In this study, the phospholipid species i.e., phosphatidylethanolamine (PE), phosphatidylcholine (PC), and sphingomyelin (SM) in human milk (HM) were compared according to their fatty acid (FA) ...composition. 34 HM samples were collected and classified into three groups (A < B < C) according to their fat content. Stearic acid (C18:0) was the main FA in PE, PC, and SM. The highest concentrations of arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosapentaenoic acid (DPA) were observed in PE, whereas docosahexaenoic acid (DHA) was predominant in SM. Although PC exhibited the highest total saturated FAs (SFAs) and PE contained the highest unsaturated FAs (UFAs), very long-chain SFAs and monounsaturated FAs (MUFAs) were preferentially distributed in SM. PC and SM had higher saturation compared to PE. Regarding the effect of the fat content of HM on the FA composition of the phospholipid species, a limited influence was observed on the composition of SFAs and MUFAs of PE, SM, and particularly PC. However, a more pronounced effect on the composition of polyunsaturated FAs (PUFAs) in phospholipids was observed, especially for linoleic acid (LA), α-linolenic acid (ALA), EPA, and DHA, indicating that the composition of FAs in the phospholipid species was probably affected by the maternal diet.
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•T-BTA complex with Eu3+ formed nanostructured fibers by the intermolecular H-bonding.•The strong blue emission of 1-Eu was selectively quenched upon adding UO22+.•An electrospun film ...incorporating 1–Eu recognized high selectivity for UO22+.
Uranyl is a radioactive, toxic pollutant commonly found in the waste remaining after nuclear fuel reprocessing, and it poses several types of risks to human health; therefore, developing absorbents and chemical probes for this compound is crucial to overcoming these issues. This study examined the sensing abilities of terpyridine-appended benzenetricarboxyamide (T-BTA) as a chromogenic probe for detecting uranyl ions (UO22+). The complex with Eu3+ (1–Eu) spontaneously formed nanostructured fibers in H2O owing to the triamide groups of T-BTA, which induced intermolecular hydrogen-bonding interactions. The strong blue emission of these nanofibers in H2O was quenched upon adding UO22+ but not upon adding any other metal ion. This high selectivity was probably because of the interactions between the nitrigen atoms of the terpyridine moieties of 1 and UO22+. Furthermore, the 1–Eu nanofibers assumed spherical morphologies when UO22+ was added. To develop a convenient UO22+ sensor, an electrospun film incorporating 1–Eu (ESF–1–Eu) was manufactured, and it exhibited high selectivity for UO22+ over a variety of rival metal ions. The plot for luminescence change of ESF–1–Eu vs UO22+ concentrations in seawater samples showed a good linearty. Thus, the ESF–1–Eu shows potential as a useful sensor for detecting and removing UO22+ in H2O.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The failure to trigger mitophagy is implicated in the pathogenesis of familial Parkinson disease that is caused by PINK1 or Parkin mutations. According to the prevailing PINK1-Parkin signaling model, ...mitophagy is promoted by the mitochondrial translocation of Parkin, an essential PINK1-dependent step that occurs via a previously unknown mechanism. Here we determined that critical concentrations of NO was sufficient to induce the mitochondrial translocation of Parkin even in PINK1 deficiency, with apparent increased interaction of full-length PINK1 accumulated during mitophagy, with neuronal nitric oxide synthase (nNOS). Specifically, optimum levels of NO enabled PINK1-null dopaminergic neuronal cells to regain the mitochondrial translocation of Parkin, which appeared to be significantly suppressed by nNOS-null mutation. Moreover, nNOS-null mutation resulted in the same mitochondrial electron transport chain (ETC) enzyme deficits as PINK1-null mutation. The involvement of mitochondrial nNOS activation in mitophagy was further confirmed by the greatly increased interactions of full-length PINK1 with nNOS, accompanied by mitochondrial accumulation of phospho-nNOS (Ser(1412)) during mitophagy. Of great interest is that the L347P PINK1 mutant failed to bind to nNOS. The loss of nNOS phosphorylation and Parkin accumulation on PINK1-deficient mitochondria could be reversed in a PINK1-dependent manner. Finally, non-toxic levels of NO treatment aided in the recovery of PINK1-null dopaminergic neuronal cells from mitochondrial ETC enzyme deficits. In summary, we demonstrated the full-length PINK1-dependent recruitment of nNOS, its activation in the induction of Parkin translocation, and the feasibility of NO-based pharmacotherapy for defective mitophagy and ETC enzyme deficits in Parkinson disease.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Purpose: Coronavirus disease 2019 (COVID-19) has affected many parts of daily life and healthcare, including cancer screening and diagnosis. The purpose of this study was to determine whether there ...was an upshift in the colorectal cancer stage at diagnosis due to delays related to the COVID-19 outbreak.Methods: From January to June of each year from 2017 to 2020, a total of 3,229 patients who were first diagnosed with colorectal cancer were retrospectively reviewed. Those enrolled from 2017 to 2019 were classified as the ‘pre-COVID’ group, and those enrolled in 2020 were classified as the ‘COVID’ group. The primary outcome was the rate of stage IV disease at the time of diagnosis.Results: There was no statistically significant difference in the proportion of stage IV patients between the pre-COVID and COVID groups (P=0.19). The median preoperative carcinoembryonic antigen level in the COVID group was higher than in the pre-COVID group in all stages (all P<0.05). In stage I, II patients who underwent radical surgery, the lymphatic invasion was more presented in COVID patients (P=0.009).Conclusion: We did not find significant stage upshifting in colorectal cancer during the COVID-19 outbreak. However, there were more initially unresectable stage IV colorectal cancer patients with a low conversion rate to resectable status, and more patients had factors related to poor prognosis. These results may become more apparent over time, so it is vital not to neglect cancer screening to not delay the diagnosis during the COVID-19 epidemic.
Background
This study aimed to compare the short‐term postoperative outcomes of single‐port robotic (SPR) using da Vinci SP® system and single port laparoscopic (SPL) right hemicolectomy and ...determine whether the novel SPR system is safe and feasible.
Methods
From January 2019 to December 2020, a total of 141 patients (41 patients for SPR and 100 patients for SPL) who electively underwent right hemicolectomy for colon cancer performed by a single surgeon were included in the study.
Results
The time to the first bowel movement was 3 (range, 1–4) days after surgery in the SPR group and 3 (2–9, range) days in the SPL group (p = 0.017). However, there were no differences in pathologic outcomes or postoperative complications.
Conclusions
SPR is a safe and feasible surgical technique and has an advantage in the time to first postoperative bowel movement over SPL with no other complications.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
This study investigates how the balance between wind and mass is treated in data assimilation, and how it affects the quality of the model states in an analysis–forecast cycle. This is done in terms ...of the dependence of balance on latitude and on the type of variable. The impact of the nonlinear balance equation is compared with regressed wind–mass balance in the 3‐Dimensional Variational data assimilation (3D‐Var) system of the Korea Institute of Atmospheric Prediction Systems (KIAPS). Its impact is significantly positive in temperature rather than in wind, despite the two‐way influence of the cross‐correlation between wind and mass, in terms of the root‐mean‐square difference (RMSD) of 6 h forecasts against the ERA‐Interim reanalysis data. This temperature effect is observed in the southern hemispheric (SH) polar jet of the mid‐troposphere, the SH midlatitudinal jet, and the mid/lower stratosphere in the Tropics, where there is strong zonal mean flow. Although the zonal wind forecast was harmed by application of the nonlinear balance, the temporal consistency of the damage is relatively weak compared to the improvement by the nonlinear balance in the temperature forecasts.
In the SH midlatitudinal jet and the mid/lower stratosphere in the Tropics, the nonlinear balance equation, including the advection term, improves the quality of temperature RMSDs in the analysis–forecast cycle by imposing the proper balance in the initial conditions. However, in the SH polar jet of the mid‐troposphere, where the observation density is relatively low, the nonlinear balance equation achieves the same effect by reducing the analysis error (i.e. generating initial conditions more accurately). The nonlinear balance equation contributes to robustly improving the model states of the analysis–forecast cycles, depending on the dynamical activity and the observation density of the corresponding regions.
In an Australian‐winter month, the impact of the nonlinear balance equation (NLI), compared to the regressed balance (REG), is significantly positive in temperature rather than in wind. In the SH midlatitudinal jet and the tropical mid/lower stratosphere, the NLI, including the advection term, improves the quality of temperature in the analysis cycle by imposing the proper balance in the initial conditions. In the SH polar front jet of the mid‐troposphere, where the observation density is relatively low, the NLI achieves the same effect by reducing the analysis error.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Adventitial cystic disease (ACD) is a rare condition that causes intermittent claudication and non-atherosclerotic disease without cardiovascular risk factors. The etiology and optimal treatment of ...ACD remain controversial. The purpose of this study was to analyze surgical treatment results for ACD and to elucidate optimal treatment options.
We retrospectively reviewed 30 patients with ACD who underwent surgery from 2006 to 2018. Twenty-two patients had arterial ACD, six had venous ACD, and two had combined venous and arterial ACD. We reviewed demographic and clinical characteristics, treatment details, and procedure outcomes.
Recurrence occurred in 6 cases either after cyst excision alone (4/17) or patch angioplasty (2/2). There was no recurrence after vessel excision with interposition grafting (0/7). Therefore, vessel excision was a statistically significant factor in recurrence prevention (P=0.026). Among the six recurrences, joint connections of the cystic lesions were found in four of the six (66.7%).
As a curative surgery for ACD, vessel excision with interposition grafting is a better strategy to prevent recurrence than simple cyst excision alone.
To accommodate accurate analyses and forecasts of a heavy rainfall event over the Korean Peninsula, the authors assimilated the GPS radio occultation (RO) data by using the Weather Research and ...Forecasting Model (WRF) and its three-dimensional variational data assimilation system (3DVAR). The employed datasets are from the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) and Challenging Minisatellite Payload (CHAMP) missions. The selected case was from late October 2006, which intensively hit the northeastern part of the Korean Peninsula with record-breaking rainfall. In this study, the local refractivity observation operator was used in assimilating GPS RO soundings. The results are more pronounced for the cycling assimilation of GPS RO data than for the one-time data assimilation. From all of the parameters investigated (temperature, geopotential height, specific humidity, and winds), the GPS RO soundings highly modified the moisture distribution in the lower troposphere and also changed the wind field via the model dynamics. For the heavy rainfall forecast, the quantitative accuracy of the precipitation forecast with the GPS RO data assimilation was in good agreement with observations in terms of the maximum rainfall amount and threat scores. The improved forecast in the experiment came from the exact positioning of the low pressure system and its consequent convergence near the rainfall area. When RO data and GPS precipitable water data were assimilated simultaneously, the moisture distribution changed horizontally and vertically such that it increased the amount of rainfall, and an accurate description of the convective system development was feasible.
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BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This study introduces the operational data assimilation (DA) system at the Korea Institute of Atmospheric Prediction Systems (KIAPS) to the numerical weather prediction community. Its development ...history and performance are addressed with experimental illustrations and the authors’ previously published studies. Milestones in skill improvements include the initial operational implementation of three-dimensional variational data assimilation (3DVar), the ingestion of additional satellite observations, and changing the DA scheme to a hybrid four-dimensional ensemble-variational DA using forecasts from an ensemble based on the local ensemble transform Kalman filter (LETKF). In the hybrid system, determining the relative contribution of the ensemble-based covariance to the resultant analysis is crucial, particularly for moisture variables including a variety of horizontal scale spectra. Modifications to the humidity control variable, partial rather than full recentering of the ensemble for humidity further improves moisture analysis, and the inclusion of more radiance observations with higher-level peaking channels have significant impacts on stratosphere temperature and wind performance. Recent update of the operational hybrid DA system relative to the previous 3DVar system is described for detailed improvements with interpretation.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Hybrid four‐dimensional ensemble variational data assimilation (hybrid 4DEnVar) is a prospective successor to three‐dimensional variational data assimilation (3DVar) in operational weather prediction ...centers currently developing a new weather prediction model and those that do not operate adjoint models. In experiments using real observations, hybrid 4DEnVar improved Northern Hemisphere (NH; 20°N–90°N) 500 hPa geopotential height forecasts up to 5 days in a NH summer month compared to 3DVar, with statistical significance. This result is verified against ERA‐Interim through a Monte Carlo test. By a regression analysis, the sensitivity of 5 day forecast is associated with the quality of the initial condition. The increased analysis skill for midtropospheric midlatitude temperature and subtropical moisture has the most apparent effect on forecast skill in the NH including a typhoon prediction case. Through attributing the analysis improvements by hybrid 4DEnVar separately to the ensemble background error covariance (BEC), its four‐dimensional (4‐D) extension, and climatological BEC, it is revealed that the ensemble BEC contributes to the subtropical moisture analysis, whereas the 4‐D extension does to the midtropospheric midlatitude temperature. This result implies that hourly wind‐mass correlation in 6 h analysis window is required to extract the potential of hybrid 4DEnVar for the midlatitude temperature analysis to the maximum. However, the temporal ensemble correlation, in hourly time scale, between moisture and another variable is invalid so that it could not work for improving the hybrid 4DEnVar analysis.
Key Points
The improved analyses of subtropical moisture and midlatitude temperature enhance forecast skills including a typhoon prediction
Ensemble correlation between moisture and another variable is applicable instantaneously
Midlatitude temperature information can be better extracted by the ensemble correlation extended to 6 h window
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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