The aquatic environment presents daily and/or seasonal variations in dissolved oxygen (DO) levels. Piava faces different DO levels in the water due to its distributional characteristics. The goal of ...this study was to describe the effects of low DO levels on plasma ion, biochemical and oxidative variables in piava juveniles. Fish were exposed to different DO levels, including 1.0, 2.0, 3.0, 4.0 and 5.0 mg L-1 of DO for 96 h, after which blood and tissue samples (liver, kidney, gill and muscle) were collected. The decrease in DO levels decreased plasma Na+, Cl-, K+ and NH3 levels as well as protein and glycogen levels in the liver, kidney and muscle; increased Na+/K+-ATPase activity in the gills and kidney as well as glucose and ammonia levels in the liver, kidney and muscle; and increased lactate levels in the kidney and muscle. Thiobarbituric acid-reacting substances, catalase and non-protein thiol levels decreased in the tissues of piavas exposed to low DO levels. It is concluded that piava can apparently cope with hypoxic conditions; however, low DO levels are a stressor, and the tolerance of piava to hypoxia involves iono-regulatory, metabolic and oxidative adjustments.
El presente trabajo analiza dos comedias homónimas, tituladas El rey Enrique el enfermo, pero totalmente diferentes con respecto al género, a la articulación de la intriga y a la psicología de las ...dramatis personae. Ambas con probabilidad fueron compuestas por seis ingenios (Moreto, Cáncer y Velasco, Martínez de Meneses, Villaviciosa, Rosete y Zabaleta) a mediados del siglo diecisiete, y tienen como protagonista a Enrique III de Castilla "el Doliente" (1393-1406) y a algunos personajes de su corte, a pesar de que las referencias históricas escasean y el interés se centra en la trama de argumento amoroso y en la presentación de la figura del soberano, frágil y enfermizo (como consta en la tradición histórica y literaria que se ocupa de él), pero firme defensor de su poder y de los valores monárquicos frente a una nobleza altanera y conflictiva. Tras considerar la compleja transmisión textual de las dos piezas, se examinan las notables divergencias y algunas convergencias entre ellas, subrayando el hecho de que ambas se sirven del pasado para referirse al presente, como suele suceder en el drama áureo de fondo histórico, y criticar veladamente la política de los últimos Austrias, Felipe IV y Carlos II, durante cuyo reinado estas comedias se redactaron y representaron.
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Prendendo il via dalla grande tradizione di studi lorchiani e dalla messe di versioni della poesia e della drammaturgia del granadino in Italia, ci si concentra sulla più recente edizione bilingue (a ...cura di Enrico Di Pastena per i tipi della pisana ETS, 2019) dell’ultima tragedia dell’autore, La casa de Bernarda Alba, composta nel 1936 a pochi mesi dalla morte, e rappresentata postuma per la prima volta l’8 marzo 1945, a Buenos Aires. Capolavoro indiscusso del teatro di García Lorca, l’opera è la più tradotta e messa in scena tra le sue pièces, anche in Italia, dove per primo la restituì nella nostra lingua Amedeo Recanati, nel 1946. L’edizione di Di Pastena, accompagnata da un esaustivo apparato esegetico, viene qui analizzata per quanto riguarda l’efficace traduzione, la brillante disamina dei temi e motivi principali di questo cupo dramma della prigionia e dell’intransigenza, e l’accurata ricostruzione di un buon numero di suoi allestimenti scenici, dagli anni Quaranta a oggi, sui palcoscenici europei, in particolare spagnoli e italiani.
As part of our ongoing studies involving the discovery of new natural prototypes with antiprotozoal activity against Trypanosoma cruzi from Brazilian plant species, the chromatographic fractionation ...of hexane extract from leaves of Nectandra barbellata afforded one new pseudo-disesquiterpenoid, barbellatanic acid. The structure of this compound was elucidated by NMR and HR-ESIMS data analysis. Barbellatanic acid displayed a trypanocidal effect with IC50 of 13.2 μM to trypomastigotes and no toxicity against NCTC cells (CC50 > 200 μM), resulting in an SI value higher than 15.1. The investigation of the lethal mechanism of barbellatanic acid in trypomastigotes, using both fluorescence microscopy and spectrofluorimetric analysis, revealed a time-dependent permeation of the plasma membrane. Based on these results, this compound was incorporated in cellular membrane models built with lipid Langmuir monolayers. The interaction of barbellatanic acid with the models was inferred by tensiometric, rheological, spectroscopical, and morphological techniques, which showed that this compound altered the thermodynamic, viscoelastic, structural, and morphological properties of the film. Taking together, these results could be employed when this prodrug interacts with lipidic interfaces, such as protozoa membranes or liposomes for drug delivery systems.
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•Barbellatanic acid was isolated from the leaves of Nectandra barbellata.•Structure of barbellatanic acid was elucidated by analysis of NMR and MS data.•Barbellatanic acid displayed activity against trypomastigote forms of Trypanosoma cruzi.•Barbellatanic acid permeated the plasma membrane and altered the physicochemical properties of cell membrane models.
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Taking as a departing point the great tradition of Lorca studies and the vast
number of versions of his poetry and theatre in Italy, this article analyses the most recent
bilingual edition (prepared ...by Enrico Di Pastena, Pisa, ETS, 2019) of Lorca’s last tragedy,
La casa de Bernarda Alba, written in 1936 and staged for the first time on March 8th, 1945
in Buenos Aires. This work is Lorca’s dramatic masterpiece and the most translated and
staged among his plays, even in Italy, where Amedeo Recanati translated it for the first
time in 1946. Di Pastena’s edition is considered as regards its effective translation, the
study of its main topics and the accurate description of a good number of its European
performances (particularly in Spain and Italy) from the forties onwards.
Prendendo il via dalla grande tradizione di studi lorchiani e dalla messe di versioni della poesia e della drammaturgia del granadino in Italia, ci si concentra sulla più recente edizione bilingue (a cura di Enrico Di Pastena per i tipi della pisana ETS, 2019) dell’ultima tragedia dell’autore, La casa de Bernarda Alba, composta nel 1936 a pochi mesi dalla morte, e rappresentata postuma per la prima volta l’8 marzo 1945, a Buenos Aires. Capolavoro indiscusso del teatro di García Lorca, l’opera è la più tradotta e messa in scena tra le sue pièces, anche in Italia, dove per primo la restituì nella nostra lingua Amedeo Recanati, nel 1946. L’edizione di Di Pastena, accompagnata da un esaustivo apparato esegetico, viene qui analizzata per quanto riguarda l’efficace traduzione, la brillante disamina dei temi e motivi principali di questo cupo dramma della prigionia e dell’intransigenza, e l’accurata ricostruzione di un buon numero di suoi allestimenti scenici, dagli anni Quaranta a oggi, sui palcoscenici europei, in particolare spagnoli e italiani.
Review of Di Pastena, E.; Nardoni, V. (a cura di) (2019).
Federico García Lorca: Poema del cante jondo, seguito da Architettura del cante jondo
. Firenze: Passigli, 186 pp.
Resumo Este artigo apresenta um estado da arte sobre grupos de pesquisa em educação matemática. É feita a análise de um conjunto de 25 trabalhos encontrados na Biblioteca Digital Brasileira de Teses ...e Dissertações e no Google Acadêmico. Os principais resultados evidenciaram a presença de artigos publicados em periódicos pelo Grupo de Pesquisa História Oral e Educação Matemática e de trabalhos que analisam/descrevem aspectos de trajetória, constituição, identidade, habitus científico, funcionamento, colaboração e/ou produção científica dos grupos de pesquisa. Conclui-se que pesquisas futuras podem privilegiar a magnitude dos grupos de pesquisa em educação matemática no Brasil.
Abstract This article presents a state of the art about research groups in mathematics education as an object of study. We analyzed a set of 25 papers validated in a survey at the Brazilian Digital Library of Theses and Dissertations and Google Scholar, elucidating their authors, titles, themes, areas of investigation and methodological approaches. The main results evidenced the presence of articles published in periodicals, by the Oral History and Mathematics Education Research Group, and works that analyze/describe aspects of trajectory, constitution, identity, scientific habitus, functioning, collaboration and/or scientific production of the research groups. We argue that future research may privilege the magnitude of research groups in mathematics education in Brazil.
Resumen Presentamos un estado del arte sobre los grupos de investigación en educación matemática como objeto de estudio. Analizamos un conjunto de 25 trabajos encontrados en la Biblioteca Digital Brasileña de Tesis y Disertaciones y en Google académico. Los principales resultados evidenciaron la presencia de artículos publicados en publicaciones periódicas por el Grupo de Investigación Historia Oral y Educación Matemática, y de trabajos que analizan/describen aspectos de trayectoria, constitución, identidad, habitus científico, funcionamiento, colaboración y/o producción científica de los grupos de investigación. Sostenemos que las investigaciones futuras pueden privilegiar la magnitud de los grupos de investigación en educación matemática en Brasil.
Résumé Présentation d’un état de l’art sur des études au sujet des groupes de recherche sur l’enseignement des mathématiques un ensemble de 25 travaux validés par un inventaire à la Bibliothèque Numérique Brésilienne de Thèses et Dissertations et au Google Académique a été analysé. Les principaux résultats ont mis en évidence l’existence d’articles parus dans des périodiques, par le Groupe de Recherche Histoire Orale et Enseignement Mathématique, et de travaux qui analysent/décrivent des aspects du parcours, de la constitution, de l’identité, de l’habitus scientifique, du fonctionnement, de la collaboration et/ou de la production scientifique des ces groupes de recherche. On soutient que des recherches futures peuvent rendre compte de l’ampleur des groupes de recherche sur l’enseignement des mathématiques au Brésil.
This study was designed to evaluate the response of hematological and biochemical parameters submitted to pegbovigrastim administration and postchallenge with lipopolysaccharide (LPS). In experiment ...1, 20 newborn Holstein calves were divided into 2 groups: the Imrestor (Elanco Saúde Animal, São Paulo, Brazil) group (IMR, n = 10), which received a 25 μg/kg of body weight (BW) subcutaneous administration of pegbovigrastim, and the control group (CTR, n = 10), which received a subcutaneous administration of 0.9% saline solution. Blood samples were collected on d 0, 10, 12, and 14 relative to birth to analyze the biochemical and hematological parameters. Moreover, growth measurements were taken on d 0, 7, 14, 21, and 60 relative to birth. The number of total leukocytes in the IMR group increased on d 12 and 14 in comparison to the CTR group, as well as the counts of segmented neutrophils, band cells, and monocytes. No differences were observed in the other hematological, biochemical, and growth parameters. In experiment 2, 20 Holstein calves from 30 to 60 d old were divided into 4 groups: group 1 (LPS, n = 5) received a 0.25 μg/kg of BW single intravenous dose of Escherichia coli LPS at d 0; group 2 (IMR, n = 5) received a 25 μg/kg of BW subcutaneous dose of pegbovigrastim at d 1; group 3 (IMR + LPS, n = 5) received a 0.25 μg/kg of BW intravenous LPS dose at d 0 and a 25 μg/kg of BW subcutaneous dose of pegbovigrastim at d 1; and group 4 (CTR, n = 5) received an intravenous dose of 0.9% sodium chloride at d 0 and a subcutaneous dose of 0.9% sodium chloride at d 1. For the analysis of biochemical and hematological parameters, blood samples were collected on d −1, 0, 1, 2, 3, 4, 8, 14, and 21 relative to LPS administration. An increase in the number of total leukocytes was observed in the IMR, IMR + LPS, and LPS groups, and the IMR group remained as the highest from d 2 to 21. The levels of paraoxonase 1 were higher in the IMR group compared with all the others. The administration of pegbovigrastim in the dairy calves increased the number of circulating leukocytes, especially neutrophils, with an increase in paraoxonase 1, without altering the metabolites for the hepatic function.
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