Mastitis, upala mliječne žlijezde jedna je od tri glavne bolesti koje utječu na profitabilnost proizvođača mlijeka i najskuplja bolest intenzivnog mliječnog govedarstva. Ekonomski gubici nastaju zbog ...odbacivanja mlijeka, povećanog izlučenja krava, troškova lijekova, rada veterinara i rada samih stočara. Međutim, sve je više dokaza da hranidba može imati značajan učinak na imunosni sustav, čime utječe na incidenciju infekcije i tijek mastitisa. Glavni utjecaj hranidbe na zdravlje vimena je putem supresije imunosnog sustava. Loš sastav obroka ne uzrokuje mastitis, ali može olakšati bakterijama da se udomaće u mliječnoj žlijezdi, što rezultira povećanom stopom mastitisa. Mliječna žlijezda krava često je izložena potencijalnim patogenima, ali većina krava ne dobije mastitis jer je njihov imunosni sustav adekvatan da spriječi infekciju. Cilj ovog rada je rasvijetliti povezanost između određenih minerala iz hrane i mastisa u mliječnih krava. Minerali dokazano imaju učinak na proizvodnju i reprodukciju, a njihov nedostatak može rezultirati imunosupresijom. Minerali koji utječu na zdravlje vimena su: selen, bakar, cink, kalcij, fosfor, magnezij, sumpor, mangan i molibden.
Mastitis, an inflammation of the mammary gland, is one of the three main diseases that affect the profitability of milk producers and the most expensive disease of intensive dairy cattle farming. Economic losses occur due to the rejection of milk, increased excretion of cows, the cost of medicines, the work of veterinarians, and the work of the herdsmen themselves. However, there is increasing evidence that nutrition can have a significant effect on the immune system, thereby influencing the incidence of infections and the course of mastitis. The main influence of feeding on udder health is through the suppression of the immune system. A poor diet does not cause mastitis, but it can make it easier for bacteria to colonize the mammary gland, resulting in an increased rate of mastitis. The mammary gland of cows is often exposed to potential pathogens, but most cows do not develop mastitis because their immune systems are adequate to prevent infection. This work aims to describe the relationship between certain minerals from food and mastitis in dairy cows. Minerals have been proven to affect production and reproduction, and their deficiency can result in immunosuppression. Minerals that affect the health of the udder are selenium, copper, zinc, calcium, phosphorus, magnesium, sulfur, manganese, and molybdenum.
Prirodni zeolit klinoptilolit je mikroporozni alumosilikatni mineral čvrste anionske rešetke, otvorene trodimenzionalne strukture u čijim porama su izmjenjivi kationi. Dodatak zeolita u obroku sve se ...više primjenjuje u hranidbi životinja. Cilj pokusa bio je ustanoviti utjecaj dodatka mikroniziranog zeolita klinoptilolita na zdravlje vimena i sastav mlijeka krava različitih laktacija u uvjetima robotizirane mužnje. Krave su hranjene parcijalnim obrokom za krave u mužnji (PMR) s dodatkom 200 g po kravi mikroniziranog zeolita klinoptilolita (Zeotex®, Mevex, Hrvatska) i koncentratom na robotskoj jedinici za hranjenje, tijekom 42 dana pokusa. Značajno (P<0,05) manji broj somatskih stanica utvrđen je u mlijeku krava 1. i 2. laktacije nakon 42 dana konzumacije zeolita u odnosu na početak pokusa. Udio mliječne masti u mlijeku krava 1. laktacije bio je značajno (P<0,05) veći nakon 42 dana konzumacije zeolita u odnosu na početak i 21. dan pokusa. Značajno (P<0,05) veća koncentracija ureje u mlijeku utvrđena je nakon 21 dan konzumacije zeolita okusa u odnosu na početak pokusa kod krava nižih laktacija. Značajno (P>0,05) smanjenje broja somatskih stanica nakon 42 dana primjene zeolita u obroku mliječnih krava potvrđuje sposobnost zeolita da pozitivno utječe na zdravlje vimena. Smanjenje broja somatskih stanica samo kod krava u 1. i 2. laktaciji daje naslutiti ograničenu sposobnost zeolita prema kroničnim infekcijama vimena kod krava viših laktacija. Značajno (P<0,05), ali prolazno povećanje ureje u mlijeku 21. dana pokusa, vjerojatno je odraz prilagodbe mikropopulacije buraga na novonastale uvjete hranidbe dodatkom zeolita. Povećanje udjela mliječne masti kod krava u prvoj laktaciji govori u prilog pozitivnog djelovanja zeolita na poboljšanje kvalitete mlijeka.
Natural zeolite clinoptilolite is a microporous aluminosilicate mineral of an open three-dimensional solid anionic lattice structure with pores of exchangeable cations. The addition of zeolite in the diet is increasingly being used in animal nutrition. The aim of the experiment was to establish the effect of micronized clinoptilolite zeolite on udder health and milk composition of cows of different lactations under conditions of robotic milking. Cows were fed a partial mixed ration (PMR) for milking cows with the addition of 200 g per cow of micronized clinoptilolite zeolite (Zeotex®, Mevex, Croatia) and concentrate on a robotic feeding unit for 42 days of the experiment. Significantly (P <0.05) lower number of somatic cells was found in the milk of 1st and 2nd lactation cows after 42 days of zeolite supplementation compared to the beginning of the experiment. The content of milk fat in the milk of lactating cows was significantly (P <0.05) higher on the 42nd day of the experiment compared to the beginning and the 21st day of the experiment. Significantly (P <0.05) higher urea concentration in milk was found on the 21st day of the experiment compared to the beginning of the experiment in lower lactating cows. A significant (P> 0.05) reduction in the number of somatic cells after 42 days of zeolite application in the diet of dairy cows confirms the ability of zeolite to positively affect udder health. The decrease in the number of somatic cells in cows of only 1st and 2nd lactation suggests a limited ability of zeolites to chronic udder infections in higher lactating cows. Significant (P <0.05), but transient increase in urea in milk on day 21 of the experiment, is probably a reflection of the adaptation of the rumen micropopulation to the new feeding conditions with the addition of zeolite. The increase in the content of milk fat in cows in the first lactation speaks in favor of the positive effect of zeolite and the improvement of milk quality.
Increased platelet reactivity and decreased response to antiplatelet drugs may result in recurrent ischemic events after acute coronary syndrome (ACS). We evaluated laboratory response to aspirin in ...patients with ACS before and after percutaneous coronary intervention (PCI) and assessed its effect on major adverse clinical events. Sixty-three consecutive patients with ACS were tested for response to aspirin by light transmittance aggregometry (LTA) and the IMPACT-R test (with arachidonic acid) before and 2 to 4 days after PCI and clopidogrel loading. Patients were followed for clinical events up to 15 months from PCI. Response to aspirin improved significantly after PCI and clopidogrel treatment (mean arachidonic acid–induced LTA decreased from 34.9 ± 3.35% before PCI to 15.2 ± 2.2% and surface coverage increased from 2.2 ± 0.27% to 6.2 ± 0.6%, p <0.0001 for the 2 methods). Improved response to aspirin after PCI correlated with response to clopidogrel (LTA and IMPACT-R, p <0.01). Patients with good laboratory response to aspirin before but not after PCI had a significantly lower major cardiovascular event rate during 15-month follow-up in multivariate analysis. In conclusion, laboratory response to aspirin is highly dynamic in patients with ACS. Improved response to aspirin after PCI may result from stabilization of coronary artery disease and/or clopidogrel treatment. Laboratory response to aspirin before PCI and clopidogrel loading is a sensitive marker for platelet reactivity that correlates with clinical outcome in patients with ACS.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Objectives This study sought to investigate the blood pressure (BP) response after transcatheter aortic valve implantation (TAVI) and its correlation with short- and mid-term clinical outcomes. ...Background TAVI is an emerging therapy for aortic stenosis patients at high surgical risk. The acute hemodynamic sequelae of this procedure and their clinical relevance are yet unclear. Methods Consecutive patients who underwent TAVI in a single center were prospectively monitored for BP response during 5 post-procedural days. Clinical parameters, adverse events, and medical treatment were recorded during hospitalization, at 30 days, and at 12 months after the procedure. Patients were divided according to their post-procedural BP response into 2 groups: increased BP and stable BP. Results One hundred and five patients were analyzed. Overall, systolic BP increased immediately after TAVI in the entire cohort by an average of 15 ± 31 mm Hg. This rise was sustained and led to intensification of antihypertensive treatment in 53 patients (51%); these patients were designated as the increased BP group. The increase in systolic BP after TAVI was associated with an increase in stroke volume and cardiac output and was not related to age, baseline cardiac function, or procedural outcomes. Patients with increased BP after TAVI had a significantly better prognosis with fewer adverse events in the hospital (21% vs. 62%, p < 0.01), after 30 days (30% vs. 71%, p < 0.01), and after 12 months (53% vs. 83%, p < 0.01) as compared with patients with stable BP. Conclusions After TAVI, a substantial number of patients have a significant rise in systolic BP necessitating long-term treatment. This increase in BP is associated with an increase in cardiac output and predicts a better clinical outcome.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Limited data are available regarding the incidence and clinical impact of renal dysfunction following cardioversion of atrial fibrillation. The objective of this study was to assess the incidence and ...implications of renal dysfunction following cardioversion of atrial fibrillation.
We conducted a nested case-control study to determine the incidence, timing, risk factors and outcome of atrial fibrillation cardioversion associated with renal dysfunction (AFCARD) in a tertiary medical center. Consecutive patients undergoing direct current cardioversion (DCCV) for atrial fibrillation in our institution during 2008-2009 with measurements of creatinine before and following cardioversion were included. AFCARD was defined as a rise in serum creatinine greater than 25% from baseline within a week following DCCV.
One hundred and twelve patients were included in the study, of whom 19 (17%) developed AFCARD. One patient required hemodialysis. Patients with AFCARD had a higher incidence of advanced heart failure, diabetes mellitus and were more frequently treated with digoxin and enoxaparin. Patients with AFCARD had a significantly decreased survival rate at 1 year (63 vs. 92%; p < 0.001).
AFCARD is relatively common and is associated with increased mortality. These findings suggest a role for close surveillance of renal function following DCCV.
This study sought to investigate the blood pressure (BP) response after transcatheter aortic valve implantation (TAVI) and its correlation with short- and mid-term clinical outcomes.
TAVI is an ...emerging therapy for aortic stenosis patients at high surgical risk. The acute hemodynamic sequelae of this procedure and their clinical relevance are yet unclear.
Consecutive patients who underwent TAVI in a single center were prospectively monitored for BP response during 5 post-procedural days. Clinical parameters, adverse events, and medical treatment were recorded during hospitalization, at 30 days, and at 12 months after the procedure. Patients were divided according to their post-procedural BP response into 2 groups: increased BP and stable BP.
One hundred and five patients were analyzed. Overall, systolic BP increased immediately after TAVI in the entire cohort by an average of 15 ± 31 mm Hg. This rise was sustained and led to intensification of antihypertensive treatment in 53 patients (51%); these patients were designated as the increased BP group. The increase in systolic BP after TAVI was associated with an increase in stroke volume and cardiac output and was not related to age, baseline cardiac function, or procedural outcomes. Patients with increased BP after TAVI had a significantly better prognosis with fewer adverse events in the hospital (21% vs. 62%, p < 0.01), after 30 days (30% vs. 71%, p < 0.01), and after 12 months (53% vs. 83%, p < 0.01) as compared with patients with stable BP.
After TAVI, a substantial number of patients have a significant rise in systolic BP necessitating long-term treatment. This increase in BP is associated with an increase in cardiac output and predicts a better clinical outcome.
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Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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