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  • Marine Biosurfactants: Bios... Marine Biosurfactants: Biosynthesis, Structural Diversity and Biotechnological Applications
    Kubicki, Sonja; Bollinger, Alexander; Katzke, Nadine ... Marine drugs, 07/2019, Volume: 17, Issue: 7
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    Biosurfactants are amphiphilic secondary metabolites produced by microorganisms. Marine bacteria have recently emerged as a rich source for these natural products which exhibit surface-active ...
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  • Phototrophic purple bacteri... Phototrophic purple bacteria as optoacoustic in vivo reporters of macrophage activity
    Peters, Lena; Weidenfeld, Ina; Klemm, Uwe ... Nature communications, 03/2019, Volume: 10, Issue: 1
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    Τhe morphology, physiology and immunology, of solid tumors exhibit spatial heterogeneity which complicates our understanding of cancer progression and therapy response. Understanding spatial ...
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  • Agar plate‐based screening ... Agar plate‐based screening methods for the identification of polyester hydrolysis by Pseudomonas species
    Molitor, Rebecka; Bollinger, Alexander; Kubicki, Sonja ... Microbial Biotechnology, January 2020, Volume: 13, Issue: 1
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    Summary Hydrolases acting on polyesters like cutin, polycaprolactone or polyethylene terephthalate (PET) are of interest for several biotechnological applications like waste treatment, biocatalysis ...
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  • Pseudomonas putida—a versat... Pseudomonas putida—a versatile host for the production of natural products
    Loeschcke, Anita; Thies, Stephan Applied microbiology and biotechnology, 08/2015, Volume: 99, Issue: 15
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    The biosynthesis of natural products by heterologous expression of biosynthetic pathways in amenable production strains enables biotechnological access to a variety of valuable compounds by ...
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  • Comparative Single-Cell Ana... Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation
    Binder, Dennis; Probst, Christopher; Grünberger, Alexander ... PloS one, 08/2016, Volume: 11, Issue: 8
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    Recombinant protein production is mostly realized with large-scale cultivations and monitored at the level of the entire population. Detailed knowledge of cell-to-cell variations with respect to ...
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  • Natural biocide cocktails: ... Natural biocide cocktails: Combinatorial antibiotic effects of prodigiosin and biosurfactants
    Hage-Hülsmann, Jennifer; Grünberger, Alexander; Thies, Stephan ... PloS one, 07/2018, Volume: 13, Issue: 7
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    Bacterial secondary metabolites are naturally produced to prevail amongst competitors in a shared habitat and thus represent a valuable source for antibiotic discovery. The transformation of newly ...
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  • Pseudomonas putida rDNA is ... Pseudomonas putida rDNA is a favored site for the expression of biosynthetic genes
    Domröse, Andreas; Hage-Hülsmann, Jennifer; Thies, Stephan ... Scientific reports, 05/2019, Volume: 9, Issue: 1
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    Since high-value bacterial secondary metabolites, including antibiotics, are often naturally produced in only low amounts, their efficient biosynthesis typically requires the transfer of entire ...
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  • Engineering of natural prod... Engineering of natural product biosynthesis in Pseudomonas putida
    Loeschcke, Anita; Thies, Stephan Current opinion in biotechnology, October 2020, 2020-10-00, 20201001, Volume: 65
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    Display omitted •Valuable natural products can be accessed via engineered microbes.•The soil bacterium Pseudomonas putida represents an effective production host.•Products are rhamnolipids, ...
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9.
  • Integration of Genetic and ... Integration of Genetic and Process Engineering for Optimized Rhamnolipid Production Using Pseudomonas putida
    Tiso, Till; Ihling, Nina; Kubicki, Sonja ... Frontiers in bioengineering and biotechnology, 08/2020, Volume: 8
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    Rhamnolipids are biosurfactants produced by microorganisms with the potential to replace synthetic compounds with petrochemical origin. To promote industrial use of rhamnolipids, recombinant ...
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  • The photosynthetic bacteria... The photosynthetic bacteria Rhodobacter capsulatus and Synechocystis sp. PCC 6803 as new hosts for cyclic plant triterpene biosynthesis
    Loeschcke, Anita; Dienst, Dennis; Wewer, Vera ... PloS one, 12/2017, Volume: 12, Issue: 12
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    Cyclic triterpenes constitute one of the most diverse groups of plant natural products. Besides the intriguing biochemistry of their biosynthetic pathways, plant triterpenes exhibit versatile ...
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