(
2900
)
. Meanwhile, we also obtain an isospin partner state
I
(
J
P
)
=
0
(
0
+
)
with
M
=
2649
MeV and
Γ
X
→
D
¯
K
=
48.1
MeV, respectively. Future experimental search for
X
(2649) will be very helpful.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Accurate control of a quantum system is a fundamental requirement in many areas of modern science ranging from quantum information processing to high-precision measurements. A significantly important ...goal in quantum control is preparing a desired state as fast as possible, with sufficiently high fidelity allowed by available resources and experimental constraints. Stimulated Raman adiabatic passage (STIRAP) is a robust way to realize high-fidelity state transfer but it requires a sufficiently long operation time to satisfy the adiabatic criteria. Here we theoretically propose and then experimentally demonstrate a shortcut-to-adiabatic protocol to speed-up the STIRAP. By modifying the shapes of the Raman pulses, we experimentally realize a fast and high-fidelity stimulated Raman shortcut-to-adiabatic passage that is robust against control parameter variations. The all-optical, robust and fast protocol demonstrated here provides an efficient and practical way to control quantum systems.
We have systematically investigated the spin-32 to spin-12 doubly charmed baryon transition magnetic moments to the next-to-next-to-leading order in the heavy baryon chiral perturbation theory ...(HBChPT). Numerical results of transition magnetic moments and decay widths are presented to the next-to-leading order: μΞcc⁎++→Ξcc++=−2.35μN, μΞcc⁎+→Ξcc+=1.55μN, μΩcc⁎+→Ωcc+=1.54μN, ΓΞcc⁎++→Ξcc++=22.0 keV, ΓΞcc⁎+→Ξcc+=9.57 keV, ΓΩcc⁎+→Ωcc+=9.45 keV.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
We perform a systematic exploration of the possible doubly charmed molecular pentaquarks composed of Σc(⁎)D(⁎) with the one-boson-exchange potential model. After taking into account the S−D wave ...mixing and the coupled channel effects, we predict several possible doubly charmed molecular pentaquarks, which include the ΣcD with I(JP)=1/2(1/2−), Σc⁎D with 1/2(3/2−), and ΣcD⁎ with 1/2(1/2−), 1/2(3/2−). The ΣcD state with 3/2(1/2−) and ΣcD⁎ state with 3/2(1/2−) may also be suggested as candidates of doubly charmed molecular pentaquarks. The ΣcD and Σc⁎D states can be searched for by analyzing the ΛcDπ invariant mass spectrum of the bottom baryon and B meson decays. The ΣcD⁎ states can be searched for in the invariant mass spectrum of ΛcD⁎π, ΛcDππ and ΛcDπγ. Since the width of Σc⁎ is much larger than that of D⁎, Σc⁎D→ΛcDπ will be the dominant decay mode. We sincerely hope these candidates for the doubly charmed molecular pentaqurks will be searched by LHCb or BelleII collaboration in the near future.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Multistability is an extraordinary nonlinear property of dynamical systems and can be explored to implement memory and switches. Here we experimentally realize the tristability in a three-mode cavity ...magnonic system with Kerr nonlinearity. The three stable states in the tristable region correspond to the stable solutions of the frequency shift of the cavity magnon polariton under specific driving conditions. We find that the system staying in which stable state depends on the history experienced by the system, and this state can be harnessed to store the history information. In our experiment, the memory time can reach as long as 5.11 s. Moreover, we demonstrate the ternary logic gate with good on-off characteristics using this multistable hybrid system. Our new findings pave a way towards cavity magnonics-based information storage and processing.
Full text
Available for:
CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM
PDF
