Fe-based bulk metallic glasses have the advantages of high strength and low coercivity. However, their plastic deformation ability is negligible. Therefore, in this study, Sn was added to a Fe–Si–B–P ...bulk metallic glass matrix to study its influence on the formation and plastic deformation ability of Fe–Si–B–P bulk metallic glasses. The results showed that the mixing enthalpy of Sn was less than that of Fe and other metal-like atoms, which caused Sn atoms to separate from Si-, B- and P-centered clusters, resulting in metal-like clusters not occupying adjacent positions and the voids between clusters being occupied by Sn atoms. With increasing Sn, the metal-metal bonds of the linked clusters increased and the macroscopic performance was manifested in an improvement in the plastic deformation ability. With 0.3 at% Sn addition, the alloy system showed the best plastic deformation ability increasing from 0.7 to 2.2% and the yield strength of 3150 MPa.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Tumor-specific fluorescent probes must fulfill the dual requirements of targeted accumulation within tumors and high-resolution imaging capabilities. To achieve both tumor-targeted accumulation and ...high-resolution imaging performance, we developed a composite comprising an acid-responsive bodipy conjugated to amphiphilic PEG-b-PLA polymer, along with folic acid (FA)-modified PEG-b-PLA as a targeting moiety for active tumor-specific accumulation. Finally, a novel assembly of hybrid fluorescent nanoparticles was successfully synthesized by integrating these two components, demonstrating exceptional responsiveness to acidic conditions for fluorescence excitation and remarkable tumor-targeted accumulation capabilities. We conducted comprehensive in vitro and in vivo investigations employing techniques such as analysis of physicochemical properties, fluorescence-based probes detection at varying pH levels, assessment of in vitro cytotoxicity, evaluation of cellular uptake capacity, analysis of lysosomal co-localization imaging, examination of tumor fluorescence images in vivo, and investigation of biological distribution patterns. The results demonstrated that the acid-responsive nanofluorescence probe we designed and synthesized possesses desirable physical and chemical characteristics, including a small particle size and low cytotoxicity. Moreover, it exhibits rapid real-time response to acidic environments and displays enhanced fluorescence intensity, enabling the real-time tracking of probe entry into tumor cells as well as intracellular lysozyme accumulation. We achieved highly specific in vivo tumor visualization by combining nanoprobes targeting folate receptor. Through imaging cervical tumor mice, we demonstrated the precise imaging performance and high targeted accumulation of FA-targeted nanofluorescence probes in tumor tissue. Furthermore, we confirmed the in vivo safety of the FA-targeted nanofluorescence probe through biological distribution analysis. These findings highlight the potential widespread application of FA-targeted acid-responsive nanofluorescence probes for selective imaging of tumor cells and tissues.Tumor-specific fluorescent probes must fulfill the dual requirements of targeted accumulation within tumors and high-resolution imaging capabilities. To achieve both tumor-targeted accumulation and high-resolution imaging performance, we developed a composite comprising an acid-responsive bodipy conjugated to amphiphilic PEG-b-PLA polymer, along with folic acid (FA)-modified PEG-b-PLA as a targeting moiety for active tumor-specific accumulation. Finally, a novel assembly of hybrid fluorescent nanoparticles was successfully synthesized by integrating these two components, demonstrating exceptional responsiveness to acidic conditions for fluorescence excitation and remarkable tumor-targeted accumulation capabilities. We conducted comprehensive in vitro and in vivo investigations employing techniques such as analysis of physicochemical properties, fluorescence-based probes detection at varying pH levels, assessment of in vitro cytotoxicity, evaluation of cellular uptake capacity, analysis of lysosomal co-localization imaging, examination of tumor fluorescence images in vivo, and investigation of biological distribution patterns. The results demonstrated that the acid-responsive nanofluorescence probe we designed and synthesized possesses desirable physical and chemical characteristics, including a small particle size and low cytotoxicity. Moreover, it exhibits rapid real-time response to acidic environments and displays enhanced fluorescence intensity, enabling the real-time tracking of probe entry into tumor cells as well as intracellular lysozyme accumulation. We achieved highly specific in vivo tumor visualization by combining nanoprobes targeting folate receptor. Through imaging cervical tumor mice, we demonstrated the precise imaging performance and high targeted accumulation of FA-targeted nanofluorescence probes in tumor tissue. Furthermore, we confirmed the in vivo safety of the FA-targeted nanofluorescence probe through biological distribution analysis. These findings highlight the potential widespread application of FA-targeted acid-responsive nanofluorescence probes for selective imaging of tumor cells and tissues.
In this paper, a reaction-diffusion vegetation-water system with time-varying delay, impulse and Lévy jump is proposed. The existence and uniqueness of the positive solution are proved. Meanwhile, ...mainly through the principle of comparison, we obtain the sufficient conditions for finite-time stability which reflect the effect of time delay, diffusion, impulse, and noise. Besides, considering the planting, irrigation and other measures, we introduce control variable into the vegetation-water system. In order to save the costs of strategies, the optimal control is analyzed by using the minimum principle. Finally, numerical simulations are shown to illustrate the effectiveness of our theoretical results.
Resolution of seismic data is critical to reservoir prediction and the near surface underground structure. Low resolution of seismic data is caused by many factors, such as the surface environment, ...shielding layer and sand body. To widen the frequency bandwidth and improve the resolution of the post-stack seismic reflection profiles, we analyze the characteristics of amplitude-spectrum of the post-stack profiles and design frequency expanding inverse filter based on the logging data for data fusion, including the loss of longitudinal frequency information and the variation of transverse frequency. This method creates broadband synthetic seismogram by using a wide bandwidth seismic wavelet and a series of reflection coefficients calculated from acoustic logging and density logging data. By analyzing the synthetic seismogram of widening frequency band with borehole seismic traces, the loss regularity of vertical frequency signal generated by low-pass filter of formation is restored. Additionally, to compare borehole seismic traces with arbitrary cross-well trace, the filtering effect about transverse variation of formation is obtained. The successful application of the inverse filter in terms of data fusion to acquire a new profile with better resolution called the seismic-logging profile, demonstrated that the proposed data fusion method has the advantage of being efficient in compensating the high frequency components of seismic section.
•We presented a method to improve the resolution of seismic data by using logging data.•Data fusion was performed to obtain a seismic-logging profile with higher resolution from a post-stack seismic profile.•The tandem inverse filter compensated the loss of vertical frequency and variation of transverse frequency.•We proved and evaluated the efficiency of the method by comparing with the information of another well.
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GEOZS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
This paper presents analysis, diagnosis and disposal with a typical internal breakdown failure of the resin impregnated paper (RIP) valve side bushing in high voltage direct current (HVDC) converter ...transformer. Based on the analysis of fault current characteristics at the time of the RIP valve side bushing failure, and field test results of insulation parameters, a method of diagnosing typical breakdown failures of valve side bushings is proposed. Through disassembly inspection of the internal overheating and arcing traces on the failure bushing, the root cause of this typical breakdown failure is found, which is upper axial flashover along the RIP condenser/SF6 interface caused by the abnormal contact of two current-carrying conductive tubes. Temperature distribution inside the bushing with an abnormal contact resistance between the copper conductive tube and aluminum conductive tube under different load current is simulated by using the finite element method. An special device is also developed for repairing defective bushing on-site, and 75 bushings with conductive contact defects have been repaired on the premise of not pushing converter transformers away from the valve hall and even without pulling out defective bushings.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Battery energy storage system (BESS) is an important component of future energy infrastructure with significant renewable energy penetration. Lead‐carbon battery is an evolution of the traditional ...lead‐acid technology with the advantage of lower life cycle cost and it is regarded as a promising candidate for grid‐side BESS deployment. However, inconsistency among lead‐carbon batteries in a BESS is a major concern which has to be carefully considered in practical operation. One of the available approaches to relieve this issue is to develop a sophisticated power allocation strategy (PAS) among multiple converters inside the BESS. This work conducts a comprehensive case study on the impact of PAS in a grid‐side 12 MW/48 MWh BESS recently constructed in Zhejiang, China (Zhicheng energy storage station, the first grid‐side lead‐carbon BESS in China). Three different PASs (i.e. averaged, state weighted and state prioritized) are investigated and benchmarked with two typical BESS application scenarios of peak shaving and frequency regulation, from real‐world experiments using the aforementioned BESS. The performance of the strategies is quantitatively evaluated by three indices defined in this work. The state prioritized strategy is found to be the most effective for this lead‐carbon BESS.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Diphlorethohydroxycarmalol (DPHC) isolated from
(IO) showed potential whitening effects against UV-B radiation. However, the components of IO as well as their molecular mechanism against ...α-melanocyte-stimulating hormone (α-MSH) have not yet been investigated. Thus, this study aimed to investigate the inhibitory effects of Ishophloroglucin A (IPA), a phlorotannin isolated from brown algae IO, and its crude extract (IOE), in melanogenesis in vivo in an α-MSH-induced zebrafish model and in B16F10 melanoma cells in vitro. Molecular docking studies of the phlorotannins were carried out to determine their inhibitory effects and to elucidate their mode of interaction with tyrosinase, a glycoprotein related to melanogenesis. In addition, morphological changes and melanin content decreased in the α-MSH-induced zebrafish model after IPA and IOE treatment. Furthermore, Western blotting results revealed that IPA upregulated the extracellular related protein expression in α-MSH-stimulated B16F10 cells. Hence, these results suggest that IPA isolated from IOE has a potential for use in the pharmaceutical and cosmetic industries.
Near-optimization is as sensible and important as optimization for both theory and applications. This paper concerns the near-optimal control of an avian influenza model with saturation on ...heterogeneous complex networks. Firstly, the basic reproduction number $ \mathcal{R}_{0} $ is defined for the model, which can be used to govern the threshold dynamics of influenza disease. Secondly, the near-optimal control problem was formulated by slaughtering poultry and treating infected humans while keeping the loss and cost to a minimum. Thanks to the maximum condition of the Hamiltonian function and the Ekeland's variational principle, we establish both necessary and sufficient conditions for the near-optimality by several delicate estimates for the state and adjoint processes. Finally, a number of examples presented to illustrate our theoretical results.
In this study, we explore a stochastic age-dependent cooperative Lotka-Volterra (LV) system with an environmental noise. By applying the theory of M-matrix, we prove the existence and uniqueness of ...the global solution for the system. Since the stochastic age-dependent cooperative LV system cannot be solved explicitly, we then construct an Euler-Maruyama (EM) numerical solution to approach the exact solution of the system. The convergence rate and the pth-moment boundedness of the scheme have also been obtained. Additionally, numerical experiments have been conducted to verify our theoretical results.
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