This article reviews recent developments in the non-Hermitian skin effect (NHSE), particularly on its rich interplay with topology. The review starts off with a pedagogical introduction on the ...modified bulk-boundary correspondence, the synergy and hybridization of NHSE and band topology in higher dimensions, as well as, the associated topology on the complex energy plane such as spectral winding topology and spectral graph topology. Following which, emerging topics are introduced such as non-Hermitian criticality, dynamical NHSE phenomena, and the manifestation of NHSE beyond the traditional linear non-interacting crystal lattices, particularly its interplay with quantum many-body interactions. Finally, we survey the recent demonstrations and experimental proposals of NHSE.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
•Reaction kinetics of SAs by various oxidants and ROS are summarized.•Transformations and toxicity changes of SAs in different processes are reviewed.•Treatment technologies are compared from both ...reaction rate and product toxicity.•AOPs combined with biochar or metal oxidants is a future trend for SA treatment.•The critical review has strong implications for emerging technological development.
Sulfonamides (SAs) are among the most widely used antibiotics to treat bacterial infections for humans and animals. They are also used in livestock agriculture to improve growth and feed efficiency in many countries. Recent years, there is a growing concern about the environmental fate and treatment technologies of SAs, in order to eliminate their potential impact on the ecosystem and human health. Additionally, SAs are frequently used as model compounds to evaluate the performance of newly developed advanced water treatment processes. Hence, understanding the chemical reaction features of SAs can provide valuable information for further technological development. In this review, the reaction kinetics, abiotic transformations and corresponding ecotoxicity changes of SAs in natural environments and water treatment processes were comprehensively analyzed to draw critical suggestion and new insights. The •OH-based AOP is proposed as an effective method for the elimination of SAs toxicity, although it is susceptible to water constituent due to low selectivity. The application of biochar or metal-based oxidants in AOPs is becoming a future trend for SA treatment. Overall, this review would provide useful information for the development of advanced water treatment technologies and the control of ecological risks related to SAs.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Sulfonamide antibiotics have been frequently detected in the aquatic environment and are of emerging concern due to their adverse bio-effect and potential of inducing antibiotic resistance. This ...study investigated the degradation kinetics of sulfonamide antibiotics in synthetic wastewater and hydrolyzed human urine by low pressure (LP) UV, UV/H2O2 and UV/peroxydisulfate (PDS). Direct photolysis rates of sulfonamide antibiotics varied and depended on the structures. Sulfonamides with a five-membered heterocyclic group underwent faster direct photolysis. For indirect photolysis processes, second-order rate constants of sulfonamide antibiotics with hydroxyl radical, sulfate radical and carbonate radical were determined, which were (6.21–9.26) × 109, (0.77–16.1) × 1010 and (1.25–8.71) × 108 M−1 s−1, respectively. A dynamic model was applied and successfully predicted the degradation kinetics of sulfonamides in different water matrices. In synthetic wastewater, carbonate radical contributed to approximately 10% of the overall removal, whereas in synthetic hydrolyzed urine, carbonate radical was the dominant reactive species to degrade sulfonamides. Sulfonamide antibiotics were eliminated more efficiently in synthetic hydrolyzed urine than in synthetic wastewater and UV/PDS was more efficient than UV/H2O2 to degrade most sulfonamides. Energy evaluation showed that UV/PDS costs less energy than LPUV and UV/H2O2 under the experimental conditions applied in this study, particularly for sulfonamides whose indirect photolysis overweighed direct photolysis. By varying UV dose and oxidant dose, the UV/H2O2 process can be optimized to achieve higher efficiency than the UV/PDS process in synthetic wastewater.
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•Sulfonamides with five-membered heterocyclic group undergo rapid direct photolysis.•Reactivity of ·OH, SO4·− and CO3·− with sulfonamides are quantitatively determined.•Most of the investigated sulfonamides are degraded faster by UV/PDS than by UV/H2O2.•Sulfonamide degradation is mainly due to carbonate radical in hydrolyzed urine.•UV/H2O2 process is more energy-efficient than UV/PDS in synthetic wastewater.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
To minimize environmental pharmaceutical micropollutants, treatment of human urine could be an efficient approach due to the high pharmaceutical concentration and toxic potential excreted in urine. ...This study investigated the degradation kinetics and mechanisms of sulfamethoxazole (SMX), trimethoprim (TMP) and N4-acetyl-sulfamethoxazole (acetyl-SMX) in synthetic fresh and hydrolyzed human urines by low-pressure UV, and UV combined with H2O2 and peroxydisulfate (PDS). The objective was to compare the two advanced oxidation processes (AOPs) and assess the impact of urine matrices. All three compounds reacted quickly in the AOPs, exhibiting rate constants of (6.09–8.53) × 109 M–1·s–1 with hydroxyl radical, and (2.35–16.1) × 109 M–1·s–1 with sulfate radical. In fresh urine matrix, the pharmaceuticals’ indirect photolysis was significantly suppressed by the scavenging effect of urine citrate and urea. In hydrolyzed urine matrix, the indirect photolysis was strongly affected by inorganic urine constituents. Chloride had no apparent impact on UV/H2O2, but significantly raised the hydroxyl radical concentration in UV/PDS. Carbonate species reacted with hydroxyl or sulfate radical to generate carbonate radical, which degraded SMX and TMP, primarily due to the presence of aromatic amino group(s) (k = 2.68 × 108 and 3.45 × 107 M–1·s–1) but reacted slowly with acetyl-SMX. Ammonia reacted with hydroxyl or sulfate radical to generate reactive nitrogen species that could react appreciably only with SMX. Kinetic simulation of radical concentrations, along with products analysis, helped elucidate the major reactive species in the pharmaceuticals’ degradation. Overall, the AOPs’ performance was higher in the hydrolyzed urine than fresh urine matrix with UV/PDS better than UV/H2O2, and varied significantly depending on pharmaceutical’s structure.
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IJS, KILJ, NUK, PNG, UL, UM
Detrital zircon provenance data for the Tananao schist in eastern Taiwan is consistent with its protolith being deposited on the South China continental margin at around, or soon after, 150Ma, rather ...than being of an exotic origin and much older as previously suggested. The absence of ca. 200Ma zircons agrees with the presence of a magmatic gap in the region after the orogenic and magmatic front migrated to central South China, due to a flat-slab subduction. The characteristic lack of input from interior South China (i.e., the lack of 1100–750Ma and 470–420Ma populations), and the immature nature of some of the schist units, suggest that they were sourced from the nearby coastal regions. On the other hand, they exhibit a dominant 190–150Ma magmatic zircon population, suggesting the presence of abundant magmatic rocks of that age along the coastal regions. This, along with our newly discovered ca. 180Ma I-type granites from eastern Zhejiang and other ca. 190–180Ma magmatic rocks recently reported from the coastal regions, led us to propose that a new continental arc was initiated after ca. 190Ma along the coastal region after a magmatic gap due to flat-slab subduction. This newly initiated arc likely persisted until ca. 90Ma, and is represented by the I-type granitic rocks in eastern Taiwan. Slab roll-back likely caused the arc system to retreat towards the Pacific Ocean after 90Ma, and ca. 60–17Ma bimodal magmatism adjacent to the South China Sea signifies continental margin extension in the lead-up to, and during, the opening of the South China Sea. We thus argue that the continental margin of East Asia was transformed from an Andean-type plate margin at 280–90Ma, to the present-day Western Pacific-type plate margin soon after 90Ma.
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► Support the flat-slab subduction model for Mesozoic South China. ► Confirm that a new continental magmatic arc was reinitiated as early as ca. 190Ma. ► Suggest an Andean-type plate margin during 280–90Ma. ► The Western Pacific-type plate margin started soon after ca. 90Ma.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The gut microbiota-derived metabolite, trimethylamine N-oxide (TMAO) plays an important role in cardiovascular disease (CVD). The fasting plasma TMAO was shown as a prognostic indicator of CVD ...incident in patients and raised the interest of intervention targeting gut microbiota. Here we develop a clinically applicable method called oral carnitine challenge test (OCCT) for TMAO-related therapeutic drug efforts assessment and personalising dietary guidance.
A pharmacokinetic study was performed to verify the design of OCCT protocol. The OCCT was conducted in 23 vegetarians and 34 omnivores to validate gut microbiota TMAO production capacity. The OCCT survey was integrated with gut microbiome, host genotypes, dietary records and serum biochemistry. A humanised gnotobiotic mice study was performed for translational validation.
The OCCT showed better efficacy than fasting plasma TMAO to identify TMAO producer phenotype. The omnivores exhibited a 10-fold higher OR to be high TMAO producer than vegetarians. The TMAO-associated taxa found by OCCT in this study were consistent with previous animal studies. The TMAO producer phenotypes were also reproduced in humanised gnotobiotic mice model. Besides, we found the faecal
gene was not associated with TMAO production; therefore, other key relevant microbial genes might be involved. Finally, we demonstrated the urine TMAO exhibited a strong positive correlation with plasma TMAO (r=0.92, p<0.0001) and improved the feasibility of OCCT.
The OCCT can be used to identify TMAO-producer phenotype of gut microbiota and may serve as a personal guidance in CVD prevention and treatment.
NCT02838732; Results.
Elimination of pharmaceuticals in source-separated human urine is a promising approach to minimize the pharmaceuticals in the environment. Although the degradation kinetics of pharmaceuticals by ...UV/H2O2 and UV/peroxydisulfate (PDS) processes has been investigated in synthetic fresh and hydrolyzed urine, comprehensive evaluation of the advanced oxidation processes (AOPs), such as product identification and toxicity testing, has not yet been performed. This study identified the transformation products of two commonly used antibiotics, trimethoprim (TMP) and sulfamethoxazole (SMX), by UV/H2O2 and UV/PDS in synthetic urine matrices. The effects of reactive species, including •OH, SO4 •–, CO3 •–, and reactive nitrogen species, on product generation were investigated. Multiple isomeric transformation products of TMP and SMX were observed, especially in the reaction with hydroxyl radical. SO4 •– and CO3 •– reacted with pharmaceuticals by electron transfer, thus producing similar major products. The main reactive species deduced on the basis of product generation are in good agreement with kinetic simulation of the advanced oxidation processes. A strain identified as a polyphosphate-accumulating organism was used to investigate the antimicrobial activity of the pharmaceuticals and their products. No antimicrobial property was detected for the transformation products of either TMP or SMX. Acute toxicity employing luminescent bacterium Vibrio qinghaiensis indicated 20–40% higher inhibitory effect of TMP and SMX after treatment. Ecotoxicity was estimated by quantitative structure–activity relationship analysis using ECOSAR.
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IJS, KILJ, NUK, PNG, UL, UM
Dysbiosis of the gut microbiome is associated with host health conditions. Many diseases have shown to have correlations with imbalanced microbiota, including obesity, inflammatory bowel disease, ...cancer, and even neurodegeneration disorders. Metabolomics studies targeting small molecule metabolites that impact the host metabolome and their biochemical functions have shown promise for studying host-gut microbiota interactions. Metabolome analysis determines the metabolites being discussed for their biological implications in host-gut microbiota interactions. To facilitate understanding the critical aspects of metabolome analysis, this article reviewed (1) the sample types used in host-gut microbiome studies; (2) mass spectrometry (MS)-based analytical methods and (3) useful tools for MS-based data processing/analysis. In addition to the most frequently used sample type, feces, we also discussed others biosamples, such as urine, plasma/serum, saliva, cerebrospinal fluid, exhaled breaths, and tissues, to better understand gut metabolite systemic effects on the whole organism. Gas chromatography-mass spectrometry (GC–MS), liquid chromatography-mass spectrometry (LC-MS), and capillary electrophoresis-mass spectrometry (CE-MS), three powerful tools that can be utilized to study host-gut microbiota interactions, are included with examples of their applications. After obtaining big data from MS-based instruments, noise removal, peak detection, missing value imputation, and data analysis are all important steps for acquiring valid results in host-gut microbiome research. The information provided in this review will help new researchers aiming to join this field by providing a global view of the analytical aspects involved in gut microbiota-related metabolomics studies.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Zeolitic imidazolate framework-67 (ZIF67) has been regarded as an effective energy storage material due to its high surface area and electroactive cobalt center. Carbonizing ZIF67 can enhance ...electrical conductivity by converting 2-methylimidazole (2-melm) to carbon with cobalt doping. In this work, a novel in situ electrospinning is proposed to fabricate carbonized ZIF67 on carbon fiber (C67@PAN-OC) as a freestanding supercapacitor electrode. Polyacrylonitrile solution containing a cobalt precursor is used for electrospinning, and produced fibers are immersed in 2-melm to form ZIF67. Individually grown carbonized ZIF67 on carbon fiber is obtained using the in situ electrospinning method, while the one-body mixed carbon electrode is formed using the ex situ electrospinning method. A highest specific capacitance (C F) of 386.3 F/g at 20 mV/s is obtained for the in situ synthesized C67@PAN-OC electrode due to the largest electrochemical surface area and the smallest resistance, while the ex situ synthesized electrode only shows a C F value of 27.7 F/g. A symmetric supercapacitor (SSC) assembled using the optimized C67@PAN-OC electrodes and gel electrolytes shows a maximum energy density of 9.64 kWh/kg at 0.55 kW/kg and a C F retention of 59.5% after 1000 times charge/discharge process. A C F retention of 75.6% after bending 100 times is also obtained for SSC.
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IJS, KILJ, NUK, PNG, UL, UM
Short-chain fatty acids (SCFAs) are gut microbial metabolites that promote the disease process in a rodent model of Parkinson disease (PD), but fecal levels of SCFAs in patients with PD are reduced. ...Simultaneous assessments of fecal and plasma SCFA levels, and their interrelationships with the PD disease process, are scarce. We aimed to compare fecal and plasma levels of different SCFA subtypes in patients with PD and healthy controls to delineate their interrelations and link to gut microbiota changes and clinical severity of PD.
A cohort of 96 patients with PD and 85 controls were recruited from National Taiwan University Hospital. Fecal and plasma concentrations of SCFAs were measured using chromatography and mass spectrometry. Gut microbiota was analyzed using metagenomic shotgun sequencing. Body mass index and medical comorbidities were evaluated and dietary information was obtained using a food frequency questionnaire. To assess motor and cognitive impairment, we used the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and the Mini-Mental Status Examination (MMSE).
Compared with controls, patients with PD had lower fecal but higher plasma concentrations of acetate, propionate, and butyrate. After adjustment for age, sex, disease duration, and anti-PD medication dosage, MDS-UPDRS part III motor scores correlated with reduced fecal levels of acetate (ρ = -0.37,
= 0.012), propionate (ρ = -0.32,
= 0.036), and butyrate (ρ = -0.40,
= 0.004) and with increased plasma propionate concentrations (ρ = 0.26,
= 0.042) in patients with PD. MMSE scores negatively correlated with plasma levels of butyrate (ρ = -0.09,
= 0.027) and valerate (ρ = -0.032,
= 0.033) after adjustment for confounders. SCFAs-producing gut bacteria correlated positively with fecal levels of SCFAs in healthy controls but revealed no association in patients with PD. In the PD patient group, the abundance of proinflammatory microbes, such as
and
, significantly correlated with decreased fecal levels and increased plasma levels of SCFAs, especially propionic acid.
Reductions in fecal SCFAs but increased plasma SCFAs were observed in patients with PD and corelated to specific gut microbiota changes and the clinical severity of PD.
This study provides Class III evidence that gut metabolite SCFAs distinguish between patients with PD and controls and are associated with disease severity in patients with PD.
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