Most research on influence maximization focuses on the network structure features of the diffusion process but lacks the consideration of multi-dimensional characteristics. This paper proposes the ...attributed influence maximization based on the crowd emotion, aiming to apply the user’s emotion and group features to study the influence of multi-dimensional characteristics on information propagation. To measure the interaction effects of individual emotions, we define the user emotion power and the cluster credibility, and propose a potential influence user discovery algorithm based on the emotion aggregation mechanism to locate seed candidate sets. A two-factor information propagation model is then introduced, which considers the complexity of real networks. Experiments on real-world datasets demonstrate the effectiveness of the proposed algorithm. The results outperform the heuristic methods and are almost consistent with the greedy methods yet with improved time performance.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Phycobilisomes are light-harvesting antenna complexes of cyanobacteria and red algae that are comprised of chromoproteins called phycobiliproteins. PBS core structures are made up of allophycocyanin ...subunits.
Halomicronema hongdechloris
(
H. hongdechloris
) is one of the cyanobacteria that produce chlorophyll
f
(Chl
f
) under far-red light and is regulated by the Far-Red Light Photoacclimation gene cluster. There are five genes encoding APC in this specific gene cluster, and they are responsible for assembling the red-shifted PBS in
H. hongdechloris
grown under far-red light. In this study, the five
apc
genes located in the FaRLiP gene cluster were heterologously expressed in an
Escherichia coli
reconstitution system. The canonical APC-encoding genes were also constructed in the same system for comparison. Additionally, five annotated phycobiliprotein lyase-encoding genes (
cpcS
) from the
H. hongdechloris
genome were phylogenetically classified and experimentally tested for their catalytic properties including their contribution to the shifted absorption of PBS. Through analysis of recombinant proteins, we determined that the heterodimer of CpcS-I and CpcU are able to ligate a chromophore to the APC-α/APC-β subunits. We discuss some hypotheses towards understanding the roles of the specialised APC and contributions of PBP lyases.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The development of high-performance electrocatalysts is a highly efficient strategy to optimize the sluggish kinetic property of the oxygen evolution reaction (OER). Herein, we synthesize a kind of ...nickel foam (NF)-supported electrocatalyst composed of a one-dimensional Co3O4 nanowire as the core and a two-dimensional NiFe-LDH nanosheet as the shell (denoted as NiFe-60/Co3O4@NF). Fluorine is introduced into the precursor Co(OH)F of Co3O4, which results in improved thermal stability and significantly increased regularly distributed oxygen vacancies, while the electrochemically deposited NiFe-LDH nanosheets possess a crystalline/amorphous hybrid structure. As a result, the hetero-interface mainly constituting Ni species from NiFe-LDH and Co3O4 from Co(OH)F contributes to the interaction between Co and Fe species and facilitates the electron transfer. Simultaneously, the interaction between oxygen vacancies in Co3O4 and coordinatively unsaturated Fe species in the amorphous area in NiFe-LDH is also determined, finally completing the electron backtracking. Benefiting from these factors, only low overpotentials of 221 and 257 mV are required to deliver the current densities of 100 and 500 mA cm–2, respectively, with a quite small Tafel slope of 34.6 mV dec–1 during OER for the well-designed NiFe-60/Co3O4@NF electrocatalyst.
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IJS, KILJ, NUK, PNG, UL, UM
To investigate the gene expression pattern and related biological changes during osteogenic differentiation of human mesenchymal stem cells (hMSCs), we downloaded expression data for four uninduced ...hMSC samples, and 12 osteogenic induction samples at day 2, 8, 12 or 25, in the GSE37558 dataset. Differentially expressed genes (DEGs) between groups were screened, followed by short time-series expression miner (STEM) analysis and weighted gene co-expression network analysis (WGCNA). Osteogenic differentiation-related genes were extracted from the GeneCards database. Next, functional enrichment was performed, and protein–protein interaction (PPI) and lncRNA–miRNA–mRNA networks were constructed. Compared to uninduced hMSC samples, 163, 341, 447 and 537 DEGs were found in osteogenic induction samples at day 2, 8, 12 and 25, respectively, showing a sustainably increased trend. From STEM, WGCNA and the GeneCards database, a total of 107 key genes associated with osteogenic differentiation were screened; these genes were enriched in biological processes, such as ossification, ECM–receptor interaction, vasculature development, cartilage development and bone mineralization, as well as the Wnt signaling pathway and the chemokine signaling pathway. The PPI network identified four hub genes, STAT5A, TWIST1, FOXO1 and LEP. The lncRNA–miRNA–mRNA network revealed regulatory axes for STAT5A, FOXO1 and LEP. Three and two regulatory axes were found for STAT5A and LEP, respectively. Multiple regulatory axes for FOXO1 were found, such as MIR155HG–miR-223–FOXO1. This study identifies candidate key targets that may play important roles in regulating osteogenic differentiation of hMSCs, and provides novel information to further investigate the molecular regulation mechanism. More experiments are required to evaluate the effects of these genes on osteogenic differentiation of hMSCs.
Summary
Drought stress is one of the abiotic stresses that limit plant growth and agricultural productivity. To further understand the mechanism of drought tolerance and identify the genes involved ...in this process, a genetic screen for altered drought response was conducted in Arabidopsis. One mutant with enhanced drought tolerance was isolated and named Arabidopsis drought tolerance mutant 1 (atdtm1), which has larger lateral organs, prolonged growth duration, increased relative water content and a reduced leaf stomatal density compared with the wild type. The loss of AtDTM1 increases cell division during leaf development. The phenotype is caused by the loss of a T‐DNA tagged gene encoding CYCLIN‐DEPENDENT KINASE C;2 (CDKC;2), which functions in the regulation of transcription by influencing the phosphorylation status of RNA polymerase II (Pol II). Here, we show that CDKC;2 affects the transcription of downstream genes such as cell cycle genes and genes involved in stomatal development, resulting in altered plant organ size as well as drought tolerance of the plant. These results reveal the crucial role of CDKC;2 in modulating both cell division and the drought response in Arabidopsis.
Significance Statement
This article provides information towards understanding the mechanisms between plant development and the drought response, in which CDKC;2 is a key player. Under standard growth conditions loss of function of CDKC;2 promotes plant growth and under drought conditions it reduces water evaporation from plant leaves, resulting in drought tolerance.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Rapidly solidified Al–0.5Mg–0.1Sn–0.02In (0.02Ga)–0.1Si (wt. %) alloys were prepared as anode alloys for Al–air battery by the single roller melt-spinning method. The corrosion behavior of the alloys ...and the Al–air battery performance were investigated in both 2 M NaCl and 4 M NaOH solutions. Results obtained have shown that the Al–0.5Mg–0.1Sn–0.02Ga–0.1Si alloy has a better electrochemical performance in the 2 M NaCl solution, while Al–0.5Mg–0.1Sn–0.02In–0.1Si alloy shows a better electrochemical performance in the 4 M NaOH solution. In the 2 M NaCl solution, both alloys suffer from a uniform corrosion. In the 4 M NaOH solution, the corrosion morphology of the alloys evolves from an intergranular corrosion to a uniform corrosion. SEM and EIS results are in good agreement with electrochemical characteristics.
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•It is feasibility of using Al–0.5Mg–0.1Sn–0.02Ga–0.1Si alloy for Al–air battery in 2 M NaCl.•In 4 M NaOH, the corrosion morphology evolution is from intergranular to uniform corrosion.•In 2 M NaCl, the alloys suffer from the uniform corrosion.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Patients with IgG4-related disease (IgG4-RD) are diagnosed in Japan by comprehensive or organ-specific diagnostic criteria. To date, organ-specific criteria have been established for several organs, ...but not for the thyroid. We attempted to establish diagnostic criteria for IgG4-related thyroid disease (IgG4-RTD) based on IgG4-RD research by The Research Program on Intractable Diseases from the Ministry of Health, Labour and Welfare of Japan. These criteria have been publicly reported to members of both the Japan Endocrine Society and the Japan Thyroid Association. Thyroid diseases associated with IgG4 include Hashimoto’s thyroiditis, Graves’ disease and Riedel’s thyroiditis. As a comprehensive definition that includes both systematic and organ-specific forms, we use the broad term ‘IgG4-related thyroid disease’. Diagnostic criteria for IgG4-RTD comprise the following five items: I) enlargement of the thyroid, II) hypoechoic lesions in the thyroid by ultrasonography, III) elevated serum IgG4 levels, IV) histopathological findings in the thyroid lesion (IgG4+ plasma cells >20/HPF and IgG4+/IgG+ plasma cell ratio >30%) and V) involvement of other organs. “Definitive” diagnosis of IgG4-RTD is made when I, II, III and IV are all fulfilled, while “probable” diagnosis of IgG4-RTD is when I, II, and IV or V are fulfilled. Patients who fulfill I, II and III criteria are considered as “possible” IgG4-RTD. We believe that the proposed diagnostic criteria contribute to more accurate diagnosis of IgG4-RTD as well as exclusion of mimicry. Furthermore, they may lead to better understanding of the clinical implications and underlying pathogenesis of IgG4-RTD.
The phytohormones abscisic acid (ABA) and indole-3-acetic acid (IAA) response pathways interact synergistically or antagonistically to regulate plant development and environmental adaptation. Here, ...we show that ABI1, a key negative regulator of ABA signaling, is essential for auxin-modulated root development. We performed a microarray analysis using the loss-of-function mutant abi1-3 and Col-0 seedlings treated with IAA. For sHSP22, an endoplasmic reticulum (ER) small heat shock protein-encoding gene, the induction by IAA was dependent on ABI1. shsp22 displayed enhanced sensitivity to ABA in primary root growth. In contrast, overexpression of full-length, but not truncated sHSP22 lacking signal peptide and ER-retention sequences, resulted in decreased ABA sensitivity. Overexpressed (OX) sHSP22 partially rescued the ABA hypersensitivity of abi1-3. In addition, sHSP22 is involved in auxin-regulated hypocotyl elongation at high temperature treatment. sHSP22 also affected accumulation of auxin efflux carrier PIN proteins due to potentiated intracellular trafficking. And sHSP22 OX lines initiated more lateral roots after auxin application. Our results suggest that sHSP22 regulates auxin response through modulating auxin polar transport, and ABI1-sHSP22 provides a novel module orchestrating ABA and auxin signaling crosstalk in Arabidopsis (Arabidopsis thaliana).
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