Background: Many breast-imaging techniques have been developed as primary clinical methods for identifying early-stage breast cancers and differentiating them from benign breast tumors. For the large ...population of China, any screening method that is rapid, economical, and accurate is worthy of evaluation.
Objective: To compare the effectiveness of mammography, color Doppler ultrasonography, and far-infrared thermography in the screening and early diagnosis of breast cancer.
Methods: Data from 2036 women with breast disease between January 2007 and May 2011 were included in this study. All patients underwent mammography, ultrasonography, and far-infrared thermography imaging. The diagnostic accuracy of the three methods was determined using postoperative pathological results as the diagnostic criterion standard.
Results: There were 480 patients found to have breast malignancies on pathological examination. The lesion diameter was <2 cm in 853 cases. Among them, breast cancer was found in 73 patients and carcinoma in situ in 22 patients. There was no difference in the accuracy of mammography and ultrasonography (96.1% versus 95.8%). However, there were significant differences between the accuracy of far-infrared thermography (97.1%) and ultrasonography and mammography. The sensitivity and specificity of far-infrared thermography was superior to that of mammography and ultrasonography in lesions <2 cm in diameter.
Conclusion: Far-infrared thermography is more accurate for breast cancer screening than ultrasonography and mammography for lesions <2 cm. It has comparable diagnostic accuracy to ultrasound and better diagnostic accuracy than mammography for lesions >2 cm in diameter.
Increasing the density in a tokamak is limited by the so-called density limit, which is generally performed as an appearance of disruption causing loss of plasma confinement, or a degradation of high ...confinement mode which could further lead to a H → L transition. The L-mode and H-mode density limit has been investigated in EAST tokamak. Experimental results suggest that density limits could be triggered by either edge cooling or excessive central radiation. The L-mode density limit disruption is generally triggered by edge cooling, which leads to the current profile shrinkage and then destabilizes a 2/1 tearing mode, ultimately resulting in a disruption. The L-mode density limit scaling agrees well with the Greenwald limit in EAST. The observed H-mode density limit in EAST is an operational-space limit with a value of 0.8∼0.9nGW. High density H-mode heated by neutral beam injection (NBI) and lower hybrid current drive (LHCD) are analyzed, respectively. The constancy of the edge density gradients in H-mode indicates a critical limit caused perhaps by e.g. ballooning induced transport. The maximum density is accessed at the H → L transition which is generally caused by the excessive core radiation due to high Z impurities (Fe, Cu). Operating at a high density (>2.8×1019 m−3) is favorable for suppressing the beam shine through NBI. High density H-mode up to 5.3×1019 m−3 (∼0.8nGW) could be sustained by 2 MW 4.6 GHz LHCD alone, and its current drive efficiency is studied. Statistics show that good control of impurities and recycling facilitate high density operation. With careful control of these factors, high density up to 0.93nGW stable H-mode operation was carried out heated by 1.7 MW LHCD and 1.9 MW ion cyclotron resonance heating with supersonic molecular beam injection fueling.
Abstract 3850
Human bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent nonhematopoietic progenitor cells, which can differentiate into osteoblasts, adipocytes, chondrocytes and ...other tissues. The most important function of BM-MSCs is to support hematopoiesis. Toll-like receptors (TLRs) are a conserved family of receptors that can be activated by both pathogen components and mammalian endogenous molecules such as heat-shock proteins and extracellular matrix breakdown products. In the past a few year, several studies reported that TLRs are expressed in hematopoietic and non-hematopoietic to modulate their biological functions. We hypothesized that MSCs are equipped with TLRs that enable them to dynamically change hematopoiesis-related cytokines expression pattern and level by sensing correspondent agonists, thus efficiently supporting hematopoiesis.
In this study, BM-MSCs were analyzed for mRNA expression of TLR 1–9 by reverse transcription-polymerase chain reaction. TLR 1–6, but not TLR 7–9 were expressed by MSCs. The expression of TLR2 and TLR4 was also confirmed by flow cytometic assay. We further explored the role of TLR2 and TLR4 in mediating the capacity of MSC to support the proliferation and differentiation of CD34+ cells. The pre-stimulation with TLR2 agonists (Pam3Cys) or TLR4 agonists (LPS) enable MSCs to enhance CD34+ cells proliferation and promote CD34+ cells differentiation towards the myeloid lineage (CD33+, CD11b+), as well as granulocyte colony formation by those cells. The production of interleukin 8 (IL-8), IL-11, stem cell factor (SCF), granulocyte colony-stimulating factor (CSF), macrophage CSF and granulocyte-macrophage CSF were also increased by stimulated MSCs. Interestingly, although Pam3Cys and LPS displayed different inductive magnitudes, they have no synergistic effect on MSCs. We hypothesized there may be some antagonistic effect between TLR2 and TLR4 intracellular signal conductive pathway, or they can downregulate the expressive level of the TLRs on MSCs.
Together, our findings suggest that TLR2 and TLR4 signalings may indirectly regulate hematopoiesis by modulating MSCs' functions. The increased haemopoietic proliferation and myeloid lineage differentiation could be mediated, at least in part, by augmented hematopoiesis-related cytokine production.
Wang:National Natural Science Foundation (30700329): Research Funding; Anhui Provincial Outstanding Young Investigator Program (08040106810): Research Funding; Fund of Anhui Provincial “115” Industrial Innovation Program: Research Funding.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Gödel Xiang, Wu; Li, Yakun; Ren, Yuquan ...
Proceedings of the 2023 ACM Symposium on Cloud Computing,
10/2023
Conference Proceeding
Over the last few years, at ByteDance, our compute infrastructure scale has been expanding significantly due to expedited business growth. In this journey, to meet hyper-scale growth, some business ...groups resorted to managing their own compute infrastructure stack running different scheduling systems such as Kubernetes, YARN which created two major pain points: the increasing resource fragmentation across different business groups and the inadequate resource elasticity between workloads of different business priorities. Isolation across different business groups (and their compute infrastructure management) leads to inefficient compute resource utilization and prevents us from serving the business growth needs in the long run.
To meet these challenges, we propose a resource management and scheduling system named Gödel, which provides a unified compute infrastructure for all business groups to run their diverse workloads under a unified resource pool. It co-locates various workloads on every machine to achieve better resource utilization and elasticity. Gödel is built upon Kubernetes, the de facto open-source container orchestration system, but with significant components replaced or enhanced to accommodate various workloads at a large scale. In production, it manages clusters with tens of thousands of machines, achieves high overall resource utilization of over 60%, and scheduling throughput of up to 5000 pods per second. This paper reports on our design and implementation with Gödel. Moreover, it discusses the lessons and best practices we learned in developing and operating it in production at ByteDance's scale.
The Large High-Altitude Air Shower Observatory (LHAASO) is being built at Haizi Mountain, Sichuan province of China at an altitude of 4410 meters. One of its main goals is to survey the northern sky ...for very-high-energy gamma ray sources via its ground-based water Cherenkov detector array (WCDA). 900 8-inch photomultiplier tubes (PMTs) CR365-02-1 from Beijing Hamamatsu Photon Techniques INC. (BHP) are installed in the WCDA, collecting Cherenkov photons produced by air shower particles crossing water. The design of the PMT base with a high dynamic range for CR365-02-1, the PMT batch test system, and the test results of 997 PMTs are presented in this paper.
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