•Flower-liked ZnO architectures and Ce doped ZnO materials were successfully synthesized by a simple precipitation route.•Ce doping can improve the sensing performance of ZnO-based gas sensor by ...adjusting the proportion of oxygen species.•0.5 at% Ce/ZnO exhibited the highest response to ethanol and the response value was about 72.6 to 100 ppm ethanol.
Flower-liked ZnO architectures and Ce doped ZnO materials with different amounts (0.2, 0.5, 1.2 and 2 at% Ce) were successfully synthesized by a simple room-temperature precipitation route. As the gas sensing materials, their sensing performance were investigated systematically. The results indicate that Ce doping can improve the performance of ZnO sensor. The ZnO doped with 0.5 at% Ce exhibited the highest response to ethanol at the operating temperature of 300 °C, and the response value was about 72.6–100 ppm ethanol. With Ce doping, the proportions of oxygen vacancy and chemisorbed oxygen species were increased obviously, which could greatly promote the gas sensing properties of surface resistance-type metal oxide semiconductors. Thus, the doping of flower-liked ZnO with Ce should be a promising approach for designing and fabricating the high performance gas sensor.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Epilepsy is one of the most common neurological disorders in childhood. However, classical antiepileptic drugs are linked with drug toxicity and cognitive function impairment in children. Hence, it ...is essential to develop a novel therapy to solve this problem. Currently, studies indicate regulating the nuclear factor-erythroid 2-related factor 2 (Nrf2)-mediated ferroptosis pathway represents a potential advanced therapy for seizures. Hence, the present study aimed to explore whether quercetin, a natural polyphenol, could alleviate seizure-induced neuron death and preserve cognitive function by inhibiting Nrf2-mediated ferroptosis.
Kainic acid-induced epileptic mice model, morris water maze (MWM) test, cell counting kit-8 (CCK-8) assays, western blotting analysis, enzyme-linked immunosorbent assay, flow cytometry, quantitative real-time reverse transcription PCR (qRT-PCR), immunofluorescence staining, and RNA sequencing analysis were employed to explore the potential mechanisms by which quercetin exerts protective effects on seizure-induced neuron death in kainic acid-induced epileptic mice model and glutamate-induced HT22 neuronal cell death.
Our findings suggested the association between the Nrf2-mediated ferroptosis pathway and seizures in a clinical setting. Quercetin pretreatment alleviates seizure-like behaviors and cognitive impairment in KA-induced epileptic mice. Additionally, in vitro, co-treatment with quercetin effectively exerts neuroprotective effects in glutamate-induced HT22 neuronal cell death. These protective effects were also closely linked to regulating the Nrf2-mediated ferroptosis pathway. Furthermore, bioinformatic profiling revealed that the SIRT1/Nrf2/SLC7A11/GPX4 pathway plays a crucial role in the Glu-induced HT22 cell death pretreated with quercetin.
These findings indicated that quercetin effectively protects against seizure-induced neuron death in vivo and in vitro and alleviates cognitive function impairment via the SIRT1/Nrf2/SLC7A11/GPX4 pathway.
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•The Nrf2-mediated ferroptosis pathway might be associated with the occurrence of seizures in a clinical setting.•Ferroptosis is involved in seizure-induced neuronal death in vivo and in vitro.•Quercetin exerts neuroprotective effects in kainic acid-induced epileptic mice via the SIRT1/Nrf2/SLC7A11/GPX4 pathway.•Quercetin could alleviate kainic acid-induced cognitive impairment through the Nrf2-mediated ferroptosis pathway.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•ZnO/g-C3N4 composite was synthesized through ultrasonic mixing and subsequent calcination process.•10 wt% g-C3N4 loaded ZnO exhibits excellent NO2 sensing at room temperature under 460 nm light ...illumination.•The excellent sensing performance can be attributed to the absorbance of g-C3N4 and charge separation between ZnO and g-C3N4.
In this work, 2D/2D ZnO/g-C3N4 heterojunction composite was synthesized through an ultrasonic mixing and subsequent calcination process. The gas-sensing performance to NO2 was investigated at room temperature activated by visible/ultra-violet LED light sources. Noticeably, when ZnO/g-C3N4 composite is illuminated by 460 nm light, it exhibits the highest response of 44.8 to 7 ppm NO2, and the response and recovery time is 142 and 190 s, respectively. Furthermore, it possesses excellent repeatability and selectivity to NO2, and the limit of detection is 38 ppb. In addition, the effect of humidity on the sensing performance under visible light was also investigated. The excellent gas-sensing performance is attributed to the absorbance of g-C3N4 in the visible light region and the charge separation at the interface between ZnO and g-C3N4.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
To effectively photocatalytic removal of Cr (VI), this work focuses on constructing the inorganic-organic hybridized heterojunction composite photocatalyst of Ag/AgCl/NH2-MIL-88B (Fe), where the ...Ag/AgCl nanoparticles were deposited on the surface of mesoporous NH2-MIL-88B (Fe) via a simple photo-assisted reduction method. The formation of the ternary Ag/AgCl/NH2-MIL-88B (Fe) composite presented more stable and higher photocatalytic reduction performance for Cr (VI) removal than that of MIL-88B (Fe) photocatalyst. Its photo-reduction rate reached to 85.7%, which was ascribed to its high separation and migration efficiency of photogenerated electrons and holes pair. The formed heterojunction structure and surface plasmon resonance effect originated from Ag/AgCl could largely enhance the absorption capacity of visible light, which promotes the excitation of photogenerated electrons, accelerates their transfer, and reduces the recombination rate of electrons and holes. Besides, a possible catalytic mechanism of this reaction is proposed by the photo-induced charge transfer path in the Ag/AgCl/NH2-MIL-88B (Fe) inorganic-organic hybridized system.
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•Ag/AgCl/NH2-MIL-88B (Fe) ternary heterostructure composite was constructed.•Its photocatalytic reduction efficiency for Cr (VI) reached to 85.7%.•The formation of the heterojunction and the SPR effect of Ag/AgCl improved photocatalytic activity effectively.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
High resolution sediment records in the Yangtze Delta front were constructed to reveal recent environmental changes in response to river basin human activities. Increases in nutrient and organic C ...influxes that began in the 1950s, together with elevated primary productivity and increased chemical fertilizer application, suggested a shift toward anthropogenic-predominated environmental changes during this period. The depletion of total organic C (TOC), total N (TN), and biogenic Si (BSi), along with the decline in sedimentation rate and coarsening of sediment coincided with the development of hydrological engineering in the river basin from the 1980s. Reservoir Si retention substantially altered river mouth primary productivity community composition from diatoms to non-diatoms, thereby changing the BSi/TOC molar ratio in the sediment profile. Estimation of biogenic component burial fluxes was conducted to assess the variation and potential impacts. A recent dramatic decline in biogenic component burial in the delta area suggested a low nutrient removal efficiency in this region, due to the decrease in sediment discharge. Consequently, more nutrients have been further transported to the inner shelf and open waters instead of being buried in the delta sediment, thereby increasing the environmental pressure in the Yangtze Delta and adjoining coastal area.
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•The decline in nutrient burial rate suggested low nutrient removal efficiency.•The anthropogenic-predominated environmental changes began in the 1950s.•Increasing hydrological engineering induced the depletion of nutrients since 1980s.
A recent decline in nutrient burial in the Yangtze Delta was found suggesting decreasing nutrient removal efficiency and increasing environmental pressure.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•A simple, rapid colorimetric platform has been proposed for detection of Ag+ by naked eyes.•The glutathione-mediated MnO2 nanosheets can catalyze colorless TMB into blue oxTMB instantaneously.•The ...limit of detection is 4.23nM, which is of sensitivity to existing other methods.•The proposed colorimetric sensor is of high sensitive and selectivity in water and practical samples.
We described a rapid and highly sensitive colorimetric method for the detection and quantification of silver ions employing glutathione (GSH)-mediated MnO2 nanosheets as an artificial oxidase. In this assay,the absorption intensity of the chromogenic reaction system enabled the quantification of silver ions. Under the optimum conditions, the linear response ranged for Ag+ was from 10nM to 800nM with a correlation coefficient of 0.996. Remarkably, limit of detection in aqueous solutions was 4.23nM, which was well below United States Environmental Protection Agency (USEPA) permissible limit in drinking water (460nM). This sensing assay had highly specificity because no significant interference occurred with 10-fold concentration of other metal ions. Moreover, the approach also could be employed to the Ag+ detection in real samples. And the recovery of Ag+ spiked in tap water ranged from 99.62% to 108.01%. Importantly, the oxidation reaction of TMB to oxTMB by MnO2 nanosheets completed instantaneously even by naked-eye readout. Therefore, the assay based on GSH-mediated MnO2 nanosheets is simple, rapid, highly sensitive and selective for the quantification of Ag+ in water and practical samples.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
A simple, visible and smartphone readable strategy has been proposed for the sensitive detection and discrimination of multiple proteins. By employing five different concentrations of NaCl salt, AuNP ...exhibited different aggregation behavior for different proteins because of differential ion strength, leading to diverse color changes. The sensing system could not only discriminate twelve proteins at the concentration of 50 nM in aqueous solution, but it could also discriminate these proteins at 200 nM in the presence of human urine with an accuracy of 100%. More importantly, based on the theory of chromatics, we could directly read out the color value using a smartphone to distinguish twelve proteins, pure Lys and HSA at various concentrations, and the mixture of these two proteins in the presence of human urine with no confusion after a hierarchical clustering analysis (HCA). The inexpensive and convenient colorimetric sensor array using the ubiquitous smartphone for signal readout has great potential for the point-of-care diagnosis without additional devices.
Many practitioners, such as pilots, frequently face working memory (WM) demands under acute stress environments, while the effect of acute stress on WM has not been conclusively studied because it is ...moderated by a variety of factors. The current study investigated how acute stress affects pilots' WM under different memory load conditions. There are 42 pilots conducting the experiments, consisting of 21 stress group participants experiencing the Trier Social Stress Test (TSST) and 21 control group participants experiencing the controlled TSST (C-TSST). Subsequently, both groups performed N-back tasks under three memory load conditions (0-back, 1-back, and 2-back). State Anxiety Inventory (S-AI), heart rate (HR), and salivary cortisol concentrations (SCC) were collected to analyze acute stress induction. The results revealed that (1) the TSST could effectively induce acute stress with higher S-AI, HR, and SCC; (2) higher memory load reduces WM accuracy (ACC) and delays response times (RT); (3) acute stress increases WM ACC under moderate load conditions (1-back task). These results suggest that acute stress may not necessarily impair WM and even improve WM performance under certain memory load conditions. Potential mechanisms of acute stress effects on WM and alternative explanations for the modulatory role of memory load consistent with the emotion and motivation regulation theory are discussed. These findings not only provide insight into the field of acute stress and WM but are also beneficial for pilot training and the development of stress management strategies.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Antimicrobial peptides (AMPs) have attracted more attention for their potential candidates for new antibiotic drugs. As a novel identified cathelicidin AMP from duck, dCATH owns broad-spectrum ...antimicrobial activities but with a noticeable toxicity. To explore dCATH-derived AMPs with reduced cell toxicity and improved cell selectivity, a series of truncated and tryptophan-replaced peptides of dCATH were designed. Two truncated peptides containing one of the two tryptophan (Trp) residues at the positions of 4 and 17 (W4 and W17) of dCATH, dCATH(1–16) and dCATH(5–20), showed strong antibacterial activity, but didn’t show obvious hemolytic activity and cytotoxicity. The derived peptides not containing Trp didn’t possess obvious antimicrobial activity, and their hemolytic and cytotoxic effect was also diminished. Also as evidence by Trp fluorescence experiment that existence of W4 and W17 was crucially important to the antimicrobial activity, hemolysis and cytotoxicity of dCATH, and one of the two Trp residues was competent and necessary to retain its antimicrobial activity. Antibacterial mechanism analysis showed that dCATH(1–16) and dCATH(5–20) killed bacterial cells by increasing permeability and causing a loss of membrane integrity. dCATH(1–16) and dCATH(5–20) possessed insignificant inhibitory activity against levels of IL-6, TNF-α, and NO in RAW 264.7 cells treated with LPS.
In vivo
, intraperitoneal administration of the two peptides significantly decreased mortality and provided protection against LPS-induced inflammation in mice challenged with lethal dose of LPS. The two peptides, dCATH(1–16) and dCATH(5–20), which possessed high antibacterial activity and cell selectivity, may herald development prospects as new antibacterial agents in the future.
Colon adenocarcinoma (COAD) is one of the most common malignancies, and its metastatic lesions are the leading cause of death in COAD patients. PANoptosis is a recently identified pathway for ...programmed cell death implicated in developing COAD. Long non-coding RNAs (lncRNAs) are key regulators of cancer occurrence and progress. Although their function has captured much attention in COAD, the relationship between COAD metastasis-associated lncRNA expression and PANoptosis remains elusive. Therefore, this study aimed to explore the potential regulatory roles of metastasis- and PANoptosis-associated lncRNAs in COAD. Nine lncRNAs associated with metastasis and PANoptosis in COAD were identified from The Cancer Genome Atlas (TCGA) and GEO databases. Their functions were analyzed by multiple bioinformatics methods, and the lncRNA-miRNA-mRNA network was constructed. Multivariate Cox analysis identified one lncRNA (SNHG7) significantly related to COAD prognosis. Subsequent analyses showed its expression correlated with tumor stage and lymph node metastasis. Moreover, drug sensitivity analysis and
experiments suggest that lncRNA SNHG7 contributes to drug resistance in COAD. In summary, lncRNA SNHG7 is a potential target for diagnosing and treating COAD and plays a crucial role in regulating apoptosis, metastasis, and drug resistance in COAD.
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