This article presents the design and demonstration of a high-bandwidth antenna-in-package (AiP) module focusing on low-loss interconnects and Yagi-Uda antenna performance fabricated on a ...100-<inline-formula> <tex-math notation="LaTeX">\mu \text{m} </tex-math></inline-formula> low coefficient-of-thermal-expansion (CTE) glass for the 28-GHz band. It shows the modeling, design, and characterization of key technology building blocks along with the process development of advanced 3-D glass packages. The building blocks include impedance-matched antenna-to-die signal transitions, Yagi-Uda antenna, and 3-D active-passive integration with backside die assembly on 100-<inline-formula> <tex-math notation="LaTeX">\mu \text{m} </tex-math></inline-formula> glass substrates. The design and stack-up optimization of antenna-integrated millimeter-wave (mm-wave) modules is discussed. Process development to achieve high-density interconnects and precise dimensional control in multilayered thin glass-based packages is also described. The characterization results of the key technology building blocks show an insertion loss of 0.021 dB per through-package via (TPV), leading to the whole-chain loss of less than 1 dB and a return loss lower than 20 dB. The fabricated Yagi-Uda antenna features high repeatability of wide bandwidth due to the process control enabled by glass substrates. The antenna measurements show a bandwidth of 28.2%, which covers the entire 28-GHz fifth-generation (5G) frequency bands (n257, n258, and n261). The flip-chip assembled low-noise amplifier with 80-<inline-formula> <tex-math notation="LaTeX">\mu \text{m} </tex-math></inline-formula> solder balls shows a maximum gain of 20 dB as desired. The performance of the glass-based package integrated antennas is benchmarked to other 5G substrate technologies, such as organic laminates or co-fired ceramic-based substrates.
Highly hydrophilic cotton fabrics were rendered superhydrophobic via electrostatic layer-by-layer assembly of polyelectrolyte/silica nanoparticle multilayers on cotton fibers, followed with a ...fluoroalkylsilane treatment. The surface morphology of the silica nanoparticle-coated fibers, which results in the variety of the hydrophobicity, can be tailored by controlling the multilayer number. Although with the static contact angle larger than 150°, in the case of 1 or 3 multilayers, the fabrics showed sticky property with a high contact angle hysteresis (>45°). For the cotton fabrics assembled with 5 multilayers or more, slippery superhydrophobicity with a contact angle hysteresis lower than 10° was achieved. The buoyancy of the superhydrophobic fabric was examined by using a miniature boat made with the fabric. The superhydrophobic fabric boat exhibited a remarkable loading capacity; for a boat with a volume of 8.0
cm
3, the maximum loading was 11.6 or 12.2
g when the boat weight is included. Moreover, the superhydrophobic cotton fabric showed a reasonable durability to withstand at least 30 machine washing cycles.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Limited data are available on metabolic responses of plants to copper (Cu)-toxicity. Firstly, we investigated Cu-toxic effects on metabolomics, the levels of free amino acids, NH4+-N, NO3--N, total ...nitrogen, total soluble proteins, total phenolics, lignin, reduced glutathione (GSH) and malondialdehyde, and the activities of nitrogen-assimilatory enzymes in ‘Shatian’ pummelo (Citrus grandis) leaves. Then, a conjoint analysis of metabolomics, physiology and transcriptomics was performed. Herein, 59 upregulated 30 primary metabolites (PMs) and 29 secondary metabolites (SMs) and 52 downregulated (31 PMs and 21 SMs) metabolites were identified in Cu-toxic leaves. The toxicity of Cu to leaves was related to the Cu-induced accumulation of NH4+ and decrease of nitrogen assimilation. Metabolomics combined with physiology and transcriptomics revealed some adaptive responses of C. grandis leaves to Cu-toxicity, including (a) enhancing tryptophan metabolism and the levels of some amino acids and derivatives (tryptophan, phenylalanine, 5-hydroxy-l-tryptophan, 5-oxoproline and GSH); (b) increasing the accumulation of carbohydrates and alcohols and upregulating tricarboxylic acid cycle and the levels of some organic acids and derivatives (chlorogenic acid, quinic acid, d-tartaric acid and gallic acid o-hexoside); (c) reducing phospholipid (lysophosphatidylcholine and lysophosphatidylethanolamine) levels, increasing non-phosphate containing lipid monoacylglycerol ester (acyl 18:2) isomer 1 levels, and inducing low-phosphate-responsive gene expression; and (d) triggering the biosynthesis of some chelators (total phenolics, lignin, l-trytamine, indole, eriodictyol C-hexoside, quercetin 5-O-malonylhexosyl-hexoside, N-caffeoyl agmatine, N′-p-coumaroyl agmatine, hydroxy-methoxycinnamate and protocatechuic acid o-glucoside) and vitamins and derivatives (nicotinic acid-hexoside, B1 and methyl nicotinate). Cu-induced upregulation of many antioxidants could not protect Cu-toxic leaves from oxidative damage. To conclude, our findings corroborated the hypothesis that extensive reprogramming of metabolites was carried out in Cu-toxic C. grandis leaves in order to cope with Cu-toxicity.
Display omitted
•Citrus leaves underwent extensive metabolic reprograming under Cu-toxicity.•Cu impaired N assimilation in leaves, thus lowering Cu-tolerance.•Cu increased carbohydrates and alcohols levels and upregulated TCA cycle in leaves.•Cu triggered the biosynthesis of some chelators, vitamins and derivatives in leaves.•MDA accumulated in Cu-toxic leaves despite increased levels of some antioxidants.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Interconnected carbon nanofibrous membranes were prepared by conventional electrospinning and bicomponent electrospinning to produce polyvinylpyrrolidone (PVP)/polyacrylonitrile (PAN) blend ...nanofibers and PVP/PAN side-by-side bicomponent nanofibers, followed by a direct pyrolysis treatment. The inter-fiber connection was highly affected by the PVP/PAN ratio and electrospinning method. The carbon nanofibers prepared from the side-by-side PVP/PAN nanofibers were found to have higher electrochemical capacitance than those from the PVP/PAN blend nanofibers.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Mechanisms of traditional Chinese medicines in improving metabolic diseases by regulating the gut microbiota mainly includes the modulation of intestinal barrier function, metabolic endotoxemia, ...inflammation, short-chain fatty acids, gut-brain axis, and bile-acid metabolism.
Display omitted
•Traditional Chinese medicine significantly improve glucose and lipid metabolism by modulating the gut microbiota.•Traditional Chinese medicine could affect the abundance of mucin-degrading bacteria, bacteria with anti-inflammatory properties, lipopolysaccharide- and short-chain fatty acid-producing bacteria, and bacteria with bile-salt hydrolase activity.•Traditional Chinese medicine could protect the intestinal barrier function, modulate metabolic endotoxemia and inflammatory responses, regulate the effects of short-chain fatty acids, modulate the gut-brain axis, regulate bile acid and tryptophan metabolism.
Metabolic diseases such as obesity, type 2 diabetes mellitus, and hyperlipidemia are associated with the dysfunction of gut microbiota. Traditional Chinese medicines (TCMs) have shown considerable effects in the treatment of metabolic disorders by regulating the gut microbiota. However, the underlying mechanisms are unclear. Studies have shown that TCMs significantly affect glucose and lipid metabolism by modulating the gut microbiota, particularly mucin-degrading bacteria, bacteria with anti-inflammatory properties, lipopolysaccharide- and short-chain fatty acid (SCFA)-producing bacteria, and bacteria with bile-salt hydrolase activity. In this review, we explored potential mechanisms by which TCM improved metabolic disorders via regulating gut microbiota composition and functional structure. In particular, we focused on the protection of the intestinal barrier function, modulation of metabolic endotoxemia and inflammatory responses, regulation of the effects of SCFAs, modulation of the gut-brain axis, and regulation of bile acid metabolism and tryptophan metabolism as therapeutic mechanisms of TCMs in metabolic diseases.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Inorganic arsenic is highly toxic and carcinogenic to humans. Exposed individuals vary in their ability to metabolize arsenic, and variability in arsenic metabolism efficiency (AME) is associated ...with risks of arsenic-related toxicities. Inherited genetic variation in the 10q24.32 region, near the arsenic methyltransferase (AS3MT) gene, is associated with urine-based measures of AME in multiple arsenic-exposed populations. To identify potential causal variants in this region, we applied fine mapping approaches to targeted sequencing data generated for exposed individuals from Bangladeshi, American Indian, and European American populations (n = 2,357, 557, and 648 respectively). We identified three independent association signals for Bangladeshis, two for American Indians, and one for European Americans. The size of the confidence sets for each signal varied from 4 to 85 variants. There was one signal shared across all three populations, represented by the same SNP in American Indians and European Americans (rs191177668) and in strong linkage disequilibrium (LD) with a lead SNP in Bangladesh (rs145537350). Beyond this shared signal, differences in LD patterns, minor allele frequency (MAF) (e.g., rs12573221 ~13% in Bangladesh ~0.2% among American Indians), and/or heterogeneity in effect sizes across populations likely contributed to the apparent population specificity of the additional identified signals. One of our potential causal variants influences AS3MT expression and nearby DNA methylation in numerous GTEx tissue types (with rs4919690 as a likely causal variant). Several SNPs in our confidence sets overlap transcription factor binding sites and cis-regulatory elements (from ENCODE). Taken together, our analyses reveal multiple potential causal variants in the 10q24.32 region influencing AME, including a variant shared across populations, and elucidate potential biological mechanisms underlying the impact of genetic variation on AME.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Herein, we demonstrate that a flexible, air-permeable, thermoelectric (TE) power generator can be prepared by applying a TE polymer (e.g. poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate)) ...coated commercial fabric and subsequently by linking the coated strips with a conductive connection (e.g. using fine metal wires). The poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) coated fabric shows very stable TE properties from 300 K to 390 K. The fabric device can generate a TE voltage output (V) of 4.3 mV at a temperature difference (ΔT) of 75.2 K. The potential for using fabric TE devices to harvest body temperature energy has been discussed. Fabric-based TE devices may be useful for the development of new power generating clothing and self-powered wearable electronics.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Energy transferred via thermal radiation between two surfaces separated by nanometer distances can be much larger than the blackbody limit. However, realizing a scalable platform that utilizes this ...near-field energy exchange mechanism to generate electricity remains a challenge. Here, we present a fully integrated, reconfigurable and scalable platform operating in the near-field regime that performs controlled heat extraction and energy recycling. Our platform relies on an integrated nano-electromechanical system that enables precise positioning of a thermal emitter within nanometer distances from a room-temperature germanium photodetector to form a thermo-photovoltaic cell. We demonstrate over an order of magnitude enhancement of power generation (P
~ 1.25 μWcm
) in our thermo-photovoltaic cell by actively tuning the gap between a hot-emitter (T
~ 880 K) and the cold photodetector (T
~ 300 K) from ~ 500 nm down to ~ 100 nm. Our nano-electromechanical system consumes negligible tuning power (P
/P
~ 10
) and relies on scalable silicon-based process technologies.
Inherited genetic variation affects local gene expression and DNA methylation in humans. Most expression quantitative trait loci (cis-eQTLs) occur at the same genomic location as a methylation QTL ...(cis-meQTL), suggesting a common causal variant and shared mechanism. Using DNA and RNA from peripheral blood of Bangladeshi individuals, here we use co-localization methods to identify eQTL-meQTL pairs likely to share a causal variant. We use partial correlation and mediation analyses to identify >400 of these pairs showing evidence of a causal relationship between expression and methylation (i.e., shared mechanism) with many additional pairs we are underpowered to detect. These co-localized pairs are enriched for SNPs showing opposite associations with expression and methylation, although many SNPs affect multiple CpGs in opposite directions. This work demonstrates the pervasiveness of co-regulated expression and methylation in the human genome. Applying this approach to other types of molecular QTLs can enhance our understanding of regulatory mechanisms.
•The traditional mineralization path of CN− was overturned in a novel Electro-Fenton system.•CN− could be converted into NO3− but not CNO− by the synergy of •OH and •O2−.•The Electro-Fenton system ...shows the feasibility of practical application for the actual cyanide residue eluent.
Traditional methods of cyanides’ (CN−) mineralization cannot overcome the contradiction between the high alkalinity required for the inhibition of hydrogen cyanide evolution and the low alkalinity required for the efficient hydrolysis of cyanate (CNO−) intermediates. Thus, in this study, a novel Electro-Fenton system was constructed, in which the free cyanides released from ferricyanide photolysis can be efficiently mineralized by the synergy of •OH and •O2−. The complex bonds in ferricyanide (100 mL, 0.25 mM) were completely broken within 80 min under ultraviolet radiation, releasing free cyanides. Subsequently, in combination with the heterogeneous Electro-Fenton process, •OH and •O2− were simultaneously generated and 92.9% of free cyanides were transformed into NO3- within 120 min. No low-toxic CNO− intermediates were accumulated during the Electro-Fenton process. A new conversion mechanism was proposed that CN− was activated into electron-deficient cyanide radical (•CN) by •OH, and then the •CN intermediates reacted with •O2− via nucleophilic addition to quickly form NO3-, preventing the formation of CNO− and promoting the mineralization of cyanide. Furthermore, this new strategy was used to treat the actual cyanide residue eluent, achieving rapid recovery of irons and efficient mineralization of cyanides. In conclusion, this study proposes a new approach for the mineralization treatment of cyanide-containing wastewater.
Display omitted .
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
PDF
