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  • Functional Role of Mitochon... Functional Role of Mitochondrial DNA in Cancer Progression
    Lin, Yang-Hsiang; Lim, Siew-Na; Chen, Cheng-Yi ... International journal of molecular sciences, 01/2022, Volume: 23, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metabolism. In the ...
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  • DHA Attenuates Cerebral Ede... DHA Attenuates Cerebral Edema Following Traumatic Brain Injury via the Reduction in Blood-Brain Barrier Permeability
    Liu, Zhuo-Hao; Chen, Nan-Yu; Tu, Po-Hsun ... International journal of molecular sciences, 08/2020, Volume: 21, Issue: 17
    Journal Article
    Peer reviewed
    Open access

    Traumatic brain injury (TBI) could result in edema and cause an increase in intracranial pressure of the brain resulting in mortality and morbidity. Although there is hyperosmolarity therapy ...
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  • Transcriptome analysis crea... Transcriptome analysis creates a new era of precision medicine for managing recurrent hepatocellular carcinoma
    Chiang, Chun-Cheng; Yeh, Hsuan; Lim, Siew-Na ... World journal of gastroenterology, 2023-Feb-07, 2023-2-7, 20230207, Volume: 29, Issue: 5
    Journal Article
    Open access

    The high incidence of hepatocellular carcinoma (HCC) recurrence negatively impacts outcomes of patients treated with curative intent despite advances in surgical techniques and other locoregional ...
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  • Efficacy and safety of pera... Efficacy and safety of perampanel in refractory and super-refractory status epilepticus: cohort study of 81 patients and literature review
    Lim, Siew-Na; Wu, Tony; Tseng, Wei-En Johnny ... Journal of neurology, 10/2021, Volume: 268, Issue: 10
    Journal Article
    Peer reviewed

    Background The effective dose of perampanel in status epilepticus (SE), refractory SE (RSE), and super-refractory SE (SRSE) in humans is unknown, and the potential of perampanel in treating SE has ...
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  • An SNP Marker Predicts Colo... An SNP Marker Predicts Colorectal Cancer Outcomes with 5-Fluorouracil-Based Adjuvant Chemotherapy Post-Resection
    Chien, Hao; Chu, Yu-De; Hsu, Yi-Ping ... International journal of molecular sciences, 06/2024, Volume: 25, Issue: 12
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    Colorectal cancer (CRC) is a global health concern, necessitating adjuvant chemotherapy post-curative surgery to mitigate recurrence and enhance survival, particularly in intermediate-stage patients. ...
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  • Aldolase B-driven lactagene... Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the Warburg effect
    Chu, Yu-De; Cheng, Li-Chun; Lim, Siew-Na ... Cell death & disease, 10/2023, Volume: 14, Issue: 10
    Journal Article
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    Open access

    Colorectal cancer (CRC) is a prevalent malignancy worldwide and is associated with a high mortality rate. Changes in bioenergy metabolism, such as the Warburg effect, are often observed in CRC. ...
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  • COX5B-Mediated Bioenergetic... COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma
    Chu, Yu-De; Lin, Wey-Ran; Lin, Yang-Hsiang ... Cancers, 06/2020, Volume: 12, Issue: 6
    Journal Article
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    Open access

    The oxidative phosphorylation machinery in mitochondria, which generates the main bioenergy pool in cells, includes four enzyme complexes for electron transport and ATP synthase. Among them, the ...
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  • Impact of an MT-RNR1 Gene P... Impact of an MT-RNR1 Gene Polymorphism on Hepatocellular Carcinoma Progression and Clinical Characteristics
    Lin, Yang-Hsiang; Chu, Yu-De; Lim, Siew-Na ... International journal of molecular sciences, 01/2021, Volume: 22, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Mitochondrial DNA (mtDNA) mutations are highly associated with cancer progression. The poor prognosis of hepatocellular carcinoma (HCC) is largely due to high rates of tumor metastasis. This ...
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  • Correlation of vocals and l... Correlation of vocals and lyrics with left temporal musicogenic epilepsy
    Tseng, Wei‐En J.; Lim, Siew‐Na; Chen, Lu‐An ... Annals of the New York Academy of Sciences, July 2018, Volume: 1423, Issue: 1
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    Whether the cognitive processing of music and speech relies on shared or distinct neuronal mechanisms remains unclear. Music and language processing in the brain are right and left temporal ...
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  • Optimizing treatment persis... Optimizing treatment persistence in epilepsy: a comparative analysis of combined antiseizure medications with different mechanisms of action
    Chang, Chun-Wei; Tseng, Wei-En Johnny; Lin, Wey-Ran ... Therapeutic advances in neurological disorders, 01/2023, Volume: 16
    Journal Article
    Peer reviewed
    Open access

    Background: Combination therapy with antiseizure medications (ASMs) is a rational strategy if monotherapy cannot effectively control seizures, thereby aiming to improve tolerance and treatment ...
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