Great challenges remain concerning the cost‐effective manufacture of high‐performance metal meshes for transparent glass heaters (TGHs). Here, a high‐performance silver mesh fabrication technique is ...proposed for TGHs using electric‐field‐driven microscale 3D printing and a UV‐assisted microtransfer process. The results show a more optimal trade‐off in sheet resistance (Rs = 0.21 Ω sq−1) and transmittance (T = 93.9%) than for indium tin oxide (ITO) and ITO substitutes. The fabricated representative TGH also exhibits homogeneous and stable heating performance, remarkable environmental adaptability (constant Rs for 90 days), superior mechanical robustness (Rs increase of only 0.04 in harsh conditions–sonication at 100 °C), and strong adhesion force with a negligible increase in Rs (2–12%) after 100 peeling tests. The practical viability of this TGH is successfully demonstrated with a deicing test (ice cube: 21 cm3, melting time: 78 s, voltage and glass thickness: 4 V, 5 mm). All of these advantages of the TGHs are attributed to the successful fabrication of silver meshes with high resolution and high aspect ratio on the glass substrate using the thick film silver paste. The proposed technique is a promising new tool for the inexpensive fabrication of high‐performance TGHs.
A high‐performance silver mesh fabrication technique is proposed for transparent glass heaters using electric‐field‐driven microscale 3D printing and a UV‐assisted microtransfer process. The silver mesh exhibits excellent photoelectric properties with Rs = 0.21 Ω sq−1 at T = 93.9%. Despite the mechanical robustness tests, adhesion fatigue, and operational stability tests, the comprehensive performance of silver mesh is hardly changed.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Mesenchymal stem cells (MSCs) can effectively regulate immune cell functions and therefore are promising for the treatment of autoimmune disorders, such as immune thrombocytopenia (ITP). Recent ...research has shown that three-dimensional (3D) culture method have many advantages over conventional culture with respect to MSC secretion and immunogenicity. In this study, 2D and 3D cultured MSCs were used to evaluate cytokine secretion, extracellular matrix (ECM) gene expression, immune regulatory activity, and therapeutic effects in a mouse model of ITP. MSCs cultured on scaffolds had higher expression levels of immune regulatory genes, such as IDO1, HLA-G, and PTGS2, and greater inhibitory activity against lymphocyte activation that those of 2D-MSCs. In addition, 3D-MSCs exhibited higher ECM expression and greater protection against interferon-γ (IFN-γ)-induced apoptosis. In a mouse study, ITP was induced by guinea pig anti-mouse platelet serum injections. Based on enzyme-linked immunosorbent assays, serum levels of the suppressive cytokine interleukin (IL)-10 were higher and IFN-γ levels were lower after intravenous injection with 3D-MSCs and with 2D-MSCs. Additionally, 3D-MSCs improved the body weight, spleen index, and platelet index relative to those for 2D-MSCs. Bone marrow homing was also significantly enhanced in the 3D group. Therefore, the 3D culture of MSCs is an effective technique for the treatment of ITP.
Computer-aided highly efficient electromagnetic particle-in-cell (PIC) (CHIPIC) code, developed at the University of Electronic Science and Technology of China, is a fully computer-aided code which ...combines modeling, calculations, and analysis with an integrated environment. CHIPIC is specifically designed for efficient modeling and simulation. CHIPIC includes a computer-aided design (CAD) system and a physical kernel. The CAD system is designed based on the common flowchart of PIC simulation to provide efficient modeling and analysis, and the physical kernel is developed to provide fast and accurate calculations. The physical kernel can run on a single processor or in parallel mode. When it runs in parallel mode, the message-pass interface and open specifications for multiprocessing are adopted. The validity of this electromagnetic PIC code is proved by simulating a magnetically insulated transmission-line-oscillator tube.
The primary objective of this work was to delve into the potential therapeutic advantages and dissect the molecular mechanisms of salidroside in enhancing erectile function in rats afflicted with ...diabetic microvascular erectile dysfunction (DMED), addressing both the whole-animal and cellular dimensions.We established a DMED model in Sprague‒Dawley (SD) rats and conducted in vivo experiments. The DMED rats were administered varying doses of salidroside, the effects of which on DMED were compared. Erectile function was evaluated by applying electrical stimulation to the cavernous nerves and measuring intracavernous pressure in real time. The penile tissue underwent histological examination and Western blotting. Hydrogen peroxide (H2O2) was employed in the in vitro trial to induce an oxidative stress for the purpose of identifying alterations in cell viability. The CCK-8 assay was used to measure the viability of corpus cavernous smooth muscle cells (CCSMCs) treated with vs. without salidroside. Flow cytometry was utilized to detect alterations in intracellular reactive oxygen species (ROS). Apoptosis was assessed through Western blotting and TdT-mediated dUTP nick-end labelling (TUNEL). Animal and cellular experiments indicate that the Nrf2/HO-1 signalling pathway may be upregulated by salidroside, leading to the improvement of erectile function in diabetic male rats by alleviating oxidative stress and reducing apoptosis in corpus cavernosum tissue.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The performance of a hemispherical resonant gyroscope (HRG) is directly affected by the sphericity error of the thin-walled spherical shell of the hemispherical shell resonator (HSR). In the ...production process of the HSRs, high-speed, high-accuracy, and high-robustness requirements are necessary for evaluating sphericity errors. We designed a sphericity error evaluation method based on the minimum zone criterion with an adaptive number of subpopulations. The method utilizes the global optimal solution and the subpopulations' optimal solution to guide the search, initializes the subpopulations through clustering, and dynamically eliminates inferior subpopulations. Simulation experiments demonstrate that the algorithm exhibits excellent evaluation accuracy when processing simulation datasets with different sphericity errors, radii, and numbers of sampling points. The uncertainty of the results reached the order of 10
mm. When processing up to 6000 simulation datasets, the algorithm's solution deviation from the ideal sphericity error remained around -3 × 10
mm. And the sphericity error evaluation was completed within 1 s on average. Additionally, comparison experiments further confirmed the evaluation accuracy of the algorithm. In the HSR sample measurement experiments, our algorithm improved the sphericity error assessment accuracy of the HSR's inner and outer contour sampling datasets by 17% and 4%, compared with the results given by the coordinate measuring machine. The experiment results demonstrated that the algorithm meets the requirements of sphericity error assessment in the manufacturing process of the HSRs and has the potential to be widely used in the future.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
•A method called APART-QSM is proposed to separate the opposing susceptibilities within a single voxel using a more comprehensive signal model.•APART-QSM is evaluated with phantom, ex-vivo and ...in-vivo experiments.•APART-QSM demonstrates an improved ability to accurately quantify iron and myelin, and also reveals fine brain subregion details.•APART-QSM can handle an arbitrary number of input GRE measurements.
The brain tissue phase contrast in MRI sequences reflects the spatial distributions of multiple substances, such as iron, myelin, calcium, and proteins. These substances with paramagnetic and diamagnetic susceptibilities often colocalize in one voxel in brain regions. Both opposing susceptibilities play vital roles in brain development and neurodegenerative diseases. Conventional QSM methods only provide voxel-averaged susceptibility value and cannot disentangle intravoxel susceptibilities with opposite signs. Advanced susceptibility imaging methods have been recently developed to distinguish the contributions of opposing susceptibility sources for QSM. The basic concept of separating paramagnetic and diamagnetic susceptibility proportions is to include the relaxation rate R2* with R2′ in QSM. The magnitude decay kernel, describing the proportionality coefficient between R2′ and susceptibility, is an essential reconstruction coefficient for QSM separation methods. In this study, we proposed a more comprehensive complex signal model that describes the relationship between 3D GRE signal and the contributions of paramagnetic and diamagnetic susceptibility to the frequency shift and R2* relaxation. The algorithm is implemented as a constrained minimization problem in which the voxel-wise magnitude decay kernel and sub-voxel susceptibilities are determined alternately in each iteration until convergence. The calculated voxel-wise magnitude decay kernel could realistically model the relationship between the R2′ relaxation and the volume susceptibility. Thus, the proposed method effectively prevents the errors of the magnitude decay kernel from propagating to the final susceptibility separation reconstruction. Phantom studies, ex vivo macaque brain experiments, and in vivo human brain imaging studies were conducted to evaluate the ability of the proposed method to distinguish paramagnetic and diamagnetic susceptibility sources. The results demonstrate that the proposed method provides state-of-the-art performances for quantifying brain iron and myelin compared to previous QSM separation methods. Our results show that the proposed method has the potential to simultaneously quantify whole brain iron and myelin during brain development and aging. The proposed model was also deployed with multiple-orientation complex GRE data input measurements, resulting in high-quality QSM separation maps with more faithful tissue delineation between brain structures compared to those reconstructed by single-orientation QSM separation methods.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Here, a novel DC‐excited doubly salient machine with a claw‐shaped modular stator and three‐dimensional (3D) complementary magnetic circuit is proposed for wind power generation application. The key ...is to artificially construct a 3D complementary structure to suppress torque ripple and employ auxiliary slot‐opening PMs to relieve DC‐saturation in the stator core and improve overload capability. The novel 3D complementary structure provides an alternative magnetic path for the main flux, so the flux leakages in the air gap at open‐circuit position are effectively cancelled, and the flux in the yoke remains relatively constant. Hence, the output torque ripple is suppressed. Furthermore, the saturation issue in the stator is solved with auxiliary permanent magnets which have opposite magnetization direction to that of DC field excitation. Therefore, the torque capacity of the machine is improved. Here, the machine structure and operation principle are introduced, and a 2D equivalent model is also developed to replace the 3D model to improve the calculation efficiency. Multi‐objective optimization algorithm is developed to improve the performance of this new machine. The validity of machine design is finally verified with 2D and 3D finite element analysis.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Flexible transparent electrodes (FTEs) with embedded metal meshes play an indispensable role in many optoelectronic devices due to their excellent mechanical stability and environmental adaptability. ...However, low‐cost, simple, efficient, and environmental friendly integrated manufacturing of high‐performance embedded metal meshes remains a huge challenge. Here, a facile and novel fabrication method is proposed for FTEs with an embedded metal mesh via liquid substrateelectric‐field‐driven microscale 3D printing process. This direct printing strategy avoids tedious processes and offers low‐cost and high‐volume production, enabling the fabrication of high‐resolution, high‐aspect ratio embedded metal meshes without sacrificing transparency. The final manufactured FTEs with 80 mm × 80 mm embedded metal mesh offers excellent optoelectronic performance with a sheet resistance (Rs) of 6 Ω sq−1 and a transmittance (T) of 85.79%. The embedded metal structure still has excellent mechanical stability and good environmental suitability under different harsh working conditions. The practical feasibility of the FTEs is successfully demonstrated with a thermally driven 4D printing structure and a resistive transparent strain sensor. This method can be used to manufacture large areas with facile, high‐efficiency, low‐cost, and high‐performance FTEs.
A facile fabrication method for flexible transaprent electrodes (FTEs) with embedded metal mesh is proposed by using liquid substrate electric‐field‐driven (LS‐EFD) microscale 3D printing process. The fabricated FTEs exhibit excellent photoelectric properties, remarkable mechanical stability and environmental adaptability. The practical feasibility of the FTEs is successfully demonstrated with a thermal‐driven 4D printing structure and a resistive transparent strain sensor.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
The Tibetan Plateau (TP) serves as a crucial ecological barrier in Asia, with vegetation playing a pivotal role in the terrestrial ecosystem by facilitating energy exchange between the land and ...atmosphere, regulating climate, and participating in the carbon cycle. In this study, we analyze the characteristics of surface vegetation on the TP in the growing season during 1982–2018 using satellite remote sensing data obtained from the National Oceanic and Atmospheric Administration (NOAA) and China Meteorological Forcing Dataset (CMFD). We investigate how these characteristics respond to climate change under different warming and humidification conditions across the TP. The main conclusions are as follows. (1) The normalized difference vegetation index (NDVI) values on the TP exhibit a gradual decrease from southeast to northwest during the growing season. There is a significant overall increasing trend at a climate tendency rate of 0.01·decade−1 (p < 0.01) from 1982 to 2018, characterized by a notable mutation of around 1998. Over the past 37 years, a polarized trend of vegetation was observed on the TP, with notable improvement in its central and eastern regions. However, there has been noticeable degradation in northwestern TP, specifically within the Kunlun Mountains and Qaidam Basin. (2) The climate of the TP demonstrates distinct regional disparities in terms of warming and humidification characteristics before and after 1998. During the period of 1982–1998 (1998–2018), the temperature increase is primarily concentrated in the northern (southern) TP, while precipitation increase is mainly observed in the southern and northwestern (northeastern and western) regions of the TP. (3) The responses of surface vegetation to climate factors exhibit significant variations across diverse climatic backgrounds. It is noteworthy that moisture conditions have a substantial impact on the response of vegetation to air temperature on the TP. During the period of 1982–1998, under relatively insufficient moisture conditions, a positive correlation was observed between air temperature and surface vegetation in the humid and semi-humid regions of the southeastern TP, while a negative correlation was found in the semi-arid regions of northeastern TP. During 1998–2018, as moisture conditions became relatively sufficient, surface vegetation in the semi-arid regions showed positive correlations with both temperature and precipitation. However, surface vegetation in the humid and semi-humid regions exhibited a significant negative correlation with precipitation. During this period, the synergistic effects between warm and humid climates in the semi-arid regions of northeastern TP and warm and dry climates in humid and semi-humid regions of southeastern TP substantially enhanced surface vegetation on the TP. Furthermore, our results indicate that thermal factors (air temperature) primarily influence variations in surface vegetation within the high-altitude arid region of the TP. During 1998–2018, a significant cooling trend was observed in the northwestern TP, which could potentially account for the degradation of surface vegetation in the Kunlun Mountains. The findings of this study establish a scientific basis for the sustainable development of grassland ecosystems on the TP.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Background Although immunotherapy shows tremendous potential in the treatment of bladder cancer (BLCA), the overall prognosis and response rates to immunotherapy in BLCA remain suboptimal. Methods We ...performed an extensive evaluation of glycosyltransferase expression patterns in BLCA patients by analyzing 210 glycosyltransferase-related genes. Subsequently, we established correlations between these glycosyltransferase patterns, prognosis, and tumor microenvironment (TME) phenotypes. To offer personalized patient assessments, we developed a glycosyltransferase risk score that accurately predicts prognosis, TME phenotypes, and molecular subtypes. Importantly, we developed a RNA-seq cohort, named Xiangya cohort, to validate our results. Results Two distinct patterns of glycosyltransferase expression were identified, corresponding to inflamed and noninflamed TME phenotypes, and demonstrated the potential to predict prognosis. We developed and validated a comprehensive risk score that accurately predicted individual patient prognosis in the TCGA-BLCA cohort. Additionally, we constructed a nomogram that integrated the risk score with several key clinical factors. Importantly, this risk score was successfully validated in external cohorts, including the Xiangya cohort and GSE48075. Furthermore, we discovered a positive correlation between this risk score and tumor-infiltrating lymphocytes in both the TCGA-BLCA and Xiangya cohorts, suggesting that patients with a higher risk score exhibited an inflamed TME phenotype and were more responsive to immunotherapy. Finally, we observed that the high and low risk score groups were consistent with the luminal and basal subtypes of BLCA, respectively, providing further validation of the risk score's role in the TME in terms of molecular subtypes. Conclusions Glycosyltransferase patterns exhibit distinct TME phenotypes in BLCA. Our comprehensive risk score provides a promising approach for prognostic prediction and assessment of immunotherapy efficacy, offering valuable guidance for precision medicine. Keywords: Glycosyltransferase, Bladder cancer, Prognosis, Tumor microenvironment, Immunotherapy
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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