Target of rapamycin (TOR), a member of the phosphatidylinositol kinase‐related kinase family, plays a critical role in the regulation of growth, metabolism, development and survival, at both the ...cellular and the organismal levels. Two paralogous Tor genes, BmTor1 and BmTor2, were identified as a pair of inverted repeats in the genome of the silkworm Bombyx mori. The synteny of BmTor1 and CG8360 indicates that BmTor1 is the orthologue while BmTor2 is a duplicate. Analyses of the two BmTor genes at both the nucleotide and amino acid levels reveal that they are evolutionally and structurally conserved. The two BmTor genes had similar expression patterns of tissue distribution with highest levels in the nervous system, and nearly identical developmental change profiles with maximal levels during the 4th‐larval‐moulting and the larval–pupal transition stages. Furthermore, both BmTor genes were up‐regulated by either starvation or the moulting hormone 20‐hydroxyecdysone (20E), while BmTor2 was more sensitive to both treatments than BmTor1. For the first time, we have identified two copies of the Tor gene in a higher eukaryote, which are induced by starvation and 20E during the larval moulting and the larval–pupal transition stage.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
To investigate the clinical effects of free transplantation of expanded ilioinguinal flaps in the reconstruction of severe scar contracture after extensive burns.
A retrospective observational study ...was conducted. From August 2017 to October 2021, 7 patients with severe scar contracture deformity caused by extensive burns were hospitalized in Tongren Hospital of Wuhan University & Wuhan Third Hospital, including 5 males and 2 females, aged 26-65 years, with scar area of 20 cm×4 cm-34 cm×14 cm. In the first stage, the rectangular skin and soft tissue expander (hereinafter referred to as the expander) with rated capacity of 500-600 mL were embedded above the inguinal ligament, and then normal saline was injected after stitch removal for expansion to meet the needs of repair surgery. In the second stage, the scar was removed by surgical excision to correct the deformity and release the adhesion and contracture; after the removal of the expanders, the expanded ilioinguinal free flaps were harvested. When a larger
To investigate the clinicopathologic features of lipoprotein glomerulopathy (LPG).
A total of 6 cases (5 males and 1 female, with a mean age of 27.5 years and age range of 11-53 years) of lipoprotein ...glomerulopathy with complete clinicopathologic data were enrolled. Except for light microscope, immunofluorescence and electron microscopic examination, renal biopsy tissues were checked by oil red O staining. The gene map of apolipoprotein E (ApoE) of 2 cases were analyzed.
All 6 cases presented with heavy proteinuria or nephrotic syndrome, and high level of low-density lipoprotein (LDL), very low-density lipoprotein (vLDL), ApoE. Family history of LPG was found in 3 cases, and 2 patients progressed to uremia, or even to death. Pathologic features showed that lipoprotein deposited in glomerulus capillary lumen and renal tubular epithelial cells. Gene analysis demonstrated that 2 cases expressed abnormal ApoE gene (162G>C and 455G>C).
Lipoprotein glomerulopathy is autosomal-recessive disease with mutation of ApoE
The outstanding thermal and mechanical properties of graphene/phenolic resin (G/PR) composites are largely related with the interfacial interactions. The interfacial properties of the G/PR composites ...were studied with molecular dynamics method, based on dozens of G/PR and graphene oxide/PR (GO/PR) interface models. The results showed that, p-π/π-π and hydrogen bond interactions are the main interactions between the G/PR and GO/PR interfaces, respectively. Strong interfacial interactions were formed between the crosslinked PRs and GO layer grafted with oxygen-containing groups. The obtained results will be beneficial to guide the design and preparation of G/PR composites with special performances.
Background: We have recently demonstrated that simple ratios of the expression levels of selected genes in tumor samples can be used to distinguish among types of thoracic malignancies. We examined ...whether this technique could predict treatment-related outcome for patients with mesothelioma. Methods: We used gene expression profiling data previously collected from 17 mesothelioma patients with different overall survival times to define two outcome-related groups of patients and to train an expression ratio-based outcome predictor model. A Student’s t test was used to identify genes among the two outcome groups that had statistically significant, inversely correlated expression levels; those genes were used to form prognostic expression ratios. We used a combination of several highly accurate expression ratios and cross-validation techniques to assess the internal consistency of this predictor model, quantitative reverse transcription–polymerase chain reaction of tumor RNA to confirm the microarray data, and Kaplan–Meier survival analysis to validate the model among an independent set of 29 mesothelioma tumors. All statistical tests were two-sided. Results: We developed an expression ratio-based test capable of identifying 100% (17/17) of the samples used to train the model. This test remained highly accurate (88%, 15/17) after cross-validation. A four-gene expression ratio test statistically significantly (P = .0035) predicted treatment-related patient outcome in mesothelioma independent of the histologic subtype of the tumor. Conclusions: Gene expression ratio-based analysis accurately predicts treatment-related outcome in mesothelioma samples. This technique could impact the clinical treatment of mesothelioma by allowing the preoperative identification of patients with widely divergent prognoses.
The traditional calculation method of the surrounding strata pressure of the tunnel does not consider the tunnel construction process. The excavation of the large-section tunnel mostly adopts the ...section excavation method, which is to excavate and support at the same time. The stress state of the pressure of surrounding strata changes gradually during the excavation process. The traditional calculation results of tunnel surrounding strata pressure are generally large. In this paper, the large-section tunnel is simplified into three parts, and the degree of influence (η1, η2, η3) of the excavation height h and width b of the advance pilot hole and the distance d between the advance and rear pilot tunnels on the surrounding rock pressure calculation are analyzed. The regression equation for calculating the influencing factors (tunnel depth H, tunnel span B, internal friction angle ϕ, and rock weight γ) of surrounding rock pressure (p) is established. Through the numerical analysis, the influence coefficient η is obtained, the weight coefficient is introduced, and the computing formula of the pressure of surrounding strata of the large-section tunnel excavation is derived. The formula is used to the computing of the pressure of surrounding strata with a large-section subway station and the correct conclusion is obtained.
The fine structure and ionization energy of the 1s2s2p (4)P state of the helium negative ion He(-) are calculated in Hylleraas coordinates, including relativistic and QED corrections up to ...O(α(4)mc(2)), O((μ/M)α(4)mc(2)), O(α(5)mc(2)), and O((μ/M)α(5)mc(2)). Higher order corrections are estimated for the ionization energy. A comparison is made with other calculations and experiments. We find that the present results for the fine structure splittings agree with experiment very well. However, the calculated ionization energy deviates from the experimental result by about 1 standard deviation. The estimated theoretical uncertainty in the ionization energy is much less than the experimental accuracy.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
In recent years, some e-commerce companies such as Amazon have adopted the cargo-to-person picking mode to improve their pickup efficiency. Under this mode, a shelf can store several types of goods ...and a type of goods can be placed on some shelves. When orders arrive, the warehouse robots move one shelf or more containing the ordered items to a fixed platform, and the pickers select the items from the shelves. It is very important to decide which shelves should be moved to increase picking efficiency. This paper addresses the problem of optimal movable-shelf selection for the cargo-to-person picking mode. The goal of this study is to minimize the total time (costs) of moving the selected shelves to finish a batch of orders. We model this problem using 0-1 linear programming and show that the problem is NP-hard. Furthermore, we propose a three-stage hybrid heuristic algorithm with polynomial complexity to solve it. We conduct numerical experiments to show the efficiency of this algorithm. 28 refs.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
We have theoretically studied the longitudinal dc conductivity of the surface state of three-dimensional (3D) topological insulators (TIs) under a linearly polarized (LP) terahertz (THz) field ...irradiation via the Floquet theory and Green's function technique. It was found that, due to the anisotropic quasienergy spectrum under the LP light, the longitudinal conductivities parallel and perpendicular to the polarized direction of the LP light are not the same. When the 3D TI's chemical potential is zero, both of the conductivities undergo an oscillation against the electron-field interaction parameter because of the contribution of the photon modulated side-band transport at different position. The oscillation is dramatically suppressed when the chemical potential is higher or lower than zero. There is a pronounced dip in the dc conductivity at a specific field frequency twice the chemical potential, which can be seen as a gap-induced metal-to-insulator transition of the surface state of 3D TIs. As the dc conductivity of the surface state of 3D TIs has such a pronounced response to the LP THz field, our investigations involving the interaction between TIs and LP THz field actually provided the possibility of TI application in THz devices.
A mathematical model is developed to control aircraft vibrations caused by runway excitation using an active landing gear system. Equations are derived to describe the integrated aircraft-active ...system. The nonlinear characteristics of the system are modelled and it is actively controlled using a Proportional Integral Derivative (PID) strategy. The performance of this system and its corresponding passive system are compared using numerical simulations. It is demonstrated that the impact loads and the vertical displacement of the aircraft's centre of gravity caused by landing and runway excitations are greatly reduced using the active system, which result in improvements to the performance of the landing gear system, benefits the aircraft's fatigue life, taxiing performance, crew/passenger comfort and reduces requirements on the unevenness of runways.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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