This paper calls for a paradigm shift in studying academic dependency, toward the paradigm of brokered dependency. Using Chinese academia as an example, I demonstrate how the neocolonial condition of ...academic dependency is always mediated through blockage-brokerage mechanisms. The two most salient blockage-brokerage mechanisms of dependency in the Chinese context are linguistic barrier and authoritarian malepistemization, and the effects of the latter consist of three layers: institutional, informational, and incorporational. On top of their domestic impacts, those mechanisms jointly exacerbate spectacularized postcoloniality in anglophone-hegemonic global academic publishing. The paradigm of brokered dependency not only represents a more nuanced approach to the study of academic dependency, but also underscores the fact that the dismantling of the neocolonial condition cannot be conceived and pursued in isolation from comprehending and confronting the authoritarian condition, especially when the latter pertains under the disguise of anticolonialism.
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NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
This article examines the puzzling phenomenon that many Chinese liberal intellectuals fervently idolize Donald Trump and embrace the alt-right ideologies he epitomizes. Rejecting 'pure tactic' and ...'neoliberal affinity' explanations, it argues that the Trumpian metamorphosis of Chinese liberal intellectuals is precipitated by their 'beacon complex', which has 'political' and 'civilizational' components. Political beaconism grows from the traumatizing lived experience of Maoist totalitarianism, sanitizes the West and particularly the United States as politically near-perfect, and gives rise to both a neoliberal affinity and a latent hostility toward baizuo. Civilizational beaconism, sharing with its nationalistic counterpart-civilizational vindicativism-the heritages of scientific racism and social Darwinism imported in late-Qing, renders the Chinese liberal intelligentsia receptive to anti-immigrant and Islamophobic paranoia, exacerbates its anti-baizuo sentiments, and catalyzes its Trumpian convergence with Chinese non-liberals.
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BFBNIB, DOBA, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Accessing and exploring large‐scale genomics data sets remains a significant challenge to researchers without specialist bioinformatics training. We present the integrated PlantGenIE.org platform for ...exploration of Populus, conifer and Arabidopsis genomics data, which includes expression networks and associated visualization tools. Standard features of a model organism database are provided, including genome browsers, gene list annotation, Blast homology searches and gene information pages. Community annotation updating is supported via integration of WebApollo. We have produced an RNA‐sequencing (RNA‐Seq) expression atlas for Populus tremula and have integrated these data within the expression tools. An updated version of the ComPlEx resource for performing comparative plant expression analyses of gene coexpression network conservation between species has also been integrated. The PlantGenIE.org platform provides intuitive access to large‐scale and genome‐wide genomics data from model forest tree species, facilitating both community contributions to annotation improvement and tools supporting use of the included data resources to inform biological insight.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NMLJ, NUK, OILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
Chronic mitochondrial stress associates with major neurodegenerative diseases. Recovering stressed mitochondria constitutes a critical step of mitochondrial quality control and thus energy ...maintenance in early stages of neurodegeneration. Here, we reveal Mul1-Mfn2 pathway that maintains neuronal mitochondrial integrity under stress conditions. Mul1 deficiency increases Mfn2 activity that triggers the first phasic mitochondrial hyperfusion and also acts as an ER-Mito tethering antagonist. Reduced ER-Mito coupling leads to increased cytoplasmic Ca
load that activates calcineurin and induces the second phasic Drp1-dependent mitochondrial fragmentation and mitophagy. Overexpressing Mfn2, but not Mfn1, mimics Mul1-deficient phenotypes, while expressing PTPIP51, an ER-Mito anchoring protein, suppresses Parkin-mediated mitophagy. Thus, by regulating mitochondrial morphology and ER-Mito contacts, Mul1-Mfn2 pathway plays an early checkpoint role in maintaining mitochondrial integrity. Our study provides new mechanistic insights into neuronal mitochondrial maintenance under stress conditions, which is relevant to several major neurodegenerative diseases associated with mitochondrial dysfunction and altered ER-Mito interplay.
The conformable fractional derivative was proposed by R. Khalil et al. in 2014, which is natural and obeys the Leibniz rule and chain rule. Based on the properties, a class of time-fractional partial ...differential equations can be reduced into ODEs using traveling wave transformation. Then the simplest equation method is applied to find exact solutions of some time-fractional partial differential equations. The exact solutions (solitary wave solutions, periodic function solutions, rational function solutions) of time-fractional generalized Burgers equation, time-fractional generalized KdV equation, time-fractional generalized Sharma–Tasso–Olver (FSTO) equation and time-fractional fifth-order KdV equation, (3+1)-dimensional time-fractional KdV–Zakharov–Kuznetsov (KdV–ZK) equation are constructed. This method presents a wide applicability to solve some nonlinear time-fractional differential equations with conformable derivative.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging ...probes and therapeutics. We show in different mouse models that the TCASS system accumulates in solid tumours. The molecules show enhanced accumulation in tumour regions via the effect of recognition induced self-assembly. Analysis of the molecular penetration in tumour tissue shows that in vivo self-assembly increases the penetration capability compared to typical soft or hard nanomaterials. Importantly, the in vivo self-assembled molecules exhibit a comparable clearance pathway to that of small molecules, which are excreted from organs of the reticuloendothelial system (liver and kidney), while are relatively slowly eliminated from tumour tissues. Finally, this system, combined with the NIR probe, shows high specificity and sensitivity for detecting bladder cancer in isolated intact patient bladders.
Abstract
In this paper, new fast computing methods for partial differential equations with variable coefficients are studied and analyzed. They are two kinds of two‐sided Krylov enhanced proper ...orthogonal decomposition (KPOD) methods. First, the spatial discrete scheme of an advection‐diffusion equation is obtained by Galerkin approximation. Then, an algorithm based on a two‐sided KPOD approach involving the block Arnoldi and block Lanczos processes for the obtained time‐varying equations is put forward. Moreover, another type of two‐sided KPOD algorithm based on Laguerre orthogonal polynomials in frequency domain is provided. For the two kinds of two‐sided KPOD methods, we present a theoretical analysis for the moment matching of the discrete time‐invariant transfer function in time domain and give the error bound caused by the reduced‐order projection between the Galerkin finite element solution and the approximate solution of the two‐sided KPOD method. Finally, the feasibility of four two‐sided KPOD algorithms is verified by several numerical results with different inputs and setting parameters.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
SARS‐CoV‐2 nucleocapsid (N) protein has been proposed as a good vaccine target. N‐specific T cells were observed in SARS‐CoV‐2 N immunized mice and COVID‐19 convalescents. It is of importance to ...identify the T cell responses triggered by SARS‐CoV‐2 N protein. Intradermal immunization with SARS‐CoV N protein was demonstrated to elicit non‐protective T cell responses which may be avoided by intranasal vaccination. Therefore, we conducted intranasal vaccination of BALB/c mice with recombinant adenovirus type‐5 expressing SARS‐CoV‐2 N protein. Such procedure induced CD8 T cell responses in the lung. Meanwhile CD4 T cell responses were observed in the spleen, which was associated with robust antibody production. Our study further supports the notion that SARS‐CoV‐2 N protein can work as a target for vaccine development.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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