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  • Search-and-replace genome e... Search-and-replace genome editing without double-strand breaks or donor DNA
    Anzalone, Andrew V; Randolph, Peyton B; Davis, Jessie R ... Nature (London), 12/2019, Volume: 576, Issue: 7785
    Journal Article
    Peer reviewed
    Open access

    Most genetic variants that contribute to disease are challenging to correct efficiently and without excess byproducts . Here we describe prime editing, a versatile and precise genome editing method ...
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42.
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43.
  • Development of potent in vi... Development of potent in vivo mutagenesis plasmids with broad mutational spectra
    Badran, Ahmed H; Liu, David R Nature communications, 10/2015, Volume: 6, Issue: 1
    Journal Article
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    Open access

    Methods to enhance random mutagenesis in cells offer advantages over in vitro mutagenesis, but current in vivo methods suffer from a lack of control, genomic instability, low efficiency and narrow ...
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44.
  • Phage-assisted continuous a... Phage-assisted continuous and non-continuous evolution
    Miller, Shannon M; Wang, Tina; Liu, David R Nature protocols, 12/2020, Volume: 15, Issue: 12
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    Directed evolution, which applies the principles of Darwinian evolution to a laboratory setting, is a powerful strategy for generating biomolecules with diverse and tailored properties. This ...
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45.
  • Phage-assisted continuous e... Phage-assisted continuous evolution of proteases with altered substrate specificity
    Packer, Michael S; Rees, Holly A; Liu, David R Nature communications, 10/2017, Volume: 8, Issue: 1
    Journal Article
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    Open access

    Here we perform phage-assisted continuous evolution (PACE) of TEV protease, which canonically cleaves ENLYFQS, to cleave a very different target sequence, HPLVGHM, that is present in human IL-23. A ...
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46.
  • Increasing the genome-targe... Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
    Kim, Y Bill; Komor, Alexis C; Levy, Jonathan M ... Nature biotechnology, 04/2017, Volume: 35, Issue: 4
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    Open access

    Base editing induces single-nucleotide changes in the DNA of living cells using a fusion protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase, and an ...
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47.
  • The developing toolkit of c... The developing toolkit of continuous directed evolution
    Morrison, Mary S; Podracky, Christopher J; Liu, David R Nature chemical biology, 06/2020, Volume: 16, Issue: 6
    Journal Article
    Peer reviewed

    Continuous directed evolution methods allow the key steps of evolution-gene diversification, selection, and replication-to proceed in the laboratory with minimal researcher intervention. As a result, ...
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48.
  • Parosmia is Associated with... Parosmia is Associated with Relevant Olfactory Recovery After Olfactory Training
    Liu, David T.; Sabha, Maha; Damm, Michael ... The Laryngoscope, March 2021, 2021-03-00, 20210301, Volume: 131, Issue: 3
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    Objective/Hypothesis This study aims to determine the association between parosmia and clinically relevant recovery of olfactory function in patients with post‐infectious olfactory dysfunction (PIOD) ...
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  • Phosphoglycerate Kinase 1 P... Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
    Qian, Xu; Li, Xinjian; Cai, Qingsong ... Molecular cell, 03/2017, Volume: 65, Issue: 5
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    Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism underlying autophagy initiation remains to be defined. Here, we demonstrate that glutamine deprivation and ...
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  • In vivo base editing of pos... In vivo base editing of post-mitotic sensory cells
    Yeh, Wei-Hsi; Chiang, Hao; Rees, Holly A ... Nature communications, 06/2018, Volume: 9, Issue: 1
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    Programmable nucleases can introduce precise changes to genomic DNA through homology-directed repair (HDR). Unfortunately, HDR is largely restricted to mitotic cells, and is typically accompanied by ...
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