Occult peritoneal metastasis (PM) in advanced gastric cancer (AGC) patients is highly possible to be missed on computed tomography (CT) images. Patients with occult PMs are subject to late detection ...or even improper surgical treatment. We therefore aimed to develop a radiomic nomogram to preoperatively identify occult PMs in AGC patients.
A total of 554 AGC patients from 4 centers were divided into 1 training, 1 internal validation, and 2 external validation cohorts. All patients’ PM status was firstly diagnosed as negative by CT, but later confirmed by laparoscopy (PM-positive n = 122, PM-negative n = 432). Radiomic signatures reflecting phenotypes of the primary tumor (RS1) and peritoneum region (RS2) were built as predictors of PM from 266 quantitative image features. Individualized nomograms of PM status incorporating RS1, RS2, or clinical factors were developed and evaluated regarding prediction ability.
RS1, RS2, and Lauren type were significant predictors of occult PM (all P < 0.05). A nomogram of these three factors demonstrated better diagnostic accuracy than the model with RS1, RS2, or clinical factors alone (all net reclassification improvement P < 0.05). The area under curve yielded was 0.958 95% confidence interval (CI) 0.923–0.993, 0.941 (95% CI 0.904–0.977), 0.928 (95% CI 0.886–0.971), and 0.920 (95% CI 0.862–0.978) for the training, internal, and two external validation cohorts, respectively. Stratification analysis showed that this nomogram had potential generalization ability.
CT phenotypes of both primary tumor and nearby peritoneum are significantly associated with occult PM status. A nomogram of these CT phenotypes and Lauren type has an excellent prediction ability of occult PM, and may have significant clinical implications on early detection of occult PM for AGC.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Aim To investigate the potential of iodine concentration (IC) determined using virtual monochromatic spectral computed tomography (CT) to predict the response of gastric carcinomas to preoperative ...neoadjuvant chemotherapy (NC). Materials and methods A total of 20 patients were enrolled who underwent two spectral CT examinations (1 week before and two cycles after NC). The percentage change in tumour thickness (%ΔCWT) and in IC on the arterial phase (%ΔIC-a) and venous phase (%ΔIC-v) after NC were calculated and compared for different histopathological regression grades and response groups. The diagnostic efficacies to discriminate good response (GR) and poor response (PR) of the above three parameters were evaluated using receiver operating characteristic (ROC) curves. Results The decrease rate of %ΔIC-a for the GR group was higher than that for the PR group (−0.59 −0.76, −0.20 versus −0.11 −0.75, 0.92, p =0.012). There was no significant difference in the %ΔIC-v and %ΔCWT values between the GR and PR groups ( p =0.076 and p =0.779, respectively). The areas under the ROC curve (AUC) values were 0.857, 0.762, and 0.542 for %ΔIC-a, %ΔIC-v, and %ΔCWT, respectively, in the response prediction. The cut-off value for identifying PR was a decrease rate of <52.9% for %ΔIC-a, and the sensitivity and specificity values were 0.857 and 0.833. Conclusion Changes in the IC for gastric carcinomas following NC were detected using spectral CT and correlated with histopathological regression. The prediction efficacy for IC was better than that for tumour thickness, with IC on the arterial phase being a better predictor than IC on the venous phase.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
An overview of Sun–Sky Radiometer Observation Network (SONET) measurements in China is presented. Based on observations at 16 distributed SONET sites in China, atmospheric aerosol parameters are ...acquired via standardization processes of operational measurement, maintenance, calibration, inversion, and quality control implemented since 2010. A climatology study is performed focusing on total columnar atmospheric aerosol characteristics, including optical (aerosol optical depth, ÅngstrÖm exponent, fine-mode fraction, single-scattering albedo), physical (volume particle size distribution), chemical composition (black carbon; brown carbon; fine-mode scattering component, coarse-mode component; and aerosol water), and radiative properties (aerosol radiative forcing and efficiency). Data analyses show that aerosol optical depth is low in the west but high in the east of China. Aerosol composition also shows significant spatial and temporal variations, leading to noticeable diversities in optical and physical property patterns. In west and north China, aerosols are generally affected by dust particles, while monsoon climate and human activities impose remarkable influences on aerosols in east and south China. Aerosols in China exhibit strong light-scattering capability and result in significant radiative cooling effects.
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BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We report the first experimental demonstration of quantum entanglement among ten spatially separated single photons. A near-optimal entangled photon-pair source was developed with simultaneously a ...source brightness of ∼12 MHz/W, a collection efficiency of ∼70%, and an indistinguishability of ∼91% between independent photons, which was used for a step-by-step engineering of multiphoton entanglement. Under a pump power of 0.57 W, the ten-photon count rate was increased by about 2 orders of magnitude compared to previous experiments, while maintaining a state fidelity sufficiently high for proving the genuine ten-particle entanglement. Our work created a state-of-the-art platform for multiphoton experiments, and enabled technologies for challenging optical quantum information tasks, such as the realization of Shor's error correction code and high-efficiency scattershot boson sampling.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
Aims
The goal was to investigate the dynamics of soil bacterial community in the chronosequence tea orchards.
Method and Results
In this study, soils from tea orchards with continuously cropping ...histories for 1, 10 and 20 years were collected for investigating rhizosphere bacterial communities using 454 pyrosequencing. The results indicated that Gammaproteobacteria, Alphaproteobacteria, Acidobacteria and Actinobacteria were the main phyla in the tea orchard soils and accounted for more than 60% of the bacterial sequences. At the genus level, the relative abundance of beneficial bacteria, such as Pseudomonas, Rhodanobacter, Bradyrhizobium, Mycobacterium and Sphingomonas, significantly decreased in the 20‐year tea orchard soils. Similar patterns of bacterial community structure were observed between 1‐year and 10‐year tea orchards, which significantly differed from those of 20‐year tea orchards. Redundancy analysis indicated that soil organic carbon and pH showed high correlations (positive or negative) with the majority of the taxa.
Conclusion
Long‐term tea cultivation altered the composition and structure of soil bacterial community, which led to the reduction in the beneficial bacteria.
Significance and Impact of the Study
The results can provide clues on how to regulate the soil microbial community and maintain the health of soils in tea orchard systems.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
This paper presents the procedure and results of the radiance-based validation approach for the Moderate Resolution Imaging Spectroradiometer (MODIS) Land-Surface Temperature (LST) product. Surface ...emissivity spectra were retrieved by a sun-shadow method from surface-leaving radiance spectra measured with a thermal infrared (TIR) spectroradiometer in the 3.5-14 µm spectral region under sunshine and sun-shadow conditions. By using the measured surface emissivity spectrum and atmospheric profiles obtained by radiosonde balloons, and the LST values at validation sites in the V5 MODIS level-2 LST products, radiative transfer simulations were made with the MODTRAN4 code to calculate the top-of-atmosphere (TOA) radiance values in MODIS band 31 (L31). By adjusting the LST input values in the simulations to match the calculated L31 values to the MODIS measured radiance (MOD L31) values, MOD L31 inverted LSTs can be obtained. The MODIS LST product was validated by comparison to the values of the MOD L31 inverted LSTs. This approach compares well with the conventional temperature-based approach. The results of the radiance-based validation indicate that the accuracy of the MODIS LST product is better than 1 K in most cases, including lake, vegetation and soil sites in clear-sky conditions. The errors in the split-window retrieved LSTs may be larger in bare soil sites and highly heterogeneous sites due to large uncertainties in surface emissivities. The results of the radiance-based validation also reveal the weakness of the split-window algorithm used for the generation of the MODIS LST product in two situations: one in cases where LSTs are larger than the air temperature at the surface level (T
s-air
) by more than 16 K and the columnar water vapour (cwv) is larger than 1.5 cm, and another in cases under the influence of thin cirrus clouds or heavy aerosol loadings. These two situations were not considered in the development of the current MODIS LST algorithm.
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BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
Background
The expression of chronic rhinosinusitis (CRS) is multidimensional. Disease heterogeneity in patients with CRS remains poorly understood. This study aimed to identify endotypes of CRS ...using cluster analysis by integrating multidimensional characteristics and to explore their association with treatment outcomes.
Methods
A total of 28 clinical variables and 39 mucosal cellular and molecular variables were analyzed using principal component analysis. Cluster analysis was performed on 246 prospectively recruited Chinese CRS patients with at least 1‐year postoperative follow‐up. Difficult‐to‐treat CRS was characterized in each generated cluster.
Results
Seven subject clusters were identified. Cluster 1 (13.01%) was comparable to the classic well‐defined eosinophilic CRS with polyps, having severe disease and the highest proportion of difficult‐to‐treat CRS. Patients in cluster 2 (16.26%) and cluster 4 (13.82%) had relatively lower proportions of presence of polyps and presented mild inflammation with moderate proportions of difficult‐to‐treat cases. Subjects in cluster 2 were highly atopic. Cluster 3 (7.31%) and cluster 6 (21.14%) were characterized by severe or moderate neutrophilic inflammation, respectively, and with elevated levels of IL‐8 and high proportions of difficult‐to‐treat CRS. Cluster 5 (4.07%) was a unique group characterized by the highest levels of IL‐10 and lacked difficult‐to‐treat cases. Cluster 7 (24.39%) demonstrated the lowest symptom severity, a low proportion of difficult‐to‐treat CRS, and low inflammation load. Finally, we found that difficult‐to‐treat CRS was associated with distinct clinical features and biomarkers in the different clusters.
Conclusions
Distinct clinicopathobiologic clusters of CRS display differences in clinical response to treatments and characteristics of difficult‐to‐treat CRS.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Face Alignment in Full Pose Range: A 3D Total Solution Zhu, Xiangyu; Liu, Xiaoming; Lei, Zhen ...
IEEE transactions on pattern analysis and machine intelligence,
2019-Jan.-1, 2019-01-00, 2019-1-1, 20190101, Volume:
41, Issue:
1
Journal Article
Peer reviewed
Open access
Face alignment, which fits a face model to an image and extracts the semantic meanings of facial pixels, has been an important topic in the computer vision community. However, most algorithms are ...designed for faces in small to medium poses (yaw angle is smaller than 45 degree), which lack the ability to align faces in large poses up to 90 degree. The challenges are three-fold. First, the commonly used landmark face model assumes that all the landmarks are visible and is therefore not suitable for large poses. Second, the face appearance varies more drastically across large poses, from the frontal view to the profile view. Third, labelling landmarks in large poses is extremely challenging since the invisible landmarks have to be guessed. In this paper, we propose to tackle these three challenges in an new alignment framework termed 3D Dense Face Alignment (3DDFA), in which a dense 3D Morphable Model (3DMM) is fitted to the image via Cascaded Convolutional Neural Networks. We also utilize 3D information to synthesize face images in profile views to provide abundant samples for training. Experiments on the challenging AFLW database show that the proposed approach achieves significant improvements over the state-of-the-art methods.
In this study, we report nonmetal plasmonic MoS2@TiO2 heterostructures for highly efficient photocatalytic H2 generation. Large area laminated MoS2 in conjunction with TiO2 nanocavity arrays is ...achieved via carefully controlled anodization, physical vapor deposition, and chemical vapor deposition processes. The broad spectral response ranging from ultraviolet-visible (UV-vis) to near-infrared (NIR) wavelengths and finite element frequency-domain simulations suggest that this MoS2@TiO2 heterostructure enhances photocatalytic activity for H+ reduction. A high H2 yield rate of 181 μmol h−1 cm−2 (equal to 580 mmol h−1 g−1 based on the loading mass of MoS2) is achieved using a low catalyst loading mass. The spatially uniform heterostructure, correlated with plasmon-resonance through the conformal MoS2 coating that effectively regulates charge transfer pathways, is proven to be vitally important for the unique solar energy harvesting and photocatalytic H2 production. As an innovative exploration, our study demonstrates that the photocatalytic activities of nonmetal, earth-abundant materials can be enhanced with plasmonic effects, which may serve as an excellent catalytic agent for solar energy conversion to chemical fuels.
Pursuing topological phases in natural and artificial materials is one of the central topics in modern physical science and engineering. In classical magnetic systems, spin waves (or magnons) and ...magnetic solitons (such as domain wall, vortex, skyrmion, etc.) represent two important excitations. Recently, the topological insulator and semimetal states in magnon- and soliton-based crystals (or metamaterials) have attracted growing attention owing to their interesting dynamics and promising applications for designing robust spintronic devices. Here, we give an overview of current progress of topological phases in structured classical magnetism. We first provide a brief introduction to spin waves and their band structure in periodic lattices. Then, we elaborate typical topological invariants and pedagogical models that are important to understand the topological nature of magnons, such as the magnon Hall effect, topological magnon insulators, Dirac (Weyl) magnon semimetals, topological magnon polarons (magnon–phonon hybrid excitations), and higher-order topological magnons. Appealing proposal of topological magnonic devices is also highlighted. We then review the collective-coordinate approach for describing the dynamics of magnetic soliton lattice. We focus on the topological properties of magnetic solitons, by theoretically analyzing the first-order topological insulating phases in low dimensional systems and higher-order topological states in breathing crystals. Finally, we discuss the experimental realization and detection of the edge states in both magnonic and solitonic crystals. We remark the challenges and future prospects before concluding this article.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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