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The hypernuclear matter is studied within the relativistic Hartree-Fock theory employing several parametrizations of the hypernuclear density functional with density-dependent couplings. The ...equations of state and compositions of hypernuclear matter are determined for each parametrization and compact stars are constructed by solving their structure equations in spherical symmetry. We quantify the softening effect of Fock terms on the equation of state, as well as discuss the impact of tensor interactions, which are absent in the Hartree theories. Starting from models of density functionals which are fixed in the nuclear sector to the nuclear phenomenology, we vary the couplings in the hyperonic sector around the central values which are fitted to the hyperon potentials in nuclear matter. We use the
SU
(6) spin-flavor and
SU
(3) flavor symmetric quark models to relate the hyperonic couplings to the nucleonic ones. We find, consistent with previous Hartree studies, that for the
SU
(6) model the maximal masses of compact stars are below the two-solar mass limit. In the
SU
(3) model we find sufficiently massive compact stars with cores composed predominantly of
Λ
and
Ξ
hyperons and a low fraction of leptons (mostly electrons). The parameter space of the
SU
(3) model is identified where simultaneously hypernuclear compact stars obey the astrophysical limits on pulsar masses and the empirical hypernuclear potentials in nuclear matter are reproduced.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, SIK, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The effectiveness of inactivated SARS-CoV-2 vaccines against the Delta variant, which has been associated with greater transmissibility and virulence, remains unclear. We conducted a test-negative ...case-control study to explore the vaccine effectiveness (VE) in real-world settings. We recruited participants aged 18-59 years who consisted of SARS-CoV-2 test-positive cases (n = 74) and test-negative controls (n = 292) during the outbreak of the Delta variant in May 2021 in Guangzhou city, China. Vaccination status was compared to estimate The VE of SARS-CoV-2 inactivated vaccines. A single dose of inactivated SARS-CoV-2 vaccine yielded the VE of only 13.8%. After adjusting for age and sex, the overall VE for two-dose vaccination was 59.0% (95% confidence interval: 16.0% to 81.6%) against coronavirus disease 2019 (COVID-19) and 70.2% (95% confidence interval: 29.6-89.3%) against moderate COVID-19 and 100% against severe COVID-19 which might be overestimated due to the small sample size. The VE of two-dose vaccination against COVID-19 reached 72.5% among participants aged 40-59 years, and was higher in females than in males against COVID-19 and moderate diseases. While single dose vaccination was not sufficiently protective, the two-dose dosing scheme of the inactivated vaccines was effective against the Delta variant infection in real-world settings, with the estimated efficacy exceeding the World Health Organization minimal threshold of 50%.
Food safety is an important public health issue, and deep learning (DL) algorithms can provide powerful tools and methods for food safety and authenticity detection. Compared with chemometric ...algorithms and traditional machine learning algorithms, the performances of DL algorithms are improved in many aspects. By learning and analyzing a large amount of data, DL models can improve the efficiency and accuracy of food safety and authenticity detection, helping to ensure the public health and safety.
This paper reviews some commonly used chemometric algorithms, traditional machine learning algorithms, and popular DL algorithms. Among them, special attentions are paid to convolutional neural network (CNN), fully convolutional network (FCN) and generative adversarial network (GAN). Moreover, the auxiliary effect of GAN on CNN is highlighted. Finally, this paper revisits recent applications of DL algorithms in the field of food safety and authenticity detection, and prospects the challenges and future directions of DL algorithms in this field.
Although DL has made many achievements in the field of food safety and authenticity detection, there is still a great potential for development. For example, the data augmentation function of GAN can assist CNN to obtain more training samples, thus improving the recognition rate. In addition, multimodal neural network (MNN) or multimodal attention network (MAN) can be also used to achieve the fusion of data from different modalities to further improve the robustness and accuracy of DL algorithms.
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•Some popular DL algorithms in food safety and authenticity detection are introduced.•The improvements of DL algorithms to chemometric and ML algorithms are summarized.•Recent applications of DL algorithms in food safety and authenticity detection are reviewed.•Future prospects of DL algorithms in food safety and authenticity detection are discussed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•MS-based untargeted metabolomics was firstly proposed to identify origins of Chinese wines.•There was strong correlation between geographical origins and metabolic profiles of wines.•The ...differential metabolites were screened as markers by OPLS-DA with pairwise modeling.•Tentative identification of differential metabolites was conducted based on MS and MS2 data.•Reliable OPLS-DA models based on markers were constructed for predicting origins of wines.
Identifying geographical origins of red wines made in specific regions is of significance since the false claim of geographical origins has been frequently exposed in China's wine industry. In this work, an untargeted metabolomic approach based on UPLC-QTOF-MS was established to discriminate geographical origins of Chinese red wines. The principal component analysis (PCA) showed significant differences between wine samples from three famous geographical origins in China. The metabolites contributing to the differentiation were screened by orthogonal partial least squares-discriminant analysis (OPLS-DA) with pairwise modeling. 40 and 46 differential metabolites in positive and negative ionization modes were putatively identified as chemical markers. Furthermore, heatmap visualization and OPLS-DA models were constructed based on these identified markers and external verification wine samples from different regions were successfully discriminated, with recognition rate up to 96.7%. This study indicated that UPLC-QTOF-MS-based untargeted metabolomics has great potential for the geographical origin traceability of Chinese red wines.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Accumulation of saturated fatty acids in the liver can cause nonalcoholic fatty liver disease (NAFLD). This study investigated saturated fatty acid induction of endoplasmic reticulum (ER) stress and ...apoptosis in human liver cells and the underlying causal mechanism. Human liver L02 and HepG2 cell lines were exposed to the saturated fatty acid sodium palmitate. MTT assay was used for cell viability, flow cytometry and Hoechst 33258 staining for apoptosis, RT-PCR for mRNA expression, and Western blot for protein expression. Silence of PRK-like ER kinase (PERK) expression in liver cells was through transient transfection of PERK shRNA. Treatment of L02 and HepG2 cells with sodium palmitate reduced cell viability through induction of apoptosis. Sodium palmitate also induced ER stress in the cells, indicated by upregulation of PERK phosphorylation and expression of BiP, ATF4, and CHOP proteins. Sodium palmitate had little effect on activating XBP-1, a common target of the other two canonical sensors of ER stress, ATF6, and IRE1. Knockdown of PERK gene expression suppressed the PERK/ATF4/CHOP signaling pathway during sodium palmitate-induced ER stress and significantly inhibited sodium palmitate-induced apoptosis in L02 and HepG2 cells. Saturated fatty acid-induced ER stress and apoptosis in these human liver cells were enacted through the PERK/ATF4/CHOP signaling pathway. Future study is warranted to investigate the role of these proteins in mediating saturated fatty acid-induced NAFLD in animal models.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The novel nuclear structure in neutron-rich nuclei — the new magicity N=32 and 34 has been confirmed by the intensive experiment measurements (F. Wienholtz et al. (2013) 17; D. Steppenbeck et al. ...(2013) 22; S. Michimasa et al. (2018) 28; etc.). However, the underlying mechanism of the new magicity is still under discussion. In this letter, we present a new mechanism that the strong couplings between the s1/2 (including both neutron and proton ones with different principle numbers) and neutron (ν) ν2p1/2 orbits, referred as “Dirac inversion partners” (DIPs) which are of the same total angular momentums but opposite parity, play a key role in opening both subshells at N=32 and 34. Such strong couplings originate from the inversion similarity between the DIPs, that the upper component of the Dirac spinor of one partner shares the same angular momentum as the lower component of the other, and vice versa. Following the revealed mechanism, it is predicted that on the proton deficient side (Z⩽20) the magicity N=32 is reserved from 52Ca until 48S, but vanishes in 46Si.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Dysregulation of the balance between cell proliferation and cell death is a central feature of malignances. Death-associated protein kinase 3 (DAPK3) regulates programmed cell death including ...apoptosis and autophagy. Our previous study showed that DAPK3 downregulation was detected in more than half of gastric cancers (GCs), which was related to tumor invasion, metastasis, and poor prognosis. However, the precise molecular mechanism underlying DAPK3-mediated tumor suppression remains unclear. Here, we showed that the tumor suppressive function of DAPK3 was dependent on autophagy process. Mass spectrometry, in vitro kinase assay, and immunoprecipitation revealed that DAPK3 increased ULK1 activity by direct ULK1 phosphorylation at Ser556. ULK1 phosphorylation by DAPK3 facilitates the ULK1 complex formation, the VPS34 complex activation, and autophagy induction upon starvation. The kinase activity of DAPK3 and ULK1 Ser556 phosphorylation were required for DAPK3-modulated tumor suppression. The coordinate expression of DAPK3 with ULK1 Ser556 phosphorylation was confirmed in clinical GC samples, and this co-expression was correlated with favorable survival outcomes in patients. Collectively, these findings indicate that the tumor-suppressor roles of DAPK3 in GC are associated with autophagy and that DAPK3 is a novel autophagy regulator, which can directly phosphorylate ULK1 and activate ULK1. Thus, DAPK3 might be a promising prognostic autophagy-associated marker.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Unveiled as a unique feature of polymer ferroelectric crystals, oriented coalescence within monolayers of poly(vinylidenefluoride‐co‐trifluoroethylene)(PVDF‐TrFE) ferroelectric crystals has been ...found regulable upon monolayer roughness, which is accompanied by the adjustment of piezoelectric responses, and thus phase polarity. Simply with the deposition of poly(3‐hexylthiophene (P3HT)‐wrapped molybdenum disulfide (MoS2) sheets, piezoelectric responses of polymer ferroelectric crystals are surprisingly enhanced further. Also dependent on the degrees of phase polarity, the binding energy of P3HT excitons declines to a level comparable to that of inorganic excitons, together with the alteration of work functions. These results suggest mutual polarization between ferroelectric lamellar crystals and originally nonpolar P3HT‐wrapped MoS2 sheets as a result of dipole‐induced dipole phase interactions. As the Fermi levels and driving forces of interfacial electron transition are also adjustable upon involved phase interactions, P3HT‐wrapped MoS2 sheets can photocatalyze hydrogen evolution with an average production rate reaching 4.474 mmol g−1 h−1, which is 1.6 times higher than the results without the aid of phase interactions. Accordingly, amplifying phase interactions has been elucidated feasible, and able to serve as a promising approach to generally promote photocatalytic reactions.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
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