•Meaning in life is significantly associated with suicidal ideation in young people.•The association between meaning in life and suicidal ideation is stronger in high-income and individualist ...countries compared to upper-middle-income and collectivist countries.•No difference in the association between meaning in life and suicidal ideation across gender and age groups was observed.
Suicidal ideation is a strong predictor of suicide among young people and is an outcome of interactions between protective and risk factors. Previous studies have focused primarily on risk factors while there is little evidence on important protective factors such as meaning in life. We conducted a systematic review and meta-analysis to examine the association between meaning in life and suicidal ideation among young people, and to explore potential moderating effects including demographics (gender and age) and social factors (economy and culture). We searched EBSCO, Embase, PsycINFO, PubMed, Scopus and Web of Science for relevant studies that reported correlations between meaning in life and suicidal ideation from their inception to October 2022. Studies were included in this review if they were empirical studies, written in English and sampled general young people aged 10–24. We employed a random-effects model meta-analysis to estimate the effect size. We identified 3168 references after removing duplicates and 11 studies (of 18 samples) were included in the review and meta-analysis. The meta-analysis revealed a moderate negative correlation between meaning in life and suicidal ideation (r = -0.51, 95％CI -0.57, −0.45) in young people. In addition, the correlation between meaning in life and suicidal ideation was stronger in high-income (r = -0.51, 95％CI -0.54, −0.48) and individualist countries (r = -0.51, 95％CI -0.53, −0.48) compared with upper-middle-income (r = -0.39, 95％CI -0.41, −0.37) and collectivist countries (r = -0.40, 95％CI -0.41, −0.38), respectively, but comparable across gender and age. We identified strong negative associations between meaning in life and suicide ideation in high-income and individualist countries. This highlights that approaches targeting enhancing meaning in life should be considered in suicide prevention and intervention, especially in high-income and individualist countries.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Summary
Living with CKD is associated with hardships for patients and their care partners. Empowering patients and care partners may help minimize the burden and consequences of CKD‐related symptoms ...to enable life participation. There is a need to broaden the focus on living well with kidney disease and re‐engagement in life. The World Kidney Day (WKD) Joint Steering Committee has declared 2021 the year of ‘Living Well with Kidney Disease’ in an effort to increase education and awareness on the important goal of patient empowerment and life participation. This calls for the development and implementation of validated patient‐reported outcome measures to address areas of life participation in routine care. It could be supported by regulatory agencies as a metric for quality care. Funding agencies could establish targeted calls for research that address the priorities of patients. Patients with kidney disease and their care partners should feel supported to live well through concerted efforts by kidney care communities including during pandemics. In the overall wellness programme for kidney disease patients, the need for prevention should be reiterated. WKD 2021 continues to call for increased awareness of the importance of preventive measures throughout populations, professionals and policy makers, applicable to both developed and developing countries.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
To investigate the feasibility of a freehand transperineal (TP) systematic prostate biopsy protocol under local anaesthesia (LA) and the value of different sectors in diagnosing prostate cancer ...(PCa).
A total of 611 consecutive freehand TP biopsies under LA in 2 hospitals were prospectively evaluated. Cancer detection rate in each of the four different sectors (anterior, mid, posterior, basal) was recorded to evaluate the value of each sector. Procedure tolerability was assessed by pain score and complications were documented.
Systematic biopsies were performed in 556 out of 611 men with a median of 20 (IQR 12-24) biopsy cores taken. The median PSA was 9.9 (Inter-quartile rangeIQR 6.4-16.2) ng/mL, and 89.0% were first biopsies. All PCa and ISUP grade group (GG) ≥ 2 PCa (HGPCa) were diagnosed in 41.4% (230/556) and 28.2% (157/556) biopsies respectively. 77.0% HGPCa was diagnosed in ≥2 sectors. Single-sector HGPCa was predominantly found in anterior or posterior sector. Omitting base sector would have missed 1.5% (1/65) HGPCa out of the 219 cases with ≥24-core biopsies performed. Further omission of mid sector would have missed 3.1% (2/65) HGPCa and 7.4% (7/94) ISUP GG1 PCa (in which 3/7 involved 2 sectors). LA TP biopsy was well tolerated and the mean pain scores of the different steps of the procedure were between 1.9-3.1 (out of 10). Post-biopsy fever occurred in 0.3% of patients (2/611) and no sepsis was reported. The risk of urinary retention in men with ≥20 cores in ≥60 ml prostate was 7.8% (14/179), compared with 1.7% (7/423) in other groups (p < 0.001).
TP sectoral prostate biopsy under LA was well tolerated with minimal sepsis risk. Basal sector biopsies had minimal additional value to HGPCa detection and its omission can be considered.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Additive Manufacturing (AM), particularly Selective Laser Melting (SLM), has revolutionized the industrial manufacturing sector owing to its remarkable design flexibility and precision. However, it ...is well known that slight changes in SLM process parameters may highly affect the surface quality of the as-built product. In this paper, we investigate the influence of SLM printing parameters (laser power, laser scanning speed, layer thickness, and hatch distance) on surface quality and develop a predictive model for surface quality based on the given printing parameters. The developed model is constructed by a Bayesian Optimization and soft Attention mechanism-enhanced Transfer learning (BOAT) framework with superior domain adaptability and generalization capability. Through experimental validation, the effectiveness of the BOAT approach in estimating printing parameters and correlating them with surface quality has been verified. The comprehensive methodology, experimental configurations, prediction results, and ensuing discussions are all presented. This study contributes to providing valuable insights and practical implications for improving the competitiveness and impact of SLM in advanced manufacturing by accurately predicting surface quality with specified printing parameters.
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•Engaging a soft attention mechanism to enhance the effectiveness of transfer learning.•Developing a BOAT approach for quantifying the effects of 3D printing parameters.•Applying BOAT to predict the surface roughness of 3D-printed samples accurately.•BOAT approach has superior domain adaptability and generalization capability.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Living with chronic kidney disease (CKD) is associated with hardships for patients and their care partners. Empowering patients and their care partners, including family members and friends involved ...in their care, may help minimize the burden and consequences of CKD-related symptoms to enable increased life participation. There is a need to broaden the focus on living well with kidney disease and reengagement in life, including emphasis on the patient being in control. The World Kidney Day (WKD) Joint Steering Committee has declared 2021 the year of “Living Well with Kidney Disease” in an effort to increase education about and awareness of the important goal of patient empowerment and life participation. This calls for the development and implementation of validated patient-reported outcome measures to assess and address areas of life participation in routine care. It could be supported by regulatory agencies as a metric for quality care or to support labeling claims for medicines and devices. Funding agencies could establish targeted calls for research that address the priorities of patients. Patients with kidney disease and their care partners should feel supported to live well through concerted efforts by kidney care communities, including during pandemics. In the overall wellness program for patients with kidney disease, the need for prevention should be reiterated. Early detection with prolonged course of wellness despite kidney disease, after effective secondary and tertiary prevention programs, should be promoted. WKD 2021 continues to call for increased awareness of the importance of preventive measures across populations, professionals, and policy makers, applicable to both developed and developing countries.
Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease ...onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to target. Similarly, the vast majority of people living with kidney disease are unaware of their condition, because in the early stages it is often silent. Even among patients who have been diagnosed, many do not receive appropriate treatment for kidney disease. Considering the serious consequences of kidney disease progression, kidney failure, or death, it is imperative that treatments are initiated early and appropriately. Opportunities to diagnose and treat kidney disease early must be maximized beginning at the primary care level. Many systematic barriers exist, ranging from patient to clinician to health systems to societal factors. To preserve and improve kidney health for everyone everywhere, each of these barriers must be acknowledged so that sustainable solutions are developed and implemented without further delay.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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