Sensor arrays are a powerful tool for multianalyte sensing and the development of an efficient sensor array has become one of the most intriguing problems. However, sensor arrays often employ lots of ...receptors which need large amounts of work to synthesise. This study describes an efficient method for the fabrication of a simple sensor array based on the competitive binding in supramolecular gels. By rationally introducing various well-designed competitive binding interactions into the supramolecular gel, which is self-assembled from a naphthylhydrazone-based organogelator, a supramolecular gel-based twenty-two-member sensor array has been created. Interestingly, the sensor array has been shown to accurately identify fourteen kinds of important ions (F
, Cl
, I
, CN
, HSO
, SCN
, S
, OH
, Al
, Fe
, Zn
, Hg
, Pb
and H
) in water. It's important to note that this sensor array needs only one synthesized receptor. Moreover, using this method, we also obtained a series of ion response fluorescent supramolecular materials, which could act as security display materials. Therefore, it's a novel and facile way for the design of a simple sensor array as well as ion response fluorescent supramolecular materials.
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IJS, KILJ, NUK, UL, UM, UPUK
Just as the heterojunctions in physics, donor–acceptor (D‐A) heterostructures are an emerging class of photoactive materials fabricated from two semiconductive components at the molecular level. ...Among them, D‐A hybrid heterostructures from organic and inorganic semiconductive components have attracted extensive attention in the past decades due to their combined advantages of high stability for the inorganic semiconductors and modifiability for the organic semiconductors, which are particularly beneficial to efficiently achieve photoinduced charge separation and transfer upon irradiations. In this review, by analogy with the heterojunctions in physics, a definition of the D‐A heterostructures and their general design and synthetic strategies are given. Meanwhile, the D‐A hybrid heterostructures are focused on and their recent advances in potential applications of photochromism, photomodulated luminescence, and photocatalysis summarized.
Donor‐acceptor (D‐A) hybrid heterostructures are an emerging class of photoactive materials fabricated from inorganic and organic semiconductive components at the molecular level, which is conductive to efficiently achieve the photoinduced charge separations. This review provides a comprehensive summary of D‐A hybrid heterostructures from the definition, design strategies to recent advances in potential applications of photochromism, photomodulated luminescence, and photocatalysis.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
The incorporation of photochromic moieties into coordination polymers is of particular interest because it can endow them with various switching functions such as electrical conductivity, ...luminescence, and magnetism. In this context, a viologen ligand as a photochromic moiety was incorporated into 3d-4f heterobimetallic hexacyanoferrates, resulting in three novel 3-D photochromic complexes with different metal cations, namely {Ln(BCEbpy) M(CN)
6
(H
2
O)
4
·2H
2
O}
n
(denoted as
CoDy
,
CoEu
, and
FeDy
, Ln = Dy, Eu; M = Fe, Co, H
2
BCEbpy·2Br =
N
,
N
′-bis(carboxymethyl)-4,4′-bipyridinium dibromide). And the photoresponsive mechanism has been well discussed based on the solid UV-vis, IR, ESR, photoluminescence, and magnetism data. Moreover, accompanying the photochromic process, these unique complexes exhibit different photomagnetic behaviors upon UV-vis irradiation at RT because of the different ferromagnetic coupling interactions between photogenerated radicals and lanthanide cations.
Three 3-D isostructural cyanide-bridged 3d-4f heterobimetallic complexes with enhanced photochromism and photomagnetism at RT have been achieved by the introduction of a photoactive viologen functionalized ligand.
Background. Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. Machine learning techniques were introduced to evaluate the optimal predictive clinical model of ...NAFLD. Methods. A cross-sectional study was performed with subjects who attended a health examination at the First Affiliated Hospital, Zhejiang University. Questionnaires, laboratory tests, physical examinations, and liver ultrasonography were employed. Machine learning techniques were then implemented using the open source software Weka. The tasks included feature selection and classification. Feature selection techniques built a screening model by removing the redundant features. Classification was used to build a prediction model, which was evaluated by the F-measure. 11 state-of-the-art machine learning techniques were investigated. Results. Among the 10,508 enrolled subjects, 2,522 (24%) met the diagnostic criteria of NAFLD. By leveraging a set of statistical testing techniques, BMI, triglycerides, gamma-glutamyl transpeptidase (γGT), the serum alanine aminotransferase (ALT), and uric acid were the top 5 features contributing to NAFLD. A 10-fold cross-validation was used in the classification. According to the results, the Bayesian network model demonstrated the best performance from among the 11 different techniques. It achieved accuracy, specificity, sensitivity, and F-measure scores of up to 83%, 0.878, 0.675, and 0.655, respectively. Compared with logistic regression, the Bayesian network model improves the F-measure score by 9.17%. Conclusion. Novel machine learning techniques may have screening and predictive value for NAFLD.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
The pathogenesis of nonalcoholic steatohepatitis (NASH) is still unclear, where involvement of circRNA is considered for its active role as "miRNA sponge". Therefore, we aimed to investigate the ...circRNA expression pattern in NASH and further construct the circRNA-miRNA-mRNA network for in-depth mechanism exploration. Briefly, NASH mice model was established by Methionine and choline deficiency (MCD) diet feeding. Liver circRNA and mRNA profile was initially screened by microarray and ensuing qRT-PCR verification was carried out. The overlapped predicted miRNAs as downstream targets of circRNAs and upstream regulators of mRNAs were verified by qRT-PCR and final circRNA-miRNA-mRNA network was constructed. Gene Ontology (GO) and KEGG pathway analysis were further applied to enrich the huge mRNA microarray data. To sum up, there were 69 up and 63 down regulated circRNAs as well as 2760 up and 2465 down regulated mRNAs in NASH group, comparing with control group. Randomly selected 13 of 14 mRNAs and 2 of 8 circRNAs were successfully verified by qRT-PCR. Through predicted overlapped miRNA verification, four circRNA-miRNA-mRNA pathways were constructed, including circRNA_002581-miR-122-Slc1a5, circRNA_002581- miR-122-Plp2, circRNA_002581-miR-122-Cpeb1 and circRNA_007585-miR-326- UCP2. GO and KEGG pathway analysis also enriched specific mRNAs. Therefore, circRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.
The construction and application of macrocycle-assembled AIE-SPNs.
Display omitted
•Macrocycles-assembled AIE-SPNs coalesced the merits of AIE, macrocycles and supramolecular polymer ...networks.•Macrocycles-assembled AIE-SPNs show nice prospect in various fields.•Recent progress on constructing and application of macrocycle-assembled AIE-SPNs has been summarized.•The mechanisms on self-assembly, AIE, stimuli-response and structure–property/application relationships are discussed.•Supply new perspectives to solve problems by the synergy of AIE, SPNs and macrocycles through supramolecular approach.
Supramolecular polymer networks (SPNs) possess abundant stimuli-responsive properties due to their reversible non-covalent assembly features, and could be used to build various smart materials. Meanwhile, aggregation-induced emission (AIE), a characteristic optical phenomenon, shows splendid prospect in a wide range of areas. The rapid development of AIE provides a novel chance for the functionalization of SPNs. In addition, macrocycles, each of them possessing their own unique merits, play a key role in constructing various functional supramolecular systems. Hence, the coalescence of macrocycle, AIE and SPNs into the macrocycle-assembled AIE-SPNs greatly expanded the properties and applications of this kind of supramolecular systems. Therefore, macrocycle-assembled AIE-SPNs have attracted more and more attentions. In this review, the mechanisms on self-assembly, AIE, stimuli-responses as well as host–guest interactions have been carefully summarized. Moreover, the structure-effect relationships including cavity size, non-covalent interaction, the type of macrocycles, structures of networks and structures of guest compounds have been discussed. The construction methods, properties and applications of macrocycles-assembled AIE-SPNs have been systematically introduced according to the type of macrocycles including crown ether, cyclodextrin, calixarene, cucurbitnuril, pillarnarene and other novel macrocycles. Moreover, the challenges and bright future of macrocycle-assembled AIE-SPNs also have been described.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Nonalcoholic fatty liver disease(NAFLD)has emerged as a common public health problem in recent decades.However,the underlying mechanisms leading to the development of NAFLD are not fully ...understood.The endoplasmic reticulum(ER)stress response has recently been proposed to play a crucial role in both the development of steatosis and progression to nonalcoholic steatohepatitis.ER stress is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed due to the accumulation of unfolded or misfolded proteins.However,delayed or insufficient responses to ER stress may turn physiological mechanisms into pathological consequences,including fat accumulation,insulin resistance,inflammation,and apoptosis,all of which play important roles in the pathogenesis of NAFLD.Therefore,understanding the role of ER stress in the pathogenesis of NAFLD has become a topic of intense investigation.This review highlights the recent findings linking ER stress signaling pathways to the pathogenesis of NAFLD.
Endothelium (EC) is a key component of blood-brain barrier (BBB), and has an important position in the neurovascular unit. Its dysfunction and death after cerebral ischemic/reperfusion (I/R) injury ...not only promote evolution of neuroinflammation and brain edema, but also increase the risk of intracerebral hemorrhage of thrombolytic therapies. However, the mechanism and specific interventions of EC death after I/R injury are poorly understood. Here we showed that necroptosis was a mechanism underlying EC death, which promoted BBB breakdown after I/R injury. Treatment of rats with receptor interacting protein kinase 1 (RIPK1)-inhibitor, necrostatin-1 reduced endothelial necroptosis and BBB leakage. We furthermore showed that perivascular M1-like microglia-induced endothelial necroptosis leading to BBB disruption requires tumor necrosis factor-α (TNF-α) secreted by M1 type microglia and its receptor, TNF receptor 1 (TNFR1), on endothelium as the primary mediators of these effects. More importantly, anti-TNFα (infliximab, a potent clinically used drug) treatment significantly ameliorate endothelial necroptosis, BBB destruction and improve stroke outcomes. Our data identify a previously unexplored role for endothelial necroptosis in BBB disruption and suggest infliximab might serve as a potential drug for stroke therapy.
Phenazine derivatives for optical sensing: a review Xiao-Ni, Qi; Dang, Li-Rong; Qu, Wen-Jun ...
Journal of materials chemistry. C, Materials for optical and electronic devices,
01/2020, Volume:
8, Issue:
33
Journal Article
Peer reviewed
Phenazine exhibiting an electron-deficient skeleton, lone pair of electrons on nitrogen atoms, and other properties (such as tunable structures, excellent optical performance and proper binding ...abilities) can effectively sense target ions or molecules
via
non-covalent interactions, involving hydrogen bonds, anion-π interactions, metal coordination and other weak forces. These distinct characteristics enable phenazine derivatives to be available in variety of sensors, which have already been demonstrated successfully in the field of sensing. More importantly, phenazine derivatives can be potentially applied in biosensors. Therefore, the latest progress related to the application of phenazine derivatives in optical sensing is summarized. It is expected that phenazine derivatives will garner much interest in the fabrication of sensors and bio sensing applications in the near future.
Phenazine exhibiting an electron-deficient skeleton, lone pair of electrons on nitrogen atoms, and other properties (such as tunable structures, excellent optical performance and proper binding abilities) can effectively sense target ions or molecules
via
non-covalent interactions, involving hydrogen bonds, anion-π interactions, metal coordination and other weak forces.
The aim of this study was to investigate the effects of forkhead box protein P3 (FOXP3) intron single nucleotide variants (SNVs) in high‐risk human papilloma virus (HR‐HPV) infection and cervical ...cancer (CC) malignant lesions. We performed FOXP3 genotyping in 350 patients with CC and 350 healthy controls using the ImLDR multiple single nucleotide polymorphism genotyping technology. The heterozygous mutation TC in rs2294021 decreased the risk of HR‐HPV infection and CC malignant lesions (TC vs. TT: OR = 0.71, 95% CI = 0.51–0.99); the dominant model TC+CC and allele C in rs2294021 decreased the risk of CC malignant lesions (TC+CC vs. TT: OR = 0.69, 95% CI = 0.50–0.95; C vs. T: OR = 0.78, 95% CI = 0.63–0.97). The heterozygous mutation GA, dominant model GA+AA and allele A in rs3761549 also decreased the risk of HR‐HPV infection and CC malignant lesions (GA vs. GG: OR = 0.70, 95% CI = 0.51–0.96; GA+AA vs. GG: OR = 0.69, 95% CI = 0.51–0.94; A vs. G: OR = 0.75, 95% CI = 0.58–0.96). Patients with CC and HR‐HPV infection carrying rs2294021 TC and rs3761549 GA had lower expression of FOXP3 protein. Haplotype analysis revealed that T‐C‐A decreased the risk of HR‐HPV infection. Furthermore, we found a significant association between immune cells infiltration and prognosis in patients with CC. Our findings demonstrated that rs2294021 and rs3761549 variants may protect against HR‐HPV and CC malignant lesions by downregulating FOXP3 and that FOXP3 was associated with immune cells infiltration, which affected the prognosis of CC.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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